Long term vitamin E feeding attenuates aortic atherosclerosis independent of plasma lipid levels in heterozygous LDL-receptor deficient mice

2000 ◽  
Vol 151 (1) ◽  
pp. 66
Author(s):  
O.L Volger ◽  
J van der Boom ◽  
W van Duyvenvoorde ◽  
K van Wijk ◽  
J Mathot ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ldl Receptor ◽  
Plasma Lipid ◽  
Aortic Atherosclerosis ◽  
Lipid Levels ◽  
Deficient Mice

Long term dietary vitamin E reduces atherosclerotic lesion size and increases plaque stability in heterozygous LDL-receptor deficient mice

2001 ◽  
Vol 2 (2) ◽  
pp. 109
Author(s):  
O.L. Volger ◽  
J. van der Boom ◽  
W. van Duyvenvoorde ◽  
E.H. Offerman ◽  
R. Leenen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ldl Receptor ◽  
Atherosclerotic Lesion ◽  
Lesion Size ◽  
Dietary Vitamin ◽  
Plaque Stability ◽  
Deficient Mice

Overexpression of human ApoAI transgene provides long-term atheroprotection in LDL receptor-deficient mice

2006 ◽  
Vol 189 (2) ◽  
pp. 255-263 ◽  
Author(s):  
David T. Valenta ◽  
Joshua J. Bulgrien ◽  
Carole L. Banka ◽  
Linda K. Curtiss
Keyword(s):  
Ldl Receptor ◽  
Deficient Mice

scholarly journals Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

Gene Therapy ◽  
2019 ◽  
Vol 26 (3-4) ◽  
pp. 121-130 ◽  
Author(s):  
Eleonora Leggiero ◽  
Giuseppe Labruna ◽  
Laura Iaffaldano ◽  
Barbara Lombardo ◽  
Adelaide Greco ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Ldl Receptor ◽  
Chimeric Protein ◽  
Aortic Atherosclerosis ◽  
Deficient Mice

scholarly journals Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice

2016 ◽  
Vol 310 (11) ◽  
pp. R1045-R1052 ◽  
Author(s):  
Martin Hellström ◽  
Madelene Ericsson ◽  
Bengt Johansson ◽  
Mahmood Faraz ◽  
Fredrick Anderson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Hypertrophy ◽  
High Density Lipoprotein ◽  
Heart Function ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Wild Type ◽  
Lipid Levels ◽  
Deficient Mice

Genetic factors confer risk for cardiovascular disease. Recently, large genome-wide population studies have shown associations between genomic loci close to LRIG3 and heart failure and plasma high-density lipoprotein (HDL) cholesterol level. Here, we ablated Lrig3 in mice and investigated the importance of Lrig3 for heart function and plasma lipid levels. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze Lrig3 expression in the hearts of wild-type and Lrig3-deficient mice. In addition, molecular, physiological, and functional parameters such as organ weights, heart rate, blood pressure, heart structure and function, gene expression in the heart, and plasma insulin, glucose, and lipid levels were evaluated. The Lrig3-deficient mice were smaller than the wild-type mice but otherwise appeared grossly normal. Lrig3 was expressed at detectable but relatively low levels in adult mouse hearts. At 9 mo of age, ad libitum-fed Lrig3-deficient mice had lower insulin levels than wild-type mice. At 12 mo of age, Lrig3-deficient mice exhibited increased blood pressure, and the Lrig3-deficient female mice displayed signs of cardiac hypertrophy as assessed by echocardiography, heart-to-body weight ratio, and expression of the cardiac hypertrophy marker gene Nppa. Additionally, Lrig3-deficient mice had reduced plasma HDL cholesterol and free glycerol. These findings in mice complement the human epidemiological results and suggest that Lrig3 may influence heart function and plasma lipid levels in mice and humans.

scholarly journals Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice

2014 ◽  
Vol 48 (6) ◽  
pp. 649-658 ◽  
Author(s):  
K. Fukui ◽  
A. Masuda ◽  
A. Hosono ◽  
R. Suwabe ◽  
K. Yamashita ◽  
...  
Keyword(s):  
Vitamin E ◽  
Related Proteins ◽  
Deficient Mice

scholarly journals Effect of dietary vicine and vitamin E supplementation on the productive performance of growing and laying chickens

1982 ◽  
Vol 47 (1) ◽  
pp. 53-60 ◽  
Author(s):  
David S. Muduuli ◽  
Ronald R. Marquardt ◽  
Wilhelm Guenter
Keyword(s):  
Vitamin E ◽  
Laying Hens ◽  
Control Diet ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
Plasma Vitamin ◽  
Liver Protein ◽  
Lipid Levels ◽  
Supplemental Vitamin ◽  
Vitamin E Supplementation

1. Experiments were conducted to study the effects of dietary vicine (2, 6-diamino-4, 5 dihydroxy pyrimidine-5 (β-D-glucopyranoside)) and supplemental vitamin E on the performance of laying hens and growing chicks.2. Chicks fed on diets that contained vicine had similar growth rates but slightly higher levels of spontaneous haemolysis of erythrocytes than birds fed on a control diet.3. Vicine when fed to laying hens had a very dramatic effect. It depressed food consumption, egg weight, fertility and hatchability of eggs, packed cell volume and erythrocyte haemoglobin levels and led to increased liver weights, liver glutathione levels, liver and plasma lipid levels, plasma lipid peroxide levels and erythrocyte haemolysis in vitro. Liver protein and plasma vitamin E:lipid levels were not altered. Vitamin E supplementation slightly increased egg weights, markedly improved fertility and hatchability of eggs and lowered liver weights and lipid levels but did not affect the other factors examined.4. It is concluded that vicine which was isolated from faba beans (Vicia faba L.) has a marked influence on the metabolism of the laying hen and only a slight effect on the growing chick. Vicine or its metabolites or both cause peroxidation of cellular components which result in abnormal lipid transport or synthesis or both, increased fragility of erythrocytes, and reduced fertility. These effects are overcome to varying extents by supplemental vitamin E.

Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice

2005 ◽  
Vol 512 (2-3) ◽  
pp. 247-249 ◽  
Author(s):  
Kerstin Steioff ◽  
Hartmut Rütten ◽  
Andreas E. Busch ◽  
Oliver Plettenburg ◽  
Yuri Ivashchenko ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Ldl Receptor ◽  
Rho Kinase ◽  
Kinase Inhibition ◽  
Deficient Mice

scholarly journals Long-Term Vitamin E-Deficient Mice Exhibit Cognitive Dysfunction via Elevation of Brain Oxidation

2015 ◽  
Vol 61 (5) ◽  
pp. 362-368 ◽  
Author(s):  
Koji FUKUI ◽  
Keisuke NAKAMURA ◽  
Masashi SHIRAI ◽  
Anna HIRANO ◽  
Hirokatsu TAKATSU ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cognitive Dysfunction ◽  
Deficient Mice

scholarly journals Effect of long-term ingestion of weakly oxidised flaxseed oil on biomarkers of oxidative stress in LDL-receptor knockout mice

2016 ◽  
Vol 116 (2) ◽  
pp. 258-269 ◽  
Author(s):  
M. S. Nogueira ◽  
M. C. Kessuane ◽  
A. A. B. Lobo Ladd ◽  
F. V. Lobo Ladd ◽  
B. Cogliati ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ldl Receptor ◽  
Plasma Lipid ◽  
Flaxseed Oil ◽  
Oxidative Stress Biomarkers ◽  
Alcoholic Fatty Liver ◽  
Atherosclerosis Progression ◽  
Glucose Levels ◽  
Cont Group

AbstractThe effect of oxidised fatty acids on atherosclerosis progression is controversial. Thus, our objective was to evaluate the effect of long-term consumption of weakly oxidised PUFA from flaxseed oil on oxidative stress biomarkers of LDL-receptor(−/−)mice. To test our hypothesis, mice were separated into three groups. The first group received a high-fat diet containing fresh flaxseed oil (CONT−), the second was fed the same diet prepared using heated flaxseed oil (OXID), and the third group received the same diet containing fresh flaxseed oil and had diabetes induced by streptozotocin (CONT+). Oxidative stress, aortic parameters and non-alcoholic fatty liver disease were assessed. After 3 months, plasma lipid profile, glucose levels, body weight, energy intake and dietary intake did not differ among groups. Likewise, oxidative stress, plasma malondialdehyde (MDA), hepatic MDA expressed as nmol/mg portion (ptn) and antioxidant enzymes did not differ among the groups. Hepatic linoleic acid,α-linolenic acid, arachidonic acid and EPA acid declined in the OXID and CONT+ groups. Aortic wall thickness, lumen and diameter increased only in the OXID group. OXID and CONT+ groups exhibited higher concentrations of MDA, expressed as μmol/mg ptn per %PUFA, when compared with the CONT− group. Our results suggest that ingestion of oxidised flaxseed oil increases hepatic MDA concentration and is potentially pro-atherogenic. In addition, the mean MDA value observed in all groups was similar to those reported in other studies that used xenobiotics as oxidative stress inducers. Thus, the diet applied in this study represents an interesting model for further research involving antioxidants.

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