scholarly journals Preventive Chemotherapy and Transmission Control (PCT) databank: a tool for planning, implementation and monitoring of integrated preventive chemotherapy for control of neglected tropical diseases

2012 ◽  
Vol 106 (4) ◽  
pp. 215-222 ◽  
Author(s):  
Aya Yajima ◽  
Alexei Mikhailov ◽  
Pamela S. Mbabazi ◽  
Albis F. Gabrielli ◽  
Simona Minchiotti ◽  
...  
Keyword(s):  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Transmission Control ◽  
Preventive Chemotherapy ◽  
Planning Implementation

The Epitome of Novel Techniques and Targeting Approaches in Drug Delivery for Treating Lymphatic Filariasis

2020 ◽  
Vol 21 (12) ◽  
pp. 1250-1263
Author(s):  
Saurabh Shrivastava ◽  
Anshita Gupta ◽  
Chanchal Deep Kaur
Keyword(s):  
Lymphatic Filariasis ◽  
Neglected Tropical Diseases ◽  
Therapeutic Interventions ◽  
Tropical Diseases ◽  
Human Beings ◽  
Therapeutic Approaches ◽  
Preventive Chemotherapy ◽  
Bioactive Substances ◽  
Lymphatic Diseases ◽  
Life Threatening

Background: Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the geographical outbreak of infection, and lack of preventive chemotherapy have brought this epidemic to the edge of Neglected Tropical Diseases. Many medications and natural bioactive substances have seen to promote filaricidal activity against the target parasitic species. However, the majority of failures have occurred in pharmaceutical and pharmacokinetic issues. Objective: The purpose of the study is to focus on the challenges and therapeutic issues in the treatment of filariasis. The review brings novel techniques and therapeutic approaches for combating lymphatic filariasis. It also offers significant developments and opportunities for such therapeutic interventions. Conclusion: Through this review, an attempt has made to critically evaluate the avenues of innovative pharmaceuticals and molecular targeting approaches to bring an integrated solution to combat lymphatic filariasis.

scholarly journals Development and validation of a framework to improve neglected tropical diseases surveillance and response at the sub-national level in Kenya

2021 ◽  
Author(s):  
Arthur Kipkemoi Saitabau Ng'etich ◽  
Kuku Voyi ◽  
Clifford Maina Mutero
Keyword(s):  
Disease Transmission ◽  
Neglected Tropical Diseases ◽  
Methodological Approach ◽  
National Level ◽  
Primary Data ◽  
Second Phase ◽  
Tropical Diseases ◽  
Preventive Chemotherapy ◽  
Response System ◽  
Surveillance And Response

Background Assessment of surveillance and response system functions focusing on notifiable diseases has widely been documented in literature. However, there is limited focus on diseases targeted for elimination or eradication, particularly preventive chemotherapy neglected tropical diseases (PC-NTDs). There are limited strategies to guide strengthening of surveillance and response system functions concerning PC-NTDs. The aim of this study was to develop and validate a framework to improve surveillance and response to PC-NTDs at the sub-national level in Kenya. Methods Framework development adopted a multi-phased approach. The first phase involved a systematic literature review of surveillance assessment studies conducted in Africa to derive generalised recommendations. The second phase utilised primary data surveys to identify disease-specific recommendations to improve PC-NTDs surveillance in Kenya. The third phase utilised a Delphi survey to assess stakeholders consensus on feasible recommendations. The fourth phase drew critical lessons from existing conceptual frameworks. The final validated framework was based on resolutions and inputs from concerned stakeholders. Results Framework components constituted inputs with the first domain combining surveillance tools, equipment and infrastructure while the second domain combined financial, technical and logistical support. Processes were categorised into four sub-domains with activities for strengthening existing surveillance tools, surveillance core, support and attribute functions. The intended results phase comprised of ten distinct outputs with the anticipated outcomes categorised into three sub domains. Lastly, the overall impact alluded to reduced disease burden, halted disease transmission and reduced costs for implementing treatment interventions to achieve PC-NTDs control and elimination. Conclusion In view of the mixed methodological approach used to develop the framework coupled with further inputs and consensus among concerned stakeholders, the validated framework appears to be relevant in guiding decisions by policy makers to strengthen the existing surveillance and response system functions towards achieving PC-NTDs elimination.

Neglected tropical diseases: comparison of the costs of integrated and vertical preventive chemotherapy treatment in Niger

2013 ◽  
Vol 5 (1) ◽  
pp. 78-84 ◽  
Author(s):  
J. Leslie ◽  
A. Garba ◽  
K. Boubacar ◽  
Y. Yaye ◽  
H. Sebongou ◽  
...  
Keyword(s):  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Chemotherapy Treatment ◽  
Preventive Chemotherapy

scholarly journals An Integrated Approach to Assess Knowledge/Perceptions and Attitudes/Practices (KAP) Regarding Major Neglected Tropical Diseases Endemic in the Mbengwi Health District, North West Region, Cameroon

2021 ◽  
Vol 11 (4) ◽  
pp. 426-434
Author(s):  
Laurentine Sumo ◽  
Ngum H. Ntonifor ◽  
Cédric G. Lenou-Nanga ◽  
Nicanor Chenkumo-Kengmoni ◽  
Vanessa T. Amana-Bokagne ◽  
...  
Keyword(s):  
Community Participation ◽  
Neglected Tropical Diseases ◽  
Health District ◽  
Cluster Sampling ◽  
Structure Questionnaire ◽  
Tropical Diseases ◽  
Cross Sectional Survey ◽  
Preventive Chemotherapy ◽  
North West ◽  
West Region

Abstract Background and objectives Preventive chemotherapy (PCT) is the main strategy currently used to control and/or eliminate onchocerciasis, lymphatic filariasis (LF) and soil transmitted helminthiasis (STH), and community participation (through implementation or adherence to PCT) is critical. This study aimed at investigating knowledge/perceptions of populations of the Mbengwi health district (North West Region, Cameroon), in relation to their attitudes/practices regarding the most prevalent neglected tropical diseases (NTDs). Methods A household-based cross-sectional survey was carried out in the Mbengwi health district (North West Region, Cameroon) using the cluster sampling technique. Clusters were selected using the probability proportionate to estimate size strategy. In each cluster, the random walk technique was used for the selection of households, and a structure questionnaire was administered to 2–3 of its members. Results A total of 254 households from 26 clusters were visited, and 514 individuals were interviewed. The sex ratio of interviewees (1.08) was unbiased, and their ages ranged between 10 and 99 years old. Though most of the respondents declared having already heard of these NTDs (41.6%, 73.9% and 90.5% for onchocerciasis, LF and STH, respectively), only a minority of them were aware of how they are acquired/transmitted (8.9%, 9.2% and 32.7% for onchocerciasis, LF and STH, respectively), or prevented (23.1%, 18.9% and 47.2% for onchocerciasis, LF and STH, respectively). Conclusions This study revealed poor knowledge/perceptions and wrong attitudes/practices of interviewees as regards to these NTDs, and these misconceptions can seriously affect the adherence and contribution of populations to the success of PCTs. It appears compulsory to reinforce information, education, and communication, with a focus on the rationale and importance behind PCTs, to optimize/improve community participation.

scholarly journals Are current preventive chemotherapy strategies for controlling and eliminating neglected tropical diseases cost-effective?

2021 ◽  
Vol 6 (8) ◽  
pp. e005456
Author(s):  
Hugo C Turner ◽  
Wilma A Stolk ◽  
Anthony W Solomon ◽  
Jonathan D King ◽  
Antonio Montresor ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Low Income ◽  
Neglected Tropical Diseases ◽  
Cost Effective ◽  
Healthcare Spending ◽  
Tropical Diseases ◽  
Preventive Chemotherapy ◽  
Middle Income ◽  
Disability Adjusted Life ◽  
The Cost

Neglected tropical diseases (NTDs) remain a significant cause of morbidity and mortality in many low-income and middle-income countries. Several NTDs, namely lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases (STH) and trachoma, are predominantly controlled by preventive chemotherapy (or mass drug administration), following recommendations set by the WHO. Over one billion people are now treated for NTDs with this strategy per year. However, further investment and increased domestic healthcare spending are urgently needed to continue these programmes. Consequently, it is vital that the cost-effectiveness of preventive chemotherapy is understood. We analyse the current estimates on the cost per disability-adjusted life year (DALY) of the preventive chemotherapy strategies predominantly used for these diseases and identify key evidence gaps that require further research. Overall, the reported estimates show that preventive chemotherapy is generally cost-effective, supporting WHO recommendations. More specifically, the cost per DALY averted estimates relating to community-wide preventive chemotherapy for lymphatic filariasis and onchocerciasis were particularly favourable when compared with other public health interventions. Cost per DALY averted estimates of school-based preventive chemotherapy for schistosomiasis and STH were also generally favourable but more variable. Notably, the broader socioeconomic benefits are likely not being fully captured by the DALYs averted metric. No estimates of cost per DALY averted relating to community-wide mass antibiotic treatment for trachoma were found, highlighting the need for further research. These findings are important for informing global health policy and support the need for continuing NTD control and elimination efforts.

scholarly journals Emerging Resistance of Neglected Tropical Diseases: A Scoping Review of the Literature

2019 ◽  
Vol 16 (11) ◽  
pp. 1925 ◽  
Author(s):  
Folahanmi T. Akinsolu ◽  
Priscilla O. Nemieboka ◽  
Diana W. Njuguna ◽  
Makafui N. Ahadji ◽  
Dora Dezso ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Assessment Tool ◽  
Neglected Tropical Diseases ◽  
Experimental Studies ◽  
Surveillance Systems ◽  
Tropical Diseases ◽  
Global Public Health ◽  
Preventive Chemotherapy ◽  
Clinical Resistance ◽  
Socio Demographic Factors

Background: Antimicrobial resistance (AMR) is a global public health threat with the potential to cause millions of deaths. There has been a tremendous increase in the use of antimicrobials, stemming from preventive chemotherapy elimination and control programs addressing neglected tropical diseases (NTDs). This study aims to identify the frequency of drug resistance for 11 major NTDs and 20 treatment drugs within a specific period by systematically analyzing the study design, socio-demographic factors, resistance, and countries of relevant studies. Methods: Adhering to PRISMA guidelines, we performed systematic reviews of the major 11 NTDs to identify publications on drug resistance between 2000 and 2016. A quality assessment tool adapted for evaluating observational and experimental studies was applied to assess the quality of eligible studies. Results: One of the major findings is that six NTDs have information on drug resistance, namely human African trypanosomiasis, leishmaniasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, and trachoma. Many studies recorded resistance due to diagnostic tests, and few studies indicated clinical resistance. Although most studies were performed in Africa where there is the occurrence of several NTDs, there was no link between disease burden and locations of study. Conclusions: Based on this study we deduce that monitoring and surveillance systems need to be strengthened to enable the early detection of AMR and the mitigation of its global spread.

scholarly journals Supporting drug development for neglected tropical diseases using mathematical modelling

2021 ◽  
Author(s):  
Martin Walker ◽  
Jonathan I D Hamley ◽  
Philip Milton ◽  
Frédéric Monnot ◽  
Sally Kinrade ◽  
...  
Keyword(s):  
Drug Development ◽  
Mathematical Modelling ◽  
Neglected Tropical Diseases ◽  
Public Health Problem ◽  
World Health ◽  
Tropical Diseases ◽  
Resource Saving ◽  
Preventive Chemotherapy ◽  
Health Organization ◽  
Chemotherapy Strategy

Abstract Drug-based interventions are at the heart of global efforts to reach elimination as a public health problem (trachoma, soil-transmitted helminthiases, schistosomiasis, lymphatic filariasis) or elimination of transmission (onchocerciasis) for five of the most prevalent neglected tropical diseases tackled via the World Health Organization preventive chemotherapy strategy. While for some of these diseases there is optimism that currently available drugs will be sufficient to achieve the proposed elimination goals, for others—particularly onchocerciasis—there is a growing consensus that novel therapeutic options will be needed. Since in this area no high return of investment is possible, minimizing wasted money and resources is essential. Here, we use illustrative results to show how mathematical modelling can guide the drug development pathway, yielding resource-saving and efficiency payoffs, from the refinement of target product profiles and intended context of use, to the design of clinical trials.

scholarly journals African regional progress and status of the programme to eliminate lymphatic filariasis: 2000–2020

2020 ◽  
Vol 13 (Supplement_1) ◽  
pp. S22-S27
Author(s):  
Kebede Deribe ◽  
Didier K Bakajika ◽  
Honorat Marie-Gustave Zoure ◽  
John O Gyapong ◽  
David H Molyneux ◽  
...  
Keyword(s):  
Vector Control ◽  
Lymphatic Filariasis ◽  
Neglected Tropical Diseases ◽  
Public Health Problem ◽  
World Health ◽  
Malaria Vector Control ◽  
Tropical Diseases ◽  
Significant Progress ◽  
African Region ◽  
Preventive Chemotherapy

Abstract To eliminate lymphatic filariasis (LF) by 2020, the World Health Organization (WHO) has launched a campaign against the disease. Since the launch in 2000, significant progress has been made to achieve this ambitious goal. In this article we review the progress and status of the LF programme in Africa through the WHO neglected tropical diseases preventive chemotherapy databank, the Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN) portal and other publications. In the African Region there are 35 countries endemic for LF. The Gambia was reclassified as not requiring preventive chemotherapy in 2015, while Togo and Malawi eliminated LF as a public health problem in 2017 and 2020, respectively. Cameroon discontinued mass drug administration (MDA) and transitioned to post-MDA surveillance to validate elimination. The trajectory of coverage continues to accelerate; treatment coverage increased from 0.1% in 2000 to 62.1% in 2018. Geographical coverage has also significantly increased, from 62.7% in 2015 to 78.5% in 2018. In 2019, 23 of 31 countries requiring MDA achieved 100% geographic coverage. Although much remains to be done, morbidity management and disability prevention services have steadily increased in recent years. Vector control interventions conducted by other programmes, particularly malaria vector control, have had a profound effect in stopping transmission in some endemic countries in the region. In conclusion, significant progress has been made in the LF programme in the region while we identify the key remaining challenges in achieving an Africa free of LF.

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