53 Monthly validation of the reference values and of the calibration of a SMAC system using data from an apparently healthy population

Introduction: However, the reference ranges for echocardiography might be varying due to ethnicity, gender and age. Therefore, the normal reference ranges obtained from the healthy Asians are important for clinical utility of echocardiography in Asia. Methods: Population-based echocardiography dataset from 6,023 healthy ethnic Asians (47.1±10.9 years, 61.3% men) were divided into 6 age decades: ≤29, 30-39, 40-49, 50-59, 60-69 and ≥70 years. We explored age- and sex-related structural/functional alterations according to 2016 American Society of Echocardiography (ASE) diastolic dysfunction (DD) criteria and their correlates with clinical N-terminal pro-brain natriuretic peptide (NT-proBNP) cut-off for heart failure (HF). Racial comparisons were made using data from London Life Sciences Prospective Population (LOLIPOP) study. Results: Age- and sex-based normative reference ranges (including mean, median, 10% and 90% lower and upper reference values) were extracted from our large healthy population. In fully adjusted models, advanced age (treated as linear) was independently associated with cardiac structural remodeling and worsened diastolic parameters: larger indexed LA volume (LAVi), lower e’, higher E/e’, and higher TR velocity; all p <0.001), and were broadly more prominent in women (P interaction : <0.05). in general, markedly lower e’, higher E/e’ and smaller LAVi were observed in ethnic Asians compared to Whites. DD defined by 2016 ASE criteria, despite at low prevalence (0.42%) in current healthy population, increased drastically with advanced age and performed perfectly in excluding abnormal NT-proBNP (≥125 pg/ml) (Specificity: 99.8%, NPV: 97.6%). Conclusions: This is to date the largest cohort exploring the normative reference values using guideline-centered diastolic parameters from healthy Asians, with senescence process played as central role in diastolic dysfunction. Observed sex and ethnic differences in defining healthy diastolic cut-offs likely impact future clinical definition for DD.

Download Full-text

Scapular balance angle reference values in a healthy population

Revista Española de Cirugía Ortopédica y Traumatología (English Edition) ◽

10.1016/j.recote.2013.12.004 ◽

2014 ◽

Vol 58 (1) ◽

pp. 24-30

Author(s):

J. Contreras ◽

D. Gil ◽

J. de Dios Errázuriz ◽

P. Ruiz ◽

C. Díaz ◽

...

Keyword(s):

Reference Values ◽

Healthy Population

Download Full-text

Adductor pollicis muscle: Reference values of its thickness in a healthy population

Clinical Nutrition ◽

10.1016/j.clnu.2009.08.012 ◽

2010 ◽

Vol 29 (2) ◽

pp. 268-271 ◽

Cited By ~ 21

Author(s):

M. Cristina Gonzalez ◽

Rodrigo R.P. Duarte ◽

Michele B. Budziareck

Keyword(s):

Reference Values ◽

Adductor Pollicis ◽

Healthy Population ◽

Adductor Pollicis Muscle

Download Full-text

Ultrasonographic Reference Values of Different Dimensions of Adrenal Glands in Healthy Dogs

Indian Journal of Animal Research ◽

10.18805/ijar.b-4276 ◽

2020 ◽

Author(s):

Akash . ◽

Gulshan Kumar ◽

R.P. Pandey

Keyword(s):

Reference Values ◽

Adrenal Glands ◽

Sagittal Plane ◽

Ultrasound Images ◽

Group Iii ◽

Group I ◽

Different Dimensions ◽

Healthy Dogs ◽

Pole Diameter ◽

Apparently Healthy

Background: The present study was conducted to measure the dimensions of the adrenal glands in apparently healthy dogs for obtaining reference values via ultrasonographic modality.Methods: This study was carried out on 18 apparently healthy dogs divided into three groups of six each viz., Group I, II and III. Ultrasonographic examination was performed in all the animals in lateral recumbency. Ultrasound images of adrenal glands were reported in the sagittal plane and different measurements of both the adrenal glands were determined.Result: Both the adrenal glands were longest in Group III and shortest in Group I. Similarly, the cranial pole diameter and caudal pole diameter was thickest in Group III and thinnest in Group I. The measurements recorded during this study can be used as reference values.

Download Full-text

Development of Mobile Application for Assessment of Basic Echocardiographic Parameters in Apparently Healthy Population

Telemedicine Journal and e-Health ◽

10.1089/tmj.2021.0302 ◽

2021 ◽

Author(s):

Irina V. Pospelova ◽

Dmitry S. Bragin ◽

Irina V. Cherepanova ◽

Victoriya N. Serebryakova ◽

Alexander A. Sokolov ◽

...

Keyword(s):

Mobile Application ◽

Healthy Population ◽

Echocardiographic Parameters ◽

Apparently Healthy

Download Full-text

U-Shaped Association Between the Triglycerides-Glucose index and the Risk of Incident Diabetes in Apparently Healthy Population: A Population-based Cohort Study

10.21203/rs.3.rs-42381/v1 ◽

2020 ◽

Author(s):

Xiuping Xuan ◽

Masahide Hamaguchi ◽

Qiuli Cao ◽

Okamura Takuro ◽

Yoshitaka Hashimoto ◽

...

Keyword(s):

Linear Regression ◽

Regression Model ◽

Linear Regression Model ◽

Piecewise Linear ◽

Incident Diabetes ◽

Smoothing Function ◽

Healthy Population ◽

Piecewise Linear Regression ◽

Tyg Index ◽

Apparently Healthy

Abstract Background Although the triglycerides-glucose (TyG) index was thought to be a practical predictor of incident diabetes, the association between them has not been well characterized. The study aimed to further examine the association between the TyG index and incident diabetes in Japanese adults. Methods The cases were extracted of the individual participating in the NAGALA (NAfld in the Gifu Area, Longitudinal Analysis) study at Murakami Memorial Hospital from 2004 to 2015, and 14297individuals apparently healthy at baseline were included in the study. Cox proportional hazards models were used to evaluate the associations between baseline TyG levels and incident of T2DM, and a two-piecewise linear regression model was use to examine the threshold effect of the baseline TyG on incident diabetes using a smoothing function. The threshold level (i.e., turning point) was determined using trial and error. A log likelihood ratio test was also conducted to compare the one-line linear regression model with a two-piecewise linear model. Results During a median follow-up period of 5.26 (women) and 5.88 (men) years, 47 women and 182 men developed Type 2 diabetes. The risk of diabetes was strongly associated with the baseline TyG index in the fully adjusted model in men but not in women, and no dose-dependent positive relationship between incident diabetes and TyG was observed across TyG tertiles. Intriguingly, two-piecewise linear regression analysis showed a U-shaped association between the TyG index and incident T2DM. The risk of incident diabetes decreased by around 90% in women with TyG < 7.27 (HR: 0.09; P = 0.0435) and 80% in men with TyG < 7.97 (HR 0.21, P = 0.002) with each increment of the TyG index after adjusting for confounders. In contrast, the risk of incident T2DM significantly elevated with the increase in TyG index in men with TyG > 7.97 (HR: 2.42, P < 0.001) and women with TyG > 7.29 (HR 2.76, P = 0.0166). Conclusions A U-shaped association was observed between the TyG index and incident T2DM among healthy individuals, with the TyG threshold of 7.97 in men and 7.27 in women. This information may be useful for reducing incident diabetes by maintaining the TyG index near these thresholds.

Download Full-text

Brugada Sign: What Is the Prevalence in an Apparently Healthy Population?

Cardiac Arrhythmias 2001 ◽

10.1007/978-88-470-2103-7_31 ◽

2002 ◽

pp. 198-205

Author(s):

A. Nava ◽

B. Bauce ◽

S. Cannas ◽

A. Rampazzo ◽

B. Martini

Keyword(s):

Healthy Population ◽

Apparently Healthy

Download Full-text

Normal reference values of multilayer longitudinal strain according to age decades in a healthy population: A single-centre experience

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jex306 ◽

2017 ◽

Cited By ~ 10

Author(s):

Gian Marco Alcidi ◽

Roberta Esposito ◽

Vincenzo Evola ◽

Ciro Santoro ◽

Maria Lembo ◽

...

Keyword(s):

Reference Values ◽

Longitudinal Strain ◽

Healthy Population ◽

Single Centre ◽

Normal Reference ◽

Single Centre Experience

Download Full-text

Normal reference values for bladder wall thickness on CT in a healthy population

Abdominal Radiology ◽

10.1007/s00261-018-1463-x ◽

2018 ◽

Vol 43 (9) ◽

pp. 2442-2445 ◽

Cited By ~ 2

Author(s):

Ghaneh Fananapazir ◽

Aleksandar Kitich ◽

Ramit Lamba ◽

Susan L. Stewart ◽

Michael T. Corwin

Keyword(s):

Reference Values ◽

Wall Thickness ◽

Bladder Wall ◽

Healthy Population ◽

Bladder Wall Thickness ◽

Normal Reference

Download Full-text

Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

Pan African Medical Journal ◽

10.11604/pamj.2018.29.205.13043 ◽

2018 ◽

Vol 29 ◽

Cited By ~ 2

Author(s):

Saad Bakrim ◽

Youssef Motiaa ◽

Ali Ouarour ◽

Azlarab Masrar

Keyword(s):

Pregnant Women ◽

Reference Values ◽

Blood Count ◽

Complete Blood Count ◽

Hematological Parameters ◽

Control Group ◽

Mean Corpuscular Hemoglobin ◽

Healthy Population ◽

Corpuscular Hemoglobin ◽

Significant Difference

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

Download Full-text