average daily dose of analog basal insulins in patients with type 2 diabetes: a matched case control analysis

Introduction. To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin.Methods. This study is a matched case-control analysis concerning the type 2 diabetes population from Grenoble Hospital University. Cases of LA were defined biologically with pH < 7.35 and lactates > 5 mmol/L. They were matched to 2 controls defined as type 2 diabetic inpatients who did not present a LA during the study period. We performed a conditional logistic regression.Results. We included 302 cases and 604 controls; mean age was 69.5 years (SD 11.93). Intercurrent diseases were significantly associated with LA. Chronic medical conditions had a minor impact on LA incidence, except hepatocellular dysfunction. Metformin was significantly associated with a higher LA probability in case of acute kidney injury (AKI) (OR = 1.79;pvalue = 0.020) but not in patients without AKI.Discussion and Conclusions. According to this study, metformin, compared to acute medical conditions, seemed not to be associated with LA in patients with type 2 diabetes; however in case of AKI, metformin may be associated with LA.

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Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes

Diabetes Mellitus ◽

10.14341/2072-0351-5845 ◽

2017 ◽

Vol 20 (3) ◽

pp. 166-171 ◽

Cited By ~ 1

Author(s):

Mikhail I. Churnosov ◽

Oksana N. Belousova ◽

Svetlana Sergeyevna Sirotina

Keyword(s):

Type 2 Diabetes ◽

Tumor Necrosis ◽

Case Control ◽

Control Analysis ◽

Polymorphic Markers ◽

Tumor Necrosis Factors ◽

Taqman Probes ◽

Healthy Control ◽

Case Control Analysis

Aim. To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNF, rs 909253 Lt, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russia. Materials and methods. The results obtained from 544 patients, of which 236 were already diagnosed with T2D and 308 were healthy control individuals, were analysed. All the loci were analysed by DNA synthesis using PCR TaqMan probes. The statistical analysis of the frequency distribution of genotypes was performed using contingency tables and the 2 test, with p 0.05. Results. A case-control analysis showed that genotype GG rs 909253Lt was a risk factor for T2D (OR = 2.36, p = 0.01). Also, individuals with genotype AA rs 767455TNFR1 had significantly earlier age of T2D manifestation than that of patients with genetic variants AG and GG (p = 0.01). Conclusion. This study demonstrated the involvement of polymorphic markers of tumor necrosis factors and their receptors in the development of T2D among the residents of the Central Black Earth Region of Russia.

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Superior socioeconomic status in patients with type 2 diabetes having gastric bypass surgery: a case-control analysis of 10 642 individuals

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2019-000989 ◽

2020 ◽

Vol 8 (1) ◽

pp. e000989

Author(s):

Magnus Sundbom ◽

Stefan Franzén ◽

Johan Ottosson ◽

Ann-Marie Svensson

Keyword(s):

Type 2 Diabetes ◽

Bariatric Surgery ◽

Socioeconomic Status ◽

Gastric Bypass Surgery ◽

Laboratory Data ◽

Case Control ◽

Control Analysis ◽

College Level ◽

Case Control Analysis

IntroductionThe incidence of type 2 diabetes mellitus (T2DM) is increasing, in parallel with the epidemic of obesity. Although bariatric surgery, which profoundly affects T2DM, has increased 10-fold since the millennium, only a fraction of diabetics is offered this treatment option.ObjectiveTo investigate the association between clinical and socioeconomic factors in selecting patients with T2DM for bariatric surgery in a publicly financed healthcare system.Research design and methodsCohort study using prospectively registered data from two nationwide quality registers, the Scandinavian Obesity Surgery Registry (SOReg) and the Swedish National Diabetes Register (NDR), and data from two government agencies. An age, gender and body mass index-matched case-control analysis containing 10 642 patients with T2DM was performed.ResultsPatients with T2DM having bariatric surgery had a higher education level (upper secondary school or college level, OR 1.42% and 95% CI (1.29 to 1.57) and 1.33 (1.18 to 1.51), respectively) as well as a higher income (OR 1.37 (1.22 to 1.53) to 1.94 (1.72 to 2.18) for quartile 2–4) than non-operated patients. Operated patients were more often married or had been married (OR 1.51 (1.37 to 1.66) and 1.65 (1.46 to 1.86), respectively) as well as natives (OR 0.84 (0.73 to 0.95) if born in the rest of Europe). Groups did not differ regarding relevant laboratory data and present medication, nor in former in-patient diagnoses.ConclusionDespite similar clinical data, superior socioeconomic status was associated with increased rate of bariatric surgery in patients with T2DM. We believe that this warrants actions, for example concerning referral patterns.

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