Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration

2000 ◽  
Vol 1485 (1) ◽  
pp. 36-44 ◽  
Author(s):  
José Pedro De La Cruz ◽  
Lourdes Quintero ◽  
Marı́a Auxiliadora Villalobos ◽  
F. Sánchez de la Cuesta
Keyword(s):  
Lipid Peroxidation ◽  
Olive Oil ◽  
Glutathione System

Dietary virgin olive oil protects against lipid peroxidation and improves antioxidant status in the liver of rats chronically exposed to ethanol

2008 ◽  
Vol 28 (7) ◽  
pp. 472-479 ◽  
Author(s):  
Abir Kasdallah-Grissa ◽  
Amel Nakbi ◽  
Nadia Koubaa ◽  
Saloua El-Fazaâ ◽  
Najoua Gharbi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Olive Oil ◽  
Antioxidant Status ◽  
Virgin Olive Oil

scholarly journals Activity lipid peroxidation and glutathione systems of lymphocytes blood in patients with diffusive toxic struma

2008 ◽  
Vol 7 (4) ◽  
pp. 47-52
Author(s):  
O. I. Urazova ◽  
Ye. B. Kravets ◽  
V. V. Novitsky ◽  
A. V. Rogalyova ◽  
O. A. Vasil’yeva ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Glutathione System ◽  
Antioxidative Protection

In this article results of research of some parameters of oxidizing metabolism in lymphocytes blood in patients with verified diffusive toxic struma (DTS) of a various degree of an expressiveness are represented. Is shown, that for the patients with DTS activity the lipid peroxidation in lymphocytes is saved in norm limits. Thus the tags of disbalance of cell glutathione system antioxidative protection are scoredat.

scholarly journals Olive oil containing olive oil fatty acid esters of plant sterols and dietary diacylglycerol reduces low-density lipoprotein cholesterol and decreases the tendency for peroxidation in hypercholesterolaemic subjects

2007 ◽  
Vol 98 (3) ◽  
pp. 563-570 ◽  
Author(s):  
Yen-Ming Chan ◽  
Isabelle Demonty ◽  
Dori Pelled ◽  
Peter J. H. Jones
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Lipid Profile ◽  
Olive Oil ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Plant Sterols ◽  
Fatty Acid Esters ◽  
Blood Lipid Profile ◽  
Apo B

Plant sterols (PS) and MUFA are well-documented cholesterol lowering agents. We aimed to determine the effect of PS esterified to olive oil fatty acids (PS-OO) on blood lipid profile and lipid peroxidation in hypercholesterolaemic subjects. Twenty-one moderately overweight, hypercholesterolaemic subjects consumed three consecutive treatment diets, each lasting 28 d and separated by 4-week washout periods, using a randomized crossover design. Diets contained 30 % energy as fat, 70 % of which was provided by olive oil (OO), and differed only in the treatment oils: OO, PS esterified to sunflower oil fatty acids (PS-SO), and PS-OO. Both PS-SO and PS-OO treatments provided 1·7 g PS /d. PS-OO and PS-SO consumption resulted in a decrease (P = 0·0483) in LDL-cholesterol (LDL-C) concentrations compared with the OO diet. Although total cholesterol and apo B-100 levels were not significantly affected, PS-SO and, to some extent, PS-OO reduced the total:HDL-cholesterol (HDL-C) ratio (P = 0·0142) and the apo B-100:apo A-I ratio (P = 0·0168) compared with the OO diet. There were no differences across diets in lipoprotein(a) (Lp(a)) and lipid peroxidation levels. However, following consumption of OO and PS-SO, Lp(a) concentrations increased (P = 0·0050 and 0·0421, respectively), while PS-OO treatment did not affect Lp(a) levels. Furthermore, there was a decrease (P = 0·0097) in lipid peroxidation levels with PS-OO treatment during the supplementation phase. Our results suggest that supplementing an OO-rich diet with PS-OO favourably alters the plasma lipid profile and may decrease the susceptibility of LDL-C to lipid peroxidation in hypercholesterolaemic subjects.

scholarly journals Effects of fish oil- and olive oil-rich diets on iron metabolism and oxidative stress in the rat

2003 ◽  
Vol 89 (1) ◽  
pp. 11-18 ◽  
Author(s):  
S. Miret ◽  
M. P. Sáiz ◽  
M. T. Mitjavila
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Fish Oil ◽  
Olive Oil ◽  
Reticulocyte Count ◽  
Tocopherol Content ◽  
Tocopheryl Acetate ◽  
Erythrocyte Membranes ◽  
And Oxidative Stress ◽  
Maize Oil

The objective of the present study was to examine the effects of fish oil (FO)- and olive oil (OO)-rich diets on Fe metabolism and oxidative stress. Rats were fed for 16 weeks with diets containing 50 g lipid/g; either OO, maize oil (MO) or FO. OO or MO diets contained a standard amount (100 m/g) of all-rac-α-tocopheryl acetate. FO diets were supplemented with 0, 100 or 200 mg all-rac-α-tocopheryl acetat/g (FO-0, FO-1 or FO-2 diets, respectively). At the end of the feeding period, we measured non-haem Fe stores in liver and spleen, and erythrocyte and reticulocyte count. We also determined antioxidants and products derived from lipid peroxidation in plasma and erythrocytes. Our results showed reduced non-haem Fe stores in rats fed any of the FO diets. Reticulocyte percentage was higher in the rats fed FO-0 and FO-1. Plasma α-tocopherol was very low in rats fed the FO-0 diet. Rats fed the FO-1 and FO-2 diets showed higher α-tocopherol in plasma than the FO-0 group but lower than the MO or OO groups. We did not observe such differences in the α-tocopherol content in erythrocyte membranes. Superoxide dismutase and glutathione peroxidase activities were lower in the erythrocytes of rats fed the FO-0 diet. The products derived from lipid peroxidation were also higher in the FO groups. The administration of FO-rich diets increased lipid peroxidation and affected Fe metabolism. On the other hand, the OO-rich diet did not increase oxidative stress and did not alter Fe metabolism. Based on these results, we conclude that FO supplementation should be advised carefully.

Effects of the Antioxidant (6,7-Dihydroxycoumarin) Esculetin on the Glutathione System and Lipid Peroxidation in Mice

Gerontology ◽  
1997 ◽  
Vol 44 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Sagrario Martín-Aragón ◽  
Juana M. Benedí ◽  
Angel M. Villar
Keyword(s):  
Lipid Peroxidation ◽  
Glutathione System

scholarly journals ОСОБЛИВОСТІ РЕАКЦІЇ ГЛУТАТІОНОВОЇ СИСТЕМИ ВНУТРІШНІХ ОРГАНІВ НА ТЛІ ЕКСПЕРИМЕНТАЛЬНОЇ ПОЛІТРАВМИ

2018 ◽  
Author(s):  
N. V. Volotovska ◽  
A. A. Hudyma
Keyword(s):  
Lipid Peroxidation ◽  
Blood Loss ◽  
Ischemia Reperfusion ◽  
Malonic Dialdehyde ◽  
Kidney Tissue ◽  
Male Rats ◽  
Mechanical Trauma ◽  
Control Group ◽  
Glutathione System ◽  
Glutathione Concentration

Nowadays stop the bleeding and fight against its consequences determines further success in the survival and rehabilitation of the victim. It is extremely important to find ways to improve the ischemic metabolism as a result of overlaying a tissue turnstile. Enzymes of the glutathione system are actively involved in combating the effects of hypoxia, therefore, the experimental detection of critical periods of depression of this protectional link is the basis for the further search for effective methods of correction and condition stabilization of the affected organism.The aim of the study – to determine the role of glutathione system of the liver and kidneys in the pathogenesis of experimental ischemia-reperfusion (EIR) in the early and remote post-traumatic periods.Materials and Methods. The object of the study – 196 males of white male rats with a body weight 220–240 g, divided into 4 groups, 10 individuals in each. Animals of the control group were withdrawn from the study without surgical intervention, while in the experimental groups, injuries were simulated: a hemostatic tourniquet on the thigh (J) over two hours; isolated blood loss from the femoral vein (40%) – (K); two-hour ischemia, combined with blood loss (J + K) and two-hour ischemia, combined with blood loss and mechanical trauma (J + K + P). The animals were withdrawn from the experiment at 1, 3, 7 and 14 days after the intervention by total bleeding from the heart.Results and Discussion. According to the activation of the lipid peroxidation, which was represented by the growth of the concentration of malonic dialdehyde, diene and trienic conjugates, an active response from the glutathione system was detected: the activation of glutathioneperoxidase activity, an increase of glutathionereductase activity against the decrease restored glutathione concentration. But in the kidney tissue the activity of glutathione system enzymes was somewhat lower, herewith in some periods, conversly, they exceeded liver parameters. These results, in our opinion, indicate that the reason of such their dividing, mainly, it is total debilitation of the glutathione system in the posttraumatical period. It was 1 and 3 days after trauma and partly depended of the injury severity. At the same time, even an isolated overlay of the hemostatic tourniquet led to significant changes of the glutathione system and was represented by response to the activation of lipid peroxidation. This confirms the necessity to continue the series of experiments.Conclusions. The obtained results of the experiments revealed a significant inhibition of the reduced glutathione concentration in the liver, and no so expressed in the kidneys. Especially depression of its activity was on the background of bleeding associated with ischemia, and bleeding associated with ischemia and mechanical trauma. Decrease of glutathioneperoxidase and glutathionereductase activity coincided with increase of lipid peroxidation.

scholarly journals The impact of endogenous intoxication on biochemical indicators of blood of cows with calves

2017 ◽  
Vol 8 (3) ◽  
pp. 438-443 ◽  
Author(s):  
B. Gutyj ◽  
Y. Grymak ◽  
M. Drach ◽  
O. Bilyk ◽  
O. Matsjuk ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Immune System ◽  
Blood Serum ◽  
Antioxidant System ◽  
Total Protein ◽  
Lipid Hydroperoxides ◽  
Glutathione System ◽  
Endogenous Intoxication ◽  
Activity Of Enzymes ◽  
The Impact

The notion “endotoxin” is conditional, for any normal metabolit has a toxic impact of its excessive accumulation in organism. Endotoxins include products of breakdown of tissue proteins, peroxides and other products of free radical oxidation, low molecular weight toxins, toxins of microorganisms. Current knowledge on the mechanism of endotoxin action on the organism of pregnant cows is based on the key role of the immune system: it provides animals with protection against the infections, eliminates extraneous elements of endogenous and exogenous origin. It is defined that under endogenous intoxication, toxic metabolites suppress the activity of immune system of organism, decreases the resistability of an organism to negative effects of environmental factors. Animals under endogenous intoxication had the following clinical symptoms: swelling of mammal gland, edemas of external genitals, anemia of mucous membranes, functional disorders of proventriculuses and intestines, animals were stressed. It was defined that under endogenous intoxication in 8–9 months of pregnancy, blood of highly-productive cows had a tendency of decrease in the number of erythrocytes by 21.0%, in the level of hemoglobin – by 24.3%, increase in the number of leucocytes by 7.6% compared to the value for blood of cows with physiological pregnancy process. The development of endogenous intoxication among pregnant cows causes disorders in protein-synthesizing function of liver, which is indicated by decrease in the level of total protein and its fractions. It was defined that endogenous intoxication decreased the content of total protein in blood by 18.4%. Over the period of study, among pregnant cows under the development of endogenous intoxication, heightened activity of amino transferaces in the blood was observed. In the ninth month of pregnancy, the activity of amino transferaces in blood serum of cows from experimental group increased by 28.6%, and the activity of aspartate aminotransferace increased by 20.1% relatively. The activity of amino transferaces and decrease in the level of total protein and its fractions in blood serum is one of the first biochemical studies on the diagnosing endotoxin manifestations and indicates destructive processes in liver. It was defined that pregnant cows under the development of endogenous intoxication suffer disorders in detoxicating function of liver and disorders in filtrating function of kidneys. The developing endogenous intoxication of pregnant cows suppresses the activity of enzymes in their glutathione system of antioxidant protection, which is indicated by decrease in the activity of glutathione peroxidase by 27.5 %, glutathione reductase by 42.9%, glucose-6-phosphate dehydrogenase by 11.2% in blood serum. The lowest activity of enzymes of glutathione system in blood of highly-productive cows under endogenous intoxication was observed in their ninth month of pregnancy, which is related to increase in activation of processes of lipid peroxidation and misbalance between the activity of antioxidant system and intensity of lipid peroxidation. Reliable increase in the content of lipid hydroperoxides by 70.9% and in concentration of malondialdehide by 54.8% was observed. Misbalance towards generation of active forms of oxygen and their metabolites, exhaustion of antioxidant system and disorders in balance cause oxidative stress. 

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