Characterization of immune responses following homologous reinfection of pigs with European subtype 1 and 3 porcine reproductive and respiratory syndrome virus strains that differ in virulence

2016 ◽  
Vol 182 ◽  
pp. 64-74 ◽  
Author(s):  
Eefke Weesendorp ◽  
Norbert Stockhofe-Zurwieden ◽  
Hans J. Nauwynck ◽  
Ditta J. Popma-De Graaf ◽  
Johanna M.J. Rebel
Keyword(s):  
Immune Responses ◽  
Respiratory Syndrome Virus ◽  
Virus Strains ◽  
European Subtype

scholarly journals Pathogenesis and antigenic characterization of a new East European subtype 3 porcine reproductive and respiratory syndrome virus isolate

2010 ◽  
Vol 6 (1) ◽  
pp. 30 ◽  
Author(s):  
Uladzimir U Karniychuk ◽  
Marc Geldhof ◽  
Merijn Vanhee ◽  
Jan VAN Doorsselaere ◽  
Tamara A Saveleva ◽  
...  
Keyword(s):  
Virus Isolate ◽  
Respiratory Syndrome Virus ◽  
East European ◽  
Antigenic Characterization ◽  
European Subtype ◽  
Subtype 3

scholarly journals Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence

2013 ◽  
Vol 163 (1-2) ◽  
pp. 1-12 ◽  
Author(s):  
Eefke Weesendorp ◽  
Sophie Morgan ◽  
Norbert Stockhofe-Zurwieden ◽  
Ditta J. Popma-De Graaf ◽  
Simon P. Graham ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Immune Responses ◽  
Experimental Infection ◽  
Respiratory Syndrome Virus ◽  
Virus Strains

scholarly journals Characterization of homologous and heterologous adaptive immune responses in porcine reproductive and respiratory syndrome virus infection

2012 ◽  
Vol 43 (1) ◽  
pp. 30 ◽  
Author(s):  
Ivan Díaz ◽  
Mariona Gimeno ◽  
Laila Darwich ◽  
Nuria Navarro ◽  
Liudmila Kuzemtseva ◽  
...  
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Respiratory Syndrome Virus ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

scholarly journals The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2274
Author(s):  
Haley E. Rymut ◽  
Laurie A. Rund ◽  
Courtni R. Bolt ◽  
Maria B. Villamil ◽  
Bruce R. Southey ◽  
...  
Keyword(s):  
Immune Activation ◽  
Management Practices ◽  
Interleukin 1 ◽  
Interleukin 2 ◽  
Blood Chemistry ◽  
Respiratory Syndrome Virus ◽  
Weaning Stress ◽  
And Control ◽  
Metabolic Hormone

Weaning stress can elicit changes in the metabolic, hormone and immune systems of pigs and interact with prolonged disruptions stemming from maternal immune activation (MIA) during gestation. The present study advances the characterization of the combined effects of weaning stress and MIA on blood chemistry, immune and hormone indicators that inform on the health of pigs. Three-week-old female and male offspring of control gilts or gilts infected with the porcine reproductive and respiratory syndrome virus were allocated to weaned or nursed groups. The anion gap and bilirubin profiles suggest that MIA enhances tolerance to the effects of weaning stress. Interleukin 1 beta and interleukin 2 were highest among weaned MIA females, and cortisol was higher among weaned relative to nursed pigs across sexes. Canonical discriminant analysis demonstrated that weaned and nursed pigs have distinct chemistry profiles, whereas MIA and control pigs have distinct cytokine profiles. The results from this study can guide management practices that recognize the effects of the interaction between MIA and weaning stress on the performance and health of pigs.

scholarly journals Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Casandra Panea ◽  
Ruoyu Zhang ◽  
Jeffrey VanValkenburgh ◽  
Min Ni ◽  
Christina Adler ◽  
...  
Keyword(s):  
Immune Responses ◽  
Intraepithelial Lymphocytes ◽  
Homeostatic Proliferation ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Site Specific ◽  
Adaptive Immune ◽  
Intestinal Segments ◽  
Repertoire Diversity

AbstractTissue-resident γδ intraepithelial lymphocytes (IELs) orchestrate innate and adaptive immune responses to maintain intestinal epithelial barrier integrity. Epithelia-specific butyrophilin-like (Btnl) molecules induce perinatal development of distinct Vγ TCR+ IELs, however, the mechanisms that control γδ IEL maintenance within discrete intestinal segments are unclear. Here, we show that Btnl2 suppressed homeostatic proliferation of γδ IELs preferentially in the ileum. High throughput transcriptomic characterization of site-specific Btnl2-KO γδ IELs reveals that Btnl2 regulated the antimicrobial response module of ileal γδ IELs. Btnl2 deficiency shapes the TCR specificities and TCRγ/δ repertoire diversity of ileal γδ IELs. During DSS-induced colitis, Btnl2-KO mice exhibit increased inflammation and delayed mucosal repair in the colon. Collectively, these data suggest that Btnl2 fine-tunes γδ IEL frequencies and TCR specificities in response to site-specific homeostatic and inflammatory cues. Hence, Btnl-mediated targeting of γδ IEL development and maintenance may help dissect their immunological functions in intestinal diseases with segment-specific manifestations.

scholarly journals Complete Genome Sequences of Six Measles Virus Strains

2018 ◽  
Vol 6 (13) ◽  
Author(s):  
My V. T. Phan ◽  
Claudia M. E. Schapendonk ◽  
Bas B. Oude Munnink ◽  
Marion P. G. Koopmans ◽  
Rik L. de Swart ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Complete Genome ◽  
Measles Virus ◽  
Genetic Characterization ◽  
Critical Component ◽  
Wild Type ◽  
Genome Sequences ◽  
Virus Strains ◽  
Generation Sequencing

ABSTRACT Genetic characterization of wild-type measles virus (MV) strains is a critical component of measles surveillance and molecular epidemiology. We have obtained complete genome sequences of six MV strains belonging to different genotypes, using random-primed next generation sequencing.

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