OP-002 - Are apoptosis and oxidative stress increased in cumulus and granulose cells from oocytes of young women with low ovarian reserve?

2016 ◽  
Vol 32 ◽  
pp. S1
Author(s):  
Rocio Nuñez Calonge ◽  
Susana Cortes ◽  
Leonor Ortega ◽  
Lisa Rancan ◽  
Elena Vara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Young Women ◽  
Ovarian Reserve ◽  
Granulose Cells ◽  
And Oxidative Stress

scholarly journals Subchronic and Low Dose of Tributyltin Exposure Leads to Reduced Ovarian Reserve, Reduced Uterine Gland Number, and Other Reproductive Irregularities in Female Mice

2020 ◽  
Vol 176 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Isabela V Sarmento ◽  
Eduardo Merlo ◽  
Silvana S Meyrelles ◽  
Elisardo C Vasquez ◽  
Genoa R Warner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ovarian Reserve ◽  
Low Dose ◽  
Reproductive Tract ◽  
Ovarian Follicles ◽  
Corpora Lutea ◽  
Female Mice ◽  
Uterine Gland ◽  
Follicular Reserve ◽  
And Oxidative Stress

Abstract Tributyltin (TBT) chloride is an endocrine disrupting chemical associated with reproductive complications. Studies have shown that TBT targets the reproductive tract, impairing ovarian folliculogenesis, and uterine morphophysiology. In this investigation, we assessed whether subchronic and low dose of TBT exposure results in abnormal ovarian follicular reserve and other irregularities in female mice. TBT was administered to female mice (500 ng/kg/day for 12 days via gavage), and reproductive tract morphophysiology was assessed. We further assessed reproductive tract inflammation and oxidative stress. Improper functioning of the reproductive tract in TBT mice was observed. Specifically, irregular estrous cyclicity and abnormal ovarian morphology coupled with reduction in primordial and primary follicle numbers was observed, suggesting ovarian reserve depletion. In addition, improper follicular development and a reduction in antral follicles, corpora lutea, and total healthy ovarian follicles together with an increase in cystic follicles were apparent. Evidence of uterine atrophy, reduction in endometrial gland number, and inflammation and oxidative stress were seen in TBT mice. Further, strong negative correlations were observed between testosterone levels and primordial, primary, and total healthy ovarian follicles. Thus, these data suggest that the subchronic and low dose of TBT exposure impaired ovarian follicular reserve, uterine gland number, and other reproductive features in female mice.

Role of oxidant–antioxidant balance in reproduction of domestic animals

2017 ◽  
Vol 57 (8) ◽  
pp. 1588 ◽  
Author(s):  
Saranika Talukder ◽  
Kendra L. Kerrisk ◽  
Gianfranco Gabai ◽  
Pietro Celi
Keyword(s):  
Oxidative Stress ◽  
Domestic Animals ◽  
Enzymatic Antioxidants ◽  
Dynamic Changes ◽  
Reproductive Process ◽  
Physiological Processes ◽  
Fluid Environment ◽  
Granulose Cells ◽  
And Oxidative Stress

Reproductive process leads to dynamic changes in metabolism and energy consumption, which may be responsible for the excessive production of free radicals (oxidants) that are generated during the physiological process of oxygen consumption. As the ovary is a metabolically active organ, it produces oxidants. Growing follicles, granulose cells of Graffian follicles and ovulated follicles all produce both enzymatic and non-enzymatic antioxidants to preserve themselves from the oxidative damage of oxidants. Oxidants and antioxidants are involved in several reproductive functions such as the regulation of follicular fluid environment, folliculogenesis, steroidogenesis, corpus luteum function, and luteolysis. In this article, the currently available literature is reviewed in relation to the roles of oxidants and oxidative stress in both normal and abnormal reproductive physiological processes.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Sign in / Sign up

Export Citation Format

Share Document