480 MULTIMODAL ANALGESIA FOR POST‐OPERATIVE PAIN MANAGEMENT IN A CANCER PATIENT UNDER CHRONIC OPIOID USE: CASE REPORT

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
B.C. Nunes ◽  
I.L. Cavalcanti ◽  
R.O. Oliveira ◽  
A.C.P.M. Pereira
Keyword(s):  
Case Report ◽  
Pain Management ◽  
Cancer Patient ◽  
Multimodal Analgesia ◽  
Use Case ◽  
Opioid Use ◽  
Post Operative Pain ◽  
Chronic Opioid Use

scholarly journals Post-operative pain management modalities employed in clinical trials for adult patients in LMIC; a systematic review

2020 ◽  
Author(s):  
Gauhar Afshan ◽  
Robyna Irshad Khan ◽  
Aliya Ahmed ◽  
Ali Sarfraz Siddiqui ◽  
Azhar Rehman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Pain Management ◽  
Postoperative Pain ◽  
Postoperative Pain Management ◽  
Multimodal Analgesia ◽  
Adult Patients ◽  
Cochrane Library ◽  
Regional Analgesia ◽  
Post Operative Pain

Abstract Background: Unrelieved postoperative pain afflicts millions each year in low and middle income countries (LMIC). Despite substantial advances in the study of pain, this area remains neglected. Current systematic review was designed to ascertain the types of clinical trials conducted in LMIC on postoperative pain management modalities over the last decade. Methods: A comprehensive search was performed in June 2019 on PubMed, Cochrane Library, CINAHL Plus, and Web of Science databases to identify relevant trials on the management of postoperative pain in LMIC. Out of 1450 RCTs, 108 studies were reviewed for quality evidence using structured form of critical appraisal skill program. Total of 51 clinical trials were included after applying inclusion/exclusion criteria. Results:Results are charted according to the type of surgery. Eleven trials on laparoscopic cholecystectomy used multimodal analgesia including some form of regional analgesia. Different analgesic modalities were studied in 4 trials on thoracotomy, but none used multimodal approach. In 11 trials on laparotomy, multimodal analgesia was employed along with the studied modalities. In 2 trials on hysterectomy, preemptive pregabalin or gabapentin were used for reduction in rescue analgesia. In 13 trials on breast surgical procedures and 10 on orthopaedic surgery, multimodal analgesia was used with some form of regional analgesia. Conclusion: We found that over the past 10 years, clinical trials for postoperative pain modalities have evolved in LMIC according to the current postoperative pain management guidelines i.e. multi-modal approach with some form of regional analgesia. The current review shows that clinical trials were conducted using multimodal analgesia including but not limited to some form of regional analgesia for postoperative pain in LMIC however this research snapshot (of only three countries) may not exactly reflect the clinical practices in all 47 countries. Post Operative Pain Management Modalities Employed in Clinical Trials for Adult Patients in LMIC; A Systematic Review

Review of nonopioid multimodal analgesia for surgical and trauma patients

2020 ◽  
Vol 77 (24) ◽  
pp. 2052-2063
Author(s):  
Stephy George ◽  
Meagan Johns
Keyword(s):  
Pain Management ◽  
Adverse Effects ◽  
Multimodal Analgesia ◽  
Transitions Of Care ◽  
Dose Titration ◽  
Patient Specific ◽  
Therapeutic Effects ◽  
Trauma Patients ◽  
Opioid Use ◽  
Nonopioid Analgesics

Abstract Purpose Pain is a frequent finding in surgical and trauma patients, and effective pain control remains a common challenge in the hospital setting. Opioids have traditionally been the foundation of pain management; however, these agents are associated with various adverse effects and risks of dependence and diversion. Summary In response to the rising national opioid epidemic and the various risks associated with opioid use, multimodal pain management through use of nonopioid analgesics such as acetaminophen, nonsteroidal anti-inflammatory drugs, α 2 agonists, N-methyl-d-aspartate (NMDA) receptor antagonists, skeletal muscle relaxants, sodium channel blockers, and local anesthetics has gained popularity recently. Multimodal analgesia has synergistic therapeutic effects and can decrease adverse effects by enabling use of lower doses of each agent in the multimodal regimen. This review discusses properties of the various nonopioid analgesics and encourages pharmacists to play an active role in the selection, initiation, and dose-titration of multimodal analgesia. The choice of nonopioid agents should be based on patient comorbidities, hemodynamic stability, and the agents’ respective adverse effect profiles. A multidisciplinary plan for management of pain should be formulated during transitions of care and is an area of opportunity for pharmacists to improve patient care. Conclusion Multimodal analgesia effectively treats pain while decreasing adverse effects. There is mounting evidence to support use of this strategy to decrease opioid use. As medication experts, pharmacists can play a key role in the selection, initiation, and dose-titration of analgesic agents based on patient-specific factors.

Expectation-setting and patient education about pain control in the perioperative setting: A qualitative study

2021 ◽  
Vol 17 (6) ◽  
pp. 455-464
Author(s):  
Josh Bleicher, MD, MS ◽  
Jordan Esplin, BS ◽  
Allison N. Blumling, MS ◽  
Jessica N. Cohan, MD, MAS ◽  
Mark Savarise, MD, MBA, FACS ◽  
...  
Keyword(s):  
Pain Management ◽  
Patient Education ◽  
Qualitative Study ◽  
Pain Control ◽  
Control Strategies ◽  
Patient Experiences ◽  
Patient Anxiety ◽  
Opioid Use ◽  
Post Operative Pain ◽  
Preoperative Expectation

Objective: Interventions aimed at limiting opioid use are widespread. These are most often targeted toward prescribers or health systems. Patients’ perspectives are too often absent during the creation of such interventions. This qualitative study aims to understand patient experiences with education about perioperative pain control, from preoperative expectation-setting to post-operative pain control strategies and ultimately opioid disposal.Design: We performed semistructured interviews focused on patient experiences in the perioperative period. Content from interview transcripts was analyzed using a constant comparative method.Setting: All participants underwent surgery at a single, academic tertiary-care center.Participants: Adult patients who had a general surgery operation in the prior 60 days.Outcome measure: Key themes from interviews about perioperative pain management, specifically related to preoperative expectation-setting and post-operative education.Results: Patients identified gaps in communication and education in three main areas: preoperative expectation setting of post-operative pain; post-operative pain control strategies, including use of opioid medications; and the importance of appropriate opioid disposal. Failure to set expectations led to either significant patient anxiety preoperatively or poor preparation for home discharge. Poor education on pain control strategies led to misinformation on when and how to use opioids. Lack of education on opioid disposal led to most participants failing to properly dispose of leftover medication.Conclusions: Gaps in education surrounding post-operative pain and opioid use can lead to patient anxiety, inappropriate use of opioids, and poor disposal rates of leftover medications. Future interventions aimed at patient education to improve pain management and opioid stewardship should be created with an understanding of patient experiences and perceptions.

scholarly journals 2-Week Post-Operative Opioid Use after Primary Hallux Valgus Correction

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0046
Author(s):  
Zachary T. Thier ◽  
Kenna C. Altobello ◽  
Tyler A. Gonzalez ◽  
J. Ben Jackson
Keyword(s):  
Body Weight ◽  
Pain Management ◽  
Hallux Valgus ◽  
The United States ◽  
Pain Medication ◽  
Clinic Visit ◽  
Objective Data ◽  
Opioid Use ◽  
Adductor Canal ◽  
Post Operative Pain

Category: Bunion; Other Introduction/Purpose: More than 200,000 surgeries for hallux valgus correction occur annually in the United States. Due to the post-operative pain associated with the procedure, opioids are often prescribed to help manage pain. The opioid epidemic has led to a 78-billion-dollar economic impact. Given the lack of objective data on opioid use and the difficulty of addressing a patient’s post-operative pain, we sought to quantify, through a prospective analysis, patient’s narcotic use after hallux valgus surgery. Objective data may help guide the surgeon in the type and number of opioids utilized after surgery. Methods: Adult patients undergoing primary hallux valgus surgery were recruited from two surgeon’s institution. At the pre- operative visit, patients were consented and completed a demographical questionnaire. Data was collected from the operative and PACU record, as well as the 2-week post-operative visit. A simple statistical analysis was performed to determine average quantity and type of opioid and non-opioid pain medication used in the PACU and for post-operative pain management. Results: 33 subjects were prospectively enrolled and followed. The average time until the first post-operative clinic visit was 13.53 days. The average opioid pain medication consumption during this period was 20.766 (0-66) pills, with a morphine milligram equivalents (MME)/kg of body weight at 1.69. (78.8%) were prescribed hydrocodone/acetaminophen 5/325mg and 7 subjects (21.2%) were prescribed oxycodone/acetaminophen 5/325 for post-operative pain management. 84.8% of subjects (28/33) received a local block, including 2 femoral, 2 ankle, 13 popliteal, 3 sciatic, 3 adductor canal, 4 popliteal and saphenous, and 1 popliteal and adductor canal. 24.2% (8/33) of subjects received opioid pain medication in the PACU post-operatively with a MME/kg of body weight at 0.135 per subject. Conclusion: Based on our prospective study, we recommend an initial prescription of 30 5mg hydro/oxycodone pain pills, as this represents the 3rd quartile of consumption.

scholarly journals Post-operative pain management modalities employed in clinical trials for adult patients in LMIC; a systematic review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gauhar Afshan ◽  
Robyna Irshad Khan ◽  
Aliya Ahmed ◽  
Ali Sarfraz Siddiqui ◽  
Azhar Rehman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Pain Management ◽  
Postoperative Pain ◽  
Postoperative Pain Management ◽  
Multimodal Analgesia ◽  
Adult Patients ◽  
Cochrane Library ◽  
Regional Analgesia ◽  
Post Operative Pain

Abstract Background Unrelieved postoperative pain afflicts millions each year in low and middle income countries (LMIC). Despite substantial advances in the study of pain, this area remains neglected. Current systematic review was designed to ascertain the types of clinical trials conducted in LMIC on postoperative pain management modalities over the last decade. Methods A comprehensive search was performed in June 2019 on PubMed, Cochrane Library, CINAHL Plus, and Web of Science databases to identify relevant trials on the management of postoperative pain in LMIC. Out of 1450 RCTs, 108 studies were reviewed for quality evidence using structured form of critical appraisal skill program. Total of 51 clinical trials were included after applying inclusion/exclusion criteria. Results Results are charted according to the type of surgery. Eleven trials on laparoscopic cholecystectomy used multimodal analgesia including some form of regional analgesia. Different analgesic modalities were studied in 4 trials on thoracotomy, but none used multimodal approach. In 11 trials on laparotomy, multimodal analgesia was employed along with the studied modalities. In 2 trials on hysterectomy, preemptive pregabalin or gabapentin were used for reduction in rescue analgesia. In 13 trials on breast surgical procedures and 10 on orthopaedic surgery, multimodal analgesia was used with some form of regional analgesia. Conclusion We found that over the past 10 years, clinical trials for postoperative pain modalities have evolved in LMIC according to the current postoperative pain management guidelines i.e. multi-modal approach with some form of regional analgesia. The current review shows that clinical trials were conducted using multimodal analgesia including but not limited to some form of regional analgesia for postoperative pain in LMIC however this research snapshot (of only three countries) may not exactly reflect the clinical practices in all 47 countries. Post Operative Pain Management Modalities Employed in Clinical Trials for Adult Patients in LMIC; A Systematic Review.

scholarly journals Manajemen Nyeri Terkini pada Pasien Pasca Seksio Sesarea

2021 ◽  
Vol 4 (1) ◽  
pp. 63-78
Author(s):  
Muh Ramli Ahmad ◽  
Rezki Hardiyanti Taufik
Keyword(s):  
Nervous System ◽  
Pain Management ◽  
Postoperative Pain ◽  
Caesarean Section ◽  
Early Mobilization ◽  
Postoperative Pain Management ◽  
Multimodal Analgesia ◽  
Post Operative Pain ◽  
Sensitization Process ◽  
Adequate Pain Management

Prosedur Seksio Sesarea (SS) seringkali menyebabkan nyeri sedang hingga berat selama 48 jam. Tujuan manajemen nyeri pascabedah adalah untuk memberikan kenyamanan pada pasien, menghambat impuls nosiseptif, dan menumpulkan respon neuroendokrin terhadap nyeri, yang dengan demikian mempercepat kembalinya fungsi fisiologis. Selain itu, manajemen nyeri yang adekuat pada pasien SS memungkinkan mobilisasi dini untuk mencegah risiko tromboemboli yang meningkat selama kehamilan dan pasien perlu bebas nyeri untuk merawat bayi serta memberikan ASI secara efektif. Mekanisme nyeri pascabedah terdiri dari sensitisasi perifer dan senstisasi sentral dari susunan saraf. Dampak klinik sensitisasi sistem saraf berupa hiperalgesia dan alodinia. Sensitisasi pascabedah akan mengakibatkan penderitaan bagi pasien sehingga pada akhirnya dapat meningkatkan angka morbiditas dan mortalitas pascabedah, oleh karena itu manajemen nyeri pascabedah harus ditujukan ke arah pencegahan dan meminimalkan terjadinya proses sensitisasi. Analgesia multimodal dengan mengkombinasi obat yang menghambat sensitisasi perifer dan sentral, dengan opioid sebagai analgesia penyelamat dapat menjadi pilihan untuk memberikan manajemen nyeri yang adekuat dan meminimalkan efek samping.   Current Practice for Post Operative Pain Management in Caesarean Section Abstract Caesarean section (CS) is frequently followed by moderate to severe pain up to 48 hours after surgery. Postoperative pain management is aimed to provide postoperative comfortness, inhibits nociceptive impulse, and blunts neuroendocrine response to pain, thus enhance the return of physiological function. Moreover, an adequate pain management in CS patients allows early mobilization in preventing the increased of thromboemboli risk during pregnancy, the need of patients to be pain free in taking care of the baby as well as effective breastfeeding. Postoperative pain mechanism consists of peripheral and central senzitisation of nervous system. Clinical impact of nervous system sensitization including hyperalgesia and allodynia. Postoperative sensitization resulted in patient’s suffering that increase morbidity and mortality rate eventually. Therefore, postoperative pain management should be directed to prevent and minimalize sensitization process. Multimodal analgesia by combining analgesics inhibited peripheral and central sensitization, with opioid as rescue analgesic may be preferred to provide adequate pain management and to minimalize the adverse effects.

scholarly journals Use of systemic lidocaine for postoperative acute pain management in single-lung transplantation: Case report

2020 ◽  
Vol 68 (2) ◽  
Author(s):  
Jairo Moyano ◽  
Paula Rodríguez ◽  
Cindy Lorena Fierro
Keyword(s):  
Case Report ◽  
Pain Management ◽  
Lung Transplantation ◽  
Acute Pain ◽  
Postoperative Period ◽  
Opioid Analgesics ◽  
Postoperative Pain Management ◽  
Multimodal Analgesia ◽  
Single Lung Transplantation ◽  
Function Recovery

Introduction: Lung transplantation is associated with severe pain, which can delay recovery. Systemic lidocaine has useful analgesic properties for managing acute pain, however little is known on its use after lung transplantation. Due to pharmacological alterations during the postoperative period, the use of analgesics implies a demanding process to avoid toxicity, so lidocaine may play a role in this scenario. In this sense, the purpose of this case report is to present the use of systemic lidocaine as an option for the management of acute pain when other analgesics have failed to do so.Case presentation: The case of a male patient with acute pain in the postoperative period of single-lung transplantation is presented. Opioids and non-opioid analgesics showed limited efficacy, so the systematic administration of lidocaine was decided. Systemic lidocaine was effective for pain control, functional recovery and opioid decrease during the postoperative period.Conclusions: Systemic lidocaine was a useful drug for postoperative pain management in lung transplantation, since it allowed adequate analgesia and lung function recovery with decreased use of opioids. This drug may be a component of multimodal analgesia in selected patients when other options have failed; however its routine use is not recommended.

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