SUN-P066: Liver Fibrosis in Women with Nonalcoholic Fatty Liver Disease Using Bioelectrical Impedance Analysis: a Cross-Sectional Study

Background: SARS-CoV-2 principally invades the respiratory system. ACE receptor are also abundant throughout the hepatobiliary system and their increased expression on hepatocyte make patients with NAFLD more vulnerable. Aim: To see outcomes of COVID positive diabetic patients suffering from Nonalcoholic fatty liver disease (NAFLD). Study design: Cross Sectional Study. Methodology: 150 diabetic and COVID PCR positive were recruited from COVID ward of Services Hospital in Lahore. Clinical parameters like BMI, SpO2, Hepatomegaly and lab parameters like HbA1C, AST ALT were noted in spreadsheet. Statistical analysis was done using SPSS v.25. Statistical significance for difference in proportions is calculated using Pearson’s Chi-Squared test. P less than 0.05 was considered statistically significant. Results: Around 84(56%) were males and 66(44%) females, smoked were 27(18%), mean age (years) was 59.7333 ±11.35023, mean BMI (kg/m²) was 30.1425±7.30673, 87(58%) patients had NAFLD, who experienced sever disease (53.2%; x^2=0.010) and more mortalities (60.2%;x^2=0.453) as compared to those who do not had condition. Conclusion: We concluded that NAFLD makes COVID-19 infected patients more fragile. Such patients experienced sever disease and more mortalities however need of mechanical ventilation remains almost equal between those who has NAFLD and those who didn’t had. Keywords: Nonalcoholic fatty liver disease, COVID-19, Diabetes, Mortality and Severity.

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Lifestyle predictors of obese and non-obese patients with nonalcoholic fatty liver disease: A cross-sectional study

Clinical Nutrition ◽

10.1016/j.clnu.2017.08.018 ◽

2018 ◽

Vol 37 (5) ◽

pp. 1550-1557 ◽

Cited By ~ 6

Author(s):

Joo Hee Kwak ◽

Dae Won Jun ◽

Seung Min Lee ◽

Yong Kyun Cho ◽

Kang Nyeong Lee ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Obese Patients ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver

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Gender differences in the prevalence of nonalcoholic fatty liver disease in the Northeast of Thailand: A population-based cross-sectional study

F1000Research ◽

10.12688/f1000research.12417.1 ◽

2017 ◽

Vol 6 ◽

pp. 1630 ◽

Cited By ~ 8

Author(s):

Ueamporn Summart ◽

Bandit Thinkhamrop ◽

Nittaya Chamadol ◽

Narong Khuntikeo ◽

Metha Songthamwat ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver ◽

Prevalence Difference ◽

Post Menopausal

Background. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. A large number of studies have strongly described larger proportions of men being afflicted with NAFLD than women; however, recent studies investigating the role of gender and NAFLD have exposed the contrary. Methods. This cross-sectional study utilized data from the baseline survey of an ongoing cohort study called the Cholangiocarcinoma Screening and Care Program (CASCAP), conducted in the northeastern region of Thailand between March 2013 and September 2015. Information regarding socio-demographic, including gender, was collected using a standardized self-administered questionnaire. NAFLD was diagnosed with ultrasonography by board-certified radiologists. A binomial regression was used for estimating the prevalence differences, odds ratios (OR) and the 95% confidence intervals (CI) of NAFLD between men and women. Results. A total of 34,709 participants (27,073 females and 7,636 males) were recruited. The prevalence of NAFLD in women was 22.9% (95% CI: 22.5 to 23.5), whereas it was only 18.3% (95% CI: 17.4 to 19.2) in men. After adjusting for age and presence of diabetes mellitus and other underlying diseases, the prevalence was significantly higher in women, with adjusted prevalence difference of 4.2% (95% CI: 3.2 to 5.2) and adjusted OR of 1.3 (95% CI: 1.2 to 1.4). Women had a higher prevalence of NAFLD than men in all age groups and the largest difference was found in those aged 56-60 years (prevalence = 27.4% versus 21.2%; adjusted prevalence difference = 9.4%; 95% CI: 7.9 to 10.9; adjusted OR = 1.8; 95% CI: 1.8 to 2.0). Conclusion. NAFLD is more likely to affect women more than men, in particular, among the population 56-60 years of age, which is the post-menopausal transitional period. Therefore, post-menopausal women should be the target for interventions or further investigation for NAFLD.

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Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s237866 ◽

2020 ◽

Vol Volume 13 ◽

pp. 619-625 ◽

Cited By ~ 6

Author(s):

Yousry Esam-Eldin Abo-Amer ◽

Aisha Sabal ◽

Rehab Ahmed ◽

Nabil Fathy Esmael Hasan ◽

Rasha Refaie ◽

...

Keyword(s):

Helicobacter Pylori ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Developing Country ◽

Fatty Liver Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver

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Comparison of visceral fat area measured by CT and bioelectrical impedance analysis in Chinese patients with gastric cancer: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2019-036335 ◽

2020 ◽

Vol 10 (7) ◽

pp. e036335

Author(s):

Bo Gao ◽

Yu Liu ◽

Chao Ding ◽

Shunli Liu ◽

Xiaotian Chen ◽

...

Keyword(s):

Gastric Cancer ◽

Bioelectrical Impedance Analysis ◽

Visceral Obesity ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Limits Of Agreement ◽

Visceral Fat Area ◽

Cross Sectional

ObjectivesBioelectrical impedance analysis (BIA) is a simple and inexpensive method to estimate body composition. However, the accuracy of BIA is unknown. We aimed to assess the accuracy of BIA in estimating visceral fat area (VFA) in patients with gastric cancer.Study designThis was a cross-sectional study comparing the accuracy of BIA in estimating VFA with the gold standard method measured by CT. VFA was measured in enrolled patients both by CT and BIA. VFA by CT at umbilical level ≥100 cm2 was considered as visceral obesity. Reliability between the two methods was assessed by intraclass correlation coefficient (ICC) and consistency was assessed by Bland-Altman method (95% limits of agreement). The area under the receiver operating characteristic curve (AUROC) was used to assess the performance of BIA in diagnosing visceral obesity.SettingThe study was conducted in China.ParticipantsFrom 1 January 2017 to 1 December 2018, a total of 157 patients diagnosed with gastric cancer were enrolled.ResultsOverall, VFA by CT and BIA in patients was 84.39±46.43 cm2 and 71.94±22.44 cm2, respectively. VFA estimated by BIA was positively correlated with VFA measured by CT using Pearson’s test (r=0.650, p<0.001). Overall, ICC for the two methods was 0.675. The mean bias between the two measurements was 12.45±36.13 cm2. The 95% limits of agreement ranged from −58.36 cm2 to 83.26 cm2. The cut-off value for diagnosing visceral obesity by BIA was 81 cm2 (AUROC: 0.822, p<0.001, 95% CI 0.758 to 0.887).ConclusionsVFA measured by BIA showed satisfactory reliability with that measured by CT. However, the absolute values of the two methods were not interchangeable. The cut-off value for VFA by BIA in diagnosing visceral obesity was 81 cm2 for patients with gastric cancer in the Chinese population.

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