PO10-TU-18 Non-invasive brain mapping of motor related areas of four limbs in CIS patients compared with normal subjects

2009 ◽  
Vol 285 ◽  
pp. S200
Author(s):  
M.H. Harirchian ◽  
M.A. Oghabian ◽  
A. Rezvanizadeh ◽  
M. Fakhri ◽  
A. Ghoreishi ◽  
...  
Keyword(s):  
Brain Mapping ◽  
Normal Subjects ◽  
Non Invasive ◽  
In Cis

scholarly journals Normative study of tympanic infrared thermometry: a non-invasive index of asymmetric cerebral activity

2008 ◽  
Vol 66 (1) ◽  
pp. 50-52 ◽  
Author(s):  
Danielle Cicarini de Landa ◽  
Joaquim P. Brasil-Neto ◽  
Raphael Boechat-Barros ◽  
Carlos Uribe
Keyword(s):  
Normal Subjects ◽  
Tympanic Temperature ◽  
Normative Values ◽  
Normative Study ◽  
Infrared Thermometry ◽  
Cerebral Activity ◽  
Confidence Levels ◽  
Non Invasive ◽  
Neurological Patients ◽  
Interaural Differences

Human and primate studies have demonstrated that performance of tasks that induce asymmetrical physiological activation of the cerebral hemispheres leads to a reduction of tympanic temperature (TT) ipsilateral to the most active hemisphere. It is possible that diseases that interfere in an asymmetrical fashion with the degree of cerebral activity cause similar TT changes. There are not, however, normative studies of the acceptable interaural difference in TT in normal subjects at rest. This study was done to establish normative values for interaural TT values measured by means of infrared tympanic thermometry in resting normal subjects not engaged in any specific task. TT values were measured in 47 normal volunteers (20 men and 27 women, aged 39.38±12.57 years old) at rest; mean interaural differences of TT were calculated. Mean right ear TT was 36.85±0.50ºC and mean left ear TT was 36.74±0.57ºC; these values are in agreement with those already reported in the literature. Mean interaural TT difference was 0.25ºC (SD 0.21ºC). These findings indicate that maximal normal values for interaural TT differences, with confidence levels of 99% and 95%, are, respectively, 0.88 and 0.67ºC. The value of interaural differences of TT as a marker of asymmetrical hemispheric activity in neurological patients will have to be established by additional studies.

scholarly journals Increased gastric Pco 2 during exercise is indicative of gastric ischaemia: a tonometric study

Gut ◽  
1999 ◽  
Vol 44 (2) ◽  
pp. 163-167 ◽  
Author(s):  
J J Kolkman ◽  
A B J Groeneveld ◽  
F G van der Berg ◽  
J A Rauwerda ◽  
S G M Meuwissen
Keyword(s):  
Clinical Importance ◽  
Invasive Procedure ◽  
Normal Subjects ◽  
Submaximal Exercise ◽  
Peak Exercise ◽  
Gastric Tonometry ◽  
Revascularisation Procedure ◽  
Non Invasive ◽  
Angiographic Findings ◽  
Gastric Ischaemia

BackgroundDiagnosis of gastric ischaemia is difficult and angiography is an invasive procedure. Angiographic findings may not correlate with clinical importance.AimsTo investigate whether tonometric measurement of intragastric Pco2during exercise can be used to detect clinically important gastric ischaemia.MethodsFourteen patients with unexplained abdominal pain or weight loss were studied. Splanchnic angiography served as the gold standard. Three patients were studied again after a revascularisation procedure. Gastric Pco2 was measured from a nasogastric tonometer, with 10 minute dwell times, and after acid suppression. Gastric and capillary Pco2 were measured before, during, and after submaximal exercise of 10 minutes duration.ResultsSeven patients had normal angiograms; seven had more than 50% stenosis in the coeliac (n=7) or superior mesenteric artery (n=4). Normal subjects showed no changes in tonometry. In patients with stenoses, the median intragastric Pco2(Pico2) at rest was 5.2 kPa (range 4.8–11.2) and rose to 6.4 kPa (range 5.7–15.7) at peak exercise; the median intragastric blood Pco2 gradient increased from 0.0 kPa (range −0.8 to 5.9) to 1.7 kPa (range 0.9 to 10.3; p<0.01). Only two subjects had abnormal tonometry at rest; all had supernormal values at peak exercise. The Pco2 gradient correlated with clinical and gastroscopic severity; in patients reexamined after revascularisation (n=3), exercise tonometry returned to normal.ConclusionGastric tonometry during exercise is a promising non-invasive tool for diagnosing and grading gastrointestinal ischaemia and evaluating the results of revascularisation surgery for symptomatic gastric ischaemia.

Non-invasive evaluation of autonomic tone changes during isometric exercise in normal subjects and in patients with coronary artery disease

1986 ◽  
Vol 13 (2) ◽  
pp. 171-183 ◽  
Author(s):  
Lorenzo De Caprio ◽  
Carlo Vigorito ◽  
Domenico Acanfora ◽  
Domenico Artiaco ◽  
Luigi Ascione ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Isometric Exercise ◽  
Normal Subjects ◽  
Autonomic Tone ◽  
Non Invasive ◽  
Artery Disease ◽  
Invasive Evaluation

EEG Based BCI Using Visual Imagery Task for Robot Control

2013 ◽  
Vol 61 (2) ◽  
Author(s):  
Husnaini Azmy ◽  
Norlaili Mat Safri
Keyword(s):  
Spectral Power ◽  
Normal Subjects ◽  
Imagery Task ◽  
Non Invasive ◽  
Cortex Area ◽  
Wireless Robot ◽  
Scalp Location ◽  
Task Conditions ◽  
Electroencephalogram Eeg ◽  
The Brain

The aim of this study is to detect the brain activation on scalp by Electroencephalogram (EEG) task–based for brain computer interface (BCI) using wirelessly control robot. EEG was measured in 8 normal subjects for control and task conditions. The objective is to determine one scalp location which will give signals that can be used to control the wireless robot using BCI and EEG, using non invasive and without subject training. In control condition subjects were ask to relax but in task condition, subjects were asked to imagine a star rotating clockwise at position 45 degrees direction pointed by the wireless robot where at this angle the target is located. At position 0 and 90 degree angle subjects were asked to relax since there is no target on that direction. Using EEG spectral power analysis and normalization, the optimum location for this task has been detected at position F8 which is in frontal cortex area and the rhythm happened at alpha frequency band. At this position, the signals from the brain should be able to drive the robot to the required direction by giving correct and accurate signals to robot moving towards target.

Hemodynamic Investigation of Flow in the Normal Portal Vein

2008 ◽  
Author(s):  
Stephanie M. George ◽  
Diego R. Martin ◽  
Don P. Giddens
Keyword(s):  
Portal Vein ◽  
Normal Subjects ◽  
The United States ◽  
Diagnostic Methods ◽  
Non Invasive ◽  
Depth Study ◽  
Portal Vein Hemodynamics ◽  
Magnetic Resonance Imaging Mri ◽  
Liver Hemodynamics ◽  
Hemodynamic Information

Cirrhosis is the twelfth leading cause of death in the United States (1). Previous studies have compared portal vein blood flow and velocity in normal subjects and patients with varying results (2–5). In comparing grades of cirrhosis, based on the “Child-Pugh” score, portal flow was significantly affected as the degree of cirrhosis increased (2–4). These previous studies have used a variety of imaging methods; the most common being Doppler Ultrasound (2–5). The use of Magnetic Resonance Imaging (MRI) and phase contrast (PC) – MRI has not been used extensively to study liver hemodynamics. When compared to ultrasound, MRI is often superior in providing anatomical and hemodynamic information. There has also been no in depth study of normal portal vein hemodynamics, an important step for understanding changes due to cirrhosis. This study seeks to preliminarily characterize normal portal venous hemodynamics in a small number of subjects utilizing both MRI and computational fluid dynamics (CFD). The long term clinical objective is to develop non-invasive diagnostic methods to evaluate and monitor the progression of cirrhosis in patients with chronic liver disease.

scholarly journals High Frequency Non-Invasive Stimulation Over the Spine: Effects on Mood and Mechanical Pain Tolerance in Normal Subjects

1997 ◽  
Vol 10 (2-3) ◽  
pp. 61-65 ◽  
Author(s):  
A. D. Towell ◽  
D. Williams ◽  
S. G. Boyd
Keyword(s):  
High Intensity ◽  
High Frequency ◽  
Healthy Subjects ◽  
Normal Subjects ◽  
Pain Tolerance ◽  
Left Shoulder ◽  
Cutaneous Stimulation ◽  
Non Invasive ◽  
Low Intensity ◽  
Clinical Pain

We investigated the effects of non-invasive high frequency (625Hz) stimulation over the spine on mechanical pain tolerance and subjective mood. Sixty healthy subjects were divided equally into three groups receiving either high intensity (250 V), low intensity (3–4 V) or sham electrical stimulation directly over the spinal cord for 30 minutes. Following high intensity stimulation, subjects felt significantly more elated, leisurely and less tense and, contrary to reports on patients with clinical pain, had lower mechanical pain tolerances. There were no correlations between changes in mood and changes in mechanical pain tolerances. These findings contrasted with the lack of any significant differences in mood or mechanical pain tolerances in a second study where 20 subjects received either high intensity or sham stimulation across the left shoulder joint. The results indicate that decreases in mechanical pain tolerance are independent of changes in mood following non-invasive high frequency, high intensity cutaneous stimulation but that both effects are dependent on that stimulation being applied over the spine.

scholarly journals Urinary adiponectin as a new diagnostic index for chronic kidney disease due to diabetic nephropathy

2019 ◽  
Vol 7 (1) ◽  
pp. e000661 ◽  
Author(s):  
Shinnosuke Yamakado ◽  
Hiroki Cho ◽  
Mikio Inada ◽  
Mika Morikawa ◽  
Yong-Huang Jiang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Molecular Weight ◽  
Kidney Disease ◽  
Normal Subjects ◽  
Non Invasive ◽  
Invasive Test ◽  
Patients With Diabetes ◽  
Precise Diagnosis ◽  
Design And Methods ◽  
Diagnostic Index

ObjectiveThe chronic kidney disease (CKD) is widely diagnosed on the basis of albuminuria and the glomerular filtration rate. A more precise diagnosis of CKD, however, requires the assessment of other factors. Urinary adiponectin recently attracted attention for CKD assessment, but evaluation is difficult due to the very low concentration of urinary adiponectin in normal subjects.Research design and methodsWe developed an ultrasensitive ELISA coupled with thionicotinamide-adenine dinucleotide cycling to detect trace amounts of proteins, which allows us to measure urinary adiponectin at the subattomole level. We measured urinary adiponectin levels in 59 patients with diabetes mellitus (DM) and 24 subjects without DM (normal) to test our hypothesis that urinary adiponectin levels increase with progression of CKD due to DM.ResultsThe urinary adiponectin levels were 14.88±3.16 (ng/mg creatinine, mean±SEM) for patients with DM, and 3.06±0.33 (ng/mg creatinine) for normal subjects. The threshold between them was 4.0 ng/mg creatinine. The urinary adiponectin levels increased with an increase in the CKD risk. Furthermore, urinary adiponectin mainly formed a medium-molecular weight multimer (a hexamer) in patients with DM, whereas it formed only a low-molecular weight multimer (a trimer) in normal subjects. That is, the increase in urinary adiponectin in patients with DM led to the emergence of a medium-molecular weight form in urine.ConclusionsOur new assay showed that urinary adiponectin could be a new diagnostic index for CKD. This assay is a non-invasive test using only urine, thus reducing the patient burden.

Continuous Wavelet Analysis of the Breathing Sounds of Obstructive Sleep Apnea Patients and Normal Subjects during Wakefulness

2014 ◽  
Vol 622 ◽  
pp. 45-50 ◽  
Author(s):  
R. Premkumar ◽  
Chokkalingam Arun ◽  
Ramakrishnan Sai Divya
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Low Cost ◽  
Upper Airway ◽  
Normal Subjects ◽  
Continuous Wavelet ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Non Invasive ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by obstruction of the upper airway. Its distinctive feature is occurrence of repetitive pauses in breathing during sleep, due to intermittent relaxing and blocking of the patients airway by the throat muscles. Continuous such actions might narrow down the throat or may completely block it. These actions cause more difference in breathing sounds and are usually associated with a reduction in blood oxygen saturation. The breathing sounds of the patients with and without obstructive sleep apnea were recorded using a non-invasive, low-cost sensor during wakefulness in supine (lying) position and Continuous wavelet 1-D analysis was performed on those signals.

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