HO-1 and miR-378 regulate tumor microenvironment and angiogenic potential of human lung cancer

Tumor immune escape plays a critical role in malignant tumor progression and leads to the failure of anticancer immunotherapy. Spi-B, a lymphocyte lineage-specific Ets transcription factor, participates in mesenchymal invasion and favors metastasis in human lung cancer. However, the mechanism through which Spi-B regulates the tumor immune environment has not been elucidated. In this study, we demonstrated that Spi-B enhanced the infiltration of tumor-associated macrophages (TAMs) in the tumor microenvironment using subcutaneous mouse models and clinical samples of human lung cancer. Spi-B overexpression increased the expression of TAM polarization- and recruitment-related genes, including CCL4. Moreover, deleting CCL4 inhibited the ability of Spi-B promoting macrophage infiltration. These data suggest that Spi-B promotes the recruitment of TAMs to the tumor microenvironment via upregulating CCL4 expression, which contributes to the progression of lung cancer.

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Anticancer activity of peptide extracted from edible mushroom; Lentinus squarrosulus in human lung cancer cells

Planta Medica ◽

10.1055/s-0036-1596829 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

S Sumkhemthong ◽

M Suksomtip ◽

P Chanvorachote ◽

C Chaotham

Keyword(s):

Lung Cancer ◽

Anticancer Activity ◽

Cancer Cells ◽

Human Lung ◽

Edible Mushroom ◽

Lung Cancer Cells ◽

Human Lung Cancer ◽

Human Lung Cancer Cells

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Ras Denitrosylation in Human Lung Cancer

Forum on Immunopathological Diseases and Therapeutics ◽

10.1615/forumimmundisther.2012006133 ◽

2012 ◽

Vol 3 (2) ◽

pp. 135-139

Author(s):

Benjamin Gaston ◽

Nadzeya Marozkina

Keyword(s):

Lung Cancer ◽

Human Lung ◽

Human Lung Cancer

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MicroRNAs expression signature in human lung cancer cell

Human Health and Medical Engineering ◽

10.2495/hhme131052 ◽

2014 ◽

Author(s):

Geyu Liang ◽

Xikai Wang ◽

Yanqiu Zhang ◽

Yanyun Fu ◽

Lihong Yin ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Cell ◽

Human Lung ◽

Human Lung Cancer ◽

Lung Cancer Cell ◽

Human Lung Cancer Cell ◽

Expression Signature

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Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

Molecular and Cellular Therapies ◽

10.26781/2052-8426-2017-02 ◽

2017 ◽

Vol 5 (1) ◽

Cited By ~ 1

Author(s):

Lingyan Wang ◽

Jiayun Hou ◽

Minghuan Zheng ◽

Lin Shi

Keyword(s):

Lung Cancer ◽

Cancer Cells ◽

Human Lung ◽

Retinoic Acid Receptor ◽

Lung Cancer Cells ◽

Human Lung Cancer ◽

Inhibitory Effects ◽

The Core ◽

Human Lung Cancer Cells ◽

Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

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