The role of phosphoinositides in membrane transport

2001 ◽  
Vol 13 (4) ◽  
pp. 485-492 ◽  
Author(s):  
Anne Simonsen ◽  
Andrew E Wurmser ◽  
Scott D Emr ◽  
Harald Stenmark
Keyword(s):  
2004 ◽  
Vol 91 (12) ◽  
pp. 2079-2085 ◽  
Author(s):  
A R Buursma ◽  
I J van Dillen ◽  
A van Waarde ◽  
W Vaalburg ◽  
G A P Hospers ◽  
...  

2010 ◽  
Vol 99 (3) ◽  
pp. 1336-1345 ◽  
Author(s):  
Koji Yano ◽  
Yoshie Masaoka ◽  
Makoto Kataoka ◽  
Shinji Sakuma ◽  
Shinji Yamashita

2005 ◽  
Vol 319 (1-3) ◽  
pp. 342-349 ◽  
Author(s):  
Alexander M. Berezhkovskii ◽  
Sergey M. Bezrukov

Metabolism ◽  
1995 ◽  
Vol 44 (6) ◽  
pp. 719-724 ◽  
Author(s):  
Gianni Biolo ◽  
Xiao-Jun Zhang ◽  
Robert R. Wolfe

1996 ◽  
Vol 135 (1) ◽  
pp. 153-167 ◽  
Author(s):  
J Peränen ◽  
P Auvinen ◽  
H Virta ◽  
R Wepf ◽  
K Simons

Rab8 is a small Ras-like GTPase that regulates polarized membrane transport to the basolateral membrane in epithelial cells and to the dendrites in neurons. It has recently been demonstrated that fibroblasts sort newly synthesized proteins into two different pathways for delivery to the cell surface that are equivalent to the apical and the basolateral post-Golgi routes in epithelial cells (Yoshimori, T., P. Keller, M.G. Roth, and K. Simons. 1996. J. Cell Biol. 133:247-256). To determine the role of Rab8 in fibroblasts, we used both transient expression systems and stable cell lines expressing mutant or wild-type (wt) Rab8. A dramatic change in cell morphology occurred in BHK cells expressing both the wt Rab8 and the activated form of the GTPase, the Rab8Q67L mutant. These cells formed processes as a result of a reorganization of both their actin filaments and microtubules. Newly synthesized vesicular stomatitis virus G glycoprotein, a basolateral marker protein in MDCK cells, was preferentially delivered into these cell outgrowths. Based on these findings, we propose that Rab8 provides a link between the machinery responsible for the formation of cell protrusions and polarized biosynthetic membrane traffic.


1998 ◽  
Vol 10 (4) ◽  
pp. 542-549 ◽  
Author(s):  
Maria Antonietta De Matteis ◽  
Jon S Morrow

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