Rapid Determination of Adulteration of Clove Essential Oil with Benzyl Alcohol and Ethyl Acetate: Towards Quality Control Analysis by FTIR with Chemometrics

Objective: The objective for new methodology was to develop a rapid analytical method for drug quantification in ointment samples and eliminate the usage of hazardous solvents in the sample and standard preparation, less elution time of component of interest to sustained green chemistry applications.Methods: Headspace (HS) chromatography was used along with gas chromatography (GC) having direct sample treatment with the help of calibration slope method.Results: All essential oil (EO) was well separated from each other and eluted 1.6 times faster from traditional classical GC method. The present method does not require any hazardous solvents for sample preparation. Conclusion: This method provides the accurate and precise results for EO added in ointment samples and can be used for routine quality control testing before releasing the final product release for the consumers.

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Development, Estimation and Validation of Lisinopril in Bulk and its Pharmaceutical Formulation by HPLC Method

E-Journal of Chemistry ◽

10.1155/2012/292754 ◽

2012 ◽

Vol 9 (1) ◽

pp. 340-344 ◽

Cited By ~ 3

Author(s):

V. Bhaskara Raju ◽

A. Lakshmana Rao

Keyword(s):

Quality Control ◽

Mobile Phase ◽

Dosage Forms ◽

Hplc Method ◽

Control Analysis ◽

Reverse Phase ◽

Quality Control Analysis ◽

Tablet Dosage ◽

Routine Quality Control

An accurate and preciseHPLCmethod was developed for the determination of lisinopril. Separation of the drug was achieved on a reverse phase C8column using a mobile phase consisting of phosphate buffer and methanol in the ratio of 35:65v/v. The flow rate was 0.8 mL/min and the detection wavelength was 215 nm. The linearity was observed in the range of 20-60 μ g/mL with a correlation coefficient of 0.9992. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of lisinopril in tablet dosage forms.

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PCBs in Older Buildings: Measuring PCB Levels in Caulk and Window Glazing Materials in Older Buildings

Environments ◽

10.3390/environments6020015 ◽

2019 ◽

Vol 6 (2) ◽

pp. 15 ◽

Cited By ~ 1

Author(s):

Lantis Osemwengie ◽

Jade Morgan

Keyword(s):

United States ◽

Quality Control ◽

Polychlorinated Biphenyls ◽

21St Century ◽

The United States ◽

Control Analysis ◽

Chemical Safety ◽

Quality Control Analysis ◽

The U.S

A method for the determination of polychlorinated biphenyls (PCBs) in caulk and glazing materials was developed and evaluated by application to a combination of 36 samples of caulk and glazing materials, from four schools in the northeastern area of the United States. Quality control analysis showed a range of 45 to 170% for spike recovery from the various samples and a range of 10.9 to 20.1% difference in precision among replicates. The result for the samples analyzed showed that three of the four schools sampled contained caulking and glazing materials with levels of PCBs >50 μg/g (range 54.6 μg/g to 445,000 μg/g). Across the four schools, 24% of collected caulk and glazing samples contained elevated PCB levels relative to the U.S. Environmental Protection Agency’s (EPA) bulk product waste criterion of 50 μg/g under “The Frank R. Lautenberg Chemical Safety for the 21st Century Act.” The PCBs determined in the samples, exhibited characteristic chromatographic patterns similar to those of Aroclors 1242, 1248, 1254, 1260, 1262, and a 1016/1254 mix.

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UV SPECTROPHOTOMETRY METHOD DEVELOPMENT AND VALIDATION OF SULFADIAZINE AND TRIMETHOPRIM IN COMBINED DOSAGE FORM

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2018v10i1.21767 ◽

2018 ◽

Vol 10 (1) ◽

pp. 103

Author(s):

Ramakrishna Veni Pokala ◽

Kusuma Kumari ◽

Hari Babu Bollikola

Keyword(s):

Present Method ◽

Method Development ◽

Rapid Determination ◽

Uv Spectrophotometry ◽

Control Analysis ◽

Quality Control Analysis ◽

Double Beam ◽

Method Development And Validation ◽

Development And Validation

Objective: A new, simple, sensitive and economical UV spectrophotometric method was developed for the simultaneous analysis of Sulfadiazine [SDA] and Trimethoprim [TMP] in pharmaceutical formulations.Methods: This UV method was developed with methanol as solvent. The wavelengths selected for analysis in the present method were 265 nm for TMP and 289 nm for SDA. Teccomp UV-2301 double beam UV/Vis spectrophotometer was used to carry out spectral analysis and the data was recorded by Hitachi software.Results: Linearity was found to be within the concentration range of 2-9 µg/ml TMP and 9.08-41 µg/ml of SDA. Accuracy of the method was determined by recovery studies. Percentage recovery was found to be 98.20-99.25 for TMP with a % RSD of 0.338, 0.506 and 0.510 for three spiked levels. % RSD was found to be 0.229 and 0.380; 0.212 and 0.328 for SDA, TMP in intra and inter-day precision respectively. The % RSD value in ruggedness was found to be 0.440 for SDA and 0.569 for TMP.Conclusion: The advantages of this method for analytical purposes lie in the rapid determination, its cost-effectiveness, easy preparation of the sample, good reproducibility. In addition to this, the present method can be recommended for simultaneous determination of SDA and TMP in routine quality control analysis in combined drug formulations.

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Quality Control Analysis of Safoof-e-Pathar Phori, A Unani Herbo-mineral Formulation

Planta Medica ◽

10.1055/s-0031-1274878 ◽

2011 ◽

Vol 77 (05) ◽

Author(s):

W Ahmad ◽

MS Khan ◽

SMA Zaidi ◽

SS Jameel ◽

S Ahmad

Keyword(s):

Quality Control ◽

Control Analysis ◽

Quality Control Analysis

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Simultaneous Determination of Six Components in Jingzhiguanxin Tablet by High-Performance Liquid Chromatography

Current Pharmaceutical Analysis ◽

10.2174/1573412914666180315120130 ◽

2019 ◽

Vol 15 (2) ◽

pp. 130-137

Author(s):

Hui Jiang ◽

Lianhao Fu ◽

Yu Wang ◽

Shaozhi Wang ◽

Xiaoxu Zhang ◽

...

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Performance ◽

Gradient Elution ◽

Tanshinone Iia ◽

Array Detector ◽

Control Analysis ◽

Active Components ◽

Quality Control Analysis

Background: Jingzhiguanxin (JZGX) tablet, a traditional Chinese prescription, is commonly used for treating coronary heart disease and angina pectoris in the clinic. There are six active components (Danshensu (DSS), Protocatechuic aldehyde (PD), Paeoniflorin (PF), Ferulic acid (FA), Salvianolic acid B (Sal B) and Tanshinone IIA (TA)) in JZGX tablet. </P><P> Objective: In this paper, a simple and reliable method was used for simultaneous determining the six active components by high-performance liquid chromatography coupled with diode array detector (HPLC-DAD). Methods: These six active components were separated on an Agilent Zorbax Eclipse XDB-C18 column (150 mmx4.6 mm, 5 µm) at 30 °C. Acetonitrile (A), methanol (B) and 0.5% H3PO4 aqueous solution (C) were used as mobile phase for gradient elution. The flow rate was 1 mL/min and the detection wavelengths were set at 280 nm for DSS, PD and Sal B, 230 nm for PF, 320 nm for FA and 270 nm for TA, respectively. Results: All of the six components showed good linearity regressions (r2≥0.9997) in the detected concentration range. The recovery rates and coefficient of variation (CV) for all analytes were 98.66%- 100.18% and 0.75%-1.89%, respectively. This method was successfully applied to simultaneously determine the six components in JZGX tablet from different batches and manufacturers. Conclusion: The validated method can be used in routine quality control analysis of JZGX tablet without any interference.

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