The Role of microRNAs in Drug Addiction

Author(s):  
Andrzej Zbigniew Pietrzykowski
Keyword(s):  
2013 ◽  
pp. 1
Author(s):  
Matt Field ◽  
Pawel Jedras ◽  
Andrew Jones
Keyword(s):  

2007 ◽  
Vol 7 ◽  
pp. 194-202 ◽  
Author(s):  
Colleen A. McClung

Drug addiction is a devastating disease that affects millions of individuals worldwide. Through better understanding of the genetic variations that create a vulnerability for addiction and the molecular mechanisms that underlie the progression of addiction, better treatment options can be created for those that suffer from this condition. Recent studies point to a link between abnormal or disrupted circadian rhythms and the development of addiction. In addition, studies suggest a role for specific genes that make up the molecular clock in the regulation of drug sensitivity, sensitization, and reward. The influence of circadian genes and rhythms on drug-induced behaviors may be mediated through the mesolimbic dopaminergic system. This system has long been implicated in the development of addiction, and recent evidence supports a regulatory role for the brain's central pacemaker and circadian gene expression in the regulation of dopaminergic transmission. This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association.


Author(s):  
Alfredo Ramos-Miguel ◽  
Maria Alvaro-Bartolome ◽  
M. Julia ◽  
Jesus A.
Keyword(s):  

2019 ◽  
Vol 21 (4) ◽  
pp. 330-343
Author(s):  
SS Hoseinizadeh ◽  
M Niazi ◽  
M Mehtari Arani ◽  
◽  
◽  
...  

Author(s):  
Iryna ROZINA

The relevance of the research is related to the need for studying the character of psychosomatic disorders in adolescence, which is insufficiently investigated and requires more in-depth research, in particular designing a comprehensive program that includes a system of training exercises to overcome psychosomatic disorders. The problem of studying psychosomatic relationships is one of the most difficult problems of modern psychology and medicine, despite the fact that the close connection between mental and somatic has been studied for several centuries. Mental trauma is a leading cause of neuroses formation and progress, its pathogenic significance is determined by the complex interaction with many other factors being a result of an individual’s life, formation of his body and personality, especially in adolescence. The subject of the research is to study special features of psychosomatic disorders, as well as to design a program for adolescents with signs of neurotic disorders. The subject matter of the research is the peculiarities of psychosomatic disorders manifestation and neurotic signs in adolescence. The article presents a theoretical analysis of modern approaches in psychology to the study of psychosomatic disorders peculiarities, their classification, considering the signs of neurotic disorders in adolescence. The work analyzes age characteristics of psychosomatic disorders in adolescence. Modern adolescents are exposed to various stressors, to the impact of audiovisual information, school overload, extra classes, exams, and a special problem that is a change in quality of life and prevalence of alcoholism, smoking, drug addiction, especially drug addiction among adolescents. The complex of these factors has negative consequences both on a psychological and physical level. Most authors who study the causes of psychosomatic illnesses recognize the important role of parents in the development of mentally and physically healthy children. Many studies highlight the role of early mother-child relationships in the formation of psychosomatic pathology. Various violations of this relationship usually lead to abnormalities in a child’s development. (M. Mahler, E. T. Eidemiller, Yustitskis, D. Winnicott, M. Klein). The results of an empirical study aimed at identifying signs of psychosomatic disorders are considered. The following methods were used: observation, questionnaires, and such methods as diagnosis of neurotic disorders in adolescence (DND), diagnosis of the level of school anxiety by Phillips, “Non-existent animal” by M.Z. Drukarevich. The peculiarities of designing and testing the correction program, which is aimed at reducing the signs of neurotic manifestations in adolescence, are revealed. Objectives of the correction program are: searching for interaction of adolescents with society, finding and testing skills of effective response to external stimuli; increasing the level of self-esteem; removal of emotional tension; reducing anxiety. The results confirm the possibility of reducing the signs of neurotic manifestations of adolescents and help to delay or completely stop a possible personality disorder.


2013 ◽  
Vol 26 (6) ◽  
pp. 334-346 ◽  
Author(s):  
Livia C.M. Rodrigues ◽  
Pedro H. Gobira ◽  
Antonio Carlos de Oliveira ◽  
Renan Pelição ◽  
Antonio Lucio Teixeira ◽  
...  

ObjectiveSubstance dependence disorder is a chronically relapsing condition characterised by neurobiological changes leading to loss of control in restricting a substance intake, compulsion and withdrawal syndrome. In the past few years, (endo)cannabinoids have been raised as a possible target in the aetiology of drug addiction. On the other hand, although the exact mechanisms of the genesis of addiction remain poorly understood, it is possible that neuroinflammation might also play a role in the pathophysiology of this condition. Studies demonstrated that (endo)cannabinoids act as immunomodulators by inhibiting cytokines production and microglial cell activation. Thus, in the present review, we explore the possible role of neuroinflammation on the therapeutic effects of cannabinoids on drug addiction.MethodsWe conducted an evidence-based review of the literature in order to assess the role of cannabinoids on the neuroinflammatory hypothesis of addiction (terms: addiction, cannabinoids and inflammation). We searched PubMed and BioMedCentral databases up to April 2014 with no date restrictions.ResultsIn all, 165 eligible articles were included in the present review. Existing evidence suggests that disruption in cannabinoid signalling during the drug addiction process leads to microglial activation and neuroinflammation.ConclusionThe literature showed that inflammation and changes in endocannabinod signalling occur in drug abuse; however, it remains uncertain whether these changes are causally or coincidentally associated with addiction. Additional studies, therefore, are needed to elucidate the contribution of neuroinflammation on the behavioural and neuroprotective effects of cannabinoids on drug addiction.


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