Parallel effects of Pulsatilla and exogenous leutocyclin on the rat ovary, uterus and thyroid

1978 ◽  
Vol 67 (04) ◽  
pp. 265-275 ◽  
Author(s):  
Suresh Prasad ◽  
K. Chandrasekhar

SummaryA comparative study of Pulsatilla (a homœopathic medicine) and leutocyclin was undertaken in female albino rats showing regular oestrus cycles. Pulsatilla in the 30th and 200th potencies was administered orally, and leutocyclin was injected in doses of 0·125 mg and 1·25 mg. 0·25 ml/dose of 90 per cent. alcohol was used as the vehicle. Pulsatilla 30 and 200 and leutocyclin at a dose of 1·25 mg markedly reduced the weight of the ovary. The higher dose of leutocyclin (1·25 mg) and both the attenuations of Pulsatilla increased the process of atresia in ovarian follicles. But a simultaneous decrease in the number and diameters of the corpora lutea was observed.Administration of Pulsatilla and leutocyclin resulted in reduction in the weight of the uterus and the height of the endometrium and luminal epithelium. There was also a reduction in the height of epithelial cells in the thyroid. Both Pulsatilla and leutocyclin enhanced mitotic division in the uterine stroma.The results indicate that leutocyclin in doses of between 0·125 mg and 1·25 mg may be used to produce similar changes in the ovary, uterus and thyroid of the rat as Pulsatilla 30 and 200.

1954 ◽  
Vol s3-95 (30) ◽  
pp. 205-215
Author(s):  
DONALD C. MATTHEWS

1. In Parribacus antarcticus and Scyllarus martensii mitotic division of germinal epithelial cells produces primary spermatocytesy whereas in Scyllarides squammosus this function of the germinal epithelium is limited to comparatively few large, oocytelike cells. 2. Metamorphosing spermatids in all three species are expelled from the sacculi of the testis by the rhythmical activity of their germinal epithelium. This probably accounts also for the clumping of the spermatozoa in the collecting tubule; each clump represents the extended contents of a single sacculus. 3. In Scyllarus martensii and Scyllarides squammosus a continuous, cord-like, encapsulated spermatogenic mass traverses the vasa deferentia, whereas in Parribacus antarcticus the spermatogenic mass separates into distinct ampullae which become encapsulated and are further provided with an enveloping sheath. This sheath between adjacent ampullae becomes ribbon-like, twists, and ultimately forms short, doubly twisted peduncles. 4. A secretion of the typhlosole in all three species surrounds the completed spermatophores and forms the homogeneous matrix. 5. Although these three species are anatomically similar, the spermatophores of Scyllarus martensii and Scyllarides squammosus resemble non-pedunculate spermatophores of the palinurids, the astacids, the homarids, and the nephropsids, whereas those of Parribacus antarcticus more nearly resemble the pedunculate spermatophores of certain pagurids. 6. Spermatophoric evidence above does not justify the inference that Parribacus antarcticus occupies a systematic position intermediate between the Macrura and the Anomura.


1981 ◽  
Vol 70 (03) ◽  
pp. 135-138 ◽  
Author(s):  
Sunil Kumar ◽  
Anil Kumar Srivastava ◽  
K. Chandrasekhar

SummaryAdult female rats were given the 200th and 10,000th potency of Caulophyllum orally on alternate days for ten days. The vehicle used was 90 per cent. alcohol.The 200th potency brought about a significant increase in ovarian and uterine weight and also in cell height of the endometrium and luminal epithelium. Increased mitotic division was also discernible. Simultaneously the stromal cells became smaller in size and exhibited retardation in mitotic division.In addition, the 200th potency treated groups showed marked retardation in the maturation of ova, with the number of maturing ova minimized. Increased atresia was noted and a perceptible decrease in the number and diameter of functional corpora lutea. The controls and animals treated with the 10,000th potency of the same drug exhibited only insignificant changes.


Author(s):  
Girish Rathod ◽  
Somanath Reddy Patil ◽  
Md. Liyakat Ahmed ◽  
K. Vijaykumar

Tramadol at the dose levels of 1mg and 3mg/100g body weight was administered to normal cycling rats for 20 days through intraperitoneal routes. At autopsy on 21st day significant reduction in the ovarian, uterine and body weight was observed. Histological observations showed decrease in the number and size of Graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absences of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total protein and glycogen content of the ovary and uterus is decreased whereas the cholesterol content is increased. The hypothalamo-hypophyseal gonadal axis is prominent regulator of reproductive activities in animals through neuro-endocrine regulation. In this study action of tramadol on ovary and uterine parameters is discussed.


2001 ◽  
Vol 49 (9) ◽  
pp. 1133-1142 ◽  
Author(s):  
Maria V.T. Lobo ◽  
F. Javier M. Alonso ◽  
Amparo Latorre ◽  
Rafael Martín del Río

The distribution of the amino acid taurine in the female reproductive organs has not been previously analyzed in detail. The aim of this study was to determine taurine localization in the rat ovary, oviduct, and uterus by immunohistochemical methods. Taurine was localized in the ovarian surface epithelium. The granulosa cells and oocytes of primordial follicles were immunonegative. In primary and antral follicles, taurine was found mainly in theca cells and oocytes, whereas the zona pellucida, antrum, and most granulosa cells were unstained. However, taurine immunoreactivity in theca cells and oocytes decreased during follicular atresia. During corpora lutea development, the number of immunopositive theca lutein cells increased as these cells invaded the granulosa-derived region. Therefore, most luteal cells from the mature corpora lutea were stained. In the regressing corpora lutea, however, taurine staining in luteal cells decreased. In the fimbriae, infundibulum, and uterotubal junction, taurine was localized in most epithelial cells. In the ampullar and isthmic segments, taurine was found in the cilia of most ciliated cells and in the apical cytoplasm of some non-ciliated cells. In the uterus, most epithelial cells were immunopositive during diestrus and metestrus, whereas most of them were immunonegative during estrus and proestrus. Moreover, taurine immunoreactivity in the oviduct and uterus decreased with pregnancy. (J Histochem Cytochem 49:1133–1142, 2001)


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