370 Pilot study in the use of melatonin for children with neurological disorders and sleep problems

1999 ◽  
Vol 3 (6) ◽  
pp. A21
Author(s):  
V. Wong ◽  
S.F. Pang
Keyword(s):  
Pilot Study ◽  
Neurological Disorders ◽  
Sleep Problems

scholarly journals Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson’s Disease: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Oriol De Fabregues ◽  
Alex Ferré ◽  
Odile Romero ◽  
Manuel Quintana ◽  
José Álvarez-Sabin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pilot Study ◽  
Sleep Quality ◽  
Rem Sleep ◽  
Rating Scale ◽  
Sleep Problems ◽  
Periodic Leg Movements ◽  
Before And After ◽  
Hamilton Anxiety Rating Scale

Background. Sleep problems in patients with advanced Parkinson’s disease (PD) have a deleterious impact on quality of life. Objective. To assess the effect of levodopa-carbidopa intestinal gel (LCIG) infusion on sleep quality in advanced PD patients. Methods. Seven patients participated in a prospective pilot study. Before and after 6 months of LCIG infusion, an overnight polysomnography was performed and the Epworth Sleepiness Scale, fatigue scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory, and the Hamilton Anxiety Rating Scale were administered. Results. PSG showed low sleep efficiency. REM sleep without atony was found in 5 patients. After 6 months of LCIG infusion, the percentage of REM sleep decreased as well as the number of arousals especially due to reduction of spontaneous arousals and periodic leg movements during REM sleep, but differences were not statistically significant. Also, scores of all study questionnaires showed a tendency to improve. Conclusion. The results show a trend toward an improvement of sleep quality after 6 months of LCIG infusion, although differences as compared to pretreatment values were not statistically significant. The sleep architecture was not modified by LCIG. Further studies with larger study samples are needed to confirm these preliminary findings.

scholarly journals Sleep Tracking and Exercise in Patients With Type 2 Diabetes Mellitus (Step-D): Pilot Study to Determine Correlations Between Fitbit Data and Patient-Reported Outcomes (Preprint)

2017 ◽  
Author(s):  
James Weatherall ◽  
Yurek Paprocki ◽  
Theresa M Meyer ◽  
Ian Kudel ◽  
Edward A Witt
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Patient Reported Outcomes ◽  
Sleep Problems ◽  
Health Data ◽  
Patient Reported

BACKGROUND Few studies assessing the correlation between patient-reported outcomes and patient-generated health data from wearable devices exist. OBJECTIVE The aim of this study was to determine the direction and magnitude of associations between patient-generated health data (from the Fitbit Charge HR) and patient-reported outcomes for sleep patterns and physical activity in patients with type 2 diabetes mellitus (T2DM). METHODS This was a pilot study conducted with adults diagnosed with T2DM (n=86). All participants wore a Fitbit Charge HR for 14 consecutive days and completed internet-based surveys at 3 time points: day 1, day 7, and day 14. Patient-generated health data included minutes asleep and number of steps taken. Questionnaires assessed the number of days of exercise and nights of sleep problems per week. Means and SDs were calculated for all data, and Pearson correlations were used to examine associations between patient-reported outcomes and patient-generated health data. All respondents provided informed consent before participating. RESULTS The participants were predominantly middle-aged (mean 54.3, SD 13.3 years), white (80/86, 93%), and female (50/86, 58%). Use of oral T2DM medication correlated with the number of mean steps taken (r=.35, P=.001), whereas being unaware of the glycated hemoglobin level correlated with the number of minutes asleep (r=−.24, P=.04). On the basis of the Fitbit data, participants walked an average of 4955 steps and slept 6.7 hours per day. They self-reported an average of 2.0 days of exercise and 2.3 nights of sleep problems per week. The association between the number of days exercised and steps walked was strong (r=.60, P<.001), whereas the association between the number of troubled sleep nights and minutes asleep was weaker (r=.28, P=.02). CONCLUSIONS Fitbit and patient-reported data were positively associated for physical activity as well as sleep, with the former more strongly correlated than the latter. As extensive patient monitoring can guide clinical decisions regarding T2DM therapy, passive, objective data collection through wearables could potentially enhance patient care, resulting in better patient-reported outcomes.

Secure Attachment and Depression Predict 6-Month Outcome in Motor Functional Neurological Disorders: A Prospective Pilot Study

2019 ◽  
Vol 60 (4) ◽  
pp. 365-375 ◽  
Author(s):  
Rozita Jalilianhasanpour ◽  
Juan Pablo Ospina ◽  
Benjamin Williams ◽  
Julie Mello ◽  
Julie MacLean ◽  
...  
Keyword(s):  
Pilot Study ◽  
Neurological Disorders ◽  
Secure Attachment ◽  
Prospective Pilot Study ◽  
Functional Neurological Disorders

Sleep disorders

2011 ◽  
Author(s):  
Paul Reading
Keyword(s):  
Mental Health ◽  
Sleep Disorders ◽  
Neurological Disorders ◽  
Sleep Problems ◽  
Well Being ◽  
Sleep Medicine ◽  
Daily Activities ◽  
Low Profile ◽  
Drive State

Despite major advances in our understanding of its neurobiology, sleep remains an enigma. Its true function and even the amount needed for optimum brain performance remain uncertain (Frank 2006). However, the need to sleep is imperative, reflecting the fact that sleepiness, like hunger and thirst, is a true drive state. Sleepiness can only be satiated by sleep itself. Moreover, severely disordered sleep can profoundly affect cognition, mental health, and physical well-being.Although sleep medicine has a traditionally low profile in neurology teaching and practice, sleep-related phenomena are frequently associated with numerous neurological disorders. Conversely, sleep problems can adversely affect familiar conditions such as headache and epilepsy. Furthermore, in large surveys, sleep-related symptoms are undoubtedly common with 25 per cent of the population reporting problems that significantly and regularly impact on daily activities.

Community Survey of Neurological Disorders in Saudi Arabia: Results of the Pilot Study in Agrabiah

1995 ◽  
Vol 15 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Saad Al-Rajeh ◽  
Olajide Bademosi ◽  
Adnan Awada ◽  
Hassan Ismail ◽  
Hussein Al-Freihi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Pilot Study ◽  
Neurological Disorders ◽  
Community Survey

scholarly journals Associating sleep problems with advanced cancer diagnosis, and immune checkpoint treatment outcomes: a pilot study

2022 ◽  
Author(s):  
Arthur Sillah ◽  
Ulrike Peters ◽  
Nathaniel F. Watson ◽  
Scott S. Tykodi ◽  
Evan T. Hall ◽  
...  
Keyword(s):  
Pilot Study ◽  
Treatment Outcomes ◽  
Advanced Cancer ◽  
Cancer Diagnosis ◽  
Immune Checkpoint ◽  
Sleep Problems

A pilot study of the utility of cerebrospinal fluid neurofilament light chain in differentiating neurodegenerative from psychiatric disorders: A ‘C-reactive protein’ for psychiatrists and neurologists?

2019 ◽  
Vol 54 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Dhamidhu Eratne ◽  
Samantha M Loi ◽  
Nirbaanjot Walia ◽  
Sarah Farrand ◽  
Qiao-Xin Li ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Pilot Study ◽  
Psychiatric Disorder ◽  
Psychiatric Disorders ◽  
Confidence Intervals ◽  
Neurological Disorders ◽  
Neurological Disorder ◽  
Healthy Controls ◽  
Diagnostic Dilemma ◽  
Neurofilament Light

Objective: Neurofilament light has shown promise as a biomarker for diagnosis, staging and prognosis in a wide range of neurological and neurodegenerative disorders. This study explored the utility of cerebrospinal fluid neurofilament light in distinguishing primary psychiatric disorders from neurodegenerative and neurological disorders, a common diagnostic dilemma for psychiatrists and neurologists. Methods: This cross-sectional retrospective pilot study assessed cerebrospinal fluid neurofilament light on patients referred to a tertiary neuropsychiatry service from 2009 to 2017 for diagnostic assessment of neuropsychiatric and neurocognitive symptoms, where a neurodegenerative disorder was a differential diagnosis, who received lumbar punctures as part of a comprehensive workup. The most recent gold-standard clinical consensus diagnosis was categorised into psychiatric disorder or neurodegenerative or neurological disorder. Data from healthy controls were available for comparison. Data extraction and diagnostic categorisation was blinded to neurofilament light results. Results: A total of 129 participants were included: 77 neurodegenerative or neurological disorder (mean age 57 years, including Alzheimer’s dementia, frontotemporal dementia), 31 psychiatric disorder (mean age 51 years, including schizophrenia, major depressive disorder) and 21 healthy controls (mean age 66 years). Neurofilament light was significantly higher in neurodegenerative or neurological disorder (M = 3560 pg/mL, 95% confidence intervals = [2918, 4601]) compared to psychiatric disorder (M = 949 pg/mL, 95% confidence intervals = [830, 1108]) and controls (M = 1036 pg/mL, 95% confidence intervals = [908, 1165]). Neurofilament light distinguished neurodegenerative or neurological disorder from psychiatric disorder with an area under the curve of 0.94 (95% confidence intervals = [0.89, 0.98]); a cut-off of 1332 pg/mL was associated with 87% sensitivity and 90% specificity. Conclusion: Cerebrospinal fluid neurofilament light shows promise as a diagnostic test to assist with the often challenging diagnostic dilemma of distinguishing psychiatric disorders from neurodegenerative and neurological disorders. Further studies are warranted to replicate and expand on these findings, including on plasma neurofilament light.

Sleep in family caregivers of patients admitted to hospice: A pilot study

2013 ◽  
Vol 12 (6) ◽  
pp. 439-444 ◽  
Author(s):  
Anners Lerdal ◽  
Caryl L. Gay ◽  
Elisabeth Saghaug ◽  
Kaare Gautvik ◽  
Ellen Karine Grov ◽  
...  
Keyword(s):  
Pilot Study ◽  
Family Caregivers ◽  
Study Protocol ◽  
Sleep Problems ◽  
Sleep Onset ◽  
Sleep Disruption ◽  
Cross Sectional ◽  
Falling Asleep ◽  
Wrist Actigraphy ◽  
Clinically Significant

AbstractObjectives:Caring for a dying family member is known to interfere with sleep, yet little is known about caregiver sleep once the patient is admitted to hospice. The aim of this pilot study was to describe the sleep of partners and other family caregivers of patients in hospice.Methods:The pilot study used a cross-sectional, descriptive, and comparative design. Participants included the primary family caregivers of patients recently admitted to a hospice in Norway. Caregiver sleep during the prior month was measured with the Pittsburgh Sleep Quality Index (PSQI). During the patient's hospice stay, caregiver sleep was measured using wrist actigraphy for four nights and three days.Results:Twenty family caregivers (12 partners and 8 other relatives) completed the study protocol without difficulty. On the PSQI, most caregivers (n = 13) reported clinically significant sleep problems during the prior month. Once the patient was admitted to hospice, actigraphy indicated that 10 caregivers had clinically significant sleep disruption (≥15% wake after sleep onset) and six averaged <7 hours of sleep per night. Partner caregivers reported more trouble falling asleep, and less sleep medication use, in the prior month than other types of family caregivers. However, once the patient was admitted to hospice, and after adjusting for caregiver age, partner caregivers experienced less sleep disruption than other caregivers.Significance of results:Findings demonstrate feasibility of the study protocol and indicate that sleep problems are common for caregivers of dying patients, even after the patient is admitted to hospice. The caregiver's relationship to the patient may be an important factor to consider in future studies.

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