scholarly journals Elevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation

1998 ◽  
Vol 32 (2) ◽  
pp. 405-412 ◽  
Author(s):  
Thomas J Dengler ◽  
Rainer Zimmermann ◽  
Klaus Braun ◽  
Margit Müller-Bardorff ◽  
Jörg Zehelein ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Allograft Rejection ◽  
Cardiac Troponin ◽  
Human Heart ◽  
Troponin T ◽  
Elevated Serum ◽  
Cardiac Troponin T ◽  
Serum Concentrations ◽  
Acute Allograft Rejection

Clinical Implications of CA 125 Elevation in Patients with Cardiac Amyloidosis: An Observational Study

2021 ◽  
Author(s):  
Muzheng Li ◽  
Zhijian Wu ◽  
Ilyas Tudahun ◽  
Qiuzhen Lin ◽  
Na Liu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cardiac Troponin ◽  
Cardiac Amyloidosis ◽  
Troponin T ◽  
Elevated Serum ◽  
Common Finding ◽  
Ca 125 ◽  
Control Group ◽  
Clinical Implications ◽  
Cardiac Troponin T

Abstract Aims: The level of serum carbohydrate antigen 125 (CA 125) elevated is a common finding in patients with cardiac amyloidosis in clinical practice. It is unclear whether CA 125 is correlated with cardiac amyloidosis. The aim of this study was to systematically evaluate the clinical implications of CA 125 elevation in patients with cardiac amyloidosis.Methods and Results: We enrolled 101 patients diagnosed with cardiac amyloidosis at the Second Xiangya Hospital, 41 patients with acute decompensated heart failure (AHF) and 39 patients with multiple myeloma (MM) who were confirmed to have no cardiac amyloidosis served as control group, respectively. In 101 patients with cardiac amyloidosis, 58 (57%) patients had elevated serum CA 125 levels, which the mean age was 61.2 ± 11.4 years. Patients with high CA 125 were more likely to present with polyserositis ( 79.3% vs 60.5%, p = 0.03) , higher levels of hemoglobin (117.22 ± 21.87 g/L vs. 106.07 ± 25.15 g/L, p = 0.01), serum potassium (4.17 ± 0.49 mmol/L vs. 3.98 ± 0.41 mmol/L, p = 0.05), low density lipoprotein-cholesterol (2.98 ± 1.65 mmol/L vs. 2.22 ± 1.10 mmol/L, p = 0.01), and cardiac troponin T (115 pg/mL vs. 59.52 pg/mL, p = 0.005) . The serum CA 125 levels were significantly higher in cardiac amyloidosis than AHF and MM. The median overall survival for patients with elevated and normal serum CA125 were 5 and 20 months, respectively (p = 0.012). According to multivariate Cox hazard analysis, CA 125 (HR 1.002, 95%CI 1.000-1.004, p = 0.020) contributed to all-cause mortality. The time-dependent receiver operating characteristic was used to reflect the accuracy of different biomarkers in predicting overall survival at various time points by the area under the curve (AUC). CA 125 has no worse prediction accuracy than cardiac troponin T, NT-proBNP and LDH according to the AUC.Conclusions: The prevalence of elevated serum CA 125 levels is more than 50% in patients with cardiac amyloidosis. As an independent prognostic predictor, highly serum CA 125 values indicated the lower overall survival and the accuracy of predicting prognosis was not inferior to the other biomarkers.

THE SERUM CONCENTRATIONS LEVEL OF CK, CK-MB AND CARDIAC TROPONIN T IN EARLY NEONATES WITH ASPHYXIA

2012 ◽  
pp. 12-17
Author(s):  
Ngoc Minh Chau Nguyen ◽  
Hung Viet Phan
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Statistical Significance ◽  
Serum Creatine Kinase ◽  
Cardiac Troponin T ◽  
Serum Concentrations ◽  
Central Hospital ◽  
Pediatric Department ◽  
Study Results

Objective: Investigate the change of serum Creatine kinase (CK), CK-MB and cardiac troponin T concentrations in early neonates with asphyxia. The relation between the change of serum Creatine kinase (CK), CK-MB and cardiac troponin T concentrations and degree of asphyxia. The serum CK, CK-MB and cardiac troponin T concentrations of asphyxiated newborn were measured in the first 24 hours after admission. Material and methods: Patients: 27 early asphyxiated neonates with apgar mark at 5 minutes from 0-7.Study site: Neonatal of Pediatric department, Hue central hospital. Methods: Prospective, description study. Results: Asphyxiated neonates had significantly higher concentration of CK, CK-MB and Troponin T than controls: mean CK 1146.7±711.7U/L vs 145.6±26.4, p<0.01; mean CK-MB 22.15±13.78ng/ml vs 2.77±1.08, p<0.01; mean Troponin T 0.099±0.08ng/ml vs ≤0.01, p<0.05. The serum CK, CK-MB and cardiac troponin T concentrations increased significantly with severity of asphyxia. Conclusion: There is an increase in CK, CK-MB and Troponin T levels in neonates with asphyxia. Correlation with statistical significance between the concentration of CK, CK-MB and troponin T with severity of asphyxia.

Diagnostic efficiency of rejection monitoring after heart transplantation with cardiac troponin T is improved in specific patient subgroups

2003 ◽  
Vol 17 (3) ◽  
pp. 284-291 ◽  
Author(s):  
Christian A Gleissner ◽  
Roland Klingenberg ◽  
Winfried Nottmeyer ◽  
Stephan Zipfel ◽  
Falk-Udo Sack ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Diagnostic Efficiency ◽  
Specific Patient ◽  
Patient Subgroups

Cost-Effectiveness of Highly Sensitive Cardiac Troponin T to Rule Out Acute Rejection After Heart Transplantation

2015 ◽  
Vol 47 (8) ◽  
pp. 2395-2396
Author(s):  
A.B. Méndez ◽  
J. Ordonez-Llanos ◽  
M. Farrero ◽  
S. Mirabet ◽  
V. Brossa ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Acute Rejection ◽  
Heart Transplantation ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Highly Sensitive ◽  
Rule Out
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