1313 Elevated serum cardiac troponin-T levels in murine coxsackieviral myocarditis was correlated with heart viral titer rather than degree of inflammation

2003 ◽  
Vol 24 (5) ◽  
pp. 249
Author(s):  
B LIM
Keyword(s):  
Cardiac Troponin ◽  
Troponin T ◽  
Elevated Serum ◽  
Cardiac Troponin T ◽  
Viral Titer ◽  
Serum Cardiac Troponin

Clinical, serum cardiac troponin T and echocardiographic evaluation for prediction of late doxorubicin cardiotoxicity

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 9536-9536
Author(s):  
E. C. Benites ◽  
M. G. Paiva ◽  
A. M. Cappellano ◽  
O. M. Felix ◽  
S. B. Marinelli ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Troponin T ◽  
Elevated Serum ◽  
Clinical Signs ◽  
Dobutamine Stress ◽  
Left Ventricular ◽  
Cardiac Troponin T ◽  
Group A ◽  
Group B ◽  
Serum Cardiac Troponin

9536 Background: To evaluate whether clinical signs or symptoms of congestive heart failure, serial assessment of systolic and diastolic cardiac function by low dose dobutamine stress echo (LDSE) and serum cardiac troponin T (cTnT) can predict doxorubicin (DOXO) cardiotoxicity. Methods: Twenty five patients with osteosarcoma enrolled in the Brazilian osteosarcoma treatment group study 2000, from january 2000 to may 2004, were studied with LDSE (>5μg/kg/min) before chemotherapy, 160 mg/m2 DOXO and after 160 mg/m2 DOXO. cTnT were measured before and during DOXO infusion. Cardiotoxicity was defined as shortening fraction (SF) less than 30% assessed by rest echo 1 to 6 months off chemotherapy. Group A comprised those without cardiotoxicity (16 patients, 10 male, 14.3 ± 4.7 years) whereas group B included those with a SF < 30% (9 patients, 6 male, 15.4 ± 3 years). Elevated serum cTnT was defined as seric levels above 0.01ng/ml. Results: Patients were submitted to a mean 3.4 LDSE and a mean of 32.5 serum cTnT. One patient (group B) presented clinical manifestation of cardiotoxicity. There was no statistical difference of elevated serum cTnT between the group B and group A (87.5% vs 46.2%; p=0,06). Left ventricular dimensions by M- MODE and transmitral Doppler inflow diastolic parameters were not significantly different between the two groups. Resting SF showed comparable values in both groups until cumulative doses of DOXO reached 160mg/m2, then the resting SF in group B was significant lower than group A (27% ± 2 and 34.1% ± 2, p<0.01). During dobutamine infusion, SF and ΔSF (dobutamine-rest) were significantly lower in group B as compared to group A at a DOXO dose 160mg/m2 (SF 36.1%±3,4 and ΔSF 2.1±2.3 vs. SF 45.2%±4.9 and ΔSF 9.4±3; p< 0.01 and p < 0.01) as well as at a DOXO dose > 160mg/m2 (30.3%±3 and 3.1±1.9 vs. 40.8%±5.9 and 7.2±4.2;p<0.01 and p<0.01). Conclusions: This study suggests that LDSE is more reliable than cTnT and clinical evaluation for predicting future subclinical cardiotoxicity,even at lower doxorubicin dose. No significant financial relationships to disclose.

Serum Cardiac Troponin T and Creatine Kinase–MB Elevations in Murine Autoimmune Myocarditis

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1927-1932 ◽  
Author(s):  
Kurt Bachmaier ◽  
Johannes Mair ◽  
Felix Offner ◽  
Christian Pummerer ◽  
Nikolaus Neu
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Autoimmune Myocarditis ◽  
Creatine Kinase Mb ◽  
Serum Cardiac Troponin

Clinical Implications of CA 125 Elevation in Patients with Cardiac Amyloidosis: An Observational Study

2021 ◽  
Author(s):  
Muzheng Li ◽  
Zhijian Wu ◽  
Ilyas Tudahun ◽  
Qiuzhen Lin ◽  
Na Liu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cardiac Troponin ◽  
Cardiac Amyloidosis ◽  
Troponin T ◽  
Elevated Serum ◽  
Common Finding ◽  
Ca 125 ◽  
Control Group ◽  
Clinical Implications ◽  
Cardiac Troponin T

Abstract Aims: The level of serum carbohydrate antigen 125 (CA 125) elevated is a common finding in patients with cardiac amyloidosis in clinical practice. It is unclear whether CA 125 is correlated with cardiac amyloidosis. The aim of this study was to systematically evaluate the clinical implications of CA 125 elevation in patients with cardiac amyloidosis.Methods and Results: We enrolled 101 patients diagnosed with cardiac amyloidosis at the Second Xiangya Hospital, 41 patients with acute decompensated heart failure (AHF) and 39 patients with multiple myeloma (MM) who were confirmed to have no cardiac amyloidosis served as control group, respectively. In 101 patients with cardiac amyloidosis, 58 (57%) patients had elevated serum CA 125 levels, which the mean age was 61.2 ± 11.4 years. Patients with high CA 125 were more likely to present with polyserositis ( 79.3% vs 60.5%, p = 0.03) , higher levels of hemoglobin (117.22 ± 21.87 g/L vs. 106.07 ± 25.15 g/L, p = 0.01), serum potassium (4.17 ± 0.49 mmol/L vs. 3.98 ± 0.41 mmol/L, p = 0.05), low density lipoprotein-cholesterol (2.98 ± 1.65 mmol/L vs. 2.22 ± 1.10 mmol/L, p = 0.01), and cardiac troponin T (115 pg/mL vs. 59.52 pg/mL, p = 0.005) . The serum CA 125 levels were significantly higher in cardiac amyloidosis than AHF and MM. The median overall survival for patients with elevated and normal serum CA125 were 5 and 20 months, respectively (p = 0.012). According to multivariate Cox hazard analysis, CA 125 (HR 1.002, 95%CI 1.000-1.004, p = 0.020) contributed to all-cause mortality. The time-dependent receiver operating characteristic was used to reflect the accuracy of different biomarkers in predicting overall survival at various time points by the area under the curve (AUC). CA 125 has no worse prediction accuracy than cardiac troponin T, NT-proBNP and LDH according to the AUC.Conclusions: The prevalence of elevated serum CA 125 levels is more than 50% in patients with cardiac amyloidosis. As an independent prognostic predictor, highly serum CA 125 values indicated the lower overall survival and the accuracy of predicting prognosis was not inferior to the other biomarkers.

PO-04 CORRELATIONS BETWEEN ARTERIAL STIFFNESS/CENTRAL HEMODYNAMICS AND SERUM CARDIAC TROPONIN T AND NATRIURETIC PEPTIDE LEVELS

2014 ◽  
Vol 8 (4) ◽  
pp. 167
Author(s):  
Hirofumi Tomiyama ◽  
Kazutaka Kimura ◽  
Chisamatsumoto ◽  
Kazuki Shiina ◽  
Akira Yamashina
Keyword(s):  
Arterial Stiffness ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Central Hemodynamics ◽  
Serum Cardiac Troponin

P-65 Relationship Between Renal Function and Serum Cardiac Troponin T in Patients with Chronic Heart Failure

2009 ◽  
Vol 4 ◽  
pp. S70
Author(s):  
Chiho Kawahara ◽  
Takayoshi Tsutamoto ◽  
Masayuki Yamaji ◽  
Keizo Nishiyama ◽  
Takashi Yamamoto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Chronic Heart Failure ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Serum Cardiac Troponin

Serum Cardiac Troponin T, But Not Troponin I, Is Elevated in Idiopathic Inflammatory Myopathies: Figure 1.

2009 ◽  
Vol 36 (12) ◽  
pp. 2711-2714 ◽  
Author(s):  
ROHIT AGGARWAL ◽  
DOROTA LEBIEDZ-ODROBINA ◽  
ALPANA SINHA ◽  
AUGUSTINE MANADAN ◽  
JOHN P. CASE
Keyword(s):  
Myocardial Ischemia ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Primary Diagnosis ◽  
Idiopathic Inflammatory Myopathies ◽  
Cardiac Troponin T ◽  
Inflammatory Myopathies ◽  
Chi Square ◽  
Serum Cardiac Troponin

Objective.To study the association of serum cardiac troponin T (cTnT) and cardiac troponin I (cTnI) with creatine kinase (CK) in patients with idiopathic inflammatory myopathies (IIM).Methods.We performed a retrospective study on patients with IIM followed by the rheumatology service of a county hospital from 2004 to 2008. Patients with myocardial ischemia and/or with renal failure were excluded. Clinical data including electromyogram, muscle biopsy, and CK, cTnT and cTnI were recorded. Patients who had simultaneous analysis of CK and cardiac troponin (cTnT or cTnI) levels were studied. CK levels were correlated with cTnT and cTnI by chi-square test and Spearman correlation.Results.We identified 49 patients with IIM (69 observations) who satisfied our inclusion criteria. The primary diagnosis was polymyositis in 23, dermatomyositis in 16, and myositis associated with connective tissue disease in 10 patients. There were 33/49 women with average age 45.8 years. Twenty-eight patients with IIM had simultaneous CK and cTnT values assayed. Of those patients, 18/23 with elevated CK also had elevated cTnT, and 5/5 patients with normal CK levels had normal cTnT levels (p = 0.005). In 41 patients with IIM who had simultaneous CK and cTnI levels assayed, only 1/29 with elevated CK had elevated cTnI, and 12/12 patients with normal CK had normal cTnI (p = 0.5). CK correlated strongly with the cTnT (r = 0.62, p = 0.001) but did not correlate with cTnI.Conclusion.Elevated cTnT, but not cTnI, was highly associated with CK in patients with IIM despite the absence of myocardial ischemia.

scholarly journals Assessment of Level of Serum Cardiac Troponin T in Neonates with Respiratory Distress Syndrome

2022 ◽  
Vol 86 (1) ◽  
pp. 124-129
Author(s):  
Amr Ismail Abd-El Moez ◽  
HanaaAbd-Elfattah Mohamed ◽  
Azza Ali Khalil ◽  
Hanan Samir Ahmed
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Cardiac Troponin ◽  
Distress Syndrome ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Serum Cardiac Troponin
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