Theoretical model for the post-transcriptional regulation of the human c-myc gene expression, involving double-stranded RNA processing

1987 ◽  
Vol 125 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Patricio Gariglio ◽  
Rosamaria Del Angel ◽  
Alfredo Herrera ◽  
Manuel Bonilla
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Theoretical Model ◽  
Rna Processing ◽  
Double Stranded Rna ◽  
Myc Gene ◽  
Post Transcriptional Regulation

scholarly journals The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1634 ◽  
Author(s):  
Ng Desi ◽  
Yvonne Tay
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Rna Processing ◽  
Cancer Development ◽  
Butterfly Effect ◽  
And Function ◽  
Post Transcriptional Regulation ◽  
The Impact ◽  
Rna Transcript

Post-transcriptional regulation plays a key role in modulating gene expression, and the perturbation of transcriptomic equilibrium has been shown to drive the development of multiple diseases including cancer. Recent studies have revealed the existence of multiple post-transcriptional processes that coordinatively regulate the expression and function of each RNA transcript. In this review, we summarize the latest research describing various mechanisms by which small alterations in RNA processing or function can potentially reshape the transcriptomic landscape, and the impact that this may have on cancer development.

scholarly journals Fast and Efficient 5′P Degradome Library Preparation for Analysis of Co-Translational Decay in Arabidopsis

Plants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 466
Author(s):  
Marie-Christine Carpentier ◽  
Cécile Bousquet-Antonelli ◽  
Rémy Merret
Keyword(s):  
Gene Expression ◽  
Quality Control ◽  
Transcriptional Regulation ◽  
High Throughput ◽  
Library Preparation ◽  
Working Day ◽  
Set Up ◽  
Post Transcriptional Regulation ◽  
Commercial Kit

The recent development of high-throughput technologies based on RNA sequencing has allowed a better description of the role of post-transcriptional regulation in gene expression. In particular, the development of degradome approaches based on the capture of 5′monophosphate decay intermediates allows the discovery of a new decay pathway called co-translational mRNA decay. Thanks to these approaches, ribosome dynamics could now be revealed by analysis of 5′P reads accumulation. However, library preparation could be difficult to set-up for non-specialists. Here, we present a fast and efficient 5′P degradome library preparation for Arabidopsis samples. Our protocol was designed without commercial kit and gel purification and can be easily done in one working day. We demonstrated the robustness and the reproducibility of our protocol. Finally, we present the bioinformatic reads-outs necessary to assess library quality control.

Post-transcriptional regulation of gene expression

Methods ◽  
2017 ◽  
Vol 126 ◽  
pp. 1-2 ◽  
Author(s):  
Howard D. Lipshitz ◽  
Julie M. Claycomb ◽  
Craig A. Smibert
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Regulation Of Gene Expression ◽  
Post Transcriptional Regulation
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