New Psoriasiform Skin Condition Is Discovered

Granuloma annulare (GA) is a benign inflammatory skin condition of unknown etiology. Various clinical forms of GA including localized, generalized, subcutaneous, patch and perforating types, have been described. Although the etiology and pathogenesis of granuloma annulare are obscure, there is much evidence for an immunological mechanism. Precipitating factors are insect bites, sunburn, photochemotherapy, drugs, physical trauma, acute phlebitis and sepsis after surgery.[1] Some authors have proposed that it might be associated with a variety of underlying conditions such as thyroid disorders, diabetes mellitus and positive tuberculin skin test.[2] For definitive diagnosis, a biopsy should be performed. We report a case of generalized GA with serpiginous borders on the dorsal aspects of the hands and arms along with an association with diabetes.

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Erythema Gyratum Repens in Long-Term Smoker

Case Reports in Dermatology ◽

10.1159/000503270 ◽

2019 ◽

Vol 11 (3) ◽

pp. 268-272

Author(s):

Andrew P. Sauvageau ◽

Jacob Mojeski ◽

Thomas W. Fiorica ◽

Craig C. Miller

Keyword(s):

Female Patient ◽

Skin Condition ◽

Morbidity And Mortality ◽

Cancer Growth ◽

Internal Malignancy ◽

Adenocarcinoma Of The Lung

Erythema gyratum repens (EGR) is a rare paraneoplastic skin condition characterized by the eruption of expanding, concentric, erythematous patches and plaques. The condition may precede a symptomatic appearance of internal malignancy, and therefore provides a unique opportunity to prevent additional morbidity and mortality secondary to undetectable cancer growth. We report the case of a 71-year-old female patient clinically diagnosed with EGR and subsequently diagnosed with otherwise asymptomatic adenocarcinoma of the lung.

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Ingol and Ingenol-Type Diterpenes from Euphorbia trigona Miller with Keratinocyte Inhibitory Activity

Plants ◽

10.3390/plants10061206 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1206

Author(s):

Reham Hammadi ◽

Norbert Kúsz ◽

Csilla Zsuzsanna Dávid ◽

Zoltán Behány ◽

László Papp ◽

...

Keyword(s):

Liquid Chromatography ◽

Cytotoxic Activity ◽

Inhibitory Activity ◽

High Performance ◽

Skin Condition ◽

Positive Control ◽

Active Species ◽

The European Union ◽

Ingenol Mebutate

Ingenol mebutate, isolated from Euphorbia peplus, is an ingenane-type diterpenoid, primarily used for the topical treatment of actinic keratosis, a premalignant skin condition. The aim of our work was to investigate other Euphorbia species to find structurally similar diterpenes that can be used as alternatives to ingenol mebutate. Pharmacological investigation of Euphorbia candelabrum, Euphorbia cotinifolia, Euphorbia ramipressa, and Euphorbia trigona revealed the potent keratinocyte (HPV-Ker cell line) inhibitory activity of these spurge species. From the methanolic extract of the aerial parts of Euphorbia trigona Miller, the most active species, five ingol (1–5) and four ingenane-type diterpenoids (6–9) were isolated by various chromatographic separation techniques, including open column chromatography, vacuum liquid chromatography, thin-layer chromatography, and high-performance liquid chromatography. The structures of the compounds were determined by NMR spectroscopic analysis and by comparison of the assignations with the literature data. The cytotoxic activity of the compounds against keratinocytes was tested in vitro by using ingenol mebutate as a positive control. Among the isolated compounds, two ingenane derivatives (6 and 7) exhibited remarkably stronger cytotoxic activity (IC50 values 0.39 μM and 0.32 μM, respectively) on keratinocytes than ingenol mebutate (IC50 value 0.84 μM). These compounds could serve as starting materials for further investigations to find alternatives to Picato® (with active substance ingenol mebutate), which was withdrawn from marketing authorization in the European Union.

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Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

Membranes ◽

10.3390/membranes11010026 ◽

2020 ◽

Vol 11 (1) ◽

pp. 26

Author(s):

Sara Metwally ◽

Daniel P. Ura ◽

Zuzanna J. Krysiak ◽

Łukasz Kaniuk ◽

Piotr K. Szewczyk ◽

...

Keyword(s):

Mechanical Properties ◽

Atopic Dermatitis ◽

Mechanical Performance ◽

Antibacterial Properties ◽

Skin Condition ◽

Fiber Morphology ◽

Suitable Material ◽

Hemp Oil ◽

Skin Moisture

Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.

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Common general surgical never events: analysis of NHS England never event data

International Journal for Quality in Health Care ◽

10.1093/intqhc/mzab045 ◽

2021 ◽

Vol 33 (1) ◽

Author(s):

Islam Omar ◽

Rishi Singhal ◽

Michael Wilson ◽

Chetan Parmar ◽

Omar Khan ◽

...

Keyword(s):

Breast Implants ◽

Skin Condition ◽

Chest Drain ◽

Event Data ◽

Wrong Site Surgery ◽

Wrong Side ◽

Retained Foreign Body ◽

Never Events ◽

Never Event ◽

Wrong Site

Abstract Background There is little available data on common general surgical never events (NEs). Lack of this information may have affected our attempts to reduce the incidence of these potentially serious clinical incidents. Objectives The purpose of this study was to identify common general surgical NEs from the data held by the National Health Service (NHS) England. Methods We analysed the NHS England NE data from April 2012 to February 2020 to identify common general surgical NEs. Results There was a total of 797 general surgical NEs identified under three main categories such as wrong-site surgery (n = 427; 53.58%), retained items post-procedure (n = 355; 44.54%) and wrong implant/prosthesis (n = 15; 1.88%). We identified a total of 56 common general surgical themes—25 each in the wrong-site surgery and retained foreign body categories and six in wrong implants category. Wrong skin condition surgery was the commonest wrong-site surgery (n = 117; 27.4%). There were 18 wrong-side chest drains (4.2%) and 18 (4.2%) wrong-side angioplasty/angiograms. There were seven (1.6%) instances of confusion in pilonidal/perianal/perineal surgeries and six (1.4%) instances of biopsy of the cervix rather than the colon or rectum. Retained surgical swabs were the most common retained items (n = 165; 46.5%). There were 28 (7.9%) laparoscopic retrieval bags with or without the specimen, 26 (7.3%) chest drain guide wires, 26 (7.3%) surgical needles and 9 (2.5%) surgical drains. Wrong stents were the most common (n = 9; 60%) wrong implants followed by wrong breast implants (n = 2; 13.3%). Conclusion This study found 56 common general surgical NEs. This information is not available to surgeons around the world. Increased awareness of these common themes of NEs may allow for the adoption of more effective and specific safeguards and ultimately help reduce their incidence.

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Improvement of skin condition by oral supplementation with sphingomyelin-containing milk phospholipids in a double-blind, placebo-controlled, randomized trial

Journal of Dairy Science ◽

10.3168/jds.2015-9529 ◽

2015 ◽

Vol 98 (10) ◽

pp. 6706-6712 ◽

Cited By ~ 8

Author(s):

S. Higurashi ◽

Y. Haruta-Ono ◽

H. Urazono ◽

T. Kobayashi ◽

Y. Kadooka

Keyword(s):

Randomized Trial ◽

Skin Condition ◽

Double Blind ◽

Double Blind Placebo ◽

Oral Supplementation

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ISA247: Quality of Life Results from a Phase II, Randomized, Placebo-Controlled Study

Journal of Cutaneous Medicine and Surgery ◽

10.2310/7750.2008.07060 ◽

2008 ◽

Vol 12 (6) ◽

pp. 268-275 ◽

Cited By ~ 9

Author(s):

Aditya K. Gupta ◽

Richard G. Langley ◽

Charles Lynde ◽

Kirk Barber ◽

Wayne Gulliver ◽

...

Keyword(s):

Quality Of Life ◽

Phase Ii ◽

Life Quality ◽

Skin Condition ◽

Controlled Study ◽

Double Blind ◽

Plaque Type ◽

Psoriasis Disability Index ◽

Stable Plaque

Background: Psoriasis is a chronic skin condition that can negatively affect a patient's quality of life (QoL), often hindering social functioning. ISA247, a novel psoriatic agent, has shown clinical efficacy in moderate to severe psoriasis sufferers, but its effect on QoL is currently not reported. Objective: The objective of this study was to assess the effect of ISA247 on the QoL in patients with stable, plaque-type psoriasis. Methods: A phase II, randomized, double-blind, placebo-controlled, parallel-group, multicenter study assessed the effects of ISA247 doses of 0.5 mg/kg/d ( n = 77) or 1.5 mg/kg/d ( n = 83) compared with placebo ( n = 41) for 12 weeks. QoL was assessed using the Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI) scales. Results: ISA247 treatment (pooled groups) significantly improved QoL scores as assessed by both the DLQI and the PDI compared with those receiving placebo ( p < .05). Treatment with the higher dose of 1.5 mg/kg/d demonstrated a significantly greater response to many of the QoL scales compared with the 0.5 mg/kg/d group ( p < .05). Conclusions: ISA247 appears to improve the QoL while also providing effective treatment for chronic, moderate to severe, plaque-type psoriasis.

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Prepuce: Phimosis, Paraphimosis, and Circumcision

The Scientific World JOURNAL ◽

10.1100/tsw.2011.31 ◽

2011 ◽

Vol 11 ◽

pp. 289-301 ◽

Cited By ~ 31

Author(s):

Yutaro Hayashi ◽

Yoshiyuki Kojima ◽

Kentaro Mizuno ◽

Kenjiro Kohri

Keyword(s):

Penile Cancer ◽

Age Groups ◽

Topical Steroid ◽

Religious Practice ◽

Skin Condition ◽

Rite Of Passage ◽

Transmitted Infection ◽

Prophylactic Measure ◽

Sexually Transmitted ◽

Male Patients

Phimosis is a condition in which the prepuce cannot be retracted over the glans penis. Actually, physiologic phimosis is common in male patients up to 3 years of age, but often extends into older age groups. Balanoposthitisis a common inflammation occurring in 4–11% of uncircumcised boys. Circumcision is generally undertaken for three reasons: first, as an item of religious practice, typically neonatally although occasionally transpubertally, as a rite of passage; second, as a prophylactic measure against future ailments for the reduction in the risk of penile cancer, urinary tract infection, and sexually transmitted infection; and third, for immediate medical indication. Balanitisxeroticaobliterans is an infiltrative skin condition that causes a pathological phimosis and has been considered to be the only absolute indication for circumcision. Various kinds of effective alternatives to circumcision have been described, including manual retraction therapy, topical steroid therapy, and several variations of preputioplasty. All of these treatments have the ability to retract the foreskin as their goal and do not involve the removal of the entire foreskin. Paraphimosis is a condition in which the foreskin is left retracted. When manipulation is not effective, a dorsal slit should be done, which is usually followed by circumcision.

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