Mo1199 Determination of Risk Factors Associated With the Development of Liver Disease in Obese Children

Abstract Background Patients with IBD are at higher risk for non-alcoholic fatty liver disease (NAFLD) comparing to general population. Complex pathogenesis of NAFLD in IBD may be related to disease-specific risk factors such as chronic inflammation, steroid exposure, drug induced hepatotoxicity, malnutrition and alteration of gut microbiota, which is emerging as a major factor in the pathogenesis of NAFLD. The goal of the study was to investigate factors associated with NADLF and advanced liver fibrosis (ALF) in patients with CD and UC. Methods This is a retrospective study on IBD patients without extraintestinal manifestations and known liver disease. NAFLD was defined as Hepatic Steatosis Index (HSI) ≥ 36, and ALF was defined as FIB-4 ≥ 2.67. Predictors of NAFLD development were analysed using Kaplan–Meier and Cox regression analyses. Results In this retrospective study, we have included 225 IBD patients; 72.4% (n = 163) patients with CD and 27.6% (n = 62) patients with UC (median age 41.2 yr, 53.7% males) which were observed for a median of 4.6 years. There were 63.1% (n = 142) patients with normal BMI, 27.6% (n = 62) overweight and 9.3% (n = 21) obese patients. Obese patients had the highest HIS score 43.9 ± 5.9, following with overweight 37.8 ± 5.7 and normal BMI 30 ± 4.3 kg/m2, p < 0.001. During the follow-up obese and overweight patients had higher risk of developing NAFLD comparing to patients with normal BMI (obese HR = 11.1 95% CI 4.3–28.3 and overweight HR = 5.55 95% CI 3.4–9.1, Logrank test p < 0.001) (Figure 1). Regarding FIB-4 score there, was no difference among different BMI categories (p = 0.192), and there was no difference in ALF development in the follow-up period (Logrank test p = 0.91). In Cox proportional-hazards regression significant predictors for NAFLD development were dyslipidaemia HR=2.11, 95% CI 1.2–3.7, overweight HR=6 95% CI 3.6–10, and obesity HR=13.4, 95% CI 7–35. Conclusion NAFLD is frequent comorbidity in patients with CD and UC, which can lead to development of advanced liver fibrosis. Our results show that patients with IBD have a high risk of NAFLD development, whereas the increased risk for ALF was not observed. Overweight and obese patients and those with dyslipidemia should be closer monitored due to significantly higher risk of NAFLD. This study points out the complexity disease-specific risk factors and importance of better stratifying IBD patients at risk of NAFLD and advanced liver fibrosis.

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P842 A STUDY OF RISK FACTORS ASSOCIATED WITH NONALCOHOLIC FATTY LIVER DISEASE [NAFLD] IN INDIANS

Journal of Hepatology ◽

10.1016/s0168-8278(14)61003-5 ◽

2014 ◽

Vol 60 (1) ◽

pp. S352

Author(s):

S.P. Singh ◽

D. Misra ◽

A. Singh ◽

B. Misra ◽

G.K. Pati ◽

...

Keyword(s):

Risk Factors ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Factors Associated

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Determination of Factors Associated with Low Birth Weight among Babies Born in Sulaimania City, Kurdistan-Iraq

Journal of the Faculty of Medicine Baghdad ◽

10.32007/jfacmedbagdad.6231751 ◽

2020 ◽

Vol 62 (3) ◽

Author(s):

Sardar Weli

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Chronic Diseases ◽

Gestational Age ◽

Kurdistan Region ◽

Level Of Education ◽

Factors Associated ◽

Low Level

Background: Low birth weight (LBW) is the main leading cause of infant death. It is contributing to a variety of short and long term poor health outcomes. Determination of risk factors associated with LBW is important to select a suitable action to prevent or reduce this outcome. Studies on LBW and maternal risk factors in the Kurdistan region of Iraq are scarce.Objectives: This study aimed to determine risk factors associated with Low birth weight in Sulaimania city, Kurdistan region of Iraq.Cases and Methods: This study was carried out in the Maternity Hospital in Sulaimania from first of July, 2019 to first of February, 2020. Participants were 300 randomly selected mothers who gave a live birth. The questionnaire form, which contains information about factors associated with low birth weight (infant’s weight at birth lower than 2.5 kg) were filled by collectors. Infants were weighed immediately after delivery, and the weight was recorded in addition to sex of the infants, gestational age (weeks), age of the mother, job of the mothers, mother’s educational levels, antenatal care attendance, gravidity, residency, exercise and history of chronic diseases of mothers were recorded.Results: The results of the present study indicate that LBW was reported in 44.7% of the participants. For the LBW group, 48.5% were males and 51.5% were females. The highest percentage of LBW was among those born preterm 75.4% and the lowest was among full term 24.6%. Many factors such as an employed mother (85.8%), no exercise during pregnancy (88.1%), residency in urban (61.9%), mothers with chronic diseases (86.6%) and low level of education (illiterate and primary) (67.9%) were found as the significant risk factors of LBW. However, other factors such as prenatal care visits, age of mothers and gravidity were not found to be associated with LBW.Conclusion: The current study concludes that multiple risk factors may be associated with LBW in Sulaimania city, Kurdistan region of Iraq. Gestational age (preterm delivery), working mothers, no regular exercise, urban residence, low level of education and mother’s diseases such as hypertension, respiratory conditions, chronic infections and diabetes mellitus were considered as the risk factors associated with LBW.

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