Cross protection of a Mannheimia haemolytica A1 Lkt-/Pasteurella multocida ΔhyaE bovine respiratory disease vaccine against experimental challenge with Mannheimia haemolytica A6 in calves

AbstractBovine respiratory disease (BRD) research has provided significant understanding of the disease over the past 26 years. Modern research tools that have been used include monoclonal antibodies, genomics, polymerase chain reaction, immunohistochemistry (IHC), DNA vaccines and viral vectors coding for immunogens. Emerging/reemerging viruses and new antigenic strains of viruses and bacteria have been identified. Methods of detection and the role for cattle persistently infected bovine viral diarrhea virus (BVDV) were identified; viral subunits, cellular components and bacterial products have been characterized. Product advances have included vaccines for bovine respiratory syncytial virus, Mannheimia haemolytica and Pasteurella multocida; the addition of BVDV2 to the existing vaccines and new antibiotics. The role of Mycoplasma spp., particularly Mycoplasma bovis in BRD, has been more extensively studied. Bovine immunology research has provided more specific information on immune responses, T cell subsets and cytokines. The molecular and genetic basis for viral–bacterial synergy in BRD has been described. Attempts have been made to document how prevention of BRD by proper vaccination and management prior to exposure to infectious agents can minimize disease and serve as economic incentives for certified health programs.

Download Full-text

Serotyping and antimicrobial resistance of Mannheimia haemolytica strains from European cattle with bovine respiratory disease

Research in Veterinary Science ◽

10.1016/j.rvsc.2018.12.021 ◽

2019 ◽

Vol 124 ◽

pp. 10-12 ◽

Cited By ~ 1

Author(s):

Sara Andrés-Lasheras ◽

Rahat Zaheer ◽

Cassidy Klima ◽

Haley Sanderson ◽

Rodrigo Ortega Polo ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Respiratory Disease ◽

Bovine Respiratory Disease ◽

Mannheimia Haemolytica ◽

European Cattle

Download Full-text

Comparison of Mannheimia haemolytica isolates from an outbreak of bovine respiratory disease

Veterinary Microbiology ◽

10.1016/j.vetmic.2015.10.020 ◽

2016 ◽

Vol 182 ◽

pp. 82-86 ◽

Cited By ~ 3

Author(s):

S. Rainbolt ◽

D.K. Pillai ◽

B.V. Lubbers ◽

M. Moore ◽

R. Davis ◽

...

Keyword(s):

Respiratory Disease ◽

Bovine Respiratory Disease ◽

Mannheimia Haemolytica

Download Full-text

Tetracycline resistance genes in isolates of Pasteurella multocida, Mannheimia haemolytica, Mannheimia glucosida and Mannheimia varigena from bovine and swine respiratory disease: intergeneric spread of the tet(H) plasmid pMHT1

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/48.5.631 ◽

2001 ◽

Vol 48 (5) ◽

pp. 631-640 ◽

Cited By ~ 49

Author(s):

C. Kehrenberg

Keyword(s):

Respiratory Disease ◽

Resistance Genes ◽

Pasteurella Multocida ◽

Tetracycline Resistance ◽

Mannheimia Haemolytica ◽

Tetracycline Resistance Genes

Download Full-text

Pasteurella multocidaand bovine respiratory disease

Animal Health Research Reviews ◽

10.1017/s1466252307001399 ◽

2007 ◽

Vol 8 (2) ◽

pp. 129-150 ◽

Cited By ~ 97

Author(s):

S. M. Dabo ◽

J. D. Taylor ◽

A. W. Confer

Keyword(s):

Respiratory Disease ◽

Bacterial Infections ◽

Pasteurella Multocida ◽

Extracellular Enzymes ◽

Bovine Respiratory Disease ◽

High Serum ◽

Stress Factors ◽

Field Efficacy ◽

Shipping Fever ◽

Colonization Factors

AbstractPasteurella multocidais a pathogenic Gram-negative bacterium that has been classified into three subspecies, five capsular serogroups and 16 serotypes.P. multocidaserogroup A isolates are bovine nasopharyngeal commensals, bovine pathogens and common isolates from bovine respiratory disease (BRD), both enzootic calf pneumonia of young dairy calves and shipping fever of weaned, stressed beef cattle.P. multocidaA:3 is the most common serotype isolated from BRD, and these isolates have limited heterogeneity based on outer membrane protein (OMP) profiles and ribotyping. Development ofP. multocida-induced pneumonia is associated with environmental and stress factors such as shipping, co-mingling, and overcrowding as well as concurrent or predisposing viral or bacterial infections. Lung lesions consist of an acute to subacute bronchopneumonia that may or may not have an associated pleuritis. Numerous virulence or potential virulence factors have been described for bovine respiratory isolates including adherence and colonization factors, iron-regulated and acquisition proteins, extracellular enzymes such as neuraminidase, lipopolysaccharide, polysaccharide capsule and a variety of OMPs. Immunity of cattle against respiratory pasteurellosis is poorly understood; however, high serum antibodies to OMPs appear to be important for enhancing resistance to the bacterium. Currently availableP. multocidavaccines for use in cattle are predominately traditional bacterins and a live streptomycin-dependent mutant. The field efficacy of these vaccines is not well documented in the literature.

Download Full-text