The role of glutathione s-transferases, P-170 glycoprotein, multidrug resistance associated protein and iododeoxyuridine labelling index in chemotherapy resistance of stomach cancer

1998 ◽  
Vol 114 ◽  
pp. A673
Author(s):  
DL Schipper ◽  
MJM Wagenmans ◽  
WHM Peters ◽  
JAJM Wils ◽  
DJT Wagener
Keyword(s):  
Multidrug Resistance ◽  
Stomach Cancer ◽  
Chemotherapy Resistance ◽  
Labelling Index ◽  
Glutathione S Transferases

scholarly journals The Role of Glutathione S-Transferases in Urinary Tract Tumors

2008 ◽  
Vol 27 (3) ◽  
pp. 360-366 ◽  
Author(s):  
Tatjana Simić ◽  
Ana Savić-Radojević ◽  
Marija Plješa-Ercegovac ◽  
Marija Matić ◽  
Tatjana Sašić ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Allelic Variation ◽  
Transitional Cell ◽  
Chemotherapy Resistance ◽  
High Recurrence Rate ◽  
Specific Chemical ◽  
Glutathione S Transferases

The Role of Glutathione S-Transferases in Urinary Tract Tumors Exposure to potential carcinogens is among the etiological factors for renal cell carcinoma (RCC) and transitional cell carcinoma (TCC) of the urinary bladder. RCC is very resistant, while TCC exhibits a high recurrence rate and multifocality. Cytosolic glutathione S-transferases (GST) are a superfamily of enzymes which protect normal cells by catalyzing conjugation reactions between electrophylic compounds, including carcinogens, and glutathione. Some GST enzymes posses hydroperoxidase activity. The most well characterized classes have been named Alpha (GSTA), Mu (GSTM), Pi (GSTP) and Theta (GSTT) and each of these classes contains several different isoenzymes. Several types of allelic variation have been identified within classes, among which GSTM1-null and GSTT1-null confer impaired catalytic activity. Individuals with the GSTM1-null genotype carry a substantially higher risk for bladder carcinogenesis. The effects of glutathione S-transferase T1 polymorphism on the increased susceptibility to RCC and TCC of urinary bladder depend on the presence of specific chemical exposures to compounds metabolized via the GSTT1-1 pathway. In the process of kidney cancerisation expression of GST alpha isoenzymes tends to decrease, consequently favoring a prooxidant environment necessary for the growth of RCC. GST pi enzyme activities are generally retained in RCC and might contribute to the chemotherapy resistance of RCC. In the malignant phenotype of TCC of the urinary bladder up regulation of various GST classes occurs. Up regulation of GSTT1-1 and GSTP1-1 might have important consequences on the tumor growth, by providing a reduced environment and inhibition of apoptotic pathways.

scholarly journals RND family efflux pumps: from antibioresistance to chemotherapy resistance

2020 ◽  
Vol 1 (1) ◽  
pp. 51-61
Author(s):  
Méliné Simsir ◽  
◽  
Isabelle Mus-Veteau ◽  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Abc Transporters ◽  
Chemotherapy Resistance ◽  
Drug Efflux ◽  
Efflux Mechanism ◽  
The Common ◽  
Chemotherapeutic Treatment ◽  
Over 40 Years

Resistance to chemotherapy can be studied comparatively to the study of resistance in microorganisms. For over 40 years, understanding mechanisms that confer MDR has been a major goal of cancer biologists. Most of the studies toward MDR in cancer cells were about ABC transporters. Unfortunately, inhibition of these transporters often resulted in over toxicity due to the important role of these ABC transporters in healthy cells. The discovery of other targets for MDR of resistant cancer cells is of significant interest. Among the protein superfamily identified as being responsible for multidrug resistance are RND. Its members are widespread in bacterial organisms, but also in Archaea and Eukaryotes. Among the common features of multidrug resistance in RND is the ability of these transmembrane proteins to efflux a broad spectrum of substrates and drugs using the proton motive force. Ptch1, member of the RND family, is overexpressed in many aggressive and metastatic cancers. Like other members of the RND family such as NPC1, it is able to transport cholesterol. It was later shown to transport chemotherapeutic drugs, and its inhibition in resistant cancer cell lines resulted in increasing chemotherapeutic treatment efficacy. However, the drug efflux mechanism of Ptch1 is still unknown. In this review, we will discuss the possibility of a drug efflux mechanism common to the different proteins from the RND family.

scholarly journals Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Yiyi Yao ◽  
Fenglin Li ◽  
Jiansong Huang ◽  
Jie Jin ◽  
Huafeng Wang
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Chemotherapy Resistance ◽  
Bone Marrow Microenvironment ◽  
Cytotoxic Effects ◽  
High Relapse Rate ◽  
Underlying Mechanisms ◽  
Acute Myeloid

AbstractDespite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persistence existence of leukemia stem cells (LSCs). Bone marrow microenvironment (BMM), the home of hematopoiesis, has been considered to play a crucial role in both hematopoiesis and leukemogenesis. When interrupted by the AML cells, a malignant BMM formed and thus provided a refuge for LSCs and protecting them from the cytotoxic effects of chemotherapy. In this review, we summarized the alterations in the bidirectional interplay between hematopoietic cells and BMM in the normal/AML hematopoietic environment, and pointed out the key role of these alterations in pathogenesis and chemotherapy resistance of AML. Finally, we focused on the current potential BMM-targeted strategies together with future prospects and challenges. Accordingly, while further research is necessary to elucidate the underlying mechanisms behind LSC–BMM interaction, targeting the interaction is perceived as a potential therapeutic strategy to eradicate LSCs and ultimately improve the outcome of AML.

scholarly journals Role of anacrRmutation in multidrug resistance ofin vitro-selected fluoroquinolone-resistant mutants ofSalmonella entericaserovar Typhimurium

2004 ◽  
Vol 238 (1) ◽  
pp. 267-272 ◽  
Author(s):  
Anne Olliver ◽  
Michel Vallé ◽  
Elisabeth Chaslus-Dancla ◽  
Axel Cloeckaert
Keyword(s):  
Multidrug Resistance ◽  
Resistant Mutants

scholarly journals The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Carolina Soekmadji ◽  
Colleen C. Nelson
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Advanced Prostate Cancer ◽  
Control Cell ◽  
Extracellular Vesicle ◽  
Multidrug Resistance Proteins ◽  
Acquired Drug Resistance ◽  
Resistance Proteins

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

scholarly journals Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

2015 ◽  
Vol 289 (3) ◽  
pp. 361-370 ◽  
Author(s):  
Sharad S. Singhal ◽  
Sharda P. Singh ◽  
Preeti Singhal ◽  
David Horne ◽  
Jyotsana Singhal ◽  
...  
Keyword(s):  
Glutathione S Transferases

The Role of Human Glutathione S-Transferases hGSTA1-1 and hGSTA2-2 in Protection against Oxidative Stress

1999 ◽  
Vol 367 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Tiejun Zhao ◽  
Sharad S. Singhal ◽  
John T. Piper ◽  
Jizhong Cheng ◽  
Utpal Pandya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glutathione S Transferases
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