Making sense of liver function tests: Is the Intelligent Liver Function Test (iLFT) cost-effective?

2018 ◽  
Vol 68 ◽  
pp. S806-S807
Author(s):  
K. Boyd ◽  
J. Dillon ◽  
S. Inglis ◽  
M. Rezaeihemami
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Cost Effective ◽  
Liver Function Tests ◽  
Making Sense ◽  
Function Tests ◽  
Function Test

scholarly journals Assessment of Liver Function Tests in Children with Typhoid Fever: A Hospital Based Study

2019 ◽  
Vol 17 (2) ◽  
pp. 21-22
Author(s):  
Shakil Ahmad
Keyword(s):  
Liver Function ◽  
Typhoid Fever ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Medical College ◽  
Endemic Diseases ◽  
Function Tests ◽  
Function Test ◽  
Loss Of Appetite

Background: Typhoid fever is among the most endemic diseases in the tropics and which causes significant morbidity and mortality. It can lead to liver damage if not properly treated. Therefore, the liver function test assessment was conducted in children with typhoid fever. Our study aimed to evaluate the liver function test abnormalities in typhoid fever. Material and methods: This was a prospective observational study conducted at the department of paediatrics, Nepalgunj Medical College and Teaching hospital, Nepalgunj for a period of one year August 2018-July 2019.In the present study total 60 children of Typhoid fever were included on the basis of inclusion and exclusion criteria. On admission a detailed history and complete physical examination was carried out. Routine investigations were also carried out. The diagnosis was confirmed by serum Widal test. Liver function tests were performed i.e. Serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT] estimation. Result: In the present study total children were 60 in which 43.33% were boys and 56.66% were girls. Fever was present in all the cases loss of appetite, cough, vomiting was present in majority of cases. On admission, SGOT and SGPT levels were found > 35 IU/L in 26 cases (43.33%) and 34 cases (56.66%) respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L. Conclusion: Our study concluded that on admission of children SGOT and SGPT levels were found > 35 IU/L in 43.33% and 56.66% respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L.

scholarly journals COMPARISON OF LIVER FUNCTION TESTS OF NORMALAND PRE-ECLAMPTIC PREGNANT FEMALES: A HOSPITAL BASED STUDY

2020 ◽  
pp. 8-9
Author(s):  
Shayista Gull
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Serum Total Protein ◽  
Function Tests ◽  
Function Test

Background: Pre-eclampsia is a multi-system disorder of unknown etiology involving almost every organ of body including kidney, liver, brain, heart, stomach and adrenals. In liver periportal hemorrhagic necrosis, ischemic lesions and fibrin deposition occurs due to thrombosis of arterioles. Objective: To compare the liver function tests in normal pregnancy and preeclampsia Methodology: This study was conducted in the Department of Obstetrics and Gynaecology, SKIMS, Soura, Kashmir for 18 months. Participants were divided into two groups: Cases: Comprised of 200 patients with toxemia of pregnancy, Controls: comprised of 500 normal, healthy normotensive pregnant women. This group was studied to get the normal values of liver enzymes and served as controls. A complete blood count, microscopic examination of urine, liver function test, kidney function test , 24 hour urinary protein estimation was done on all participants. Results: Among the cases, 49(24.5%) patients while 76 (15.2%) controls had deranged serum bilirubin. Ninety-nine(49.5%) cases had deranged ALT while 16(3.2%) controls had so. Among the cases, 103(51.5%) had deranged AST level while it was deranged in 64(12.8%) controls. ALP and serum total protein followed similar pattern (more deranged in cases than controls). Conclusion: Liver function test impairment occurs in preeclampsia which is characterized by rise in mean level of serum transaminase levels and serum bilirubin level and fall in serum total protein and albumin level.

scholarly journals Drug eruptions and hepatic involvement: a study

2018 ◽  
Vol 4 (4) ◽  
pp. 501
Author(s):  
Vimala Manne ◽  
Padmaja Pinjala
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Drug Induced ◽  
Medical College ◽  
Hepatic Involvement ◽  
Function Tests ◽  
Drug Eruptions ◽  
Function Test ◽  
Drug Rash

<p class="abstract"><strong>Background:</strong> Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.</p><p class="abstract"><strong>Methods:</strong> 112 cases of patients with drug rash whom we have a tendency to saw within the department of medicine as out-patients and in-patients since 2015 to 2018 in Osmania General Hospital, Katuri Medical College and Hospital and Dr. V. R. K Women’s Medical College, Teaching Hospital and Research Centre were enclosed during this study. Total number of cutaneous drug rash cases enrolled: 83 Total number of drug rash cases with Liver Function Test abnormalities: 17.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 83 patients of drag rash 20% (17) had liver function test abnormalities while 80% (66) had normal hepatic function. Out of 17 drug rash cases with liver function test abnormalities 35% (6) were between 4-14 years of age group. Out of 17 drug rash cases with liver function test abnormalities 70.6% (12) were males and 29.4% (5) were females.</p><p class="abstract"><strong>Conclusions:</strong> To conclude, a sound knowledge of morphological patterns of drug rashes with hepatic involvement, drugs implicated in causing drug rashes and hepatic dysfunction and an easy detection of impending danger by the simple biochemical tests (liver function tests) can evert a major crisis and thus help the clinicians to better manage their cases.</p>

scholarly journals An observational study on effect of carbon dioxide pneumoperitoneum on liver function test in laparoscopic cholecystectomy

2019 ◽  
Vol 6 (8) ◽  
pp. 2751
Author(s):  
Anilkumar Bellad ◽  
Kartik Sahu
Keyword(s):  
Carbon Dioxide ◽  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Causative Factor ◽  
Blood Samples ◽  
Carbon Dioxide Pneumoperitoneum ◽  
Function Tests ◽  
Function Test

Background: In many studies it was noticed that following a laparoscopic cholecystectomy (LC), liver function parameters were disturbed. The carbon dioxide pneumoperitoneum causes changes in the splanchnic microcirculation and can affect cardiac, pulmonary, liver and kidney physiology. Alterations in intracranial pressure, blood acid- base control and the immune system have also been seen. This study was done to know the effects of carbon dioxide pneumoperitoneum on liver function tests in LC. Aim of the study was to study the significance of alterations in Liver function tests and procedure’s safetyMethods: Blood samples of 100 patients who underwent laparoscopic cholecystectomy preoperatively once and post operatively after 24 hours were collected. These blood samples were tested for LFT. The pre op and post op levels of these liver function test values were compared.Results: The level of serum AST, ALT, bilirubin (total) and ALP were increased significantly during the first 24 hrs. Postoperatively after laparoscopic cholecystectomy as compared to baseline values and the levels of serum albumin and total proteins were decreased.Conclusions: There may be a transient elevation of hepatic enzymes after LC and the major causative factor seemed to be CO2 pneumoperitoneum. 

scholarly journals Effect of Ramadan Fasting on Body Composition, Biochemical Profile, and Antioxidant Status in a Sample of Healthy Individuals

2020 ◽  
Vol 18 (4) ◽  
Author(s):  
Asna Urooj ◽  
Namratha Pai Kotebagilu ◽  
Lohith Mysuru Shivanna ◽  
Satish Anandan ◽  
Akshatha Nagaraja Thantry ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Liver Function ◽  
Biochemical Parameters ◽  
Liver Function Tests ◽  
Free Living ◽  
Ramadan Fasting ◽  
Random Blood Sugar ◽  
Function Tests ◽  
Function Test

Background: Muslims fast during the month of Ramadan by abstinence from food and drink every day from dawn to sunset. Studies have reported contradictory results with respect to the changes in body weight and biochemical parameters. No study has been conducted on the association between fasting and body weight and biochemical parameters in the Indian setting on healthy Muslim subjects. Objectives: To assess the effect of fasting during Ramadan on biochemical parameters such as lipid profile, liver function test, renal function test, antioxidant status, random blood sugar, hemoglobin, body composition, and blood pressure in a sample of healthy individuals. Methods: In this study, 52 healthy free-living participants (25 males, 27 females, 21-64 years) who met the inclusion and exclusion criteria and completed both follow-ups (before and after Ramadan) were studied. Participants were fasting 12 hours a day for at least 21 days, including menstruating women. It was a free-living study with no dietary restrictions. Anthropometry, lipid profile, liver and renal function tests were measured by standard methods. Body composition was analyzed by bioelectrical impedance. Results: Significant beneficial changes in albumin, alanine aminotransferase, creatinine, and high-density lipoprotein (HDL) were observed, while total cholesterol, random blood sugar, aspartate aminotransferase, and alkaline phosphatase enzymes remained unchanged after Ramadan. Fasting did bring in some changes in body composition; among both men and women, mean weight loss ranged from 0.81 - 1.4 kg in majority of the subjects, which was due to loss in muscle mass. Moderate changes in intra- and extracellular water content was observed after fasting. Conclusions: Significant improvements were observed in HDL levels and liver function tests, which can be attributed to the loss of body weight. Improvement in liver function tests may be related to the changes in cytokines and alteration in sleep patterns. Ramadan-like fasting, along with the nutritional education prior to fasting, may be beneficial and effective in the spiritual and overall well-being.

scholarly journals Oral antifungal: the safety and efficacy of oral itraconazole in dermatophytosis

2019 ◽  
Vol 8 (11) ◽  
pp. 2470
Author(s):  
Vaishali Thakare ◽  
Nandita K. Patel ◽  
Sharmila Patil ◽  
Navin Modi
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Tertiary Care ◽  
Liver Function Tests ◽  
Hepatic Function ◽  
Care Hospital ◽  
Hepatic Transaminases ◽  
Function Test ◽  
History Of ◽  
Oral Itraconazole

Background: The systemic antifungals like Griseofulvin, Itraconazole, Terbinafine, Ketoconazole and Fluconazole are widely used for superficial fungal infection. Hepatotoxicity with oral antifungals is well established fact. The rate of transient asymptomatic changes in liver function tests accounts for about 0.5 - 10% of all patients treated with systemic antifungals. Clinical hepatic toxicity is seen less frequently. The aim of this study is to evaluate the effect of oral Itraconazole on hepatic function and it’s efficacy in patients with extensive dermatophytosis.Methods: The total of 524 patients with extensive dermatophytosis were included in our study which was conducted in a tertiary care hospital in Navi Mumbai.Results: Itraconazole, a systemic antifungal agent is efficiently used in treatment of superficial and deep mycoses. It inhibits fungal cytochrome P450 dependent enzyme and thus impaires conversion of lanosterol to ergosterol. Adverse reactions to itraconazole includes drug reactions, gastrointestinal upset, headache, dizziness, thrombocytopenia, gynecomastia, reversible edema of extremities and metabolic side effects like hypokalemia, and hypertriglyceridemia. The level of hepatic transaminases increases in about 1%-5% of patients who have received continuous therapy with systemic itraconazole. Clinical hepatitis rarely occurs in patients and, recovery generally ensues with the cessation of medication.Conclusions: The baseline and post treatment liver function test is important to monitor if patient is on higher dose and longer duration of itraconazole therapy. The screening for high risk patients like poor liver function test, history of alcoholism, history of liver disease should be taken before stating the therapy.

How to interpret and manage abnormal liver blood test results in older people

2021 ◽  
pp. 1-8
Author(s):  
Mohsan Subhani ◽  
Abhishek Sheth ◽  
Bilal Ahmad ◽  
Stephen Ryder
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Test Results ◽  
Older Population ◽  
The Metabolic Syndrome ◽  
Function Tests ◽  
Function Test ◽  
Common Observation

Ageing impairs liver function and reduces the liver's regenerative capacity. With the predicted increase in the older population, the burden of liver disease will proportionally rise in this age group. Elevated levels of liver enzymes in an otherwise asymptomatic older individual (≥65 years) are a common observation and positively associated with the metabolic syndrome, whereas a decline in albumin levels is linked with a rise in all-cause and liver-specific mortality. Deranged liver function tests do not always indicate liver disease, nor do normal liver function tests exclude liver disease. Therefore, clinicians need to consider individual patient risk factors during the assessment of abnormal liver function tests. This article discusses various liver function tests, their pathophysiology, and the approach to interpret and manage common abnormalities in liver function test results and liver disease in the older population.

scholarly journals The effect of acute complicated appendicitis on liver function test

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Kulsoom MoulaBux ◽  
Sughra Parveen ◽  
Mazhar Iqbal ◽  
Ayesha Mehboob
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Medical Center ◽  
Liver Function Tests ◽  
Complicated Appendicitis ◽  
Total Leukocyte Count ◽  
Negative Appendectomy ◽  
Creative Commons ◽  
Gangrenous Appendicitis ◽  
Function Test

Objectives: To determine the diagnostic role of hyperbilirubinemia in acute appendicitis like suppurative and gangrenous appendicitis. Methods: This observational study was conducted at Ward-3, Jinnah Postgraduate Medical Center (JPMC), Karachi from 1st June 2019 to 1st June 2020. Males and females above 12 years of age were included. Serum liver function tests and leukocyte counts were carried out. Appendectomies were done, the operative findings and histopathology reports were noted. Hyperbilirubinemia was related with the stages of appendicitis. Results were analyzed by SPSS version 25. Results: There were one hundred twenty patients. Thirty-eight (31.66%) were females and eighty-two (68.33%) were males. Age range was 13 to 60 years. Ten patients (8.33%) were between 13 – 20 years, sixty five (54.16%) were 21 to 30 years, thirty (25%) were 31 – 40 years, ten (8.33%) were 41 – 50 years and five patients (4.17%) were above 50 years of age. Sixty-two (51.66%) patients had simple appendicitis and fifty-four (45%) had complicated appendicitis like suppurative (26.66%) and (16.66%) gangrenous appendicitis. Negative appendectomy was found in four (3.33%). Hyperbilirubinemia was found (100%) in gangrenous, (94.12%) in suppurative and (12.3%) in catarrhal appendicitis. Enzymes like Alanine transaminase and Aspartate transaminase were raised (50%) in gangrenous, (50%) in suppurative and (9.67%) in catarrhal appendicitis. TLC was raised in 112 (96.55%) out of 116 patients and total leukocyte count was normal in negative appendectomies. Conclusions: It is concluded that hyperbilirubinemia is strong diagnostic predictor for complicated appendicitis.\ doi: https://doi.org/10.12669/pjms.37.2.3356 How to cite this:MoulaBux K, Parveen S, Iqbal M, Mehboob A. The effect of acute complicated appendicitis on liver function test. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3356 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Biochemical liver function tests parameters do not indicate any difference in the degree of hepatotoxicity in patients with metastatic colorectal carcinoma treated with conventional anticancer drugs regardless the use of bevacizumab

2017 ◽  
Vol 74 (8) ◽  
pp. 757-762
Author(s):  
Kristina Denic ◽  
Dino Tarabar ◽  
Slobodan Obradovic ◽  
Nemanja Stanic ◽  
Jelena Spasic ◽  
...  
Keyword(s):  
Liver Function ◽  
Anticancer Drugs ◽  
Treatment Protocol ◽  
Liver Function Tests ◽  
The Other ◽  
Function Tests ◽  
Test Parameters ◽  
Function Test ◽  
Group 2 ◽  
Group 1

Background/Aim. Colorectal carcinoma (CRC) is one the most frequent malignant disease with early liver metastasis. It requires the timely use of anticancer drugs. Current treatment of metastatic CRC consists of conventional anticancer drugs use, but they cause liver damage which is manifested by disorder in biochemical liver function parameters. The addition of one of monoclonal antibodies, e.g. bevacizumab improves their therapeutic effect, but its influence on caused biochemical disturbances is not completely known. Therefore the aim of this study was to compare the level of liver function test parameters in patients treated with conventional anticancer drugs with parameters in patients additionally treated with bevacizumab. Methods. The study was performed on the two groups of adult patients with liver metastatic CRC assigned according to the treatment protocol. One group of the patients (n = 44) was treated with FOLFOX4 (the group 1), and the other one (n = 52) with bevacizumab added to FOLFOX4 treatment protocol (the group 2). Depending on the response of patients, the duration of treatment varied from 2 to 6 months. Standard liver function tests were performed before and after the completion of the treatment. Results. Initial values of some biochemical function test parameters [alkaline phosphatase (ALP) in the group 1 of patients, gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) in both groups] were increased in relation to the normal reference values, with some intergroup differences (p = 0.001). Biochemical disturbances of liver function tests in the group of patients treated with conventional anticancer drugs were due to not only their metastases but also due to the hepatotoxic effect of drugs used. After the treatment, significant differences in biochemical liver tests parameters were found in aspartate aminotransferase (AST), alanine aminotransferase (ALP), GGT and LDH, being lower in the group 2 (patients additionally treated by bevacizumab) (p values were: 0.002 for AST; 0.001 for ALP and GGT; 0.000 for LDH). The levels of the other studied parameters, alanine aminotransferase (ALT) bilirubin, and proteins did not differ significantly between groups both pre- or post-treatment. Conclusion. Both, metastatic CRC and treatment with the conventional anticancer drugs induce significant disturbances of several liver function parameters. The addition of bevacizumab to the conventional anticancer drugs did not affect these disturbances.

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