M1600 Focal Adhesion Kinase (FAK) Plays a Critical Role in Early Cell Migration By Affecting the Microtubular Cytoskeleton

2009 ◽  
Vol 136 (5) ◽  
pp. A-392 ◽  
Author(s):  
J. Adrian Lunn ◽  
Enrique Rozengurt
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Critical Role ◽  
Microtubular Cytoskeleton

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 ◽  
Vol 109 (7) ◽  
pp. 1787-1794 ◽  
Author(s):  
L.A. Cary ◽  
J.F. Chang ◽  
J.L. Guan
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cho Cells ◽  
Critical Role ◽  
Cellular Interactions ◽  
Cellular Functions ◽  
And Migration ◽  
Biochemical Signals

Cellular interactions with the extracellular matrix proteins play important roles in a variety of biological processes. Recent studies suggest that integrin-mediated cell-matrix interaction can transduce biochemical signals across the plasma membrane to regulate cellular functions such as proliferation, differentiation and migration. These studies have implicated a critical role of focal adhesion kinase (FAK) in integrin-mediated signal transduction pathways. We report here that overexpression of FAK in CHO cells increased their migration on fibronectin. A mutation of the major autophosphorylation site Y397 in FAK abolished its ability to stimulate cell migration, while phosphorylation of Y397 in a kinase-defective FAK by endogenous FAK led to increased migration. We also find that the wild-type and the kinase-defective FAK were associated with Src and Fyn in CHO cells whereas the F397 mutant was not. These results directly demonstrate a functional role for FAK in integrin signaling leading to cell migration. They also provide evidence for the functional significance of FAK/Src complex formation in vivo.

Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration

2012 ◽  
Vol 42 (2) ◽  
pp. 436-446 ◽  
Author(s):  
Sean A. Parsons ◽  
Ritu Sharma ◽  
Dawn L. Roccamatisi ◽  
Hong Zhang ◽  
Björn Petri ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Critical Role

New concepts regarding focal adhesion kinase promotion of cell migration and proliferation

2006 ◽  
Vol 99 (1) ◽  
pp. 35-52 ◽  
Author(s):  
Braden D. Cox ◽  
Meera Natarajan ◽  
Michelle R. Stettner ◽  
Candece L. Gladson
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
New Concepts ◽  
Cell Migration And Proliferation

scholarly journals JSAP1/JIP3 Cooperates with Focal Adhesion Kinase to Regulate c-Jun N-terminal Kinase and Cell Migration

2005 ◽  
Vol 280 (45) ◽  
pp. 37772-37781 ◽  
Author(s):  
Takahisa Takino ◽  
Mitsutoshi Nakada ◽  
Hisashi Miyamori ◽  
Yumi Watanabe ◽  
Tokiharu Sato ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion

scholarly journals The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

2021 ◽  
Vol 15 (1) ◽  
pp. 58-73
Author(s):  
Andrea A. Villanueva ◽  
Pilar Sanchez-Gomez ◽  
Ernesto Muñoz-Palma ◽  
Sofía Puvogel ◽  
Bárbara S. Casas ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Neuroblastoma Cell ◽  
Integrin Β1 ◽  
Kinase Activation ◽  
Signaling Axis
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