Increased prostate cancer glucose metabolism detected by FDG-PET/CT in localised Gleason 8-10 prostate cancers identifies very high-risk patients for early recurrence and resistance to castration

Abstract Objectives We aimed to develop and validate radiologic scores from [18F]FDG PET/CT and MRI to guide individualized induction chemotherapy (IC) for patients with T3N1M0 nasopharyngeal carcinoma (NPC). Methods A total of 542 T3N1M0 patients who underwent pretreatment [18F]FDG PET/CT and MRI were enrolled in the training cohort. A total of 174 patients underwent biopsy of one or more cervical lymph nodes. Failure-free survival (FFS) was the primary endpoint. The radiologic score, which was calculated according to the number of risk factors from the multivariate model, was used for risk stratification. The survival difference of patients undergoing concurrent chemoradiotherapy (CCRT) with or without IC was then compared in risk-stratified subgroups. Another cohort from our prospective clinical trial (N = 353, NCT03003182) was applied for validation. Results The sensitivity of [18F]FDG PET/CT was better than that of MRI (97.7% vs. 87.1%, p < 0.001) for diagnosing histologically proven metastatic cervical lymph nodes. Radiologic lymph node characteristics were independent risk factors for FFS (all p < 0.05). High-risk patients (n = 329) stratified by radiologic score benefited from IC (5-year FFS: IC + CCRT 83.5% vs. CCRT 70.5%; p = 0.0044), while low-risk patients (n = 213) did not. These results were verified again in the validation cohort. Conclusions T3N1M0 patients were accurately staged by both [18F]FDG PET/CT and MRI. The radiologic score can correctly identify high-risk patients who can gain additional survival benefit from IC and it can be used to guide individualized treatment of T3N1M0 NPC. Key Points • [18F]FDG PET/CT was more accurate than MRI in diagnosing histologically proven cervical lymph nodes. • Radiologic lymph node characteristics were reliable independent risk factors for FFS in T3N1M0 nasopharyngeal carcinoma patients. • High-risk patients identified by the radiologic score based on [18F]FDG PET/CT and MRI could benefit from the addition of induction chemotherapy.

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Prognostic value of 18F-FDG PET/CT and MRI features in patients with high-risk and very-high-risk cutaneous squamous cell carcinoma

British Journal of Radiology ◽

10.1259/bjr.20211003 ◽

2022 ◽

Author(s):

Masaya Kawaguchi ◽

Hiroki Kato ◽

Kanako Matsuyama ◽

Yoshifumi Noda ◽

Fuminori Hyodo ◽

...

Keyword(s):

High Risk ◽

Fdg Pet ◽

Prognostic Value ◽

Cutaneous Squamous Cell Carcinoma ◽

Maximum Diameter ◽

Depth Of Invasion ◽

Mri Features ◽

Pet Ct ◽

Fdg Pet Ct ◽

Very High

Objectives: This study aimed to evaluate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) features in patients with high-risk and very-high-risk cutaneous squamous cell carcinoma (cSCC). Methods: This study included 54 consecutive patients with surgically resected primary high-risk and very-high-risk cSCC who underwent preoperative FDG-PET/CT and/or MRI. Among them, 14 patients (26%) had recurrences. We retrospectively reviewed the FDG-PET/CT (n = 34) and MRI (n = 48) and investigated the clinical significance and prognostic value of imaging features in cSCC. Results: On FDG-PET/CT, the maximum standardized uptake value (SUVmax) of the primary tumor (13.0 ± 6.4 vs. 6.9 ± 5.3, p < 0.05) was higher in cSCC with recurrence than in cSCC without recurrence. On MRI, the maximum diameter of the lesion (46.8 ± 24.1 mm vs 30.4 ± 17.0 mm, p < 0.05) and the frequency of muscle/tendon/bone invasion (42% vs 11%, p < 0.05) were significantly greater in cSCC with recurrence than in cSCC without recurrence. In the univariate analysis, prognostic factors for recurrence were SUVmax of the primary tumor (p < 0.01), the maximum diameter of the lesion (p < 0.05), and depth of invasion (p < 0.05). The areas under the receiver operating characteristic curves of the SUVmax (0.78) were superior to those of the maximum diameter (0.71) and depth of invasion (0.60). Conclusions: SUVmax, maximum diameter, and depth of invasion were useful parameters for prognostic factors predicting recurrence in patients with high-risk and very-high-risk cSCC. Advances in knowledge: SUVmax represents a prognostic factor.

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Increased Prostate Cancer Glucose Metabolism Detected by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Localised Gleason 8–10 Prostate Cancers Identifies Very High–risk Patients for Early Recurrence and Resistance to Castration

European Urology Focus ◽

10.1016/j.euf.2018.03.008 ◽

2019 ◽

Vol 5 (6) ◽

pp. 998-1006 ◽

Cited By ~ 6

Author(s):

Etienne Lavallée ◽

Michelle Bergeron ◽

François-Alexandre Buteau ◽

Annie-Claude Blouin ◽

Nicolas Duchesnay ◽

...

Keyword(s):

Prostate Cancer ◽

Computed Tomography ◽

Early Recurrence ◽

Emission Tomography ◽

Fluorodeoxyglucose Positron Emission Tomography ◽

Positron Emission ◽

Risk Patients ◽

Prostate Cancers ◽

Very High ◽

Fluorodeoxyglucose Positron Emission

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The use of FDG‐PET/CT to detect early recurrence after resection of high‐risk stage III melanoma

Journal of Surgical Oncology ◽

10.1002/jso.26155 ◽

2020 ◽

Vol 122 (7) ◽

pp. 1328-1336

Author(s):

Emma H. A. Stahlie ◽

Bernies Hiel ◽

Marcel P. M. Stokkel ◽

Yvonne M. Schrage ◽

Winan J. Houdt ◽

...

Keyword(s):

High Risk ◽

Fdg Pet ◽

Early Recurrence ◽

Stage Iii ◽

Pet Ct ◽

Stage Iii Melanoma ◽

Fdg Pet Ct

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GLUT1 expression in high-risk prostate cancer: correlation with 18F-FDG-PET/CT and clinical outcome

Prostate Cancer and Prostatic Diseases ◽

10.1038/s41391-020-0202-x ◽

2020 ◽

Vol 23 (3) ◽

pp. 441-448 ◽

Cited By ~ 3

Author(s):

Salma Meziou ◽

Cassandra Ringuette Goulet ◽

Hélène Hovington ◽

Véronique Lefebvre ◽

Étienne Lavallée ◽

...

Keyword(s):

Prostate Cancer ◽

High Risk ◽

Clinical Outcome ◽

Fdg Pet ◽

High Risk Prostate Cancer ◽

Pet Ct ◽

Risk Prostate Cancer ◽

Glut1 Expression ◽

18F Fdg ◽

Fdg Pet Ct

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FDG-PET/CT, a Promising Exam for Detecting High-Risk Myeloma Patients?

Cancers ◽

10.3390/cancers12061384 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1384

Author(s):

Anne-Victoire Michaud-Robert ◽

Bastien Jamet ◽

Clément Bailly ◽

Thomas Carlier ◽

Philippe Moreau ◽

...

Keyword(s):

Multiple Myeloma ◽

High Risk ◽

Fdg Pet ◽

High Morbidity ◽

Reliable Technique ◽

High Risk Patients ◽

Imaging Results ◽

Pet Ct ◽

Risk Patients ◽

Fdg Pet Ct

Multiple myeloma (MM) is a haematological neoplasm characterized by a clonal proliferation of malignant plasma cells in the bone marrow. MM is associated with high morbidity and mortality and variable survival, which can be very short for some patients but over 10 years for others. These differences in survival are explained by intra- and inter-tumoral heterogeneity and demonstrate the potential benefits of adapting the treatment course for high-risk patients with a poorer prognosis. Indeed, identification of these high-risk patients is necessary and is based on the identification of high-risk biomarkers including clinical variables, genomics and imaging results. Positron emission tomography combined with computed tomography using 18F-deoxyfluoroglucose (FDG-PET/CT) is a reliable technique for the initial staging of patients with symptomatic multiple myeloma (MM), and has been included in the IMWG (International Myeloma Working Group) recommendations in 2019. According to clinical studies, FDG-PET/CT characteristics could be used to define high-risk patients at initial diagnosis of symptomatic MM. The goal of this review is to demonstrate the prognostic value of FDG-PET in symptomatic MM patients, particularly in identifying high-risk patients, and thus, to best adapt therapeutic management in the future.

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