Intraoperative Resting-State Functional Connectivity and Resting-State Networks in Patients with Intracerebral Lesions: Detectability and Variations Between Sessions

2020 ◽  
Vol 133 ◽  
pp. e197-e204 ◽  
Author(s):  
Hussam Metwali ◽  
Mathijs Raemaekers ◽  
Katja Kniese ◽  
Amir Samii
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Resting State Networks ◽  
Resting State Functional Connectivity

scholarly journals Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Nigul Ilves ◽  
Pilvi Ilves ◽  
Rael Laugesaar ◽  
Julius Juurmaa ◽  
Mairi Männamaa ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Functions ◽  
Resting State ◽  
Outcome Measurement ◽  
Pediatric Stroke ◽  
Resting State Networks ◽  
Neurocognitive Deficits ◽  
Resting State Functional Connectivity ◽  
Perinatal Stroke ◽  
Brain Functions

Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke collected from the Estonian Pediatric Stroke Database. Neurodevelopment of children was assessed by the Pediatric Stroke Outcome Measurement and the Kaufman Assessment Battery. The study included 36 children (age range 7.6–17.9 years): 10 with periventricular venous infarction (PVI), 7 with arterial ischemic stroke (AIS), and 19 controls. There were no differences in severity of hemiparesis between the PVI and AIS groups. A significant increase in default mode network connectivity (FDR 0.1) and lower cognitive functions (p<0.05) were found in children with AIS compared to the controls and the PVI group. The children with PVI had no significant differences in the resting-state networks compared to the controls and their cognitive functions were normal. Our findings demonstrate impairment in cognitive functions and neural network profile in hemiparetic children with AIS compared to children with PVI and controls. Changes in the resting-state networks found in children with AIS could possibly serve as the underlying derangements of cognitive brain functions in these children.

scholarly journals Resting state functional connectivity in early post-anesthesia recovery is characterized by globally reduced anticorrelations

2019 ◽  
Author(s):  
Tommer Nir ◽  
Yael Jacob ◽  
Kuang-Han Huang ◽  
Arthur E. Schwartz ◽  
Jess W. Brallier ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Regions Of Interest ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Healthy Human ◽  
Healthy Older Adults ◽  
Human Volunteers ◽  
Resting State Connectivity

ABSTRACTThough a growing body of literature is addressing the possible longer-term cognitive effects of anesthetics, to date no study has delineated the normal trajectory of neural recovery due to anesthesia alone in older adults. We obtained resting state functional magnetic resonance imaging scans on 62 healthy human volunteers between ages forty and eighty before, during, and after sevoflurane (general) anesthesia, in the absence of surgery, as part of a larger study on cognitive function post-anesthesia. Resting state networks expression decreased consistently one hour after emergence from anesthesia. This corresponded to a global reduction in anticorrelated functional connectivity post-anesthesia, seen across individual regions-of-interest. Positively correlated functional connectivity remained constant across peri-anesthetic states. All measures returned to baseline 1 day later, with individual regions-of-interest essentially returning to their pre-anesthesia connectivity levels. These results define normal peri-anesthetic changes in resting state connectivity in healthy older adults.

scholarly journals Altered Resting-State Functional Connectivity Between Awake and Isoflurane Anesthetized Marmosets

2020 ◽  
Vol 30 (11) ◽  
pp. 5943-5959 ◽  
Author(s):  
Yuki Hori ◽  
David J Schaeffer ◽  
Kyle M Gilbert ◽  
Lauren K Hayrynen ◽  
Justine C Cléry ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Physiological Stress ◽  
Pure Oxygen ◽  
Preclinical Model ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Training Requirements ◽  
Isoflurane Anesthesia ◽  
Medical Air

Abstract The common marmoset (Callithrix jacchus) is a New World primate that is becoming increasingly popular as a preclinical model. To assess functional connectivity (FC) across the marmoset brain, resting-state functional MRI (RS-fMRI) is often performed under isoflurane anesthesia to avoid the effects of motion, physiological stress, and training requirements. In marmosets, however, it remains unclear how isoflurane anesthesia affects patterns of FC. Here, we investigated the effects of isoflurane on FC when delivered with either medical air or 100% pure oxygen, two canonical methods of inhalant isoflurane anesthesia delivery. The results demonstrated that when delivered with either medical air or 100% oxygen, isoflurane globally decreased FC across resting-state networks that were identified in awake marmosets. Generally, although isoflurane globally decreased FC in resting-state networks, the spatial structure of the networks was preserved. Outside of the context of RS networks, we indexed pair-wise functional connectivity between regions across the brain and found that isoflurane substantially altered interhemispheric and thalamic FC. Taken together, these findings indicate that RS-fMRI under isoflurane anesthesia is useful to evaluate the global structure of functional networks, but may obfuscate important nodes of some network components when compared to data acquired in fully awake marmosets.

scholarly journals Meditation-State Functional Connectivity (msFC): Strengthening of the Dorsal Attention Network and Beyond

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Brett Froeliger ◽  
Eric L. Garland ◽  
Rachel V. Kozink ◽  
Leslie A. Modlin ◽  
Nan-Kuei Chen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Control Group ◽  
Meditation Practice ◽  
Regression Analyses ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Attention Network ◽  
Dorsal Attention Network ◽  
Meditation Experience

Meditation practice alters intrinsic resting-state functional connectivity (rsFC) in the default mode network (DMN). However, little is known regarding the effects of meditation on other resting-state networks. The aim of current study was to investigate the effects of meditation experience and meditation-state functional connectivity (msFC) on multiple resting-state networks (RSNs). Meditation practitioners (MPs) performed two 5-minute scans, one during rest, one while meditating. A meditation naïve control group (CG) underwent one resting-state scan. Exploratory regression analyses of the relations between years of meditation practice and rsFC and msFC were conducted. During resting-state, MP as compared to CG exhibited greater rsFC within the Dorsal Attention Network (DAN). Among MP, meditation, as compared to rest, strengthened FC between the DAN and DMN and Salience network whereas it decreased FC between the DAN, dorsal medial PFC, and insula. Regression analyses revealed positive correlations between the number of years of meditation experience and msFC between DAN, thalamus, and anterior parietal sulcus, whereas negative correlations between DAN, lateral and superior parietal, and insula. These findings suggest that the practice of meditation strengthens FC within the DAN as well as strengthens the coupling between distributed networks that are involved in attention, self-referential processes, and affective response.

scholarly journals Auditory Stimulation Modulates Resting-State Functional Connectivity in Unresponsive Wakefulness Syndrome Patients

2021 ◽  
Vol 15 ◽  
Author(s):  
Melanie Boltzmann ◽  
Simone B. Schmidt ◽  
Christoph Gutenbrunner ◽  
Joachim K. Krauss ◽  
Martin Stangel ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Brain Activity ◽  
Auditory Stimulation ◽  
Unresponsive Wakefulness Syndrome ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Fmri Study ◽  
Scanner Noise ◽  
High Level

Passive listening to music is associated with several psychological and physical benefits in both, healthy and diseased populations. In this fMRI study, we examined whether preferred music has effects on the functional connectivity within resting-state networks related to consciousness. Thirteen patients in unresponsive wakefulness syndrome (UWS) and 18 healthy controls (HC) were enrolled. Both groups were exposed to different auditory stimulation (scanner noise, preferred music, and aversive auditory stimulation). Functional connectivity was analyzed using a seed-based approach. In HC, no differences were found between the three conditions, indicating that their networks are already working at high level. UWS patients showed impaired functional connectivity within all resting-state networks. In addition, functional connectivity of the auditory network was modulated by preferred music and aversive auditory stimulation. Hence, both conditions have the potential to modulate brain activity of UWS patients.

scholarly journals Sex-specific Associations Between Traumatic Experiences and Resting-state Functional Connectivity in the Philadelphia Neurodevelopmental Cohort

2020 ◽  
Author(s):  
Shiying Wang ◽  
Jeffrey G. Malins ◽  
Heping Zhang ◽  
Jeffrey R. Gruen
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Traumatic Events ◽  
Traumatic Experiences ◽  
Resting State Networks ◽  
Functional Magnetic Resonance ◽  
Resting State Functional Connectivity ◽  
Intrinsic Connectivity ◽  
Parameter Values ◽  
Connectivity Distribution

AbstractBackgroundTraumatic experiences during childhood or adolescence are a significant risk factor for multiple psychiatric disorders and adversely affect cognitive functions. Resting-state functional magnetic resonance imaging has been used to investigate the effects of traumatic experiences on functional connectivity, but the impact of sex differences has not been well documented. This study investigated sex-specific associations between resting-state functional connectivity and traumatic experiences in typically developing youth.MethodsThe sample comprised 1395 participants, ages 8 to 21 years, from the Philadelphia Neurodevelopmental Cohort. Resting-state functional connectivity was characterized by voxel-wise intrinsic connectivity distribution parameter values derived from resting-state functional magnetic resonance imaging. Traumatic experiences were assessed based on a structured psychiatric evaluation. Sex, the number of traumatic events, and their interaction were regressed onto voxel-wise intrinsic connectivity distribution parameter values. Brain regions that passed cluster correction were used as seeds to define resting-state networks.ResultsAfter quality control, the final sample included 914 participants (mean (SD) age, 14.6 (3.3) years; 529 (57.8%) females; 437 (47.8%) experienced at least one kind of traumatic event). Four discrete anatomical clusters showed decreased functional connectivity as the number of traumatic events increased. The resting-state networks defined by using these four clusters as seeds corresponded with the somatomotor network. Sex-specific associations were identified in another four clusters for which males showed increased connectivity, and females showed decreased connectivity as the number of traumatic events increased. The resting-state networks defined by the four sex-specific clusters corresponded with the default mode network.ConclusionsTraumatic experiences are associated with an alteration of resting-state functional connectivity in the somatomotor network in youth without psychiatric diagnoses. The associations differ in direction between males and females in the default mode network, suggesting sex-specific responses to early exposure to trauma.

scholarly journals 0417 Associations Between Rest-Activity Patterns and Resting-State Networks in Older Adults

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A159-A160
Author(s):  
C Moon ◽  
R A Cole ◽  
Q Xiao ◽  
M W Voss
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Sleep Duration ◽  
Resting State ◽  
Activity Pattern ◽  
Activity Patterns ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
F Statistics ◽  
Rest Activity

Abstract Introduction Resting-state functional connectivity is coherent brain activity in a task-free state that strongly correlates to task-evoked sensory, motor, and higher-order cognitive systems. Certain networks show decreased functional connectivity with aging. Aging is associated with changes in circadian rhythms and sleep-wake cycles. Limited research has been conducted on how circadian activity and sleep are related to markers of functional brain aging. The purpose of this study was to explore whether rest-activity patterns and shorter sleep duration are related to functional connectivity of specific resting-state networks in older adults. Methods A total of 124 cognitively normal participants (mean age (SD) = 67.2 (5.7), 42% men) underwent 3.0 T MRI and week-long wrist actigraphy protocols. Rest-activity pattern was analyzed using an extended cosine model calculating acrophase (time of peak activity) and pseudo-F statistics of goodness-of-fit (a measure of overall rhythmicity). We used resting-state fMRI scans to measure functional connectivity in association and sensory networks as defined by the Schaefer 17 network functional atlas. Multiple linear regression analysis was used to investigate how rest-activity pattern parameters and sleep duration are associated with resting-state functional connectivity, adjusting for age, sex, and sleep apnea. Results We found that the average acrophase was 2:30 PM (SD = 54 min), and delayed acrophase (average vs. delayed [+1SD]) was associated with lower functional connectivity of the right-lateralized default mode network A (p=0.02), and higher pseudo-F statistics was associated with higher functional connectivity in networks including left dorsal attention B (p=0.001), right somatomotor A (p = 0.05), and somatomotor B (both p=0.02). Longer sleep duration was associated with higher right executive control B (p=0.03). Conclusion The overall rhythmicity of diurnal rest-activity patterns and longer sleep duration are associated with some resting-state functional networks. Further investigation is needed to understand the mechanisms between circadian rhythm and brain function. Support National Institute of Health, U of Iowa Aging Mind Brain Initiative, Center on Aging

scholarly journals Strengthened thalamoparietal functional connectivity in patients with hemifacial spasm: a cross-sectional resting-state fMRI study

2020 ◽  
Vol 93 (1108) ◽  
pp. 20190887 ◽  
Author(s):  
Xuan Niu ◽  
Hui Xu ◽  
Chenguang Guo ◽  
Tong Yang ◽  
Dustin Kress ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Hemifacial Spasm ◽  
Resting State ◽  
Resting State Fmri ◽  
Association Cortex ◽  
Resting State Networks ◽  
Supramarginal Gyrus ◽  
Resting State Functional Connectivity ◽  
Cross Sectional ◽  
The Right

Objective: In spite of the well-known importance of thalamus in hemifacial spasm (HFS), the thalamic resting-state networks in HFS is still rarely mentioned. This study aimed to investigate resting-state functional connectivity (FC) of the thalamus in HFS patients and examine its association with clinical measures. Methods: 25 HFS patients and 28 matched healthy controls underwent functional MRI at rest. Using the left and right thalamus as seed regions respectively, we compared the thalamic resting-state networks between patient and control groups using two independent sample t-test. Results: Compared with controls, HFS patients exhibited strengthened bilateral thalamus-seeded FC with the parietal cortex. Enhanced FC between right thalamus and left somatosensory association cortex was linked to worse motor disturbance, and the increased right thalamus-right supramarginal gyrus connection were correlated with improvement of affective symptoms. Conclusion: Our findings indicate that the right thalamus–left somatosensory association cortex hyperconnectivity may represent the underlying neuroplasticity related to sensorimotor dysfunction. In addition, the upregulated FC between the right thalamus and right supramarginal gyrus in HFS, is part of the thalamo-default mode network pathway involved in emotional adaptation. Advances in knowledge: This study provides new insights on the integrative role of thalamo-parietal connectivity, which participates in differential neural circuitry as a mechanism underlying motor and emotional functions in HFS patients.

scholarly journals A Paradigm for Measuring Resting State Functional Connectivity in Young Children Using fNIRS and Freeplay

2020 ◽  
Author(s):  
Jaeah Kim ◽  
Alexander Ruesch ◽  
Nin Rebecca Kang ◽  
Theodore J. Huppert ◽  
Jana Kainerstorfer ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Young Children ◽  
Resting State ◽  
Near Infrared ◽  
Functional Networks ◽  
Resting State Networks ◽  
New Paradigm ◽  
Resting State Functional Connectivity ◽  
Functional Near Infrared Spectroscopy ◽  
Test Retest Reliability

AbstractResting state functional connectivity (RSFC) reflects the organization of functional networks in the brain. Functional networks measured during “resting”, or task-absent, state are correlated with cognitive function, and much development of these networks occurs between infancy and adulthood. However, RSFC research in the intermediate years (especially between ages 3 and 5 years) has been limited, mainly due to a paucity of child-appropriate neural measures and behavioral paradigms. This paper presents a new paradigm to measure RSFC in young children, utilizing functional near-infrared spectroscopy (fNIRS) and Freeplay, a simple behavioral setup designed to approximate resting state in children. In Experiment 1, we recorded fNIRS data from children aged 3-8 years and adults aged 18-21 years and examined feasibility and validity of our measure of RSFC, and compared measures across the two groups. In Experiment 2, we recorded longitudinal data at two points (approximately 3 months apart) from children aged 3-5 years, and examined reliability under a variety of measures. In both experiments, all children were able to complete testing and provide usable data, a significant improvement over fMRI-based RSFC measurement in children. Results suggest this paradigm is practical and has good construct validity and test-retest reliability, and may contribute towards increasing the availability of reliable data on resting state networks in early childhood. In particular, these are some of the first positive results on the feasibility of reliably measuring functional connectivity in children aged 3-5 years.

scholarly journals Weaker connectivity in resting state networks is associated with disinhibited eating in older adults

2022 ◽  
Author(s):  
Anthony Brennan ◽  
Lars Marstaller ◽  
Hana Burianová ◽  
David Benton ◽  
Claire J. Hanley ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Age Groups ◽  
Eating Behaviour ◽  
Healthy Eating Index ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Alternative Healthy Eating Index ◽  
Disinhibited Eating

Abstract Background/objectives Obesity affects more than forty percent of adults over the age of sixty. Aberrant eating styles such as disinhibition have been associated with the engagement of brain networks underlying executive functioning, attentional control, and interoception. However, these effects have been exclusively studied in young samples overlooking those most at risk of obesity related harm. Methods Here we assessed associations between resting-state functional connectivity and disinhibited eating (using the Three Factor Eating Questionnaire) in twenty-one younger (aged 19–34 years, BMI range: 18–31) and twenty older (aged 60–73 years, BMI range: 19–32) adults matched for BMI. The Alternative Healthy Eating Index was used to quantify diet quality. Results Older, compared to younger, individuals reported lower levels of disinhibited eating, consumed a healthier diet, and had weaker connectivity in the frontoparietal (FPN) and default mode (DMN) networks. In addition, associations between functional connectivity and eating behaviour differed between the two age groups. In older adults, disinhibited eating was associated with weaker connectivity in the FPN and DMN––effects that were absent in the younger sample. Importantly, these effects could not be explained by differences in habitual diet. Conclusions These findings point to a change in interoceptive signalling as part of the ageing process, which may contribute to behavioural changes in energy intake, and highlight the importance of studying this under researched population.

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