P.211 Natural history of chronic HCV infection: potential influence of polymorphisms in cytokine and HFE gene

2006 ◽  
Vol 36 ◽  
pp. S126-S127
Author(s):  
S.M. Abdullaev ◽  
L.M. Samokhodskaya ◽  
T.M. Ignatova ◽  
N.A. Mukhin ◽  
V.A. Tkachuk
Keyword(s):  
Natural History ◽  
Hcv Infection ◽  
Hfe Gene ◽  
Potential Influence ◽  
History Of ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Treatment of HCV Infection in Children

2000 ◽  
Vol 14 (suppl b) ◽  
pp. 41B-44B ◽  
Author(s):  
Ruggiero Francavilla ◽  
Giorgina Mieli-Vergani
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Epidemiological Data ◽  
Hcv Infection ◽  
Western World ◽  
Common Cause ◽  
Number Of Children ◽  
History Of ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

HepatitisCvirus (HCV) infection is the most common cause of chronic liver disease in the western world. Despite extensive epidemiological data in adults, the exact number of children infected is still unknown, and little is known about the natural history of chronic HCV infection in childhood. The authors review studies focusing onHCVinfection in children, and summarize the results, including the efficacy of interferon, and interferon plus ribavirin combination treatment of HCV hepatitis in childhood.

Hepatitis C and HIV Co-Infection

2017 ◽  
Author(s):  
Jennifer Cohen Price ◽  
Priyanka Amin ◽  
Antoine Douaihy
Keyword(s):  
Hepatitis C ◽  
Natural History ◽  
The United States ◽  
Hcv Infection ◽  
Hepatic Decompensation ◽  
History Of ◽  
Chronic Hcv ◽  
Direct Acting ◽  
End Stage ◽  
Shared Risk

Chronic infection with hepatitis C virus (HCV) is a leading cause of end-stage liver disease and is the most common indication for liver transplantation in the United States. Because of shared risk factors, individuals living with HIV infection are disproportionately affected by HCV. Moreover, co-infection with HIV accelerates the natural history of chronic HCV infection, increasing the risk of cirrhosis, hepatocellular carcinoma, hepatic decompensation, and death. Highly effective medications such as direct-acting antivirals (DAA) to cure HCV are now available and have the potential to profoundly improve the health of HIV-HCV-co-infected individuals. However, addressing the many gaps in the HCV care cascade is necessary to fully achieve the benefits of these drugs. This chapter reviews the natural history of HIV-HCV co-infection, the psychiatric comorbidities associated with HCV infection, the evolution of HCV treatment, and the barriers to care that HIV-HCV-co-infected individuals continue to face.

scholarly journals Prevalence of Diabetes Type 2 in Hepatitis C Infected Patients in Kpk, Pakistan

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Ghani Ur Rehman ◽  
Mohammad Ali ◽  
Farooq Shah ◽  
Amjad Iqbal ◽  
Ayaz Ahmad ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Diabetes Type 2 ◽  
Educational Background ◽  
Hcv Infection ◽  
Male And Female ◽  
Female Patients ◽  
History Of ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Hepatitis C (HCV) and diabetes mellitus are the two main health concerns that cause devastating health and financial worries worldwide. It has been observed in the past that both diseases have a high correlation that might be due to the abnormal conditions of the liver. But the mechanism of the prevalence of diabetes in patients with chronic HCV infection still remains unclear. In our study, we have investigated T2DM in the male and female patients at Lady Reading Hospital (LRH), Peshawar. The blood samples of both in- and outpatients were analysed in the PCR laboratories of LRH from December 2014 to April 2015. Great prevalence of diabetes in hepatitis C infected male and female patients was observed during this study. The data were collected from the patients through a preplanned questionnaire that included name of the patient, HCV, being diabetic, age, gender, location, educational background, family history of the disease, other diseases, and any treatments if taken. The results of our study have found 26.42% prevalence of T2DM in HCV infected patients. So we conclude that HCV infection may be one of the reasons that could lead to T2DM.

Impact of sustained virological response to chronic hepatitic C antiviral therapy on new onset diabetes mellitus type 2 after controlling for metabolic syndrome

2017 ◽  
Vol 65 (4) ◽  
pp. 765-771 ◽  
Author(s):  
Prashant Pandya ◽  
Chaitanya Pant ◽  
Ryan Taylor ◽  
Olurinde Oni
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Hcv Infection ◽  
History Of ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
New Onset

The high cost associated with antiviral treatment for chronic hepatitis C virus (HCV) infection mandates further investigation in the context of preventing complications such as type 2 diabetes mellitus (DM2). We determined the cumulative incidence of DM2 in subjects with chronic HCV infection who received concomitant pegylated interferon (Peg-IFN) and ribavirin. We conducted a retrospective analysis of data obtained from Veterans Administrations Informatics and Computing Infrastructure (VINCI) to identify an adult cohort of patients without diabetes with chronic HCV infection who received Peg-IFN-based therapy between October 2001 and December 2011. Patients with history of HIV, hepatitis B infection, hepatocellular cancer (HCC), non-HCC cancers, and history of transplantation were excluded. Sustained virological response (SVR) was defined as negative HCV RNA 3 months after completion of therapy. Using Cox proportional hazards regression for multivariable analysis, we determined that patients who achieved SVR were at a significantly less risk of developing DM2. Adjusted survival rates showed that the responders' group was significantly less likely to develop DM2 over time (HR 0.60, CI 0.48 to 0.74, p<0.001). Peg-IFN-based therapy in chronic HCV patients that resulted in SVR significantly decreased the risk of developing DM2 and independently predicts the development of new onset disease after controlling for correlates of metabolic syndrome.

scholarly journals Hepatitis C virus screening of high-risk patients in a community hospital emergency department: Retrospective review of patient characteristics and future implications

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252976
Author(s):  
Ji Seok Park ◽  
Judy Wong ◽  
Hillary Cohen
Keyword(s):  
Hepatitis C ◽  
Tobacco Use ◽  
Screening Test ◽  
Linkage To Care ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Spontaneous Clearance ◽  
History Of ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Background Chronic hepatitis C virus infection (HCV) is a common infectious disease that affects more than 2.7 million people in the US. Because the emergency department (ED) can present an ideal opportunity to screen patients who may not otherwise get routine screening, we implemented a risk-based screening program for ED patients and established a system to facilitate linkage to care. Methods and findings A risk-based screening algorithm for HCV was programmed to trigger an alert in Epic electronic medical record system. Patients identified between August 2018 and April 2020 in the ED were tested for HCV antibody reflex to HCV RNA. Patients with a positive screening test were contacted for the confirmatory test result and to establish medical care for HCV treatment. Patient characteristics including age, sex, self-awareness of HCV infection, history of previous HCV treatment, history of opioids use, history of tobacco use, and types of insurance were obtained. A total of 4,525 patients underwent a screening test, of whom 131 patients (2.90%) were HCV antibody positive and 43 patients (0.95%) were HCV RNA positive, indicating that only 33% of patients with positive screening test had chronic HCV infection. The rate of chronic infection was higher in males as compared to females (1.34% vs 0.60%, p = 0.01). Patients with history of opioid use or history of tobacco use were found to have a lower rate of spontaneous clearance than patients without each history (opioids: 48.6% vs 72.0%, p = 0.02; tobacco: 56.6% vs 80.5%, p = 0.01). Among 43 patients who were diagnosed with chronic hepatitis C, 26 were linked to a clinical setting that can address chronic HCV infection, with linkage to care rate of 60.5%. The most common barrier to this was inability to contact patients after discharge from the ED. Conclusions A streamlined EMR system for HCV screening and subsequent linkage to care from the ED can be successfully implemented. A retrospective review suggests that male sex is related to chronic HCV infection, and history of opioid use or history of tobacco use is related to lower HCV spontaneous clearance.

scholarly journals The seroprevalence of untreated chronic hepatitis C virus (HCV) infection and associated risk factors in male Irish prisoners: a cross-sectional study, 2017

2019 ◽  
Vol 24 (14) ◽  
Author(s):  
Desmond Crowley ◽  
John S Lambert ◽  
Graham Betts-Symonds ◽  
Walter Cullen ◽  
Mary Keevans ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Hepatitis ◽  
Cross Sectional Study ◽  
Hcv Infection ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Chronic Hcv Infection ◽  
Associated Risk Factors ◽  
Chronic Hcv

Introduction Data on chronic hepatitis C (HCV) infection prevalence in European prisons are incomplete and impact the public health opportunity that incarceration provides. Aims We aimed to estimate the seroprevalence of untreated chronic HCV infection and to identify associated risk factors in an Irish male prison. Methods We conducted a cross-sectional study involving a researcher-administered questionnaire, review of medical records and HCV serology. Results Of 422 prisoners (78.0% of the study population) who participated in the study, 298 (70.6%) completed the questionnaire and 403 (95.5%) were tested for HCV antibodies. Of those tested, 92 (22.8%) were HCV antibody-positive, and of those, 53 (57.6%) were HCV RNA-positive, 23 (25.0%) had spontaneous clearance, 16 (17.4%) had a sustained viral response, 10 (11.0%) were co-infected with HIV and six (6.0%) with HBV. The untreated chronic HCV seroprevalence estimate was 13.1% and the seroprevalence of HCV among prisoners with a history of injecting drug use (IDU) was 79.7%. Risk factors significantly associated with past HCV infection were IDU (p < 0.0001), having received a prison tattoo (p < 0.0001) or a non-sterile community tattoo (p < 0.0001), sharing needles and other drug-taking paraphernalia (p < 0.0001). Small numbers of prisoners had a history of sharing razors (n=10; 3.4%) and toothbrushes (n=3; 1.0%) while incarcerated. On multivariable analysis, history of receiving a non-sterile community tattoo was the only significant risk factor associated with HCV acquisition (after IDU was removed from the model) (p = 0.005, β = 0.468). Conclusion The level of untreated chronic HCV infection in Irish prisons is high, with IDU the main associated risk.

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