scholarly journals Successful transatlantic bilateral hand transplant in a young female highly sensitized to HLA class II antigens

2021 ◽  
Vol 65 ◽  
pp. 101377
Author(s):  
Saïd C. Azoury ◽  
F. Bradley Johnson ◽  
Matthew Levine ◽  
Stephanie Veasey ◽  
Christine McAndrew ◽  
...  
Keyword(s):  
Class Ii ◽  
Young Female ◽  
Hla Class Ii ◽  
Class Ii Antigens

scholarly journals Inhibitor (IK) of IFN-γ induced HLA class II antigens expression also inhibits HLA class II constitutive expression in the human Raji B cell line

Oncogene ◽  
1997 ◽  
Vol 14 (12) ◽  
pp. 1453-1461 ◽  
Author(s):  
Jocelyn Vedrenne ◽  
Eric Assier ◽  
Raffaele Pereno ◽  
Haniaa Bouzinba-Segard ◽  
Bruno Azzarone ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Line ◽  
Constitutive Expression ◽  
Class Ii ◽  
Hla Class Ii ◽  
Ifn Γ ◽  
Class Ii Antigens

scholarly journals HLA class II antigens and haplotypes associated with susceptibility of leukemias and myelodysplastic syndrome

Genetika ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. 361-370
Author(s):  
Svetlana Vojvodic ◽  
Dusica Ademovic-Sazdanic
Keyword(s):  
Risk Factors ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Hla Antigens ◽  
Positive Association ◽  
Class Ii ◽  
Hla Class Ii ◽  
Negative Association ◽  
Male Patients ◽  
Class Ii Antigens

Genetical and environmental factors play an interactive role in the development of acute and chronic leukemias. HLA antigens have been considered as possible genetic risk factors. The aim of this work was to investigate a possible association between HLA class II polymorphisms and leukemias and myelodysplastic syndrome. In the present study we investigated HLA class II antigens, DR/DQ and DR51/DR52/DR53 haplotypes in 100 patients: 7 suffering from myelodysplastic syndrome (MDS),37 from acute lymphoblastic leukemia(ALL),32 from acute myeloid leukemia (AML) and 24 from chronic myeloid leukemia(CML). A panel of 210 healthy unrelated individuals of the same origin, from Vojvodina, served as controls. HLA phenotyping was performed by two color fluorescence method. In patients suffering from MDS was found a positive association with DR7(RR=2.598,EF=0.175) and DQ7(3)(RR=4.419, EF=0.632), while negative association was found for DR15(2)(RR=0.405, PF=0.172) and DQ6(1) (RR=0.889, PF=0,936).Positive association was found in the group of patients with ALL for DR7(RR=2.391,EF=0.688) and DQ2(RR=1.62, EF=0.15),while negative association was found with DQ5(1)(RR=0.075, PF=0.324). In the group of patients with AML, there were positive associations with DR11(5)(RR=1.732,EF=0.211),DQ2(RR= 1.594, EF=0.151) and DQ7(3) (RR=2.547,EF=0.266),while possible protective antigen was DQ5(1) (RR=0.107,RF=0.701). Higher RR than 1 and EF>0.15, in patients suffering from CML was found for DQ6(1)(RR=1.661,EF=0.232), while negative association was found for DR4 (RR=0.182,PF=0.155).Possible protective haplotype in this study was DR3DQ8(3) for patients suffering from AML(RR=0.007, PF=0.501).The distribution of DR53-DR53 haplotypes showed significant difference in male patients with ALL(6% vs 0.09%), while DR52-DR52 haplotype was significantly less frequent in male patients with CML (4% vs 20.47%) and female patients with MDS (1% vs 18.57%), respectively, in comparison to controls. We deduced that DR7 antigen in male patients with ALL has the greatest impact to the higher frequency of DR53-DR53 haplotype in this type of leukemia. The role of HLA antigens as risk factors for development of leukemias in our population was shown and furthermore it could be useful in clinical practice.

HLA Class II Antigens on Melanoma Cells

1990 ◽  
pp. 197-211 ◽  
Author(s):  
G. Parmiani ◽  
A. Anichini ◽  
C. Castelli ◽  
G. Fossati
Keyword(s):  
Class Ii ◽  
Melanoma Cells ◽  
Hla Class Ii ◽  
Class Ii Antigens

Human Leukocyte Antigen-DR Expression is Significantly Related to an Increased Disease-Free and Disease-Specific Survival in Patients With Cervical Adenocarcinoma

2016 ◽  
Vol 26 (8) ◽  
pp. 1503-1509 ◽  
Author(s):  
Sanne Samuels ◽  
Vivian M. Spaans ◽  
Michelle Osse ◽  
Lex A.W. Peters ◽  
Gemma G. Kenter ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Squamous Cell ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Disease Specific Survival ◽  
Leukocyte Antigen ◽  
Class Ii Antigens ◽  
Disease Free ◽  
Disease Specific

ObjectivesHuman leukocyte antigen (HLA) class II antigens are expressed on antigen-presenting cells, that is, macrophages, dendritic cells, and B lymphocytes. Under the influence of IFN-γ, HLA class II molecules can also be expressed on T lymphocytes, epithelial and endothelial cells. In addition, HLA class II antigens can be expressed in a variety of malignancies; however, the link with prognosis and ultimately patient survival is controversial.MethodsThe pattern of HLA-DRA expression in cervical carcinoma was studied using immunohistochemistry. In total, 124 cervical carcinomas were examined, of which 60 (48.4%) were squamous cell carcinomas and 64 (51.6%) were adenocarcinomas.ResultsIn squamous cell carcinoma, HLA-DRA was expressed in 41 (68.3%) of 60 tumors, whereas in adenocarcinoma, HLA-DRA was expressed in 60 (93.8%) of 64 tumors (P< 0.001). In adenocarcinoma, HLA-DRA expression was associated with an increased disease-free survival (211.0 ± 13.0 vs 53.3 ± 30.5 months;P= 0.004) and disease-specific survival (226.45 ± 11.5 vs 75.8 ± 27.6 months;P= 0.002).ConclusionsUpregulation of HLA-DRA is significantly related to an increased disease-free and disease-specific survival in cervical adenocarcinoma. These data warrant further analysis of the functional role of HLA-DRA in these tumors.

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