Hyperglycemia is a Significant Risk Factor for Recurrence of Hepatocellular Carcinoma After Curative Ablation Therapy and Related to Poor Survival

Abstract OBJECTIVES Spread through air space (STAS) is recognized as a pattern of invasion in lung adenocarcinoma and has been reported to be a predictor of recurrence and survival in patients with early-stage lung adenocarcinoma. However, this parameter has not been studied well in stage III (N2) lung adenocarcinoma. In this study, we evaluated the association between STAS invasion patterns and recurrence and survival in stage III (N2) lung adenocarcinoma. METHODS We retrospectively reviewed data from 76 patients at University of Tokyo with stage III (N2) lung adenocarcinoma who underwent surgery from August 1998 to December 2013. Statistical analysis was performed to determine the impact of STAS invasion clinicopathological features and clarify the relationship between this pattern of invasion and survival. RESULTS Tumour STAS was observed in 46 of 76 patients (60.5%) and was significantly associated with the presence of lymphatic invasion (P < 0.001), papillary components (P < 0.001) and micropapillary components (P < 0.001). STAS was also significantly associated with recurrence (5-year recurrence-free probability: 19.0% vs 46.1%, P < 0.05). Univariate analyses showed that STAS was a significant risk factor for recurrence (hazard ratio 1.94, 95% confidence interval 1.07–3.51; P = 0.029). CONCLUSIONS The presence of STAS invasion pattern is a significant risk factor for recurrence in stage III (N2) lung adenocarcinoma.

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Screening for Hepatocellular Carcinoma in Patients with Hepatitis B

Viruses ◽

10.3390/v13071318 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1318

Author(s):

Yashasavi Sachar ◽

Mayur Brahmania ◽

Renumathy Dhanasekaran ◽

Stephen E. Congly

Keyword(s):

Hepatocellular Carcinoma ◽

Chronic Hepatitis ◽

Risk Factor ◽

High Risk ◽

Hepatitis B ◽

Risk Stratification ◽

Significant Risk ◽

Health Resources ◽

Significant Risk Factor ◽

Significant Morbidity

Chronic hepatitis B (CHB) infection is a significant risk factor for developing hepatocellular carcinoma (HCC). As HCC is associated with significant morbidity and mortality, screening patients with CHB at a high risk for HCC is recommended in an attempt to improve these outcomes. However, the screening recommendations on who to screen and how often are not uniform. Identifying patients at the highest risk of HCC would allow for the best use of health resources. In this review, we evaluate the literature on screening patients with CHB for HCC, strategies for optimizing adherence to screening, and potential risk stratification tools to identify patients with CHB at a high risk of developing HCC.

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Inferior Surface Leukoplakia of Vocal Folds: Risk of Recurrence: A Preliminary Study

Ear Nose & Throat Journal ◽

10.1177/0145561321989437 ◽

2021 ◽

pp. 014556132198943

Author(s):

Hisashi Hasegawa ◽

Hiroumi Matsuzaki ◽

Kiyoshi Makiyama ◽

Takeshi Oshima

Keyword(s):

Risk Factor ◽

Vocal Fold ◽

Significant Risk ◽

Vocal Folds ◽

Significant Risk Factor ◽

Clinicopathological Characteristics ◽

Inferior Surface ◽

Preliminary Study ◽

Risk Factor For Recurrence ◽

Vocal Fold Leukoplakia

Objectives: This study aimed to identify vocal fold leukoplakia (VFL) lesions on the inferior surface as a risk factor for recurrence. Methods: This was a retrospective study with data collected from 2001 to 2018. The study comprised 37 patients with VFL, divided into the nonrecurrent and recurrent groups. We examined the clinicopathological characteristics and the surgical procedures performed in each patient. Results: Among the 37 patients, 15 (40.5%) had residual (3) or recurrent (12) VFL. Of those patients with and without recurrence, 8 of 12 (66.7%) and 6 of 22 (27.3%), respectively, had inferior surface lesions of the vocal fold at the initial operation ( P = .036). Recurrences were significantly higher in patients with inferior surface lesions. Other evaluated factors did not show significance for recurrence. Conclusion: The presence of VFL lesions on the inferior surface is a significant risk factor for recurrence.

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