scholarly journals Association between blood cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Eun-San Kim ◽  
Sangah Shin ◽  
Yoon Jae Lee ◽  
In-Hyuk Ha
Keyword(s):  
Dose Response ◽  
Multinomial Logistic Regression ◽  
Mass Density ◽  
Positive Association ◽  
Bone Mass Density ◽  
Significant Positive Association ◽  
Menopausal Women ◽  
Blood Cadmium ◽  
Post Menopausal ◽  
Blood Cadmium Levels

Abstract Summary We aimed to investigate the association between cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women. There was a significant positive association between cadmium levels and the risk of osteopenia and osteoporosis, but further studies for dose response are required. Purpose Cadmium exposure can exert detrimental effects on bone health, particularly in post-menopausal women. However, previous studies have failed to report an association in Korean post-menopausal women. We aimed to investigate the association between cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women. Methods In total, 5432 participants from the 4th and 5th Korean National Health and Nutrition Examination Survey (KNHANES) were randomly sampled for measurements of heavy metal concentrations in the blood, bone mass density (BMD), and nutrient intake. We analyzed data for 1031 post-menopausal women ≥50 years of age. Blood cadmium levels were categorized into quartiles, and a multinomial logistic regression model was used for analysis. Results There was a significant positive association between cadmium levels and the risk of osteopenia and osteoporosis, but the odds ratio (OR) at the 4th level was lower than that at the 3rd level (OR and 95% confidence interval (CI) for osteopenia: 2nd quartile: 1.24, 0.88-1.74; 3rd quartile: 3.22, 2.24-4.64; 4th quartile: 1.27, 0.87-1.85; P for trend <0.001; OR and 95% CI for osteoporosis: 2nd quartile: 1.54, 1.05-2.25; 3rd quartile: 3.63, 2.31-5.69; 4th quartile: 1.70, 1.03-2.81; P for trend <0.001). This trend was consistent in the sensitivity analysis. Conclusion Our findings suggest that there is an association between blood cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women. However, further prospective studies are required to determine whether there is a dose-response relationship and address potential selection bias, especially in patients with femoral neck osteoporosis.

The influence of thyroid disorders on bone density and biochemical markers of bone metabolism

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Konstantinos Tsevis ◽  
Eftihios Trakakis ◽  
Vasilios Pergialiotis ◽  
Eleni Alhazidou ◽  
Melpomeni Peppa ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Mass ◽  
Thyroid Function ◽  
Mass Density ◽  
Bone Mass Density ◽  
Thyroid Disorders ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopausal ◽  
The Impact

Abstract Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women. Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital. A consecutive series of post-menopausal women was included, after excluding patients under hormone treatment (including levothyroxine supplementation) and those who received raloxifene, tamoxifen or tibolone during the study period as well as those who received treatment during the previous 12 months were excluded from the present study. Results Overall, 188 women were included in the present study. Among them, 143 women had normal thyroid function, 32 women had hyperthyroidism and 13 women had HT. Correlation of thyroid function indices with osteoporosis indices revealed statistically significant correlations between thyroxine (T4) and free triiodothyronine (T3) with T-, Z-scores and BMD. Logistic regression analysis concerning the impact of HT and hyperthyroidism on T-score, Z-score and bone mass density revealed that both pathological entities negatively affect bone health (p < 0.05). Conclusion The findings of our study suggest that not only hyperthyroidism, but also HT negatively affects BMD. Future studies should investigate this association and corroborate our findings.

High bone-mass density as a marker for breast cancer in post-menopausal women

The Breast ◽  
2001 ◽  
Vol 10 (4) ◽  
pp. 313-317 ◽  
Author(s):  
O. Ganry ◽  
B. Tramier ◽  
P. Fardellone ◽  
N. Raverdy ◽  
A. Dubreuil
Keyword(s):  
Breast Cancer ◽  
Bone Mass ◽  
Mass Density ◽  
Bone Mass Density ◽  
High Bone Mass ◽  
Menopausal Women ◽  
High Bone ◽  
Post Menopausal

Bone mass density in post-menopausal women

1997 ◽  
Vol 58 (3) ◽  
pp. 287-291 ◽  
Author(s):  
E.V. Cosmi ◽  
M. Minozzi ◽  
B. Riosa ◽  
J.J. Piazze ◽  
L. Pollastrini ◽  
...  
Keyword(s):  
Bone Mass ◽  
Mass Density ◽  
Bone Mass Density ◽  
Menopausal Women ◽  
Post Menopausal

Bone mass density selectively correlates with serum markers of oxidative damage in post-menopausal women

2013 ◽  
Vol 51 (2) ◽  
Author(s):  
Carlo Cervellati ◽  
Gloria Bonaccorsi ◽  
Eleonora Cremonini ◽  
Carlo M. Bergamini ◽  
Alfredo Patella ◽  
...  
Keyword(s):  
Bone Mass ◽  
Oxidative Damage ◽  
Mass Density ◽  
Serum Markers ◽  
Bone Mass Density ◽  
Menopausal Women ◽  
Post Menopausal

Dose‐response effects of exercise on bone mineral density and content in post‐menopausal women

2019 ◽  
Vol 29 (8) ◽  
pp. 1121-1129 ◽  
Author(s):  
Paola Gonzalo‐Encabo ◽  
Jessica McNeil ◽  
Devon J. Boyne ◽  
Kerry S. Courneya ◽  
Christine M. Friedenreich
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Dose Response ◽  
Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals The visceral fat area to leg muscle mass ratio is significantly associated with the risk of hyperuricemia among women: a cross-sectional study

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xiao-He Wang ◽  
Wei-Ran Jiang ◽  
Min-Ying Zhang ◽  
Ying-Xin Shi ◽  
Yun-Ping Ji ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Significant Positive Association ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Menopausal Women ◽  
Leg Muscle

Abstract Background A significant positive association was found in previous studies among obesity, visceral fat accumulation, and hyperuricemia. The purpose of this study was to explore the association between the ratio of visceral fat area to leg muscle mass (VFA-to-LMM) and hyperuricemia, and verify the role of gender differences in the association. Methods A total of 3393 (43.3% are men) participants from Tianjin Union Medical Center-Health Management Center were recruited for this cross-sectional study. The VFA-to-LMM ratio was used as the independent variable. Hyperuricemia, a serum uric acid level ≥ 416 μmol/L in men and in menopausal women and ≥ 357 μmol/L in premenopausal women, was used as the dependent variable. Multiple logistic regression analysis was used to estimate the odds ratio and the 95% confidence interval between the VFA-to-LMM ratio and hyperuricemia. Results The overall prevalence of hyperuricemia was 14.8% (8.9% in women, and 22.5% in men). After adjustment by age, smoking status (for males), menopause status (for females), drinking status, exercise frequency, blood pressure, alanine aminotransferase, fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, creatinine, and history of diseases, a strong positive association was found between the VFA-to-LMM ratio and hyperuricemia in both men (4th vs. 1st quartile 1.60, 95%CI: 1.03–2.49) and women (4th vs. 1st quartile 5.22, 95%CI: 2.44–12.56). After additional adjustment by BMI, there was still a significant positive association in women (4th vs. 1st quartile 2.57, 95%CI: 1.06–6.77). The results of subgroup analysis showed that pre-menopausal women (4th vs. 1st quartile OR: 3.61) have a higher risk of hyperuricemia than postmenopausal women (4th vs. 1st quartile OR: 1.94) with the increase of the VFA-to-LMM ratio. Besides, the interaction analysis results showed the highest risk of hyperuricemia when VFA and LMM were both in the highest quantile (OR: 11.50; 95% CI: 4.86–31.98). Conclusion The VFA-to-LMM ratio was positively associated with the risk of hyperuricemia in women after adjustment by confounders. Pre-menopausal women have a higher risk of hyperuricemia than postmenopausal women with the increase of the VFA-to-LMM ratio. In addition, the highest risk of hyperuricemia was demonstrated when both VFA and LMM were at the highest quartile.

scholarly journals Prevalence of Osteoporosis and Risk of Developing Fragility Fracture in Post-Menopausal Women

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Muhammad Hafiz Bin Hamzah ◽  
Aminudin Che Ahmad
Keyword(s):  
Hip Fracture ◽  
Fragility Fracture ◽  
Assessment Tool ◽  
Health Concern ◽  
Bone Mass Density ◽  
Average Risk ◽  
Average Percentage ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Prevalence Of Osteoporosis

Introduction: Osteoporosis and fragility fracture pose major health concern and cause significant financial burdens in healthcare system. The objectives of this study were to determine the prevalence of osteoporosis among post-menopausal women and to predict the risk of having the major osteoporotic and hip fracture in 10 years using the WHO Fracture Risk Assessment Tool. Materials and Methods: This was a cross-sectional study spanning over a two-year period (from June 2015 to June 2017) investigating post-menopausal women who did their Bone Mass Density (BMD) test at Hospital Melaka. Collected BMD data and parameters were used for analysif of the prevalence of osteoporosis among the study population and FRAX calculation was used to predict the average risk of fragility fracture in 10 years. Statistical analysis was done using SPSS statistical package. Results: Prevalence of osteoporosis among 388 post-menopausal women age 45 to 90 years old was 29.9%. More than half of patients had osteoporosis were Chinese (51%) followed by Malay (43%), Indian (5%) and others (1%). The 10 years average percentage of developing major osteoporosis was 10.81 ± 9.55 %, while the average percentage of developing hip fracture was 4.20 ± 6.53. Conclusion: Prevalence of the post-menopausal women who were osteoporotic was about 30% which is comparable to other countries (Japan, Egypt, Australia, Mexico, Argentina and India). The 10 years average percentage of developing major osteoporosis and hip fracture in our study is quite high, approximately around 20% and 10%, respectively.

QUALITATIVE DIFFERENCES IN GONADOTROPHIC EXTRACTS FROM URINE OF POST-MENOPAUSAL WOMEN

1957 ◽  
Vol 15 (2) ◽  
pp. 119-125 ◽  
Author(s):  
K. WALTER
Keyword(s):  
Tannic Acid ◽  
Dose Response ◽  
Human Urine ◽  
Distilled Water ◽  
Response Curves ◽  
Mouse Uterus ◽  
Menopausal Women ◽  
Dose Response Curves ◽  
Concentrated Solution ◽  
Post Menopausal

SUMMARY 1. A gonadotrophic preparation made from post-menopausal human urine with tannic acid had more activity on the mouse uterus than would be predicted from the results of the test on the prostate of the hypophysectomized rat. 2. In one experiment, when gonadotrophic principles were adsorbed on kaolin at pH 6 from a very concentrated solution of post-menopausal gonadotrophin in distilled water, even larger quantitative differences were found in the results of these two tests. 3. There was no significant deviation of the dose-response curves from parallelism in either test. 4. The data suggest that there is more than one gonadotrophin in post-menopausal urine.

The impact of the metabolic syndrome on bone mass density: a prospective case control study

2017 ◽  
Vol 33 (3) ◽  
Author(s):  
Eleni Alhazidou ◽  
Vasilios Pergialiotis ◽  
Periklis Panagopoulos ◽  
Charalampos Chrelias ◽  
Erifili Hatziagelaki ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bone Mass ◽  
Case Control Study ◽  
Mass Density ◽  
Case Control ◽  
Bone Mass Density ◽  
Menopausal Women ◽  
Turnover Markers ◽  
Control Study ◽  
Prospective Case Control Study

AbstractBackgroundObesity and metabolic syndrome (MetS) during the perimenopausal period and in menopause have been linked to altered bone mass density (BMD) in various experimental studies. However, current clinical studies provide conflicting results in this field. The purpose of the present study was to evaluate this association.Materials and methodsWe conducted a prospective case control study that was based on a consecutive series of menopausal women who attended the Reproductive Endocrinology Outpatient Clinic of our hospital between January 2013 and December 2016.ResultsOne hundred and forty post-menopausal women were included in the present study. After stratifying the women in two groups according to the presence of MetS we observed that bone turnover markers remained unaffected by the presence of MetS (p > 0.05). On the other hand, both the T- and Z-scores of women with MetS were significantly higher compared to healthly postmenopausal women [T-score: 0.4 (−0.7 to 1.3) vs. −1 (−1.62 to −0.1), p < 0.001] [Z-score: 0.55 (−0.3 to 1.7) vs. −0.4 (−1.1 to 0.4), p = 0.003].ConclusionsAccording to the findings of our study the presence of MetS during the perimenopausal years seems to have a mild benefit on bone mass density. The pathophysiology that underlies this effect remains unclear as bone turnover markers seem to be unaffected by MetS.

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