scholarly journals SIMPLE AND ECONOMICAL METHOD FOR SPECIATION AND RESISTOTYPING OF CLINICALLY SIGNIFICANT COAGULASE NEGATIVE STAPHYLOCOCCI

2006 ◽  
Vol 24 (3) ◽  
pp. 201-204
Author(s):  
R Goyal ◽  
NP Singh ◽  
A Kumar ◽  
I Kaur ◽  
M Singh ◽  
...  
Keyword(s):  
Coagulase Negative Staphylococci ◽  
Economical Method ◽  
Clinically Significant

scholarly journals 577. Incidence and Outcomes of Positive Outpatient Surveillance Blood Cultures in Hematopoietic Stem Cell Transplant (HSCT) Patients with Graft Versus Host Disease (GvHD) On High Dose ≥ 0.5 mg/kg/day (HD) and Low Dose < 0.5mg/kg/day (LD) Steroid Therapy

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S353-S354
Author(s):  
Sarah Perreault ◽  
Molly Schiffer ◽  
Jennifer Zhao ◽  
Dayna McManus ◽  
Francine Foss ◽  
...  
Keyword(s):  
Steroid Therapy ◽  
Central Line ◽  
Blood Cultures ◽  
High Dose ◽  
Cell Transplant ◽  
Coagulase Negative Staphylococci ◽  
Hematopoietic Stem ◽  
Surveillance Cultures ◽  
Number Of Patients ◽  
Clinically Significant

Abstract Background Treatment of GvHD with steroids increases the risk of infection in HSCT patients due to additive immunosuppression and may delay the diagnosis of infection due to lack of symptoms. Outpatient surveillance blood cultures in HSCT with GvHD being treated with HD steroids has demonstrated a blood culture positivity rate of 3.5%. Currently, the utility of surveillance cultures in patients receiving LD steroid therapy is unknown. Our practice includes weekly outpatient surveillance cultures for all GvHD patients treated with steroids regardless of the dose. The primary endpoint of this study was to assess the incidence of positive surveillance blood cultures in GvHD patients receiving HD or LD steroids. Secondary endpoints included number of patients treated, hospitalization, 30 day mortality due to infection, and organisms isolated. Methods This was a single-center, retrospective review of GvHD patients at Yale New Haven Hospital between January 2013 and May 2019. Patients were excluded if: lack of signs or symptoms of GvHD, treatment with steroids for any indication other than GvHD, and active GvHD without central line. Cultures from patients receiving antibiotics for concurrent infection were also excluded. Results A total of 71 patients met criteria with 901 blood cultures. On HD, eight patients (14%) had 12 positive cultures (4%), and on LD, 16 patients (25%) had 22 positive cultures (4%) (p=0.15). Treatment occurred in six patients (75%) with four (24%) requiring hospitalization on HD, and 12 patients (75%) with 10 (83%) requiring hospitalization on LD (p=0.45). The median duration of steroid therapy was 93 and 236 days with a median dose of steroids of 1mg/kg/day and 0.15mg/kg/day, respectively. The number of positive cultures/1000 steroid days was 1.2 on HD and 0.5 on LD (RR 2.2). 30 day mortality was only noted in one patient (8%) on LD. The most common organism in both groups was Coagulase-negative staphylococci with all six cultures on HD classified as contaminants and 6/10 cultures requiring treatment on LD. Conclusion Although the relative risk of positive surveillance blood cultures in HD patients compared to LD was twofold higher, there were clinically significant infections identified in the LD group. Disclosures All Authors: No reported disclosures

Usefulness of a Test for Slime Production as a Marker for Clinically Significant Infections with Coagulase-Negative Staphylococci

1986 ◽  
Vol 153 (2) ◽  
pp. 332-339 ◽  
Author(s):  
D. S. Davenport ◽  
R. M. Massanari ◽  
M. A. Pfaller ◽  
M. J. Bale ◽  
S. A. Streed ◽  
...  
Keyword(s):  
Coagulase Negative Staphylococci ◽  
Slime Production ◽  
Clinically Significant

scholarly journals Genomic investigation of clinically significant coagulase-negative staphylococci

2021 ◽  
Author(s):  
Kevin Cole ◽  
Bridget Atkins ◽  
Martin Llewelyn ◽  
John Paul
Keyword(s):  
High Resolution ◽  
Genomic Analysis ◽  
Staphylococcal Infection ◽  
Clinical Samples ◽  
Future Research ◽  
Emerging Pathogens ◽  
Coagulase Negative Staphylococci ◽  
Content Type ◽  
History Of ◽  
Clinically Significant

Introduction. Coagulase-negative staphylococci have been recognized both as emerging pathogens and contaminants of clinical samples. High-resolution genomic investigation may provide insights into their clinical significance. Aims. To review the literature regarding coagulase-negative staphylococcal infection and the utility of genomic methods to aid diagnosis and management, and to identify promising areas for future research. Methodology. We searched Google Scholar with the terms ( Staphylococcus ) AND (sequencing OR (infection)). We prioritized papers that addressed coagulase-negative staphylococci, genomic analysis, or infection. Results. A number of studies have investigated specimen-related, phenotypic and genetic factors associated with colonization, infection and virulence, but diagnosis remains problematic. Conclusion. Genomic investigation provides insights into the genetic diversity and natural history of colonization and infection. Such information allows the development of new methodologies to identify and compare relatedness and predict antimicrobial resistance. Future clinical studies that employ suitable sampling frames coupled with the application of high-resolution whole-genome sequencing may aid the development of more discriminatory diagnostic approaches to coagulase-staphylococcal infection.

Coagulase-Negative Staphylococcal Bacteremia in Neonates: Confusion Continued

PEDIATRICS ◽  
1990 ◽  
Vol 86 (2) ◽  
pp. 320-322
Author(s):  
MORVEN S. EDWARDS
Keyword(s):  
Intensive Care ◽  
Premature Infants ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Blood Cultures ◽  
Coagulase Negative Staphylococci ◽  
Low Birth Weight Infants ◽  
Potential Source ◽  
Clinically Significant ◽  
Substantial Morbidity

Colonization of neonates with coagulase-negative staphylococci occurs predictably during the first weeks of life, serving as a potential source of bacteremia in very low birth weight infants.1,2 Clinical features alone are insufficient to distinguish sepsis caused by neonatal pathogens other than coagulase-negative staphylococci3 or to differentiate sepsis from noninfectious disorders in these tiny patients. Inasmuch as coagulase-negative staphylococci are the most frequent blood culture isolates from patients in most neonatal intensive care units4,5 and are a cause of substantial morbidity,6 the statement of Freeman et al7 that "blood cultures positive for coagulase-negative staphylococci are almost four times as likely to be perceived as clinically significant if obtained from extremely premature infants" is not surprising.

scholarly journals Pathogenic features of clinically significant coagulase-negative staphylococci in hospital and community infections in Benin

2017 ◽  
Vol 307 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Chimène Nanoukon ◽  
Xavier Argemi ◽  
Frédéric Sogbo ◽  
Jeanne Orekan ◽  
Daniel Keller ◽  
...  
Keyword(s):  
Coagulase Negative Staphylococci ◽  
Clinically Significant
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