The role of the serotonin 2A receptor in the fabric and modulation of personal meaning in lysergic acid diethylamide (LSD)-induced states

AbstractToday, there is an increased interest in research on lysergic acid diethylamide (LSD) because it may offer new opportunities in psychotherapy under controlled settings. The more we know about how a drug works in the brain, the more opportunities there will be to exploit it in medicine. Here, based on our previously published papers and investigations, we suggest that LSD-induced visual hallucinations/phosphenes may be due to the transient enhancement of bioluminescent photons in the early retinotopic visual system in blind as well as healthy people.

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Serotonin-2A receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of GABA

Psychopharmacology ◽

10.1007/s00213-011-2369-2 ◽

2011 ◽

Vol 218 (4) ◽

pp. 725-732 ◽

Cited By ~ 17

Author(s):

Thatiane de Oliveira Sergio ◽

Valquiria Camin de Bortoli ◽

Helio Zangrossi

Keyword(s):

Gray Matter ◽

Periaqueductal Gray ◽

Receptor Regulation ◽

Periaqueductal Gray Matter ◽

Serotonin 2A Receptor ◽

Dorsal Periaqueductal Gray ◽

Serotonin 2A

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Psychedelic use and intimate partner violence: The role of emotion regulation

Journal of Psychopharmacology ◽

10.1177/0269881118771782 ◽

2018 ◽

Vol 32 (7) ◽

pp. 749-755 ◽

Cited By ~ 9

Author(s):

Michelle S Thiessen ◽

Zach Walsh ◽

Brian M Bird ◽

Adele Lafrance

Keyword(s):

Intimate Partner Violence ◽

Emotion Regulation ◽

Partner Violence ◽

Physical Violence ◽

Community Sample ◽

Negative Relationship ◽

Intimate Partner ◽

Lysergic Acid ◽

Lysergic Acid Diethylamide

Background: Recent evidence suggests that psychedelic use predicts reduced perpetration of intimate partner violence among men involved in the criminal justice system. However, the extent to which this association generalizes to community samples has not been examined, and potential mechanisms underlying this association have not been directly explored. Aims: The present study examined the association between lifetime psychedelic use and intimate partner violence among a community sample of men and women. The study also tested the extent to which the associations were mediated by improved emotion regulation. Methods: We surveyed 1266 community members aged 16–70 (mean age=22.78, standard deviation =7.71) using an online questionnaire that queried substance use, emotional regulation, and intimate partner violence. Respondents were coded as psychedelic users if they reported one or more instance of using lysergic acid diethylamide and/or psilocybin mushrooms in their lifetime. Results/outcomes: Males reporting any experience using lysergic acid diethylamide and/or psilocybin mushrooms had decreased odds of perpetrating physical violence against their current partner (odds ratio=0.42, p<0.05). Furthermore, our analyses revealed that male psychedelic users reported better emotion regulation when compared to males with no history of psychedelic use. Better emotion regulation mediated the relationship between psychedelic use and lower perpetration of intimate partner violence. This relationship did not extend to females within our sample. Conclusions/interpretation: These findings extend prior research showing a negative relationship between psychedelic use and intimate partner violence, and highlight the potential role of emotion regulation in this association.

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The role of protein kinase C in the regulation of serotonin-2A receptor expression

Journal of Neurochemistry ◽

10.1046/j.1471-4159.2001.00261.x ◽

2001 ◽

Vol 77 (2) ◽

pp. 589-597 ◽

Cited By ~ 13

Author(s):

Antje Anji ◽

Nicole R. Sullivan Hanley ◽

Meena Kumari ◽

Julie G. Hensler

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Receptor Expression ◽

Serotonin 2A Receptor ◽

Kinase C ◽

Serotonin 2A

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Role of the 5-HT2A Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study

Journal of Neuroscience ◽

10.1523/jneurosci.1939-17.2018 ◽

2018 ◽

Vol 38 (14) ◽

pp. 3603-3611 ◽

Cited By ~ 24

Author(s):

Katrin H. Preller ◽

Leonhard Schilbach ◽

Thomas Pokorny ◽

Jan Flemming ◽

Erich Seifritz ◽

...

Keyword(s):

Social Interaction ◽

Lysergic Acid ◽

Lysergic Acid Diethylamide ◽

Self And Other ◽

Fmri Study

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The Role of Serotonin in Concanavalin A-Induced Liver Injury in Mice

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/7504521 ◽

2020 ◽

Vol 2020 ◽

pp. 1-16 ◽

Cited By ~ 1

Author(s):

Qing Pang ◽

Hao Jin ◽

Xiquan Ke ◽

Zhongran Man ◽

Yong Wang ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Injury ◽

Inflammatory Response ◽

Concanavalin A ◽

Serum Levels ◽

Hepatocyte Apoptosis ◽

Con A ◽

Serotonin 2A Receptor ◽

Serotonin 2A

Serotonin is involved in the pathological processes of several liver diseases via the regulation of inflammatory response and oxidative stress. We aimed to investigate the role of serotonin in Concanavalin A- (Con A-) induced acute liver injury (ALI). ALI was induced in C57B/6 wild-type (WT) mice and tryptophan hydroxylase 1 (TPH1) knockout mice through tail vein injection of Con A (15 mg/kg body weight). Another group of TPH1 knockout ALI mice was supplied with 5-hydroxytryptophan (5-HTP) in advance to recover serotonin. The blood and liver tissues of mice were collected in all groups. Markedly increased serum levels of serotonin were identified after the injection of Con A. Increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and stronger hepatic tissue pathology were detected, suggesting that serotonin could mediate Con A-induced liver damage. Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-γ), and tumor necrosis-alpha (TNF-α), after the administration of Con A. In addition, serotonin significantly increased the intrahepatic levels of oxidative stress markers malonaldehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) and decreased antioxidant stress indicator glutathione (GSH) in Con A-treated mice. Additionally, serotonin promoted hepatocyte apoptosis and autophagy based on B-cell lymphoma-2 (Bcl-2), Bcl-2-asociated X protein (Bax), and Beclin-1 levels and TUNEL staining. More importantly, serotonin activated nuclear factor kappa B (NF-κB) and upregulated the hepatic expressions of high mobility group protein B1 (HMGB1), toll-like receptor-4 (TLR4), and downstream molecules in Con A-mediated liver injury. Serotonin 2A receptor was upregulated in liver tissue after Con A injection, and serotonin 2A receptor antagonist Ketanserin protected against Con A-induced hepatitis. These results indicated that serotonin has the potential to aggravate Con A-induced ALI via the promotion of inflammatory response, oxidative stress injury, and hepatocyte apoptosis and the activation of hepatic HMGB1-TLR signaling pathway and serotonin 2A receptor.

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