120 Primary tumor derived preclinical model mimics human colon cancer: a novel platform to study cancer biology and to evaluate anti-cancer drugs

2010 ◽  
Vol 8 (7) ◽  
pp. 45
Author(s):  
M. Sundaram ◽  
D. Pinto ◽  
B. Majumder ◽  
K. Ameer ◽  
P. Majumder
Keyword(s):  
Colon Cancer ◽  
Primary Tumor ◽  
Cancer Biology ◽  
Human Colon ◽  
Preclinical Model ◽  
Cancer Drugs ◽  
Human Colon Cancer ◽  
Anti Cancer

Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: A potential natural anti-cancer substance

2009 ◽  
Vol 276 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Masahiko Imai ◽  
Hidetomo Kikuchi ◽  
Takanori Denda ◽  
Kunio Ohyama ◽  
Chieko Hirobe ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Line ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Cytotoxic Effects ◽  
Anti Cancer

scholarly journals Anti-cancer effects of 2-oxoquinoline derivatives on the HCT116 and LoVo human colon cancer cell lines

2012 ◽  
Vol 12 (6) ◽  
pp. 8062-8070 ◽  
Author(s):  
FENG-QI FANG ◽  
HUI-SHU GUO ◽  
JIE ZHANG ◽  
LI-YING BAN ◽  
JI-WEI LIU ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines ◽  
Anti Cancer

Synthesis, Characterization and Cytotoxic Effect of Some New Thiazolyl Hydrazone Derivatives of 1-Indanone

2021 ◽  
Vol 43 (2) ◽  
pp. 244-244
Author(s):  
Urooj Nazim Urooj Nazim ◽  
Silpa Narayanan Silpa Narayanan ◽  
Mohsin Ali Mohsin Ali ◽  
Khalid Mohammed Khan Khalid Mohammed Khan ◽  
Basharat Ali Basharat Ali ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Human Cancer ◽  
Human Colon ◽  
Human Leukemia ◽  
Spectroscopic Techniques ◽  
Human Colon Cancer ◽  
Human Cancer Cells ◽  
Anti Cancer ◽  
Derivatives Of ◽  
Cancer Activity

In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25and#177;0.02 to 5.04and#177;0.2 and#181;M. On the other hand all the compounds didn’t show cytotoxic activity against other forms of human cancer cells.

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