The importance of acylation-stimulating protein levels in male patients with nonalcoholic liver diseases

2003 ◽  
Vol 38 ◽  
pp. 185
Author(s):  
S. Bagci ◽  
Z. Yesilova ◽  
A. Tuzun ◽  
Y. Ates ◽  
A. Uygun ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Protein Levels ◽  
Acylation Stimulating Protein ◽  
Male Patients

scholarly journals Mortality and hospitalization for liver disease in the Western Amazon from 2008 to 2017

2021 ◽  
Vol 31 (1) ◽  
pp. 116-124
Author(s):  
Alex Nunes Callado ◽  
Italla Maria Pinheiro Bezerra ◽  
Fernando Adami ◽  
Luiz Vinícius de Alcantara Sousa ◽  
Luiz Carlos de Abreu
Keyword(s):  
Liver Diseases ◽  
Alcohol Intake ◽  
Ecological Study ◽  
Hospital Admissions ◽  
Secondary Data ◽  
Mortality Rates ◽  
Hospitalization Rates ◽  
Series Design ◽  
Study Results ◽  
Male Patients

Introduction: As liver diseases (LDs) occur as liver damage takes place, their causes are variable and mostly caused by viruses and alcohol intake. The cases of LDs have increased significantly; they are also charged with mortality rates and hospitalizations. Objective: to analyze mortality and hospitalizations due to LDs in the Western Amazon. Methods: Ecological study with time series design using secondary data related to deaths and hospital admissions for LDs in the Western Amazon. Results: The number of cases of mortality due to male diseases is higher in men, considering the period from 2008 to 2017. The study results also show that the affected patients are mostly over 50 and under 20 years old, who are the least likely to die. Regarding hospitalization rates, male patients have the highest number of hospitalizations and are not different from mortality; patients over the age of 50 also represent the largest hospitalization cases. Conclusion: There is a tendency towards stability in cases of mortality and hospitalization due to liver diseases in the Western Amazonia.

scholarly journals Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dong Hwan Ho ◽  
Sanghak Yi ◽  
Hyemyung Seo ◽  
Ilhong Son ◽  
Wongi Seol
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dependent Manner ◽  
Protein Levels ◽  
Significant Difference ◽  
Daily Dose ◽  
Male Patients ◽  
And Gender ◽  
Urine Exosomes ◽  
Potential Use

Parkinson’s disease (PD) is a difficult disease to diagnose although it is the second most common neurodegenerative disease. Recent studies show that exosome isolated from urine contains LRRK2 or DJ-1, proteins whose mutations cause PD. To investigate a potential use for urine exosomes as a tool for PD diagnosis, we compared levels of LRRK2,α-synuclein, and DJ-1 in urine exosomes isolated from Korean PD patients and non-PD controls. LRRK2 and DJ-1, but notα-synuclein, were detected in the urine exosome samples, as reported previously. We initially could not detect any significant difference in these protein levels between the patient and the control groups. However, when age, disease duration, L-dopa daily dose, and gender were considered as analytical parameters, LRRK2 and DJ-1 protein levels showed clear gender-dependent differences. In addition, DJ-1 level was significantly higher (1.7-fold) in male patients with PD than that in male non-PD controls and increased in an age-dependent manner in male patients with PD. Our observation might provide a clue to lead to a novel biomarker for PD diagnosis, at least in males.

scholarly journals Association of Gender With Outcomes in Hospitalized Patients With 2019-nCoV Infection in Wuhan

2021 ◽  
Vol 9 ◽  
Author(s):  
Huiwu Han ◽  
Xiaobei Peng ◽  
Fan Zheng ◽  
Guiyuan Deng ◽  
Xiaocui Cheng ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Severe Pneumonia ◽  
General Information ◽  
Self Report ◽  
Psychological Status ◽  
Elderly Male ◽  
Female Patients ◽  
Protein Levels ◽  
Male Patients ◽  
And Control

Aim: The aim of this study was to analyze the association of gender with psychological status and clinical outcomes among patients with 2019-nCoV infection to provide new directions for the prevention and control of the pandemic.Methods: One hundred and thirty-eight patients with confirmed 2019-nCoV infection at Wuhan Union Hospital, between February 8 and March 31, 2020, were included in the study analysis. General information and data on clinical characteristics were collected from patients' medical records. Participants' responses to self-report measures of psychological status were also collected.Results: Anxiety levels, depression levels, and recovery rates were significantly higher among women compared to men. Conversely, chronic disease history and smoking rates, dry cough incidence, C-reactive protein levels, and disease severity were significantly higher among men than women (p < 0.05).Conclusion: Female patients experienced more severe psychological issues, due to higher levels of anxiety and stress, than male patients; indicating that more attention should be paid to the psychological care of female patients. In contrast, the general condition of male patients was more severe, particularly among elderly male patients with a history of chronic disease and smoking, suggesting that, to prevent and control 2019-nCoV infection, male patients should be encouraged to quit smoking as soon as possible to reduce the risk of severe pneumonia.

Metformin decreases circulating acylation-stimulating protein levels in polycystic ovary syndrome

2007 ◽  
Vol 23 (12) ◽  
pp. 710-715 ◽  
Author(s):  
Cagatay Oktenli ◽  
Taner Ozgurtas ◽  
Murat Dede ◽  
Yavuz S. Sanisoglu ◽  
Mufit C. Yenen ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Protein Levels ◽  
Acylation Stimulating Protein

scholarly journals Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress

Obesity ◽  
2013 ◽  
Vol 21 (8) ◽  
pp. 1613-1617 ◽  
Author(s):  
Serkan Celik ◽  
Fatih Tangi ◽  
Emrah Kilicaslan ◽  
Yavuz S. Sanisoglu ◽  
Cagatay Oktenli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Levels ◽  
Acylation Stimulating Protein ◽  
Markers Of Oxidative Stress

scholarly journals Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Xia Wang ◽  
Yan-jun Cui ◽  
Jia Qi ◽  
Min-min Zhu ◽  
Tian-liang Zhang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Liver Diseases ◽  
Nuclear Translocation ◽  
Reduced Glutathione ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Protein Levels ◽  
Intracellular Ros ◽  
L02 Cells

Several previous studies have demonstrated the excellent antioxidant activity of fucoxanthin against oxidative stress which is closely related to the pathogenesis of liver diseases. The present work was to investigate whether fucoxanthin could protect human hepatic L02 cells against hydrogen peroxide- (H2O2-) induced oxidative damage. Its effects on H2O2-induced cell viability, lactate dehydrogenase (LDH) leakage, intracellular reduced glutathione, and reactive oxygen species (ROS) contents, along with mRNA and protein relative levels of the cytoprotective genes including Nrf2, HO-1, and NQO1, were investigated. The results showed that fucoxanthin could upregulate the mRNA and protein levels of the cytoprotective genes and promote the nuclear translocation of Nrf2, which could be inhibited by the PI3K inhibitor of LY294002. Pretreatment of fucoxanthin resulted in decreased LDH leakage and intracellular ROS content but enhanced intracellular reduced glutathione. Interestingly, pretreatment using fucoxanthin protected against the oxidative damage in a nonconcentration-dependent manner, with fucoxanthin of 5 μM demonstrating the optimal effects. The results suggest that fucoxanthin exerts cytoprotective effects against H2O2-induced oxidative damage in L02 cells, which may be through the PI3K-dependent activation of Nrf2 signaling.

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