Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy

The Lancet ◽  
1998 ◽  
Vol 352 (9136) ◽  
pp. 1257-1263 ◽  
Keyword(s):  
Vitamin A ◽  
Randomised Trial ◽  
Early Infancy ◽  
Vitamin A Supplementation

scholarly journals The impact of different doses of vitamin A supplementation on male and female mortality. A randomised trial from Guinea-Bissau

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Dorthe Yakymenko ◽  
Christine S Benn ◽  
Cesario Martins ◽  
Birgitte R Diness ◽  
Ane B Fisker ◽  
...  
Keyword(s):  
Vitamin A ◽  
Randomised Trial ◽  
Female Mortality ◽  
Vitamin A Supplementation ◽  
Male And Female ◽  
Guinea Bissau ◽  
The Impact ◽  
Different Doses

scholarly journals The effects of maternal and infant vitamin A supplementation on vitamin A status: a randomised trial in Kenya

2007 ◽  
Vol 98 (2) ◽  
pp. 422-430 ◽  
Author(s):  
R. A. Ayah ◽  
D. L. Mwaniki ◽  
P. Magnussen ◽  
A. E. Tedstone ◽  
T. Marshall ◽  
...  
Keyword(s):  
Vitamin A ◽  
Controlled Trial ◽  
Randomised Trial ◽  
Maternal Serum ◽  
High Dose ◽  
Serum Retinol ◽  
Double Blind ◽  
Vitamin A Supplementation ◽  
Factors Affecting ◽  
Vitamin A Status

Postpartum vitamin A supplementation of mothers and infants is recommended, but the efficacy has been questioned. In this double-blind, placebo-controlled trial, Kenyan mother–infant pairs were randomised to maternal vitamin A (400 000 IU) or placebo < 24 h postpartum, and infant vitamin A (100 000 IU) or placebo at 14 weeks. Milk retinol was determined at weeks 4, 14 and 26, and maternal and infant serum retinol at weeks 14 and 26. Infant retinol stores were assessed at week 26, using a modified relative dose response (MRDR) test. Among 564 women, serum retinol at 36 weeks gestation was 0·81 (sd 0·21) μmol/l, and 33·3 % were < 0·7 μmol/l. Maternal serum retinol was not different between groups, but milk retinol was higher in the vitamin A group: (0·67 v. 0·60 μmol/l; 0·52 v. 0·44 μmol/l; 0·50 v. 0·44 μmol/l at 4, 14 and 26 weeks, respectively). When expressed per gram fat, milk retinol was higher in the vitamin A group only at 4 weeks. Infant serum retinol was not different between groups. However, although most infants had deficient vitamin A stores (MRDR>0·06 %) at 26 weeks, vitamin A to infants, but not mothers, resulted in a lower proportion of infants with deficient vitamin A stores (69 v. 78 %). High-dose postpartum vitamin A supplementation failed to increase serum retinol and infant stores, despite modest effects on milk retinol. Infant supplementation, however, increased stores. There is a need for a better understanding of factors affecting absorption and metabolism of vitamin A.

Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial

The Lancet ◽  
1999 ◽  
Vol 354 (9174) ◽  
pp. 203-209 ◽  
Author(s):  
Anuraj H Shankar ◽  
Blaise Genton ◽  
Richard D Semba ◽  
Moses Baisor ◽  
Joseph Paino ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Young Children ◽  
Vitamin A ◽  
Papua New Guinea ◽  
Randomised Trial ◽  
New Guinea ◽  
Vitamin A Supplementation

Randomised trial of effect of vitamin A supplementation on antibody response to measles vaccine in Guinea-Bissau, west Africa

The Lancet ◽  
1997 ◽  
Vol 350 (9071) ◽  
pp. 101-105 ◽  
Author(s):  
Christine Stabell Benn ◽  
Peter Aaby ◽  
Carlitos Balé ◽  
Jørn Olsen ◽  
Kim Fleischer Michaelsen ◽  
...  
Keyword(s):  
Vitamin A ◽  
Antibody Response ◽  
West Africa ◽  
Randomised Trial ◽  
Measles Vaccine ◽  
Vitamin A Supplementation ◽  
Guinea Bissau

scholarly journals The effect of at-birth vitamin A supplementation on differential leucocyte counts and in vitro cytokine production: an immunological study nested within a randomised trial in Guinea-Bissau

2012 ◽  
Vol 109 (3) ◽  
pp. 467-477 ◽  
Author(s):  
Mathias J. Jørgensen ◽  
Ane B. Fisker ◽  
Erliyani Sartono ◽  
Andreas Andersen ◽  
Christian Erikstrup ◽  
...  
Keyword(s):  
Vitamin A ◽  
Differential Effect ◽  
Controlled Trial ◽  
Geometric Mean ◽  
Randomised Trial ◽  
Relative Risk Ratio ◽  
Immunological Study ◽  
Vitamin A Supplementation ◽  
Guinea Bissau ◽  
Tnf Α

Vitamin A supplementation (VAS) at birth was not associated with improved survival in a randomised, placebo-controlled trial in Guinea-Bissau. However, a negative sex-differential effect, which became evident after diphtheria–tetanus–pertussis (DTP) vaccination, was noted; among girls who had received DTP, VAS at birth was associated with two-fold higher mortality than placebo. The objective of the present study was to investigate the immunological effects of VAS at birth within a subgroup of participants in the randomised trial. Guided by the mortality results, we further explored whether VAS had a differential effect according to sex and DTP status. At 6 weeks after randomisation and supplementation, we measured differential leucocyte counts and TNF-α, interferon-γ, IL-10, IL-13 and IL-5 production in a whole-blood culture assay. A total of 471 children were included. VAS compared with placebo at birth was associated with a higher proportion of monocytes (relative risk ratio 1·26, 95 % CI 1·07, 1·49, P= 0·04), while spontaneous TNF-α production was lower in the VAS group (geometric mean ratio 0·54, 95 % CI, 0·37, 0·78, P= 0·001). Stratified analysis showed that VAS was associated with lower TNF-α and IL-10 production for girls without DTP and boys with DTP, resulting in significant three-way interactions between VAS, sex and DTP vaccination status (P= 0·03 and P= 0·04, respectively) for spontaneous TNF-α and IL-10 production. The results substantiate the potential role of VAS as an immunomodulatory intervention, which has different effects depending on concomitant health interventions and the sex of the recipient.

scholarly journals Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial

The Lancet ◽  
2013 ◽  
Vol 381 (9876) ◽  
pp. 1469-1477 ◽  
Author(s):  
Shally Awasthi ◽  
Richard Peto ◽  
Simon Read ◽  
Sarah Clark ◽  
Vinod Pande ◽  
...  
Keyword(s):  
Vitamin A ◽  
School Children ◽  
Randomised Trial ◽  
North India ◽  
Cluster Randomised Trial ◽  
Vitamin A Supplementation ◽  
Cluster Randomised

scholarly journals The Effect of 50 000 IU Vitamin A with BCG Vaccine at Birth on Growth in the First Year of Life

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ane Bærent Fisker ◽  
Christine Stabell Benn ◽  
Birgitte Rode Diness ◽  
Cesario Martins ◽  
Amabelia Rodrigues ◽  
...  
Keyword(s):  
Vitamin A ◽  
Randomised Trial ◽  
First Year ◽  
Anthropometric Measures ◽  
Vitamin A Supplementation ◽  
Growth Difference ◽  
Z Scores ◽  
Dtp Vaccine ◽  
The Difference ◽  
First Year Of Life

Vitamin A supplements may interact with diphtheria-tetanus-pertussis (DTP) vaccine causing increased female mortality. In a randomised trial of neonatal vitamin A supplementation (VAS), we examined growth during the first year of life in 808 children, pursuing the hypothesis that a negative interaction between VAS and DTP in girls would be reflected in growth. Length and weight were measured at 6 weekly visits and WHO-growth-reference z-scores derived. Neonatal VAS had no effect on anthropometric measures at 12 months, but may interact sex differentially with routine vaccines. While BCG was the most recent vaccine, neonatal VAS benefitted growth (difference in weight-for-length z-score (dWFL: 0.31(95% CI: 0.03–0.59)). While DTP was the most recent vaccine, VAS tended to affect growth adversely in girls (dWFL = −0.21 (−0.48–0.06)). After measles vaccine (MV) there was no overall effect of neonatal VAS. The VAS effect differed significantly between the BCG and DTP windows (P=0.03), and the difference was borderline significant between the DTP and MV windows for girls (P=0.09).

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