scholarly journals MP49: Does reduced cough capacity in minor thoracic trauma leads to more atelectasis development?

CJEM ◽  
2020 ◽  
Vol 22 (S1) ◽  
pp. S60-S60
Author(s):  
M. Emond ◽  
S. Hegg ◽  
E. Thériault

Introduction: Minor thoracic trauma (MTI) accounts for approximately 15% of all injuries treated in the emergency department (ED). Many of which are minor and will be handle on an outpatient basis. MTI and rib fractures especially cause non-negligible pain. The pain experienced by patients can lead to reduce pulmonary function, decrease mucous clearance and decrease cough capacity leading in infectious problems and atelectasis. To our knowledge, there is no study of atelectasis development caused by reduced cough capacity in the setting of MTI. Objective: Evaluate if a variation in cough capacity leads to atelectasis development. Evaluate if there was a difference in cough capacity perception between the nurse, the physician and the patient himself. Methods: A prospective observational cohort study (2006-2012) in 4 ED recruited patients with a chief complaint of MTI, ≥ 16 years old, discharged home from the ED. Exclusion criteria: 1) a confirmed hemothorax, pneumothorax, fail chest, lung contusion or any other important thoracic or abdominal internal injury at the initial visit or unable to attend follow-up visits. Patients were assessed at 7- and 14- days. For each patient, age, sex, mechanism of injury, dyspnea, COPD/asthma and smoking status were collected. Chest x-ray was done at each visit; pulmonary complications were assessed by a blind radiologist. Cough capacity was assessed on a scale of 0 to 10 by a nurse, physician and patient himself at 0, 7- and 14- days. Pain was scored on a scale of 0 to 10. Chi -squared and odds ratio (IC: 95%. p ≤ 0.05) were assessed to determine if the cough capacity variation leads to atelectasis development. A Pearson correlation test was assessed the correlation in cough capacity among participants. Results: 1474 patients were recruited. Initial visit: 9% had atelectasis, 7 days: 7% and 4.6% at 14 days. 1105 patients were retained for analysis after exclusion of missing data. The median initial pain score was 7-8 for all patient categories. At 7 days, the odds ratio of atelectasis development were (score (0-3) 1.18 (0.42-3.34); score (4-7) 1.20 (0.48-3.03); p<=0.05). The Pearson correlation of cough capacity assessment, in patients without atelectasis were (0.53 nurse vs. patient; 0.37 physician vs. patient; 0.51 nurse vs. physician p<=0.05). As for the cough capacity perception correlation in patients with atelectasis were (0.62 nurse vs. patient; 0.40 physician vs. patient; 0.51 nurse vs. physician; p<=0.05). Conclusion: There is no statistically significant difference in atelectasis development depending on cough capacity and there is poor correlation regarding the perception of cough capacity except for the nurse. It would be interesting to develop a patient reported outcome measure questionnaire which targets minor thoracic trauma as it is a common emergency department complaint and it could help us improve medical management and patient quality of life

2021 ◽  
Author(s):  
Ori Haisraely ◽  
Yaacov Richard Lawrence ◽  
Ron Lewin ◽  
Orit Kaidar-Person ◽  
Ilana Weiss ◽  
...  

Abstract Purpose: To evaluate urinary continence and sexual potency following radical prostatectomy and adjuvant radiotherapy. Materials/Methods: Expanded Prostate Cancer Index Composite (EPIC) surveys of patients with localized prostate cancer treated with surgery followed by adjuvant/salvage pelvic radiotherapy (S+RT) were analyzed. A control cohort was primary radiotherapy (RT). Results: Surveys at least 1 year after treatment were available for 130 S+RT and 374 RT patients. For S+RT vs. RT, the mean urinary incontinence score was 68 [6.25 -100] versus 86.4 [CI-95 39.5-100] (p<0.001), confirming 6.5 points of clinically significant difference. The adjusted odds ratio for superior urinary function was 2.67 (1.7-4.1, p<0.001) for primary radiotherapy. The odds ratio of having both poor urinary and sexual performance was 0.29 in RT arm (0.14-0.58, p<0.001) when adjusted to age and ADT use, group risk stratification, co morbidities and smoking status. Conclusion: In this cross sectional study, Surgery with adjuvant/salvage RT was associated with significantly worse patient reported urinary continence outcomes at 1-year post treatment, lower odds of achieving perfect urinary continence and a threefold risk of reverse ‘bifecta’ with inferior urinary continence and sexual performance. Longitudinal studies of evolving toxicity are required to validate these findings.


2021 ◽  
Author(s):  
Ori Haisraely ◽  
Yaacov Richard Lawrence ◽  
Ron Lewin ◽  
Orit Kaidar-Person ◽  
Ilana Weiss ◽  
...  

Abstract Purpose: To evaluate urinary continence and sexual potency following radical prostatectomy and adjuvant radiotherapy.Materials/Methods: Expanded Prostate Cancer Index Composite (EPIC) surveys of patients with localized prostate cancer treated with surgery followed by adjuvant/salvage pelvic radiotherapy (S+RT) were analyzed. A control cohort was primary radiotherapy (RT). Reverse "bifecta" was defined as a score less than 60 in both incontinence and sexual domains. Superior urinary function was defined as a score above 90. The clinically important difference was calculated using a distribution approach.Results: Surveys at least 1 year after treatment were available for 130 S+RT and 374 RT patients. For S+RT vs. RT, the mean urinary incontinence score was 68 [6.25 -100] versus 86.4 [CI-95 39.5-100] (p<0.001), confirming 6.5 points of clinically significant difference. The adjusted odds ratio for superior urinary function was 2.67 (1.7-4.1, p<0.001) for primary radiotherapy. The odds ratio of having both poor urinary and sexual performance (reverse " bifecta") was 0.29 in RT arm (0.14-0.58, p<0.001) when adjusted for age and Androgen Deprivation Therapy (ADT) , group risk stratification, comorbidities and smoking status.Conclusion: In this cross sectional study, Surgery with adjuvant/salvage RT was associated with significantly worse patient reported urinary continence outcomes at 1-year post treatment, lower odds of achieving perfect urinary continence and a threefold risk of reverse ‘bifecta’ with inferior urinary continence and sexual performance. Longitudinal studies of evolving toxicity are required to validate these findings. Patients referred for surgery with a high probability of requiring adjuvant or salvage radiotherapy should be informed regarding the potential composite toxicity of both surgery and radiotherapy.


2017 ◽  
Vol 07 (01) ◽  
pp. 051-056 ◽  
Author(s):  
John Williams ◽  
Hadley Weiner ◽  
Andrew Tyser

Background Proximal row carpectomy (PRC) and four-corner arthrodesis (FCA) are common surgical procedures used to treat degenerative wrist conditions; however, complications and failures can occur. Purpose This study aimed to investigate and compare the long-term rate of secondary surgeries including conversion to total wrist arthrodesis in patients who underwent PRC or FCA. Materials and Methods A retrospective chart review of all patients who underwent PRC or FCA in the past 20 years at a tertiary referral institution and associated Veterans Affairs (VA) hospital was performed. Patient demographics, comorbidities, surgical indications, and associated complications were tabulated. Patients were contacted via phone to obtain additional follow-up information regarding any additional surgeries, 10-point visual analog scale (VAS) for pain, quick Disabilities of the Arm, Shoulder, and Hand (quickDASH) scores, hand dominance, and occupational data. Results A total of 123 wrists made up the final dataset. Sixty-two wrists treated with PRC and 61 wrists treated with FCA were reviewed at a mean follow-up of 8.2 years. We did not find a significant difference in the rate of conversion to total wrist arthrodesis between the PRC (14.5%) and FCA (19.5%, p = 0.51) cohorts. Secondary operations were significantly greater in the FCA group (34.4%) compared with the PRC group (16.1%, p = 0.02). Females were 2.6 times more likely than males to undergo secondary operations when controlling for surgical procedure and smoking status (p = 0.04). We did not detect a significant difference in VAS pain or in quickDASH scores between the two groups (p = 0.35, 0.48, respectively). Conclusion PRC and FCA have comparable patient reported outcomes and wrist arthrodesis conversion rates at a mean follow-up of 8.2 years. In contrast, the FCA patient group had a significantly higher rate of secondary operations, including those for nonunion, symptomatic hardware, and other implant-related issues, when combined with wrist arthrodesis conversion. Level of Evidence Level IV, therapeutic study.


2020 ◽  
Vol 8 (11) ◽  
pp. 232596712096453
Author(s):  
Kyle R. Sochacki ◽  
Marc R. Safran ◽  
Geoffrey D. Abrams ◽  
Joseph Donahue ◽  
Constance Chu ◽  
...  

Background: Studies have reported relatively high failure rates of isolated meniscal repairs. Platelet-rich plasma (PRP) has been suggested as a way to increase growth factors that enhance healing. Purpose: To compare (1) meniscal repair failures and (2) patient-reported outcomes after isolated arthroscopic meniscal repair augmented with and without PRP. Study Design: Systematic review; Level of evidence, 3. Methods: A systematic review was performed using the PRISMA (Preferred Reporting Items for Systematic Meta-Analyses) guidelines. Multiple databases were searched for studies that compared outcomes of isolated arthroscopic meniscal repair augmented with PRP versus without PRP in human patients. Failures and patient-reported outcome scores were reported for each study and compared between groups. Study heterogeneity was assessed using I 2 for each outcome measure before meta-analysis. Study methodological quality was analyzed. Continuous variable data were reported as mean and standard deviation from the mean. Categorical variable data were reported as frequency with percentage. All P values were reported with significance set at P < .05. Results: Five articles were analyzed (274 patients [110 with PRP and 164 without PRP]; 65.8% male; mean age, 29.1 ± 4.6 years; mean follow-up, 29.2 ± 22.1 months). The risk of meniscal repair failure ranged from 4.4% to 26.7% for PRP-augmented repairs and 13.3% to 50.0% for repairs without PRP. Meniscal repairs augmented with PRP had significantly lower failure rates than repairs without PRP (odds ratio, 0.32; 95% CI, 0.12-0.90; P = .03). One of the 5 studies reported significantly higher outcomes in the PRP-augmented group versus the no-PRP group for the International Knee Documentation Committee (IKDC), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Knee injury and Osteoarthritis Outcome Score (KOOS) ( P < .05 for all). The remaining 4 studies reported no significant difference between groups with regard to outcomes for the IKDC, Lysholm knee scale, visual analog scale for pain, or Tegner activity level. Conclusion: Although the studies were of mostly of low quality, isolated arthroscopic meniscal repairs augmented with PRP led to significantly lower failure rates (10.8% vs 27.0%; odds ratio, 0.32; P = .03) as compared with repairs without PRP. However, most studies reported no significant differences in patient-reported outcomes.


Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4211-4211
Author(s):  
Sarah A Bennett ◽  
Lara N Roberts ◽  
Rosie Rogers ◽  
Lynda Bonner ◽  
Raj K Patel ◽  
...  

Abstract Abstract 4211 Platelet size is thought to reflect reactivity; Mean platelet volume (MPV) was recently reported as a possible predictor for VTE, but it is not clear whether ethnic origin impacts on this risk factor. King's serves an ethnically diverse community and to assess whether MPV is a predictor of VTE in our population, we conducted a retrospective analysis of consecutive patients referred to our DVT service between January 2007 and October 2009. Patients with a confirmed first lower limb DVT (provoked n=153, unprovoked n=110) were included as subjects and controls (n=151) were derived from consecutive patients referred with objective exclusion of a DVT and no previous history of VTE, active cancer or surgery in the previous 6 weeks. All patients had a full blood count at presentation analysed on an automated analyser (using optical light scatter for MPV) within 4 hours of collection. There was no difference in mean age (54.7 vs 54.8), smoking status or ethnic group (51% vs 52.3% white, 38.4% vs 33.8% black and 10.6% vs 13.9% other) between subjects and controls respectively. Males accounted for 47.5% of subjects and 27.2% of controls. DVTs were unprovoked in 41.8% with 13.7% associated with surgery, 7.6% cancer, 10.6% pregnancy or hormone therapy. The remainder (25.1%) were secondary to cast, trauma, immobilisation or travel. Mean MPV was significantly higher in subjects than controls (8.17 vs 7.79, p=0.001) with a more marked difference in those with unprovoked DVT compared with controls (8.28 vs 7.79, p<0.001). The platelet count was lower in the DVT group (median, range 270, 21–812 vs 293, 31–642 p=0.027), with a more marked difference in those with unprovoked DVT (median, range 250, 21–584 vs 293, 31–642 p<0.001). Relative risk associated with MPV > 9.18 (90th centile) was 1.26 (95% CI 1.08– 4.76, p=0.01) and increased to 1.59 (1.18-2.1, p=0.008) in those with unprovoked DVT. Relative risk associated with platelet count <210 (10th centile) was 1.21 (1.02-1.43, p=0.06) and increased with unprovoked DVT to 1.70 (1.3-2.2, p=0.002). An inverse correlation between MPV and platelet count was confirmed (-0.305, p<0.001). Logistic regression was undertaken to investigate effect of MPV, platelet count, age and smoking status. MPV was the only significant risk factor for DVT with odds ratio 1.39 (1.14-1.68). For unprovoked DVT, both MPV and platelet count contributed to risk with odds ratio of 1.36 (1.06-1.74, p=0.015) and 0.997 (0.994-1.0, p=0.037) respectively. Further analysis was undertaken to compare MPV in white (provoked 84, unprovoked 50, controls 79) and black (provoked 55, unprovoked 46, controls 51) subgroups. There was no difference in mean age between white and black subjects or controls. Interestingly, in the black subgroup 73.9% of males had an unprovoked DVT compared with 26.1% of females. This gender difference was not seen in the white subgroup (unprovoked 37.9% males, 36.8% females) and was not explained by the presence of pregnancy or hormone use (18 vs 18.4% black vs white females). There was no significant difference in MPV or platelet count between white and black subjects or white and black controls. There remained a significant difference between white subjects and white controls mean MPV (8.1 vs 7.7, p=0.014) accentuated in the unprovoked subgroup (8.3 vs7.7, P=0.007); median platelet count was only significantly lower for unprovoked DVT compared to controls (251.5, 21–509 vs 285, 31–687, p=0.02). MPV was also significantly higher in black subjects compared to controls (8.3 vs 7.8, p=0.011), and platelet count was significantly lower (256, 129–811 vs 293, 138–642 p=0.032). MPV was no different between unprovoked DVTs and controls, however the effect of platelet count was accentuated (244.5, 167–584 vs 293, 138–642 p<.001). Logistic regression confirmed male gender as the only predictive factor for unprovoked VTE in the black subgroup (OR 5.8, 95% CI 2.36–14, p<0.001); neither MPV nor platelet count contributed to DVT risk. Limitations include the retrospective nature of the study, number of subjects, unavailable body mass indices and the discrepant gender distribution between controls and subjects. In summary, MPV is a risk factor for DVT in both white and black populations, though this link appears to hold true for unprovoked DVT in white populations only. Disclosures: No relevant conflicts of interest to declare.


2017 ◽  
Vol 42 (7) ◽  
pp. 742-746 ◽  
Author(s):  
R. M. Zimmerman ◽  
E. Paryavi ◽  
N. B. Zimmerman ◽  
K. R. Means

A multicentre database was used to compare complications in 231 patients with an elevated International Normalized Ratio with 1626 control patients with a normal International Normalized Ratio. Patients with International Normalized Ratios measured within 48 hours of hand surgery were identified. Logistic regression models were used to assess the association between anticoagulation and reoperation rates, emergency department visits and hospital readmissions for the first 30 days after operation. The group with a raised International Normalized Ratio had a significantly higher Charlson Comorbidity Score. An elevated International Normalized Ratio was associated with an odds ratio for a post-operative emergency department visit of 3.3 and an odds ratio of 4.7 for readmission. There was no statistically significant difference in early reoperations between the two groups. Level of evidence: III


2020 ◽  
Author(s):  
Robert Clark Wu ◽  
Vikas Patel ◽  
Sabreena Moosa ◽  
Laura Langer ◽  
Thomas E. MacMillan ◽  
...  

Abstract BackgroundWearable devices such as Fitbits may provide important insights about hospitalized patients that include data on low activity and poor sleep. Monitoring this information could spur interventions to improve mobility and sleep which may reduce the adverse effects associated with hospitalization. However, there is a lack of studies assessing the accuracy of wearables in hospitalized medical patients. The purpose of our study was to determine the accuracy of Fitbit heart rate, sleep and physical activity in hospitalized medical patients.MethodsWe conducted a prospective cohort feasibility study enrolling 50 medical inpatients at two hospitals providing them with a Fitbit Charge. Our main measures were Fitbit heart rate, sleep and activity data as well as nurse recorded heart rates, patient reported sleep, and nurse assessments of activity.ResultsOf the 50 patients who consented to the study, 47 patients wore the devices. Comparing pairs of heart rate data from Fitbit and nurse recorded vital signs for the same minute, there were 261 pairs available for comparison. The mean difference was 0.45 bpm (SD: 13.0, Pearson correlation: 0.68 P<0.001) and the 95% limits of agreement were -25 to 26 bpm. The association between the patient-reported sleep score and Fitbit total sleep duration was 0.19 (P=0.24) and between the self-reported hours of sleep and Fitbit total sleep duration was 0.21 (P=0.21). The correlation between nurse-recorded activity and Fitbit daily steps was 0.06 (P=0.52). ConclusionsFitbit heart rates correlated well with nurse-recorded heart rate but did not correlate well with nurse assessments of activity nor with patient self-assessment of sleep. This study highlights limitations of the accuracy of current wearable wrist-worn device algorithms in activity and sleep detection in patients in hospital. The findings call into question the validity of Fitbits for assessment of patient activity and sleep in the hospital setting and suggest that they should not be routinely used without further validation.Trial RegistrationClinicalTrials.gov NCT03646435


2020 ◽  
Author(s):  
Robert Clark Wu ◽  
Vikas Patel ◽  
Sabreena Moosa ◽  
Laura Langer ◽  
Thomas E. MacMillan ◽  
...  

Abstract Background: Wearable devices such as Fitbits may provide important insights about hospitalized patients that include data on low activity and poor sleep. Monitoring this information could spur interventions to improve mobility and sleep which may reduce the adverse effects associated with hospitalization. However, there is a lack of studies assessing the accuracy of wearables in hospitalized medical patients. The purpose of our study was to determine the accuracy of Fitbit heart rate, sleep and physical activity in hospitalized medical patients.Methods: We conducted a prospective cohort feasibility study enrolling 50 medical inpatients at two hospitals providing them with a wrist-worn Fitbit Charge. Our main measures were Fitbit heart rate, sleep and activity data as well as nurse recorded heart rates, patient reported sleep, and nurse assessments of activity.Results: Of the 50 patients who consented to the study, 47 patients wore the devices. Comparing pairs of heart rate data from Fitbit and nurse recorded vital signs for the same minute, there were 261 pairs available for comparison. The mean difference was 0.45 bpm (SD: 13.0, Pearson correlation: 0.68 P<0.001) and the 95% limits of agreement were -25 to 26 bpm. The association between the patient-reported sleep score and Fitbit total sleep duration was 0.19 (P=0.24) and between the self-reported hours of sleep and Fitbit total sleep duration was 0.21 (P=0.21). The correlation between nurse-recorded activity and Fitbit daily steps was 0.06 (P=0.52). Conclusions: Fitbit heart rates correlated well with nurse-recorded heart rate but did not correlate well with nurse assessments of activity nor with patient self-assessment of sleep. This study highlights limitations of the accuracy of current wearable wrist-worn device algorithms in activity and sleep detection in patients in hospital. The findings call into question the validity of Fitbits for assessment of patient activity and sleep in the hospital setting and suggest that they should not be routinely used without further validation.Trial Registration: ClinicalTrials.gov NCT03646435


1986 ◽  
Vol 56 (03) ◽  
pp. 250-255 ◽  
Author(s):  
C Boyer ◽  
M Wolf ◽  
C Rothschild ◽  
M Migaud ◽  
J Amiral ◽  
...  

SummaryA new solid phase enzyme-linked immunosorbent assay (ELISA) was developed for the quantitation of human Factor VII antigen (F VII Ag), using a monospecific rabbit anti-F VII antiserum. Anti-F VII F(ab′)2 fragments were adsorbed to polystyrene plates. The binding of serial dilutions of control or test plasma, containing F VII, was detected by incubation with peroxidase-labeled anti- FV II IgG followed by the addition of hydrogen peroxyde and O-phenylenediamine. This ELISA is specific, sensitive (detection limit: 0.05%) and accurate (coefficient of variation: 1.5-4% for within- and 1.6-9% for between-assays). F VII coagulant activity (F VII C) and F VII Ag were determined in large populations of controls and patients. In normal plasma (n = 38), F VII Ag ranged from 83 to 117% and the correlation coefficient between F VII Ag and F VII C was 0.94. In patients with severe (F VII C inf. 1%) congenital F VII deficiency (n = 5), F VII Ag was undetectable in two cases (inf. 0.05%) and markedly reduced (0.35 to 5.6%) in the three other cases. In patients with liver cirrhosis (n = 15), F VII Ag ranged from 21 to 59% and was in good correlation with F VII C (r = 0.84). In dicoumarol treated patients (n = 15), the levels of F VII Ag ranged from 51% to 79% and a poor correlation (r = 0.52) with F VIIC was observed. In “compensated” DIC (n = 5), levels of F VII Ag varied from 60 to 186%, with significantly higher F VII C levels (from 143 to 189%). In contrast, in “decompensated” DIC (n = 7), low F VII Ag and F VII C levels were observed (from 7 to 27%). In patients with deep-vein thrombosis (n = 25), high levels of F VII Ag (from 102 to 136%) and F VII C (from 110 to 150%) were demonstrated. In surgical patients, no significant difference was observed before and one day after intervention.


2018 ◽  
Vol 7 (4) ◽  
pp. 42-49 ◽  
Author(s):  
Korkmaz YİĞİTER ◽  
Hakan TOSUN

The aim of this study is to investigate the effects of participation in a 1-week summer camp on thehopelessness and self-esteem of the university students attending Sport Sciences Faculty. Participants were 36university students assigned to experiment group using a random procedure. Coopersmith Self-esteem and Beck Hopelessness Scales were completed at the beginning and end of the summer camp by designed the university. The obtained data were analysed in the SPSS 18.0 program and the significance level was taken as 0.05. The descriptive statistics, independent simple t test, paired simple t test and Pearson correlation were used for analyse the data in the study. According to the results of the research, no significant difference was observed in the comparison of the hopelessness and self-esteem levels between pre and post-test. In addition, there was a significant difference in the hopelessness level of male and female students but any significant difference was not observed in terms of self-esteem. There was a significant relationship between hopelessness and self-esteem pre and post-test. These result shows that a 1-week summer camp cannot change the hopelessness or self-esteem level. However, as the self-esteem rises, the rate of despair decreases whereas as the despair rises, the selfesteem decreases.


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