Scale-up of services and research priorities for diagnosis, management, and control of tuberculosis: a call to action

The Lancet ◽  
2010 ◽  
Vol 375 (9732) ◽  
pp. 2179-2191 ◽  
Author(s):  
Ben J Marais ◽  
Mario C Raviglione ◽  
Peter R Donald ◽  
Anthony D Harries ◽  
Afranio L Kritski ◽  
...  
Keyword(s):  
Scale Up ◽  
Research Priorities ◽  
Call To Action ◽  
And Control

scholarly journals Potential applications of halophilic microorganisms for biological treatment of industrial process brines contaminated with aromatics

2021 ◽  
Author(s):  
Thomas Mainka ◽  
David Weirathmüller ◽  
Christoph Herwig ◽  
Stefan Pflügl
Keyword(s):  
Wastewater Treatment ◽  
Process Monitoring ◽  
Industrial Wastewater ◽  
Continuous Process ◽  
Scale Up ◽  
Monitoring And Control ◽  
Saline Wastewater ◽  
Halophilic Microorganisms ◽  
Industrial Sectors ◽  
And Control

Abstract Saline wastewater contaminated with aromatic compounds can be frequently found in various industrial sectors. Those compounds need to be degraded before reuse of wastewater in other process steps or release to the environment. Halophiles have been reported to efficiently degrade aromatics, but their application to treat industrial wastewater is rare. Halophilic processes for industrial wastewater treatment need to satisfy certain requirements: a continuous process mode, low operational expenditures, suitable reactor systems and a monitoring and control strategy. The aim of this review is to provide an overview of halophilic microorganisms, principles of aromatic biodegradation, and sources of saline wastewater containing aromatics and other contaminants. Finally, process examples for halophilic wastewater treatment and potential process monitoring strategies are discussed. To further illustrate the significant potential of halophiles for saline wastewater treatment and to facilitate development of ready-to-implement processes, future research should focus on scale-up and innovative process monitoring and control strategies.

scholarly journals Prioritizing progressive MS rehabilitation research: A call from the International Progressive MS Alliance

2021 ◽  
pp. 135245852199997
Author(s):  
Kathleen M Zackowski ◽  
Jennifer Freeman ◽  
Giampaolo Brichetto ◽  
Diego Centonze ◽  
Ulrik Dalgas ◽  
...  
Keyword(s):  
Symptom Management ◽  
Psychosocial Support ◽  
Management Strategies ◽  
Research Priorities ◽  
Significant Progress ◽  
Call To Action ◽  
Rehabilitation Research ◽  
Relapsing Remitting ◽  
Upper Extremity Impairment

Background: People with multiple sclerosis (MS) experience myriad symptoms that negatively affect their quality of life. Despite significant progress in rehabilitation strategies for people living with relapsing-remitting MS (RRMS), the development of similar strategies for people with progressive MS has received little attention. Objective: To highlight key symptoms of importance to people with progressive MS and stimulate the design and implementation of high-quality studies focused on symptom management and rehabilitation. Methods: A group of international research experts, representatives from industry, and people affected by progressive MS was convened by the International Progressive MS Alliance to devise research priorities for addressing symptoms in progressive MS. Results: Based on information from the MS community, we outline a rationale for highlighting four symptoms of particular interest: fatigue, mobility and upper extremity impairment, pain, and cognitive impairment. Factors such as depression, resilience, comorbidities, and psychosocial support are described, as they affect treatment efficacy. Conclusions: This coordinated call to action—to the research community to prioritize investigation of effective symptom management strategies, and to funders to support them—is an important step in addressing gaps in rehabilitation research for people affected by progressive MS.

Research priorities in multiple sclerosis in Latin America: a multi-stakeholder call to action to improve patients care

2021 ◽  
pp. 103038
Author(s):  
Juan I. Rojas ◽  
Edgar Carnero Contentti ◽  
Patricio Abad ◽  
Adriana Aguayo ◽  
Ricardo Alonso ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Latin America ◽  
Research Priorities ◽  
Call To Action ◽  
Multi Stakeholder

scholarly journals The Use of Granular Cyclopentanone as Alternative to Artificial Source of Carbon Dioxide in Improved Passive Outdoor Host Seeking Device (POHD)

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Stella T. Kessy ◽  
Bruno A. Nyundo ◽  
Ladslaus L. Mnyone ◽  
Issa N. Lyimo
Keyword(s):  
Electrical Power ◽  
Scale Up ◽  
Residual Activity ◽  
Yeast Fermentation ◽  
Power Sources ◽  
Host Seeking ◽  
Relative Attractiveness ◽  
Residual Malaria Transmission ◽  
Control Devices ◽  
And Control

Reliable sources of CO2 that are relatively cheap, obtainable, and easy to sustain are immediately required for scaling up of odor-baited mosquito surveillance and control devices. Several odor-baited devices are in the pipeline; however, their scale-up against residual malaria transmission, particularly in resource poor areas, is limited by the unavailability of reliable sources of CO2 and reliance on electrical power sources among other factors. We evaluated the use of granular cyclopentanone as an alternative to artificial or yeast fermentation-produced CO2 in passive outdoor host seeking device (POHD). Experiments were conducted against semifield reared An. arabiensis within the semifield system (SFS) at Ifakara Health Institute. Mosquitoes were tested against odor-baited POHDs augmented with yeast fermentation-produced CO2, granular cyclopentanone, attractive blends (Mbita or Ifakara), or their combinations. An insecticide, bendiocarb, was a killing agent used as a proxy for marking the mosquitoes visit the POHDs. Relative attractiveness of different treatment combinations was compared based on the proportion of dead mosquitoes that visited the POHD. The POHD augmented with granules of cyclopentanone alone was attractive to An. arabiensis as much as, or more than, POHDs augmented with yeast fermentation-produced CO2. The POHD baited with CO2 attracted more mosquitoes than those POHDs baited with synthetic blends alone; when these blends are combined with CO2, they attracted more mosquitoes than individual blends. More importantly, such POHDs baited with cyclopentanone attracted far greater proportion of mosquitoes than the POHD baited with either Mbita or Ifakara blend alone. The granular cyclopentanone strongly enhanced/potentiated the attractiveness of POHD baited with Mbita blends against mosquitoes compared to that of POHD baited with Ifakara blend. Moreover, the granular cyclopentanone retained its residual activity against An. arabiensis for up to 2 months after application particularly when used in combination with Mbita blend. In conclusion, this study demonstrates that cyclopentanone granules have the potential to substitute sources of CO2 in outdoor-based surveillance and control devices, thus warranting evaluation of such alternative under realistic field conditions.

Implementation Strategies

2018 ◽  
Author(s):  
Byron J. Powell ◽  
Krystal G. Garcia ◽  
Maria E. Fernandez
Keyword(s):  
Scale Up ◽  
Research Priorities ◽  
Cancer Control ◽  
Implementation Strategies ◽  
Routine Care ◽  
The State ◽  
Evidence Based ◽  
Implementation Barriers ◽  
Research And Practice ◽  
Effective Strategies

Implementation strategies are methods or techniques that can be used to enhance the adoption, implementation, scale-up, and sustainment of evidence-based cancer control practices into routine care. This chapter defines implementation strategies, presents several taxonomies of implementation strategies that can be used to address multilevel implementation barriers, describes guidelines for reporting and specifying implementation strategies to ensure the efficient generation of knowledge and the replication of effective strategies in research and practice, briefly overviews the state of evidence for strategies, and suggests ways in which they can be carefully developed and applied to address the needs of specific contexts. The chapter concludes by presenting several research priorities related to implementation strategies.

An improved and robust scale-up process aided with identification and control of critical process impurities in darunavir ethanolate

2019 ◽  
Vol 46 (1) ◽  
pp. 267-281
Author(s):  
Sathyanarayana Girigani ◽  
Harnam Singh ◽  
Sankar Rao Kola ◽  
Vijayalaxmi Dayanand Yelmeli ◽  
Venu Gopal Regula ◽  
...  
Keyword(s):  
Scale Up ◽  
Darunavir Ethanolate ◽  
And Control ◽  
Critical Process

scholarly journals Mental health and HIV: research priorities related to the implementation and scale up of ‘treat all’ in sub-Saharan Africa

2018 ◽  
Vol 4 ◽  
pp. 16-25 ◽  
Author(s):  
Angela M. Parcesepe ◽  
Charlotte Bernard ◽  
Robert Agler ◽  
Jeremy Ross ◽  
Marcel Yotebieng ◽  
...  
Keyword(s):  
Mental Health ◽  
Scale Up ◽  
Research Priorities ◽  
Sub Saharan Africa ◽  
Hiv Research ◽  
Sub Saharan ◽  
Treat All

Exploring the Everyday Lives of Children in Winnipeg, Canada

2019 ◽  
Vol 27 (3) ◽  
pp. 545-561
Author(s):  
Elizabeth Huynh ◽  
Ashley Stewart-Tufescu
Keyword(s):  
Life Story ◽  
Well Being ◽  
Subjective Well Being ◽  
Structured Interviews ◽  
Call To Action ◽  
Social Actors ◽  
School Aged Children ◽  
Canadian Context ◽  
The Everyday ◽  
And Control

Over the past decade there has been a call to action for researchers to explore children’s subjectivities in the context of well-being. How children understand and experience well-being in a Canadian context was examined in this study. Twenty-one children between 8 and 12 years of age participated in semi-structured interviews facilitated by the Life Story Board™. Three main themes emerged: (1) freedom and control, (2) child rights and social supports, and (3) children’s participation as social actors. Results from this study highlighted the importance of children needing to feel heard by parents and teachers; children being recognised as rights-holders with opportunities to actualise their rights; and children having meaningful opportunities to participate in matters which concerns them in everyday life as important components of subjective well-being. Results may serve to inform child-serving professionals, policymakers, and parents and guardians about how school-aged children from this Canadian context conceptualize and experience well-being.

scholarly journals Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Olushayo Oluseun Olu ◽  
Joy Luba Lomole Waya ◽  
Sylvester Maleghemi ◽  
John Rumunu ◽  
David Ameh ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Preventive Measures ◽  
Negative Impact ◽  
Control Strategies ◽  
Scientific Evidence ◽  
Scale Up ◽  
High Impact ◽  
The Social ◽  
And Control

Abstract The ongoing pandemic of the coronavirus disease 2019 has spread rapidly to all countries of the world. Africa is particularly predisposed to an escalation of the pandemic and its negative impact given its weak economy and health systems. In addition, inadequate access to the social determinants of health such as water and sanitation and socio-cultural attributes may constrain the implementation of critical preventive measures such as hand washing and social distancing on the continent. Given these facts, the continent needs to focus on targeted and high impact prevention and control strategies and interventions which could break the chain of transmission quickly. We conclude that the available body of scientific evidence on the coronavirus disease 2019 holds the key to the development of such strategies and interventions. Going forward, we recommend that the African research community should scale up research to provide scientific evidence for a better characterization of the epidemiology, transmission dynamics, prevention and control of the virus on the continent.

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