Abstract #1081 Primary Hyperthyroidism with an Elevated Thyroid Stimulating Hormone – A Diagnostic Challenge

Thyroid-stimulating hormone- (TSH-) secreting pituitary adenoma (TSH-oma) is a rare cause of secondary hyperthyroidism and can be misdiagnosed as primary hyperthyroidism. We report a case of a 15-year-old male patient who was one of two monozygotic twins and exhibited hyperthyroidism syndrome. The laboratory results showed secondary hyperthyroidism, with increased levels of free T3 (FT3) and free T4 (FT4) and no TSH inhibition. Magnetic resonance imaging (MRI) and histopathological examination of the pituitary gland confirmed pituitary microadenoma. The patient was treated with methimazole, propranolol, and somatostatin analogs to restore euthyroidism before undergoing an endoscopic transsphenoidal resection of the pituitary tumor. After surgery, the hyperthyroidism symptoms improved, thyroid hormones normalized, and MRI of the pituitary gland showed the complete removal of the tumor with no recurrence after 2 years of follow-up.

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Permanent congenital hypothyroidism with blood spot thyroid stimulating hormone <10 mU/L

Archives of Disease in Childhood ◽

10.1136/archdischild-2015-309564 ◽

2016 ◽

Vol 103 (1) ◽

pp. 65-67 ◽

Cited By ~ 7

Author(s):

Jeremy H Jones ◽

Sarah Smith ◽

Catherine Dorrian ◽

Avril Mason ◽

M Guftar Shaikh

Keyword(s):

Congenital Hypothyroidism ◽

Thyroid Stimulating Hormone ◽

Lower Threshold ◽

Diagnostic Challenge ◽

Thyroxine Therapy ◽

Thyroid Ectopia ◽

Neonatal Blood ◽

The Uk ◽

Blood Spot ◽

Stimulating Hormone

BackgroundThe UK recommended lower threshold for neonatal blood spot thyroid stimulating hormone (TSH) screening for congenital hypothyroidism (CHT) is 10.0 mU/L. Some laboratories use lower thresholds. This will lead to referral of mildly or unaffected infants but some will require thyroxine therapy.MethodsLaboratory referrals with a first or repeat capillary TSH between 8.0 and <10.0 mU/L were identified (January 2004 to March 2014). The outcome of these cases was examined.Results26 infants had one or more blood spot TSH values between 8.0 and 9.99 mU/L; 65% had transient elevated neonatal TSH while one is awaiting diagnostic challenge. The remaining eight (31%) have permanent CHT; three with dyshormonogenesis, two with thyroid ectopia and the others met the criteria for definite CHT. Two out of three with dyshormonogenesis presented with decompensated hypothyroidism.ConclusionsInfants with permanent and occasionally severe CHT may have a screening TSH below the UK recommended lower cut-off.

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Effects of thyroid stimulating hormone on cumulus cell expansion and survival during mouse folliculogenesis in vitro

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86138-2 ◽

1998 ◽

Vol 5 (1) ◽

pp. 54A-54A

Author(s):

A SCHUTTAINE ◽

H FOELLMER ◽

E JONES

Keyword(s):

Cell Expansion ◽

Cumulus Cell ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Abstract #1089: The Correlation of Thyroid Stimulating Hormone with Lipid Profile, Body Mass Index and Other Biochemical Parameters

Endocrine Practice ◽

10.1016/s1530-891x(20)42398-5 ◽

2015 ◽

Vol 21 ◽

pp. 238

Author(s):

Subodh Banzal ◽

Sonal Banzal ◽

Sonia Tiwari

Keyword(s):

Body Mass Index ◽

Lipid Profile ◽

Body Mass ◽

Biochemical Parameters ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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CLINICAL EVALUATION OF THE THYROID STIMULATING HORMONE ACTIVITY IN EXOPHTHALMOS

Acta Endocrinologica ◽

10.1530/acta.0.0380577 ◽

1961 ◽

Vol 38 (4) ◽

pp. 577-584 ◽

Cited By ~ 3

Author(s):

Sven Erik Björkman ◽

Torsten Denneberg ◽

Inge Hedenskog

Keyword(s):

Clinical Evaluation ◽

Thyroid Stimulating Hormone ◽

Significant Rise ◽

Hormone Activity ◽

Control Subjects ◽

Long Duration ◽

Stimulating Factor ◽

Stimulating Hormone

ABSTRACT A method for demonstrating the presence of a thyroid stimulating factor in the blood of patients with progressive exophthalmos after thyroidectomy or after treatment with radioiodine is described. The method consists of transfusing freshly drawn blood from the patients to euthyroid recipients and subsequently following the PBI level of the recipients at regular intervals. Six exophthalmic patients tested in this manner were found to have such a factor in their circulating blood. After transfusion of their blood a significant rise in the PBI level of the recipients could be demonstrated. Two other patients, one with exophthalmos of long duration did not show this response nor did it occur after transfusion of blood from two control subjects. In one case the action of this factor was compared with that of animal thyrotrophin and found to be of the same magnitude.

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