A micro-Finite Element analysis of fluidic and solid mechanical stimuli in bone tissue engineering scaffolds

2006 ◽  
Vol 39 ◽  
pp. S415
Author(s):  
D. Lacroix ◽  
C. Sandino ◽  
M. Villagomez ◽  
M.-P. Ginebra ◽  
J.A. Planell
Keyword(s):  
Tissue Engineering ◽  
Finite Element Analysis ◽  
Finite Element ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Stimuli ◽  
Tissue Engineering Scaffolds ◽  
Element Analysis

Micro-finite element models of bone tissue-engineering scaffolds

Biomaterials ◽  
2006 ◽  
Vol 27 (30) ◽  
pp. 5326-5334 ◽  
Author(s):  
Damien Lacroix ◽  
Arnaud Chateau ◽  
Maria-Pau Ginebra ◽  
Josep A. Planell
Keyword(s):  
Tissue Engineering ◽  
Finite Element ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Finite Element Models ◽  
Tissue Engineering Scaffolds

scholarly journals Finite Element Analysis of Porosity Effects on Mechanical Properties for Tissue Engineering Scaffold

2020 ◽  
Vol 11 (2) ◽  
pp. 8836-8843
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Finite Element Analysis ◽  
Finite Element ◽  
Pore Size ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Vital Role ◽  
Tissue Engineering Scaffolds ◽  
Element Analysis

Porosity plays a vital role in the development of tissue engineering scaffolds. It influences the biocompatibility performance of the scaffolds by increasing cell proliferation and allowing the transportation of the nutrients, oxygen, and metabolites in the blood rapidly to generate new tissue structure. However, a high amount of porosity can reduce the mechanical properties of the scaffold. Thus, this study aims to determine the geometry of the porous structure of a scaffold which exhibits good mechanical properties while maintaining its porosity at a percentage of more than 80%. Circle and square geometries were used since they are categorized as simple geometry. A unit cell of 12mm x 12mm x 12mm for square shape and pore area of 25π mm2 for circle shape was modeled and simulated by using Finite Element Analysis. The simulation consists of a compression test that determines which geometry exhibits better Young’s Modulus. Since the circle geometry has better Young’s Modulus, the pore size was furthered varied while maintaining the porosity of the scaffold to be above 80%. The same method of the simulation was done on the models. The result shows that the smallest pore size model has the highest Young’s Modulus, which still able to maintain the porosity at 80%.

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

scholarly journals THREE-DIMENSIONAL NANOCOMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING: FROM DESIGN TO APPLICATION

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250005 ◽  
Author(s):  
BIN DUAN ◽  
MIN WANG ◽  
WILLIAM W. LU
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Rabbit Model ◽  
Bone Morphogenetic Protein 2 ◽  
Human Umbilical Cord ◽  
Porous Structures ◽  
Tissue Engineering Scaffolds ◽  
Surface Modified ◽  
Nanocomposite Scaffolds

Selective laser sintering (SLS), a rapid prototyping technology, was investigated for producing bone tissue engineering scaffolds. Completely biodegradable osteoconductive calcium phosphate (Ca-P)/poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) scaffolds were successfully fabricated via SLS using Ca-P/PHBV nanocomposite microspheres. In the SLS manufacturing route, the architecture of tissue engineering scaffolds (pore shape, size, interconnectivity, etc.) can be designed and the sintering process can be optimized for obtaining scaffolds with desirable porous structures and mechanical properties. SLS was also shown to be very effective in producing highly complex porous structures using nanocomposite microspheres. To render SLS-formed Ca-P/PHBV scaffolds osteoinductive, recombinant human bone morphogenetic protein-2 (rhBMP-2) could be loaded onto the scaffolds. For achieving a controlled release of rhBMP-2 from scaffolds, surface modification of Ca-P/PHBV scaffolds by gelatin entrapment and heparin immobilization was needed. The immobilized heparin provided binding affinity for rhBMP-2. Surface modified Ca-P/PHBV nanocomposite scaffolds loaded with rhBMP-2 enhanced the proliferation of human umbilical cord derived mesenchymal stem cells (hUCMSCs) and also their alkaline phosphatase activity. In in vivo experiments using a rabbit model, surface modified Ca-P/PHBV nanocomposite scaffolds loaded with rhBMP-2 promoted ectopic bone formation, exhibiting their osteoinductivity. The strategy of combining advanced scaffold fabrication, nanocomposite material, and controlled growth factor delivery is promising for bone tissue regeneration.

scholarly journals Full Contoured Tooth-Implant Supported 3-Pointic All-Ceramic Denture During Occlusal Load Transfer in Lateral Region

2016 ◽  
Vol 61 (2) ◽  
pp. 843-846 ◽  
Author(s):  
J. Żmudzki ◽  
P. Malara ◽  
G. Chladek
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Bone Tissue ◽  
Load Transfer ◽  
Element Analysis ◽  
Lateral Region ◽  
The Finite Element Analysis ◽  
All Ceramic ◽  
Dental Professional ◽  
Wide Zone

Abstract Implant and a tooth supported dentures are avoided by dentists because of uneven distribution of occlusal loads between a stiffer implant and a more pliable tooth. The hypothesis was that a 3-point all-ceramic bridge supported on a natural second premolar tooth and a two-pieces typical implant bears safely mastication loads. The finite element analysis showed that the implant splinted by all-ceramic zirconium bridge with the second premolar was safe under lateral mastication load, but there was found an overload at wide zone of bone tissue around the implant under the load of 800 N. The patients can safely masticate, but comminution of hard food should be avoided and they should be instructed that after such an indiscretion they need to contact a dental professional, because, in spite of integrity of the prosthesis, the bone tissue around the implant may fail and there is a hazard of intrusion of the tooth.

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