scholarly journals COMPARISON OF LIVER FUNCTION TESTS OF NORMALAND PRE-ECLAMPTIC PREGNANT FEMALES: A HOSPITAL BASED STUDY

2020 ◽  
pp. 8-9
Author(s):  
Shayista Gull
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Total Protein ◽  
Serum Bilirubin ◽  
Complete Blood Count ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Serum Total Protein ◽  
Function Tests ◽  
Function Test

Background: Pre-eclampsia is a multi-system disorder of unknown etiology involving almost every organ of body including kidney, liver, brain, heart, stomach and adrenals. In liver periportal hemorrhagic necrosis, ischemic lesions and fibrin deposition occurs due to thrombosis of arterioles. Objective: To compare the liver function tests in normal pregnancy and preeclampsia Methodology: This study was conducted in the Department of Obstetrics and Gynaecology, SKIMS, Soura, Kashmir for 18 months. Participants were divided into two groups: Cases: Comprised of 200 patients with toxemia of pregnancy, Controls: comprised of 500 normal, healthy normotensive pregnant women. This group was studied to get the normal values of liver enzymes and served as controls. A complete blood count, microscopic examination of urine, liver function test, kidney function test , 24 hour urinary protein estimation was done on all participants. Results: Among the cases, 49(24.5%) patients while 76 (15.2%) controls had deranged serum bilirubin. Ninety-nine(49.5%) cases had deranged ALT while 16(3.2%) controls had so. Among the cases, 103(51.5%) had deranged AST level while it was deranged in 64(12.8%) controls. ALP and serum total protein followed similar pattern (more deranged in cases than controls). Conclusion: Liver function test impairment occurs in preeclampsia which is characterized by rise in mean level of serum transaminase levels and serum bilirubin level and fall in serum total protein and albumin level.

scholarly journals Assessment of Liver Function Tests in Children with Typhoid Fever: A Hospital Based Study

2019 ◽  
Vol 17 (2) ◽  
pp. 21-22
Author(s):  
Shakil Ahmad
Keyword(s):  
Liver Function ◽  
Typhoid Fever ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Medical College ◽  
Endemic Diseases ◽  
Function Tests ◽  
Function Test ◽  
Loss Of Appetite

Background: Typhoid fever is among the most endemic diseases in the tropics and which causes significant morbidity and mortality. It can lead to liver damage if not properly treated. Therefore, the liver function test assessment was conducted in children with typhoid fever. Our study aimed to evaluate the liver function test abnormalities in typhoid fever. Material and methods: This was a prospective observational study conducted at the department of paediatrics, Nepalgunj Medical College and Teaching hospital, Nepalgunj for a period of one year August 2018-July 2019.In the present study total 60 children of Typhoid fever were included on the basis of inclusion and exclusion criteria. On admission a detailed history and complete physical examination was carried out. Routine investigations were also carried out. The diagnosis was confirmed by serum Widal test. Liver function tests were performed i.e. Serum glutamic oxaloacetic transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT] estimation. Result: In the present study total children were 60 in which 43.33% were boys and 56.66% were girls. Fever was present in all the cases loss of appetite, cough, vomiting was present in majority of cases. On admission, SGOT and SGPT levels were found > 35 IU/L in 26 cases (43.33%) and 34 cases (56.66%) respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L. Conclusion: Our study concluded that on admission of children SGOT and SGPT levels were found > 35 IU/L in 43.33% and 56.66% respectively. On discharge after 7 days of antibiotic, majority of patients had SGOT and SGPT levels < 35 IU/L.

scholarly journals Drug eruptions and hepatic involvement: a study

2018 ◽  
Vol 4 (4) ◽  
pp. 501
Author(s):  
Vimala Manne ◽  
Padmaja Pinjala
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Drug Induced ◽  
Medical College ◽  
Hepatic Involvement ◽  
Function Tests ◽  
Drug Eruptions ◽  
Function Test ◽  
Drug Rash

<p class="abstract"><strong>Background:</strong> Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.</p><p class="abstract"><strong>Methods:</strong> 112 cases of patients with drug rash whom we have a tendency to saw within the department of medicine as out-patients and in-patients since 2015 to 2018 in Osmania General Hospital, Katuri Medical College and Hospital and Dr. V. R. K Women’s Medical College, Teaching Hospital and Research Centre were enclosed during this study. Total number of cutaneous drug rash cases enrolled: 83 Total number of drug rash cases with Liver Function Test abnormalities: 17.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 83 patients of drag rash 20% (17) had liver function test abnormalities while 80% (66) had normal hepatic function. Out of 17 drug rash cases with liver function test abnormalities 35% (6) were between 4-14 years of age group. Out of 17 drug rash cases with liver function test abnormalities 70.6% (12) were males and 29.4% (5) were females.</p><p class="abstract"><strong>Conclusions:</strong> To conclude, a sound knowledge of morphological patterns of drug rashes with hepatic involvement, drugs implicated in causing drug rashes and hepatic dysfunction and an easy detection of impending danger by the simple biochemical tests (liver function tests) can evert a major crisis and thus help the clinicians to better manage their cases.</p>

scholarly journals Liver function tests in patients of pre-eclampsia in Bhilai, Chhattisgarh, India: a clinical study

2018 ◽  
Vol 7 (12) ◽  
pp. 5102
Author(s):  
Rashid Lodhi ◽  
Navanil Roy
Keyword(s):  
Blood Pressure ◽  
Liver Function ◽  
Pregnant Women ◽  
Total Protein ◽  
Liver Enzymes ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Mean Value ◽  
Function Tests ◽  
The Mean

Background: Pre-eclampsia is a multisystem disorder, which occurs only in pregnant women during the second and third trimesters of pregnancy and is associated with raised blood pressure and proteinuria. Liver function Test (LFT) abnormalities occur in 3% of the pregnancies and probably the lesion that causes elevated serum liver enzymes. This study was conducted to compare the liver function tests in pre-eclampsia with normal pregnancy.Methods: This study was carried out on 60 pregnant women after 20 weeks of gestation admitted in Obstetrics and Gynaecology units of Shri Shankaracharya Institute of Medical Sciences, Bhilai, and Chhattisgarh. The subjects were divided into two groups. Group A comprised of 30 cases of pre-eclampsia having blood pressure ≥ 140/90mm Hg, proteinuria in 24 hours ≥ 300 mg and edema.  Group B had 30 normal pregnant women after 20 weeks of gestation. The data including parity, period of gestation, blood pressure and presenting complaints of all subjects were recorded. Serum bilirubin, total protein, albumin and plasma levels of liver enzymes ALT and AST were measured.Results: The mean value of serum bilirubin in cases was 3.45 and in controls it was 0.50. The mean value of enzymes ALT in cases was 92.7 while in the controls it was 22.37. Mean serum AST in the cases was 85.43 and in the controls,  it was 21.96. Total protein in cases was 7.77 and controls it was 7.26. Albumin level in cases was 4.62 and controls were 4.17.Conclusions: Increased concentrations of serum bilirubin, total protein, albumin and liver enzymes ALT, AST were found in pre-eclampsia cases.

scholarly journals An observational study on effect of carbon dioxide pneumoperitoneum on liver function test in laparoscopic cholecystectomy

2019 ◽  
Vol 6 (8) ◽  
pp. 2751
Author(s):  
Anilkumar Bellad ◽  
Kartik Sahu
Keyword(s):  
Carbon Dioxide ◽  
Laparoscopic Cholecystectomy ◽  
Liver Function ◽  
Liver Function Test ◽  
Liver Function Tests ◽  
Causative Factor ◽  
Blood Samples ◽  
Carbon Dioxide Pneumoperitoneum ◽  
Function Tests ◽  
Function Test

Background: In many studies it was noticed that following a laparoscopic cholecystectomy (LC), liver function parameters were disturbed. The carbon dioxide pneumoperitoneum causes changes in the splanchnic microcirculation and can affect cardiac, pulmonary, liver and kidney physiology. Alterations in intracranial pressure, blood acid- base control and the immune system have also been seen. This study was done to know the effects of carbon dioxide pneumoperitoneum on liver function tests in LC. Aim of the study was to study the significance of alterations in Liver function tests and procedure’s safetyMethods: Blood samples of 100 patients who underwent laparoscopic cholecystectomy preoperatively once and post operatively after 24 hours were collected. These blood samples were tested for LFT. The pre op and post op levels of these liver function test values were compared.Results: The level of serum AST, ALT, bilirubin (total) and ALP were increased significantly during the first 24 hrs. Postoperatively after laparoscopic cholecystectomy as compared to baseline values and the levels of serum albumin and total proteins were decreased.Conclusions: There may be a transient elevation of hepatic enzymes after LC and the major causative factor seemed to be CO2 pneumoperitoneum. 

scholarly journals Reversal of Jaundice in Two Patients with Inoperable Cholangiocarcinoma Treated with Cisplatin and Gemcitabine Combination

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Maarten Criel ◽  
Filip Geurs ◽  
Siegfried Ponette ◽  
Katrien Bulte ◽  
Johan Ponette
Keyword(s):  
Liver Function ◽  
Combination Chemotherapy ◽  
Serum Bilirubin ◽  
Liver Function Tests ◽  
Normal Serum ◽  
Tumor Type ◽  
Chemotherapeutic Approach ◽  
Function Tests ◽  
Severe Jaundice

Two patients are presented with severe jaundice, due to inoperable cholangiocarcinoma. The chemotherapeutic approach in patients with severe jaundice is discussed. Many schedules of chemotherapy were developed in this tumor type with normal serum bilirubin. We report here the first successful use of cisplatin and gemcitabine combination chemotherapy in these patients. Tolerability was good and liver function tests gradually improved.

scholarly journals EFFECT OF ALCOHOLISM ON LIVER FUNCTION TEST IN RURAL POPULATION IN INDIA

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
Richa K Lath ◽  
Aniruddha Jibhkate
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Damage ◽  
Total Protein ◽  
Liver Enzymes ◽  
Normal Individual ◽  
Public Health Problem ◽  
Albumin Level ◽  
Study Group ◽  
Function Test

Background: alcoholism is one of the major socioeconomic as well as public health problem in India. The problem is occurring equally in urban as well as in rural India. This study was carried out in essence of liver damage in alcoholics and alteration in the biochemical enzymes in the serum with respect to liver damage. Method: 100 alcoholics and 100 non alcoholic patients were selected from the hospital OPD. Liver function test was performed in both the study group. Liver  enzymes ALT,AST,ALP and the total protein and albumin level were compared in  the study group and controls. Results: The results showed there is significant increase in the liver enzymes ALT,AST,ALP in the alcoholic patients as compared to normal individual and significant fall in concentration of the total protein and albumin level in the alcoholics. Keywords: Alcoholics, liver function test

An Unusual Case of Hypereosinophilic Syndrome

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4965-4965
Author(s):  
Anwarul Islam
Keyword(s):  
Liver Function ◽  
Bronchoalveolar Lavage ◽  
Short Duration ◽  
Hypereosinophilic Syndrome ◽  
Liver Function Tests ◽  
Organ Damage ◽  
Abnormal Liver Function ◽  
Unknown Etiology ◽  
End Organ Damage ◽  
Function Tests

Abstract Hypereosinophilic syndrome (HES) is defined as (1) persistent marked eosinophilia of over 6 months duration, (2) of unknown origin (3) complicated by end organ damage. An association between hypereosinophilia of short duration and exposure to sawdust has yet not been reported. We report a 75 years old white male who presented with a four day history of extreme fatigue, diarrhea and fever. A CBC on admission revealed WBC 18.0 x109/L, hemoglobin 17.5 g/dL and platelets 170 x109/L with 2% eosinophils along with slightly abnormal liver function tests and raised BUN (54 mg/dL) and creatinine (3.0 mg/dL). A CT of the abdomen and pelvis revealed mild mural thickening of the rectum, sigmoid and descending colon. The impression on admission was gastroenteritis with dehydration. The patient was given IV hydration and empirically started on intravenous metronidazole and levofloxacin; and cultures were obtained which turned out to be negative. The patient’s condition soon worsened. He developed respiratory distress and because of apparent sepsis he was transferred to the ICU. His antibiotics were changed to vancomycin, cefepime, flagyl and fluconazole with no apparent improvement. On the 6th day of his admission a CBC revealed WBC 27.7 x109/L, hemoglobin 13.5 g/dL and platelets 27 x109/L with 43% eosinophils and his kidney and liver function continued to deteriorate. A search for tissue invasive parasitic disease was negative and a bronchoalveolar lavage from the left lung demonstrated only 3% eosinophils and no eosinophils were seen in the bronchoalveolar lavage from the right lung. At this point a hematology consult was requested. Because of his marked and progressive eosinophilia, no apparent cause and evidence of end organ damage a diagnosis of HES was made. The patient was immediately placed on high dose methyl prednisolone to which he responded well. After three weeks of hospitalization his blood counts were normalized and he was discharged. Following his recovery the patient gave a lucid history that he is a freelance wood carver and a few days prior to his falling ill he was massively exposed to sawdust while cleaning the vacuum apparatus of his wood cutting machine. One of the criteria for the diagnosis of HES is unknown etiology but in this case it was most likely to be due to the exposure to sawdust. On one hand the patient showed evidence of HES in that his eosinophil counts were markedly elevated (Abs Eos 9.8 109/L, normal = < 0.7) and also showed evidence of end organ damage in the form of thrombocytopenia, abnormal liver function tests, and elevated BUN and creatinine levels. However, unlike classic HES the patient’s hypereosinophilia was of short duration (only weeks not months) and there was a definite probable cause of his hypereosinophilia (exposure to sawdust). Further, the patient also responded well to steroid therapy without any recurrence of the disease two years after his initial presentation. This case suggests that inhaled environmental antigens may be associated with some cases of HES. Disclosures No relevant conflicts of interest to declare.

Findings on Liver Biopsy in Patients with Abnormal Liver Function Tests of Unknown Etiology

2010 ◽  
Vol 105 ◽  
pp. S99
Author(s):  
Gaurav Singhvi ◽  
Jian Xie ◽  
Nikhiel Rau ◽  
Vivek Trivedi ◽  
Sridevi Bellamkonda ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Biopsy ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Unknown Etiology ◽  
Function Tests
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