Bone mass density in post-menopausal women

Abstract Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women. Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital. A consecutive series of post-menopausal women was included, after excluding patients under hormone treatment (including levothyroxine supplementation) and those who received raloxifene, tamoxifen or tibolone during the study period as well as those who received treatment during the previous 12 months were excluded from the present study. Results Overall, 188 women were included in the present study. Among them, 143 women had normal thyroid function, 32 women had hyperthyroidism and 13 women had HT. Correlation of thyroid function indices with osteoporosis indices revealed statistically significant correlations between thyroxine (T4) and free triiodothyronine (T3) with T-, Z-scores and BMD. Logistic regression analysis concerning the impact of HT and hyperthyroidism on T-score, Z-score and bone mass density revealed that both pathological entities negatively affect bone health (p < 0.05). Conclusion The findings of our study suggest that not only hyperthyroidism, but also HT negatively affects BMD. Future studies should investigate this association and corroborate our findings.

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High bone-mass density as a marker for breast cancer in post-menopausal women

The Breast ◽

10.1054/brst.2000.0247 ◽

2001 ◽

Vol 10 (4) ◽

pp. 313-317 ◽

Cited By ~ 14

Author(s):

O. Ganry ◽

B. Tramier ◽

P. Fardellone ◽

N. Raverdy ◽

A. Dubreuil

Keyword(s):

Breast Cancer ◽

Bone Mass ◽

Mass Density ◽

Bone Mass Density ◽

High Bone Mass ◽

Menopausal Women ◽

High Bone ◽

Post Menopausal

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Bone mass density selectively correlates with serum markers of oxidative damage in post-menopausal women

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2012-0095 ◽

2013 ◽

Vol 51 (2) ◽

Cited By ~ 37

Author(s):

Carlo Cervellati ◽

Gloria Bonaccorsi ◽

Eleonora Cremonini ◽

Carlo M. Bergamini ◽

Alfredo Patella ◽

...

Keyword(s):

Bone Mass ◽

Oxidative Damage ◽

Mass Density ◽

Serum Markers ◽

Bone Mass Density ◽

Menopausal Women ◽

Post Menopausal

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The impact of the metabolic syndrome on bone mass density: a prospective case control study

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2017-0053 ◽

2017 ◽

Vol 33 (3) ◽

Cited By ~ 1

Author(s):

Eleni Alhazidou ◽

Vasilios Pergialiotis ◽

Periklis Panagopoulos ◽

Charalampos Chrelias ◽

Erifili Hatziagelaki ◽

...

Keyword(s):

Metabolic Syndrome ◽

Bone Mass ◽

Case Control Study ◽

Mass Density ◽

Case Control ◽

Bone Mass Density ◽

Menopausal Women ◽

Turnover Markers ◽

Control Study ◽

Prospective Case Control Study

AbstractBackgroundObesity and metabolic syndrome (MetS) during the perimenopausal period and in menopause have been linked to altered bone mass density (BMD) in various experimental studies. However, current clinical studies provide conflicting results in this field. The purpose of the present study was to evaluate this association.Materials and methodsWe conducted a prospective case control study that was based on a consecutive series of menopausal women who attended the Reproductive Endocrinology Outpatient Clinic of our hospital between January 2013 and December 2016.ResultsOne hundred and forty post-menopausal women were included in the present study. After stratifying the women in two groups according to the presence of MetS we observed that bone turnover markers remained unaffected by the presence of MetS (p > 0.05). On the other hand, both the T- and Z-scores of women with MetS were significantly higher compared to healthly postmenopausal women [T-score: 0.4 (−0.7 to 1.3) vs. −1 (−1.62 to −0.1), p < 0.001] [Z-score: 0.55 (−0.3 to 1.7) vs. −0.4 (−1.1 to 0.4), p = 0.003].ConclusionsAccording to the findings of our study the presence of MetS during the perimenopausal years seems to have a mild benefit on bone mass density. The pathophysiology that underlies this effect remains unclear as bone turnover markers seem to be unaffected by MetS.

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Association between blood cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women

Archives of Osteoporosis ◽

10.1007/s11657-021-00887-9 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Eun-San Kim ◽

Sangah Shin ◽

Yoon Jae Lee ◽

In-Hyuk Ha

Keyword(s):

Dose Response ◽

Multinomial Logistic Regression ◽

Mass Density ◽

Positive Association ◽

Bone Mass Density ◽

Significant Positive Association ◽

Menopausal Women ◽

Blood Cadmium ◽

Post Menopausal ◽

Blood Cadmium Levels

Abstract Summary We aimed to investigate the association between cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women. There was a significant positive association between cadmium levels and the risk of osteopenia and osteoporosis, but further studies for dose response are required. Purpose Cadmium exposure can exert detrimental effects on bone health, particularly in post-menopausal women. However, previous studies have failed to report an association in Korean post-menopausal women. We aimed to investigate the association between cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women. Methods In total, 5432 participants from the 4th and 5th Korean National Health and Nutrition Examination Survey (KNHANES) were randomly sampled for measurements of heavy metal concentrations in the blood, bone mass density (BMD), and nutrient intake. We analyzed data for 1031 post-menopausal women ≥50 years of age. Blood cadmium levels were categorized into quartiles, and a multinomial logistic regression model was used for analysis. Results There was a significant positive association between cadmium levels and the risk of osteopenia and osteoporosis, but the odds ratio (OR) at the 4th level was lower than that at the 3rd level (OR and 95% confidence interval (CI) for osteopenia: 2nd quartile: 1.24, 0.88-1.74; 3rd quartile: 3.22, 2.24-4.64; 4th quartile: 1.27, 0.87-1.85; P for trend <0.001; OR and 95% CI for osteoporosis: 2nd quartile: 1.54, 1.05-2.25; 3rd quartile: 3.63, 2.31-5.69; 4th quartile: 1.70, 1.03-2.81; P for trend <0.001). This trend was consistent in the sensitivity analysis. Conclusion Our findings suggest that there is an association between blood cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women. However, further prospective studies are required to determine whether there is a dose-response relationship and address potential selection bias, especially in patients with femoral neck osteoporosis.

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Implausible high bone mass density scores as assessed at the lumbar spine by dual X-ray absorptiometry and their correlation with conventional X-ray studies

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0034-1372060 ◽

2014 ◽

Vol 122 (03) ◽

Author(s):

A Nigge ◽

R Fritzen ◽

M Haase ◽

S Schinner ◽

M Schott ◽

...

Keyword(s):

Lumbar Spine ◽

Bone Mass ◽

Mass Density ◽

Bone Mass Density ◽

High Bone Mass ◽

X Ray ◽

High Bone

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The influence of bone quality on radiological outcome in 50 consecutive acetabular fractures treated with a pre-contoured anatomic suprapectineal plate

Archives of Orthopaedic and Trauma Surgery ◽

10.1007/s00402-021-03867-3 ◽

2021 ◽

Author(s):

Maximilian J. Hartel ◽

Tareq Naji ◽

Florian Fensky ◽

Frank O. Henes ◽

Darius M. Thiesen ◽

...

Keyword(s):

Total Hip Arthroplasty ◽

Bone Mass ◽

Bone Quality ◽

Hip Arthroplasty ◽

Mass Density ◽

Acetabular Fractures ◽

Bone Mass Density ◽

Radiological Outcome ◽

Total Hip ◽

The Impact

Abstract Purpose To investigate the range of indications of an anatomical-preshaped three-dimensional suprapectineal plate and to assess the impact of the bone mass density on radiologic outcomes in different types of acetabular fractures. Patients and methods A consecutive case series of 50 acetabular fractures (patient age 69 ± 23 years) treated with suprapectineal anatomic plates were analyzed in a retrospective study. The analysis included: Mechanism of injury, fracture pattern, surgical approach, need for additional total hip arthroplasty, intra- or postoperative complications, as well as bone mass density and radiological outcome on postoperative computed tomography. Results Most frequently, anterior column fracture patterns with and without hemitransverse components as well as associated two column fractures were encountered. The anterior intrapelvic approach (AIP) was used in 98% (49/50) of the cases as primary approach with additional utilization of the first window of the ilioinguinal approach in 13/50 cases (26%). Determination of bone density revealed impaired bone quality in 70% (31/44). Postoperative steps and gaps were significantly greater in this subgroup (p < 0.05). Fracture reduction quality for postoperative steps revealed anatomic results in 92% if the bone quality was normal and in 46% if impaired (p < 0.05). In seven cases (14%), the plate was utilized in combination with acute primary arthroplasty. Conclusion A preshaped suprapectineal plate provides good radiological outcomes in a variety of indications in a predominantly geriatric cohort. Impaired bone quality has a significantly higher risk of poor reduction results. In cases with extensive joint destruction, the combination with total hip arthroplasty was a valuable option.

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