2020 POSTER Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor is an Effective Radiosensitizer for the Treatment of Colorectal Cancer

2011 ◽  
Vol 47 ◽  
pp. S194
Author(s):  
Y.H. Chen ◽  
S.H. Kuo ◽  
M.F. Wei ◽  
S.L. Pan ◽  
C.W. Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Phosphoinositide 3 Kinase

Dual Phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer

2015 ◽  
Vol 357 (2) ◽  
pp. 582-590 ◽  
Author(s):  
Yu-Hsuan Chen ◽  
Ming-Feng Wei ◽  
Chun-Wei Wang ◽  
Hsiao-Wei Lee ◽  
Shiow-Lin Pan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Phosphoinositide 3 Kinase

Expression of phosphorylated mammalian target of rapamycin in colorectal cancer and its significance

2009 ◽  
Vol 29 (5) ◽  
pp. 517-520
Author(s):  
Hong-gang XIANG ◽  
Zhi-qian HU ◽  
Wei-jun WANG ◽  
Jian XU ◽  
Jian ZHANG ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin

Lupeol Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/ Mammalian Target of Rapamycin Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 206-210
Author(s):  
Feng Chen ◽  
Bei Zhang
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Protein Kinase ◽  
Cell Viability ◽  
Cancer Cells ◽  
Protein Kinase B ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Ovarian Cancer Cells ◽  
Phosphoinositide 3 Kinase

Lupeol exhibits multiple pharmacological activities including, anticancerous, anti-inflammatory, and antioxidant. The aim of this study was to explore the anticancerous activity of lupeol on ovarian cancer cells and examine its mechanism of action. To this end, increasing concentrations of lupeol on cell viability, cell cycle, and apoptosis in Caov-3 cells were evaluated. Lupeol inhibited cell viability, induced G1 phase arrest in cell cycle, increased cell apoptosis, and inhibited the ratio of phospho-Akt/protein kinase B and phospho-mammalian target of rapamycin/mammalian target of rapamycin. In conclusion, these data suggest that lupeol may play a therapeutic role in ovarian cancer.

Abstract 4156: Interaction between therabphillin-3A-likegene and phosphorylation of mammalian target of rapamycin (mTOR) in colorectal cancer

2012 ◽  
Author(s):  
Venkat R. Katkoori ◽  
Sandeep Choudhary ◽  
Abraham R. Butler ◽  
Chandrakumar Shanmugam ◽  
Liselle L. Bovell ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin
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