Adenocarcinoma as an independent risk factor for early-stage intermediate-risk cervical carcinoma

2011 ◽  
Vol 120 ◽  
pp. S104-S105
Author(s):  
C. Mathews ◽  
S. Goodrich ◽  
R. Farrell ◽  
C. DeSimone ◽  
L. Seamon ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cervical Carcinoma ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Intermediate Risk

Abstract 15764: Evaluation of Pulmonary Hypertension World Health Organization Group II in the Perioperative Setting

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Martin Marak ◽  
Danielle Tatum ◽  
Denzil Moraes
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Risk Factor ◽  
World Health Organization ◽  
Independent Risk Factor ◽  
World Health ◽  
Intermediate Risk ◽  
Surgical Risk ◽  
Group Ii ◽  
Health Organization

Introduction: The World Health Organization (WHO) categorizes pulmonary hypertension (PHTN) into 5 groups. Group II classification denotes PHTN secondary to left-heart disease and accounts for nearly 75% of all cases. However, there is limited data regarding the effect of PHTN Group II status on outcomes in the perioperative setting. Hypothesis: PHTN WHO Group II is an independent risk factor for adverse cardiopulmonary events in the perioperative setting. Methods: Retrospective review of patients who underwent intra-abdominal surgery between January 2014 - August 2019 and had previously obtained an echocardiogram. PHTN Group II was defined as estimated pulmonary artery pressure (EPAP) > 30mmHg on echocardiogram . Other forms of PHTN were excluded. Major adverse cardiovascular events (MACE) were defined as heart failure exacerbation, arrhythmia, myocardial infarction, 30 day readmission, and death. Surgical risk was categorized as low (laparoscopic) or intermediate (open). Results: By echocardiogram findings, 65 of the 178 (36.3%) patients included were Group II PHTN. Between surgical risk classes, Group II PHTN was older (mean age 73.7 years v 60.5; P< 0.01), had more comorbidities including systolic (9.70% v 21.5%, P=0.03) and diastolic (22.1% v 34.5%, P < 0.01) heart failure, and were more likely to have a MACE ( 6.2% v 43.1%, P < 0.01). PHTN Group II patients with intermediate-risk surgeries demonstrated significantly more MACE than control (11.2% v 43.7%, P <0.01) without significant difference in comorbidities. Conclusions: Group II PHTN is an independent risk factor for MACE in patients undergoing intermediate risk surgery compared to non-PHTN counterparts. Additional studies involving severity of pulmonary hypertension may provide further insight into risk stratification.

Uterine corpus invasion as a risk factor in patients with early-stage cervical carcinoma receiving radical surgery.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17012-e17012
Author(s):  
Yifan Li ◽  
Ning Li ◽  
Lingying Wu
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Carcinoma ◽  
Radical Surgery ◽  
Early Stage ◽  
Univariate Analysis ◽  
Uterine Corpus ◽  
Node Metastasis

e17012 Background: To explore whether pathologically verified uterine corpus invasion (UCI) is a risk factor for patients with early-stage (IB1-IIA2) cervical carcinoma receiving radical surgery. Methods: A mathed-case comparison of early-stage cervical carcinoma patients with pathologically verified UCI to patients without UCI on a 1:1 ratio was conducted. High risk factors (lymph node metastasis, paremetrial invasion, vaginal margin invasion) and intermediate risk factors (lymphovascular space invasion (LVSI) and deep stromal invasion) were completely matched between UCI and non-UCI groups. Kaplan-Meier and Log-rank test were applied for univariate analysis, and COX proportional hazard regression models were used for multivariate analysis. Results: 1320 consecutive patients with cervical carcinoma received surgery in our centerfrom Jan. 1st2009 to Dec 31st2014. 79 (5.98%) cases with UCI were identified. Median follow-up time was 43 months. There were 22 cases with recurrence. In UCI group, the recurrence rate was 20.3% (16/79), and in non-UCI group the recurrence rate was 7.6% (6/79). On univariate analysis, SCC, neoadjuvant chemotherapy (NACT), lymph node metastasis, parametrial invasion, LVSI, deep stromal invasion, vaginal invasion and UCI were significantly associated with disease free survival (DFS). After multivariate analysis, UCI ( p= 0.02, RR3.832, 95% CI1.235-11.893)and lymph node metastasis ( p= 0.042, RR 2.890, 95% CI1.038-8.045) were still independent risk factors for deceased DFS. Conclusions: Pathologically verified uterine corpus invasion might be an independent risk factor for decreased DFS in patients with early-stage cervical carcinoma receiving radical surgery.

Comparison of no adjuvant treatment and radiotherapy in early‐stage cervical carcinoma with intermediate risk factors

2020 ◽  
Vol 149 (3) ◽  
pp. 298-302
Author(s):  
Huseyin Akilli ◽  
Yusuf A. Tohma ◽  
Ayça N. Bulut ◽  
Latife Atasoy Karakas ◽  
Asuman N. Haberal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Carcinoma ◽  
Adjuvant Treatment ◽  
Early Stage ◽  
Intermediate Risk

scholarly journals Efficacy analysis of intraoperative radiotherapy in patients with early-stage breast cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Lin Wang ◽  
Minmin Zhu ◽  
Yuelong Cui ◽  
Xudong Zhang ◽  
Guowen Li
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Clinical Efficacy ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Intraoperative Radiotherapy ◽  
Disease Free Survival ◽  
Early Stage Breast Cancer ◽  
Rank Test ◽  
Wound Complications

Abstract Background To analyze the clinical efficacy of intraoperative radiotherapy (IORT) after breast-conserving surgery (BCS) in patients with early-stage breast cancer (BC), and to investigate the relationship between its influencing factors and clinical efficacy and prognosis. Methods A total of 73 patients with early-stage BC who underwent IORT after BCS in our hospital were selected in this research. Results Kaplan-Meier survival analysis was used to analyze the related factors of BCS and IORT of disease-free survival (DFS) and overall survival (OS). It was found that only age (χ2 = 14.035, P = 0.003) was statistically positively correlated with the patient’s DFS, and local recurrence and metastasis rate and mortality were higher in patients over 70 years old. Log rank test was used to analyze multiple factors. Only the diameter of the applicator (χ2 = 70.378, P < 0.05) was statistically significant with wound complications, and the larger the diameter, the higher incidence of wound complications. The remaining risk factors did not increase the incidence of wound complications. COX multivariate analysis showed that age was an independent risk factor for DFS rate and the risk factor had no significant effect on the OS rate of patients undergoing IORT after BCS. Conclusions IORT may be a safe form of treatment for the selected patients with early-stage BC, and can achieve satisfactory esthetic effect. Larger applicator diameters may increase the incidence of wound complications. Age is an independent risk factor for DFS in early-stage BC patients undergoing IORT after BCS.

scholarly journals Recurrence-Free Survival Stage IB1-IIA2 Intermediate Risk Group (Based on Kartu Delgado) Cervical Carcinoma after Radical Surgery and Adjuvant Radiotherapy

2016 ◽  
Author(s):  
Andi Friadi
Keyword(s):  
Prognostic Factor ◽  
Cervical Carcinoma ◽  
Adjuvant Radiotherapy ◽  
Obstet Gynecol ◽  
Radical Surgery ◽  
Early Stage ◽  
Gynecologic Oncology ◽  
Intermediate Risk ◽  
Recurrence Free Survival ◽  
Free Survival

Objective: To evaluate the benefits of adjuvant radiotherapy (ART) based on Kartu Delgado (simple form of Gynecologic Oncology Group (GOG) scoring system) aimed at women with early stage cervical cancer after radical surgery. Method: Fifty patients were enrolled for this study. Twenty one patients from 2011-2012 were given ART following surgery based on their Kartu Delgado score from as follows: score 120 were given ART. Their score and recurrence were compared with 29 patients who were treated in 2009-2010 (based on single prognostic factor). Result: We observed eighteen recurrences for the duration this study. Thirteen patients from the period of 2009-2010 and five patients from the period of 2011-2012. Most recurrences occurred in patients from 2009-2010 with score > 120 but were not designated ART. Two-years recurrence-free survival (RFS) for subjects with score 120 with ART was 64.29%. Conclusion: Adjuvant radiotherapy given based on Kartu Delgado reduced the number of recurrences in women with stage IB-IIA cervical cancer after treated by surgery. [Indones J Obstet Gynecol 2014; 3: 146-152] Keywords: cervical carcinoma, intermediate risk, prognostic factor, radical hysterectomy

Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma

2013 ◽  
Vol 130 (3) ◽  
pp. 463-469 ◽  
Author(s):  
Jutta Huvila ◽  
Lauri Talve ◽  
Olli Carpén ◽  
Per-Henrik Edqvist ◽  
Fredrik Pontén ◽  
...  
Keyword(s):  
Risk Factor ◽  
Progesterone Receptor ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Endometrial Adenocarcinoma ◽  
Receptor Negativity

scholarly journals Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer

2013 ◽  
Vol 128 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Gunjal Garg ◽  
Feng Gao ◽  
Jason D. Wright ◽  
Andrea R. Hagemann ◽  
David G. Mutch ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

scholarly journals FABP4 is an independent risk factor for lymph node metastasis and poor prognosis in patients with cervical cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guoqing Li ◽  
Qiulei Wu ◽  
Lanqing Gong ◽  
Xiaohan Xu ◽  
Jing Cai ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cells ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Fatty Acid Binding ◽  
Node Metastasis ◽  
Cervical Cancer Cells

Abstract Background Pelvic lymph node metastasis (LNM) is a crucial independent prognostic factor in cervical cancer (CCa) and serves as an indicator for radiation therapy as the primary or an adjuvant treatment option. However, preoperative diagnosis of LNM remains challenging. Thus, we aimed to identify biomarkers of LNM in patients with presumed early-stage CCa. Methods The differentially expressed genes (DEGs) between tumours with different lymph node statuses were identified by using The Cancer Genome Atlas database. Then, univariate Cox regression analysis and Kaplan–Meier analyses were utilized to screen overall survival (OS)-associated genes. Multivariate Cox analysis and logistical analysis were utilized to evaluate independent risk factors for OS and LNM, respectively. Subsequently, the protein level of fatty acid binding protein 4 (FABP4) was detected in normal cervical and CCa tissues by immunohistochemistry assays. EdU assays were performed to determine whether FABP4 altered the proliferation of cervical cancer cells. Wound healing and Transwell assays were conducted to explore the effects of FABP4 depletion on migratory and invasive abilities of cervical cancer cells. F-actin fluorescence staining were performed to investigate morphological change and Western blotting analyses were performed to determine epithelial mesenchymal transition-related marker expression and downstream signalling pathways. Results A total of 243 DEGs, including 55 upregulated and 188 downregulated DEGs, were found in CCa patients with LNM versus those without LNM. Among these, FABP4 was found to be closely associated with poor OS. Multivariate analysis uncovered that FABP4 was an independent risk factor for OS and LNM in patients with CCa. The immunohistochemical results verified dramatically increased FABP4 expression in CCa tissues compared to normal cervical epithelia and its association with poor OS and LNM. In vitro, The proliferation, migration and invasion of cervical cancer cells were significantly inhibited after knocking down of FABP4, which was accompanied by elevated expression of E-cadherin and downregulated expression of N-cadherin, Vimentin and p-AKT. Conclusions FABP4 might be a promising biomarker of LNM and survival in patients with early-stage CCa and therefore could significantly contribute to the development of personalized prognosis prediction and therapy optimization.

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