Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study

Abstract Background Understanding ulcerative colitis (UC) disease activity assessed via the full, modified or partial Mayo Score may help clinicians apply results from clinical trials to practice and facilitate interpretation of recent and older studies. Methods Mayo Score variables were assessed in a cross-sectional study of 2608 UC patients. Results Permutations of Mayo Scores were highly correlated, and models predicting the omitted variable from each permutation demonstrated significant agreement between predicted and observed values. Conclusions Partial/modified Mayo Scores may be used to predict endoscopic and Physician's Global Assessment scores, and serve as proxies for the full Mayo Score in clinical practice/trials.

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Comparison of predicted psychological distress among workers between artificial intelligence and psychiatrists: a cross-sectional study in Tsukuba Science City, Japan

BMJ Open ◽

10.1136/bmjopen-2020-046265 ◽

2021 ◽

Vol 11 (6) ◽

pp. e046265

Author(s):

Shotaro Doki ◽

Shinichiro Sasahara ◽

Daisuke Hori ◽

Yuichi Oi ◽

Tsukasa Takahashi ◽

...

Keyword(s):

Neural Network ◽

Artificial Intelligence ◽

Psychological Distress ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Explanatory Variables ◽

The Neural Network ◽

Significant Difference ◽

Total Data

ObjectivesPsychological distress is a worldwide problem and a serious problem that needs to be addressed in the field of occupational health. This study aimed to use artificial intelligence (AI) to predict psychological distress among workers using sociodemographic, lifestyle and sleep factors, not subjective information such as mood and emotion, and to examine the performance of the AI models through a comparison with psychiatrists.DesignCross-sectional study.SettingWe conducted a survey on psychological distress and living conditions among workers. An AI model for predicting psychological distress was created and then the results were compared in terms of accuracy with predictions made by psychiatrists.ParticipantsAn AI model of the neural network and six psychiatrists.Primary outcomeThe accuracies of the AI model and psychiatrists for predicting psychological distress.MethodsIn total, data from 7251 workers were analysed to predict moderate and severe psychological distress. An AI model of the neural network was created and accuracy, sensitivity and specificity were calculated. Six psychiatrists used the same data as the AI model to predict psychological distress and conduct a comparison with the AI model.ResultsThe accuracies of the AI model and psychiatrists for predicting moderate psychological distress were 65.2% and 64.4%, respectively, showing no significant difference. The accuracies of the AI model and psychiatrists for predicting severe psychological distress were 89.9% and 85.5%, respectively, indicating that the AI model had significantly higher accuracy.ConclusionsA machine learning model was successfully developed to screen workers with depressed mood. The explanatory variables used for the predictions did not directly ask about mood. Therefore, this newly developed model appears to be able to predict psychological distress among workers easily, regardless of their subjective views.

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Predictive value of rectal aberrant crypt foci for intraepithelial neoplasia in ulcerative colitis – a cross-sectional study

Scandinavian Journal of Gastroenterology ◽

10.3109/00365521.2014.951390 ◽

2014 ◽

Vol 49 (10) ◽

pp. 1219-1229 ◽

Cited By ~ 2

Author(s):

Paulo Freire ◽

Pedro Figueiredo ◽

Ricardo Cardoso ◽

Maria Manuel Donato ◽

Manuela Ferreira ◽

...

Keyword(s):

Ulcerative Colitis ◽

Predictive Value ◽

Intraepithelial Neoplasia ◽

Cross Sectional Study ◽

Aberrant Crypt Foci ◽

Sectional Study ◽

Cross Sectional

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COVID-19 Vaccine Hesitancy among Patients with Inflammatory Bowel Disease Receiving Biologic Therapies in Kuwait: A Cross-Sectional Study

Vaccines ◽

10.3390/vaccines10010055 ◽

2021 ◽

Vol 10 (1) ◽

pp. 55

Author(s):

Mohammad Shehab ◽

Yasmin Zurba ◽

Ali Al Abdulsalam ◽

Ahmad Alfadhli ◽

Sara Elouali

Keyword(s):

Ulcerative Colitis ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Cross Sectional Study ◽

Biologic Therapies ◽

Sectional Study ◽

Cross Sectional ◽

Female Patients ◽

Inflammatory Bowel ◽

To Receive

Background: COVID-19 vaccinations have been shown to be effective in reducing risk of severe infection, hospitalization, and death. They have also been shown to be safe and effective in patients with inflammatory bowel disease (IBD) who are receiving biologic therapies. In this study, we aimed to evaluate the prevalence of vaccination among patients receiving biologic therapies for IBD. Methods: A single-center prospective cross-sectional study conducted at a tertiary care inflammatory bowel disease center in Kuwait. Data from patients with inflammatory bowel disease (IBD) who attended the gastroenterology infusion clinic from 1 June 2021 until 31 October 2021 were retrieved. Patients who received infliximab or vedolizumab at least six weeks before recruitment were included. The primary outcome was prevalence of COVID-19 vaccination. The secondary outcome was to assess whether prevalence of COVID-19 vaccination differed based on sex, age, type of biologic therapy and nationality. Results: The total number of inflammatory bowel disease (IBD) patients enrolled in the study was 280 (56.0% male and 44.0% female). Of the total, 112 (40.0%) patients were diagnosed with ulcerative colitis and 168 (60.0%) with Crohn’s disease. The number of ulcerative colitis patients who were vaccinated was 49 (43.8%) and the number of Crohn’s disease patients who were vaccinated was 68 (40.5%). The median age was 33.2 years and BMI was 24.8 kg/m2. With respect to the total number of patients, 117 (41.8%) were vaccinated with either BNT162b2 or ChAdOx1 nCoV-19 and 163 (58.2%) were not vaccinated. Female patients were more likely to receive the vaccine compared to male patients (83.0% vs. 63.8%, p < 0.001). In addition, patients above the age 50 were more likely to receive the vaccine than patients below the age of 50 (95.6% vs. 31.2% p < 0.001). Expatriates were more likely to receive the vaccine than citizens (84.8% vs. 25.0%, p < 0.001). There was no statistical difference between patients on infliximab and vedolizumab with regard to prevalence of vaccination (40.0% vs 48.0%, p = 0.34). Conclusion: The overall prevalence of COVID-19 vaccination among patients with inflammatory bowel disease (IBD) on biologic therapies was lower than that of the general population and world health organization (WHO) recom-mendation. Female patients, patients above the age of 50, and expatriates were more likely to receive the vaccine. Physicians should reinforce the safety and efficacy of COVID-19 vaccines among patients, especially IBD patients on biologic therapies, who express hesitancy towards them.

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Factors associated with disability in patients with ulcerative colitis: A cross‐sectional study

Journal of Digestive Diseases ◽

10.1111/1751-2980.12837 ◽

2020 ◽

Vol 21 (2) ◽

pp. 81-87 ◽

Cited By ~ 1

Author(s):

Carla Marinelli ◽

Fabiana Zingone ◽

Marco Inferrera ◽

Greta Lorenzon ◽

Alessandra Rigo ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated

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P457 IBD couples and their offspring: a European survey

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.586 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S407-S408

Author(s):

A Oliveira ◽

M P Costa-Santos ◽

C Frias Gomes ◽

J Sabino ◽

A Sampaio ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cross Sectional Study ◽

Cumulative Probability ◽

European Federation ◽

Sectional Study ◽

Cross Sectional ◽

Electronic Survey ◽

Increased Risk ◽

National Patient ◽

Inflammatory Bowel

Abstract Background Small studies have shown that the frequency of inflammatory bowel disease (IBD) is significantly increased after marriage to an individual with the disease relative to what would be expected by chance alone. Furthermore, the offspring of these couples have a significantly increased risk of developing the disease. The aim of this study was to identify couples where both spouses have IBD and their offspring in a larger cohort and to characterise their phenotype. Methods This was a cross-sectional study including couples where both members were affected with IBD and their offspring. An electronic survey in seven languages was distributed by the European Crohn’s and Colitis Organization (ECCO), European Federation of Crohn’s and Ulcerative Colitis Associations (EFCCA) and national patient′s associations from June 2018 to December 2019. Results We identified 51 couples where both members had IBD. There was consanguinity in one couple. There was a representation of couples living in nine different countries. Thirty (59%) couples were concordant for IBD, 14 for Crohn’s disease (CD) and 16 for ulcerative colitis (UC). Within 49 couples, 21 (43%) were diagnosed prior to cohabitation, in 7 (14%) one spouse was diagnosed before and the other after a mean of 7.2 ± 8.9 years after cohabitation, and in 21 (43%) the onset of disease was after cohabitation for both (the first member developed IBD after a mean of 8.3 ± 8.4 years of cohabitation and the second one 4.1 ± 4.5 years after the first). The prevalence of IBD in the 58 children born from these couples was 9%. The cumulative probability of developing disease in the progeny was 3% at 10 years, 11% at 15 years and 15% at 20 years of age. Conclusion This survey identified 51 couples with IBD across Europe; 59% were concordant for IBD type and in 57% the diagnosis of at least one spouse was made after cohabitation. In a wider population, the risk for the progeny was at most 15% at the age of 20, lower than previously reported.

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A cross-sectional study of 130 Brazilian patients with Crohn’s disease and ulcerative colitis: analysis of articular and ophthalmologic manifestations

Clinical Rheumatology ◽

10.1007/s10067-007-0797-5 ◽

2007 ◽

Vol 27 (4) ◽

pp. 503-509 ◽

Cited By ~ 45

Author(s):

Cristina Costa Duarte Lanna ◽

Maria de Lourdes Abreu Ferrari ◽

Sidney Lemos Rocha ◽

Evaldo Nascimento ◽

Marco Antônio Parreiras de Carvalho ◽

...

Keyword(s):

Ulcerative Colitis ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Prevalence of inflammatory bowel disease in the Australian general practice population: A cross-sectional study

PLoS ONE ◽

10.1371/journal.pone.0252458 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0252458

Author(s):

Doreen Busingye ◽

Allan Pollack ◽

Kendal Chidwick

Keyword(s):

Ulcerative Colitis ◽

General Practice ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

Practice Population ◽

Inflammatory Bowel

The burden of inflammatory bowel disease (IBD) in Australia is increasing but national data about the current prevalence are limited. We aimed to estimate the prevalence of IBD (including Crohn’s disease, ulcerative colitis and unspecified IBD) as well as Crohn’s disease and ulcerative colitis separately in a general practice population in Australia. We also assessed risk factors associated with Crohn’s disease and ulcerative colitis. We conducted a cross-sectional study using data from MedicineInsight, a national database of general practice electronic health records, from 1 July 2017 to 30 June 2019. The prevalence of IBD was calculated and stratified by sociodemographic characteristics. Logistic regression analysis was conducted to assess risk factors associated with Crohn’s disease and ulcerative colitis. The study comprised 2,428,461 regular patients from 481 practices. The estimated crude prevalence of IBD was 653 per 100,000 patients; Crohn’s disease was 306 per 100,000 and ulcerative colitis was 334 per 100,000. Males were independently associated with a lower risk of Crohn’s disease (OR: 0.86; 95% CI: 0.81, 0.90) but a greater risk of ulcerative colitis (OR: 1.12; 95% CI: 1.06, 1.17) than females. Compared to non-smokers, patients who were current smokers were associated with a greater risk of Crohn’s disease (OR: 1.13; 95% CI: 1.04, 1.23) but a lower risk of ulcerative colitis (OR: 0.52; 95% CI: 0.47, 0.57). Other factors positively associated with both Crohn’s disease and ulcerative colitis were age (≥ 25 years), non-Indigenous status and socioeconomic advantage. Our findings provide a current estimate of the prevalence of IBD, Crohn’s disease and ulcerative colitis in a large national general practice population in Australia and an assessment of the factors associated with Crohn’s disease and ulcerative colitis. These data can assist in estimating the health burden and costs, and planning for health services.

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