Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of α5-laminin(s) and α3β1 integrin

2007 ◽  
Vol 313 (18) ◽  
pp. 3819-3831 ◽  
Author(s):  
Tomoyuki Kawataki ◽  
Tetsu Yamane ◽  
Hirofumi Naganuma ◽  
Patricia Rousselle ◽  
Ingegerd Andurén ◽  
...  
Keyword(s):  
Cell Migration ◽  
Glioma Cell ◽  
Integrin Receptors ◽  
Α3β1 Integrin ◽  
Glioma Cell Migration

Role of high molecular weight extracellular matrix proteins in glioma cell migration

1997 ◽  
Vol 23 (2) ◽  
pp. 102-112 ◽  
Author(s):  
R. Mahesparan ◽  
B. B. Tysnes ◽  
K. Edvardsen ◽  
H. K. Haugeland ◽  
I. Garcia Cabrera ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Extracellular Matrix ◽  
Cell Migration ◽  
High Molecular Weight ◽  
Glioma Cell ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Glioma Cell Migration

scholarly journals A model for glioma cell migration on collagen and astrocytes

2007 ◽  
Vol 5 (18) ◽  
pp. 75-83 ◽  
Author(s):  
M Aubert ◽  
M Badoual ◽  
C Christov ◽  
B Grammaticos
Keyword(s):  
Cell Migration ◽  
Gap Junction ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Migration Patterns ◽  
Gap Junction Communication ◽  
Experimental Findings ◽  
Glioma Cell Migration ◽  
Gap Junction Inhibition

We present a model for the migration of glioma cells on substrates of collagen and astrocytes. The model is based on a cellular automaton where the various dynamical effects are introduced through adequate evolution rules. Using our model, we investigate the role of homotype and heterotype gap junction communication and show that it is possible to reproduce the corresponding experimental migration patterns. In particular, we confirm the experimental findings that inhibition of homotype gap junctions favours migration while heterotype inhibition hinders it. Moreover, the effect of heterotype gap junction inhibition dominates that of homotype inhibition.

Functional Role of Matrix gla Protein in Glioma Cell Migration

2017 ◽  
Vol 55 (6) ◽  
pp. 4624-4636 ◽  
Author(s):  
Mu-Hui Fu ◽  
Chih-Yen Wang ◽  
Yun-Ti Hsieh ◽  
Kuan-Min Fang ◽  
Shun-Fen Tzeng
Keyword(s):  
Cell Migration ◽  
Functional Role ◽  
Glioma Cell ◽  
Matrix Gla Protein ◽  
Glioma Cell Migration

Role of Synaptojanin 2 in Glioma Cell Migration and Invasion

2004 ◽  
Vol 64 (22) ◽  
pp. 8271-8275 ◽  
Author(s):  
Ya-yu Chuang ◽  
Nhan L. Tran ◽  
Nicole Rusk ◽  
Mitsutoshi Nakada ◽  
Michael E. Berens ◽  
...  
Keyword(s):  
Cell Migration ◽  
Glioma Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Glioma Cell Migration

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

2006 ◽  
Vol 349 (3) ◽  
pp. 939-947 ◽  
Author(s):  
Christopher A. Lipinski ◽  
Nhan L. Tran ◽  
Andrea Dooley ◽  
Yuan-Ping Pang ◽  
Carole Rohl ◽  
...  
Keyword(s):  
Cell Migration ◽  
Glioma Cell ◽  
Critical Role ◽  
Ferm Domain ◽  
Glioma Cell Migration

Role of high molecular weight extracellular matrix proteins in glioma cell migration

1997 ◽  
Vol 23 (3) ◽  
pp. 102-112 ◽  
Author(s):  
R. Mahesparan ◽  
B. B. Tysnes ◽  
K. Edvardsen ◽  
H. K. Haugeland ◽  
I. Garcia Cabrera ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Extracellular Matrix ◽  
Cell Migration ◽  
High Molecular Weight ◽  
Glioma Cell ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Glioma Cell Migration

scholarly journals Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation

2012 ◽  
Vol 23 (14) ◽  
pp. 2635-2644 ◽  
Author(s):  
Tao Tao ◽  
Chun Cheng ◽  
Yuhong Ji ◽  
Guangfei Xu ◽  
Jianguo Zhang ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Lines ◽  
Glioma Cell ◽  
Tumor Necrosis Factor Receptor ◽  
Migration And Invasion ◽  
Human Glioma ◽  
Tissue Samples ◽  
Cell Migration And Invasion ◽  
Glioma Cell Migration

The Notch signaling regulator Numblike (Numbl) is expressed in the brain, but little is known regarding its role in the pathophysiology of glial cells. In this paper, we report that Numbl expression was down-regulated in high-grade human glioma tissue samples and glioblastoma cell lines. To investigate the role of Numbl in glioma migration and invasion, we generated human glioma cell lines in which Numbl was either overexpressed or depleted. Overexpression of Numbl suppressed, while elimination of Numbl promoted, the migration and invasion of glioma cells. Numbl inhibited glioma migration and invasion by dampening NF-κB activity. Furthermore, Numbl interacted directly with tumor necrosis factor receptor–associated factor 5 (TRAF5), which signals upstream and is required for the activation of NF-κB, and committed it to proteasomal degradation by promoting K48-linked polyubiquitination of TRAF5. In conclusion, our data suggest that Numbl negative regulates glioma cell migration and invasion by abrogating TRAF5-induced activation of NF-κB.

Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway

2013 ◽  
Vol 31 (4) ◽  
pp. 234-241 ◽  
Author(s):  
Zheng-Xiang Han ◽  
Xiao-Xia Wang ◽  
Shang-Nuan Zhang ◽  
Jin-Xia Wu ◽  
He-ya Qian ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathway ◽  
Glioma Cell ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Glioma Cell Migration

scholarly journals Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor

Oncogene ◽  
2018 ◽  
Vol 38 (10) ◽  
pp. 1734-1750 ◽  
Author(s):  
J. P. Zepecki ◽  
K. M. Snyder ◽  
M. M. Moreno ◽  
E. Fajardo ◽  
A. Fiser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Migration ◽  
Tumor Growth ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Glioma Cell Migration
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