Genetics of canine diabetes mellitus part 2: Current understanding and future directions

2021 ◽  
Vol 270 ◽  
pp. 105612
Author(s):  
Alice L. Denyer ◽  
Brian Catchpole ◽  
Lucy J. Davison
Keyword(s):  
Diabetes Mellitus ◽  
Current Understanding ◽  
Future Directions ◽  
Canine Diabetes Mellitus

Inflammatory Markers Associated With Diabetes Mellitus – Old and New Players

2020 ◽  
Vol 26 ◽  
Author(s):  
Emir Muzurović ◽  
Zoja Stanković ◽  
Zlata Kovačević ◽  
Benida Šahmanović Škrijelj ◽  
Dimitri P Mikhailidis
Keyword(s):  
Diabetes Mellitus ◽  
Inflammatory Markers ◽  
High Specificity ◽  
Future Directions ◽  
Effective Strategies ◽  
Advantages And Disadvantages ◽  
Type 2 Dm ◽  
Increased Risk ◽  
Made In

: Diabetes mellitus (DM) is a chronic and complex metabolic disorder, and also an important cause of cardiovascular (CV) diseases (CVDs). Subclinical inflammation, observed in patients with type 2 DM (T2DM), cannot be considered the sole or primary cause of T2DM in the absence of classical risk factors, but it represents an important mechanism that serves as a bridge between primary causes of T2DM and its manifestation. Progress has been made in the identification of effective strategies to prevent or delay the onset of T2DM. It is important to identify those at increased risk for DM by using specific biomarkers. Inflammatory markers correlate with insulin resistance (IR) and glycoregulation in patients with DM. Also, several inflammatory markers have been shown to be useful in assessing the risk of developing DM and its complications. However, the intertwining of pathophysiological processes and the not-quite-specificity of inflammatory markers for certain clinical entities limits their practical use. In this review we consider the advantages and disadvantages of various inflammatory biomarkers of DM that have been investigated to date as well as possible future directions. Key features of such biomarkers should be high specificity, non-invasiveness and cost-effectiveness.

Canine diabetes mellitus: from phenotype to genotype

2007 ◽  
Vol 0 (0) ◽  
pp. 070706190648004-??? ◽  
Author(s):  
B. Catchpole ◽  
L. J. Kennedy ◽  
L. J. Davison ◽  
W. E. R. Ollier
Keyword(s):  
Diabetes Mellitus ◽  
Canine Diabetes Mellitus

Canine diabetes mellitus: what is new?

2015 ◽  
Vol 20 (8) ◽  
pp. 442-446 ◽  
Author(s):  
Stijn Niessen
Keyword(s):  
Diabetes Mellitus ◽  
Canine Diabetes Mellitus

scholarly journals Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches

2019 ◽  
Vol 8 (5) ◽  
pp. 450-455 ◽  
Author(s):  
Maryam Moshref ◽  
Bonnie Tangey ◽  
Chen Gilor ◽  
Klearchos K. Papas ◽  
Peter Williamson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regenerative Medicine ◽  
Translational Model ◽  
Concise Review ◽  
Canine Diabetes Mellitus

scholarly journals Recent advances in understanding necrotizing enterocolitis

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 107 ◽  
Author(s):  
Mashriq Alganabi ◽  
Carol Lee ◽  
Edoardo Bindi ◽  
Bo Li ◽  
Agostino Pierro
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Advanced Disease ◽  
Current Understanding ◽  
Disease Development ◽  
Current Management ◽  
Future Directions ◽  
Ongoing Research ◽  
Factors Associated

Necrotizing enterocolitis is a devastating intestinal disease affecting preterm infants. In spite of ongoing research and advancement in neonatal care, mortality remains high, especially in infants with advanced disease. The mechanism of disease development, the progression of intestinal injury, and management remain areas of ongoing research and controversy. In this review, we examine our current understanding of the disease, its epidemiology, the risk factors associated with the development of the disease, and its pathophysiology. We also describe current management and new emerging research highlighting potential future directions.

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