scholarly journals O-12: Ten years of paediatric inflammatory bowel disease incidence in the north of Scotland

2014 ◽  
Vol 8 ◽  
pp. S400
Author(s):  
F.A. Jagger ◽  
F.L. Cameron ◽  
S. Loganathan ◽  
G.L. Hold ◽  
R. Hansen
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Incidence ◽  
The North ◽  
Inflammatory Bowel

scholarly journals Inflammatory bowel disease: the role of inflammatory cytokine gene polymorphisms

2004 ◽  
Vol 13 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Joanna Balding ◽  
Wendy J. Livingstone ◽  
Judith Conroy ◽  
Lesley Mynett-Johnson ◽  
Donald G. Weir ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Incidence ◽  
Strong Association ◽  
Tnf Α ◽  
Genes Encoding ◽  
Inflammatory Processes ◽  
Inflammatory Bowel ◽  
Cytokine Gene Polymorphisms

THE mechanisms responsible for development of inflammatory bowel disease (IBD) have not been fully elucidated, although the main cause of disease pathology is attributed to up-regulated inflammatory processes. The aim of this study was to investigate frequencies of polymorphisms in genes encoding pro-inflammatory and anti-inflammatory markers in IBD patients and controls. We determined genotypes of patients with IBD (n=172) and healthy controls (n=389) for polymorphisms in genes encoding various cytokines (interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF), IL-10, IL-1 receptor antagonist). Association of these genotypes to disease incidence and pathophysiology was investigated. No strong association was found with occurrence of IBD. Variation was observed between the ulcerative colitis study group and the control population for the TNF-α-308 polymorphism (p=0.0135). There was also variation in the frequency of IL-6-174 and TNF-α-308 genotypes in the ulcerative colitis group compared with the Crohn's disease group (p=0.01). We concluded that polymorphisms in inflammatory genes are associated with variations in IBD phenotype and disease susceptibility. Whether the polymorphisms are directly involved in regulating cytokine production, and consequently pathophysiology of IBD, or serve merely as markers in linkage disequilibrium with susceptibility genes remains unclear.

scholarly journals Inflammatory Bowel Disease Incidence and Prevalence in Southern Alberta

1990 ◽  
Vol 4 (5) ◽  
pp. 187-192 ◽  
Author(s):  
Faith G Davis ◽  
Michael G Grace ◽  
Noel Hershfield
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Disease Incidence ◽  
Demographic Data ◽  
Age Distribution ◽  
Incidence Rates ◽  
Southern Alberta ◽  
Inflammatory Bowel

Incidence and prevalence rates of inflammatory bowel disease were estimated for 1976-81 in southern Alberta. Cases were identified using hospital and physician records and membership lists of the Canadian Foundation for Ileitis and Colitis. A mail survey was conducted to obtain demographic data. Population data were obtained from Statistics Canada. The overall prevalence rate of IBO in men was 69.1 per 105 and 97.6 per 105 in women. Incidence rates of IBD were 6.0 per 105 per year in men and 9.2 per 105 per year in women. These six differences were due to Crohn's disease as female incidence rates were twice that of male rates 6.3 per 105 per year versus 3. L per LOS per year. A bimodal age distribution and female predominance in the younger age groups was apparent for Crohn's disease.

scholarly journals Inflammatory bowel disease and cardiovascular disease incidence and mortality: A meta-analysis

2018 ◽  
Vol 25 (15) ◽  
pp. 1623-1631 ◽  
Author(s):  
Hong-Hao Sun ◽  
Feng Tian
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Incidence ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Effect Model ◽  
Incidence And Mortality ◽  
Inflammatory Bowel ◽  
Cardiovascular Disease Incidence

Background The risk of cardiovascular disease occurrence and death in inflammatory bowel disease patients is still unclear. Design Meta-analysis. Methods Pertinent studies were identified by searching articles in PubMed and Web of Knowledge to December 2017 and reviewing the reference lists of the retrieved articles. We used the fixed-effect model to pool the study-specific estimates when there was no indication of heterogeneity; otherwise, the random-effect model was used. Results A total of 27 articles was included, of which 11 studies reported the risk of cardiovascular disease incidence and 16 studies reported the risk of cardiovascular disease death. The pooled relative risks were 1.25 (95% confidence interval (CI): 1.08, 1.44), 1.17 (95% CI: 1.07, 1.27) and 1.12 (95% CI: 1.05, 1.21) for cerebrovascular disease, coronary heart disease and myocardial infarction, respectively. In particular, the pooled relative risk was much higher in females. The pooled standardized mortality ratios were 1.01 (95% CI: 0.90, 1.14) for Crohn's disease patients and 0.93 (95% CI: 0.86, 1.01) for ulcerative colitis patients with low heterogeneity across studies. No publication bias was detected. Conclusions There was a positive association between inflammatory bowel disease and higher risk of cardiovascular disease incidence, particularly in females. Such an association was not observed for cardiovascular disease mortality.

scholarly journals P666 A 7 years study on epidemiologic aspects of inflammatory bowel disease in the north east of Italy

2013 ◽  
Vol 7 ◽  
pp. S278
Author(s):  
T. Slongo ◽  
R. Marcello ◽  
F. Ferrara ◽  
G. Battistella ◽  
H. Heras Salvat ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
North East ◽  
The North ◽  
Inflammatory Bowel

scholarly journals The Changing Epidemiology of Inflammatory Bowel Disease: What Goes Up May Come Down

2019 ◽  
Vol 26 (4) ◽  
pp. 591-592 ◽  
Author(s):  
Hamed Khalili
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Incidence ◽  
Temporal Trends ◽  
Epidemiologic Studies ◽  
Incidence Rates ◽  
Western World ◽  
Geographic Variations ◽  
Newly Industrialized Countries ◽  
Inflammatory Bowel

Abstract Recent epidemiologic studies have shown that although the incidence of inflammatory bowel disease (IBD) is rapidly increasing in newly industrialized countries, at the turn of the 21st century the incidence had stabilized in the Western world. In this issue of Inflammatory Bowel Diseases, Torabi and colleagues present their findings on the temporal trends and geographic variations in IBD incidence in Manitoba from 1990 to 2012 using the Manitoba Health population registry and the University of Manitoba IBD epidemiology database. Their results demonstrate an overall decrease in the incidence of IBD during the study period. They also found significant regional variations in disease incidence within Manitoba, with rates of new diagnosis of IBD remaining high in several regions. Lastly, the study found that a higher proportion of the indigenous population had a lower rate of IBD. These findings provide new insights on the changing epidemiology of IBD in the Western world. The overall declining incidence of IBD and identification of persistently low and high-risk populations in Manitoba, which traditionally has had some of the highest incidence rates of IBD, is intriguing and can provide new avenues of research for epidemiologists in the field.

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