Risk Factors for Central Line–Associated Bloodstream Infections in the Era of Prevention Bundles

2014 ◽  
Vol 36 (2) ◽  
pp. 214-216 ◽  
Author(s):  
Devin Callister ◽  
Pauline Limchaiyawat ◽  
Samantha J. Eells ◽  
Loren G. Miller
Keyword(s):  
Risk Factors ◽  
Bloodstream Infection ◽  
Hemodynamic Monitoring ◽  
Bloodstream Infections ◽  
Central Line ◽  
Infection Risk ◽  
Case Control ◽  
Infect Control Hosp ◽  
Infection Risk Factors ◽  
Independent Risk Factors

Little is known about central line–associated bloodstream infection risk factors in the bundle era. In our case-control investigation, we found that independent risk factors for central line–associated bloodstream infection at our center included the number of recent lab tests, catheter duration, and lack of hemodynamic monitoring as the insertion indication.Infect Control Hosp Epidemiol 2014;00(0): 1–3

Distribution of Central Line-Associated Bloodstream Infections Determined From Washington State’s Annual Reporting Validation Program, 2009–2013

2016 ◽  
Vol 38 (4) ◽  
pp. 489-492
Author(s):  
Jason M. Lempp ◽  
M. Jeanne Cummings ◽  
David W. Birnbaum
Keyword(s):  
Bloodstream Infection ◽  
Healthcare Quality ◽  
Bloodstream Infections ◽  
Central Line ◽  
Infect Control Hosp ◽  
Public Healthcare ◽  
Healthcare Associated Infection ◽  
Reporting Accuracy ◽  
Annual Reporting ◽  
Healthcare Associated

Healthcare-associated infection reporting validation is essential because this information is increasingly used in public healthcare quality assurances and care reimbursement. Washington State’s validation of central line-associated bloodstream infection reporting applies credible quality sciences methods to ensure that hospital reporting accuracy is maintained. This paper details findings and costs from our experience.Infect Control Hosp Epidemiol 2017;38:489–492

Respiratory syncytial virus infection-risk factors for hospital admission: a case-control study

2007 ◽  
Vol 92 (11) ◽  
pp. 1314-1321 ◽  
Author(s):  
HE Nielsen ◽  
V Siersma ◽  
S Andersen ◽  
B Gahrn-Hansen ◽  
CH Mordhorst ◽  
...  
Keyword(s):  
Risk Factors ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Hospital Admission ◽  
Case Control Study ◽  
Infection Risk ◽  
Case Control ◽  
Infection Risk Factors ◽  
Syncytial Virus ◽  
Control Study

scholarly journals Clinical analysis of bloodstream infection of Escherichia coli in patients with pancreatic cancer

2019 ◽  
Author(s):  
Changsen Bai ◽  
Xiuse Zhang ◽  
Dong Yang ◽  
Ding Li ◽  
Wenfang Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Bloodstream Infection ◽  
Multivariate Logistic Regression Analysis ◽  
Bloodstream Infections ◽  
Clinical Analysis ◽  
Infection Group ◽  
Independent Risk Factors

Abstract Background To study the common pathogens and cancer types of bloodstream infection (BSI) in cancer patients, find the risk factors and conduct clinical analysis.Methods The clinical data of 2302 patients with BSI in Tianjin Medical University Cancer Institute and Hospital (TMUCIH) from January 2011 to December 2018 were retrospectively analyzed. 31 pancreatic cancer patients complicated with Escherichia coli BSI and 93 pancreatic cancer patients without BSI at the same period with similar sex and age were divided into infection group and non-infection group.Results 645 strains (28%) of Escherichia coli were the main pathogens causing BSI in patients with cancer. 57 cases (8.8%) of cancer patients with Escherichia coli BSI were from pancreatic oncology department, among which 31 cases were diagnosed as pancreatic cancer by pathology. Multivariate logistic regression analysis showed that hospitalization days≥7, chemotherapy and neutrophil>5.5×10 9 /L were independent risk factors for pancreatic cancer patients complicated with BSI (P < 0.05). Quantitative analysis of serum-related indicators in infection patients and non-infection patients showed significant differences between albumin, prealbumin and neutrophils in infection and non-infection group. The ratio of Escherichia coli producing extended-spectrum ß-lactamase is 49.3 and 48.1 in pancreatic cancer and non-pancreatic patients. Escherichia coli resistant to carbapenems is rare, they were highly sensitive to Cephamycin and Piperacillin/tazobactam.Conclusions Escherichia coli, the main pathogen causing BSI of cancer patients, is more common in pancreatic cancer patients. The independent risk factors include hospitalization days≥7 days, chemotherapy and neutrophils larger than 5.5×10 9 /L. Quantitative indicators of neutrophil counts, albumin and prealbumin contribute to the early diagnosis of bloodstream infections. Early use of medication, while timely adjustment based on clinical drug sensitivity results will help reduce patient morbidity and mortality.

Respiratory syncytial virus infection--risk factors for hospital admission: a case-control study

2003 ◽  
Vol 92 (11) ◽  
pp. 1314-1321 ◽  
Author(s):  
Nielsen HE ◽  
Siersma V ◽  
Andersen S ◽  
Gahrn-Hansen B ◽  
Mordhorst CH ◽  
...  
Keyword(s):  
Risk Factors ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Hospital Admission ◽  
Case Control Study ◽  
Infection Risk ◽  
Case Control ◽  
Infection Risk Factors ◽  
Syncytial Virus ◽  
Control Study

scholarly journals Clinical Analysis of Hospital-acquired Bloodstream Infection in the Elderly

2019 ◽  
Vol 1 (01) ◽  
Author(s):  
Baojun Sun
Keyword(s):  
Risk Factors ◽  
Renal Insufficiency ◽  
Elderly Patients ◽  
Bloodstream Infection ◽  
Sofa Score ◽  
Chronic Renal Insufficiency ◽  
Bloodstream Infections ◽  
The Elderly ◽  
Independent Risk Factors ◽  
Hospital Acquired

Objective: This study was designed to get epidemiological characteristics, etiology characteristics, prognosis assessment and prognostic factors of hospital-acquired bloodstream infection (HABSI) in the elderly in Chinese PLA General Hospital and aimed at providing a reference for HABSI in the elderly on clinical diagnosis and treatment to improve the prognosis. Methods: The clinical data and pathology data of 210 cases of the elderly patients with HABSI from 2009 to 2012 in geriatric wards were retrospectively analyzed. Compare the clinical assessment effects of APACHE-II score, SAPS-II score and SOFA score to HABSI prognosis in the elderly by plotting the receiver operating characteristic curve. Use univariate and multivariate logistic regression analysis to get prognostic factors of HABSI in the elderly. Results: Univariate analysis of mortality: Day 1 apache -> 18 II score, lung infection, invasive ventilation, chronic hepatic insufficiency, chronic renal insufficiency, substantive organ malignant tumor, deep venipuncture, indwelling gastric tube indwelling ureter, complicated with shock and acquired bloodstream infections in the elderly patients with 7 days survival state association is significant. Day-1 SOFA score>7, chronic liver dysfunction, chronic renal insufficiency, concurrent shock, hemodialysis and 28-day survival status of patients with acquired bloodstream infection in elderly hospitals were significantly associated. Multivariate unconditioned logistic regression analysis related to death: Day-1APACHE-II score>18, parenchymal malignant tumors, and concurrent shock are independent risk factors for 7-day death in elderly patients with acquired bloodstream infection. Day-1 SOFA score>7, chronic renal insufficiency, and concurrent shock are independent risk factors for 28-day mortality in elderly patients with acquired bloodstream infection. Conclusion: The incidence of acquired bloodstream infections in the elderly was 1.37%. The 7-day and 28-day mortality rates were 8.10% and 22.38%, respectively. Concurrent shock is 26.7%. The 28-day mortality rate of concurrent shock patients was 48.21%. The best outcome score for the 7-day prognosis of elderly patients with acquired bloodstream infection was the Day-1APACHE-II score, followed by the Day-1 SOFA score. The best score for the 28-day prognostic assessment was the Day-1 SOFA score.

scholarly journals 775. Risk Factors for Healthcare Associated Central Line-Associated Bloodstream Infection (CLABSI) to Identify Novel Infection Prevention Areas - A Case-Control Study

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S484-S485
Author(s):  
Aung Myat Oo ◽  
Pin Hong Jin ◽  
Edwin Philip ◽  
Molly Kue Bien How ◽  
May Kyawt Aung ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bloodstream Infection ◽  
Infection Prevention ◽  
Case Control Study ◽  
Tertiary Care ◽  
Central Line ◽  
Case Control ◽  
Care Hospital ◽  
Healthcare Associated ◽  
Control Study

Abstract Background The International Nosocomial Infection Control Consortium surveillance reported Central line-associated bloodstream infection (CLABSI) rate of 4.1 per 1000 central-line days in 703 ICUs in 50 countries. Methods At the Singapore General Hospital (SGH) a 1,700-bed tertiary care hospital, we conducted a retrospective matched case control study over a 3-year period from 2018 to 2020, to identify risk-factors associated with the development of healthcare associated CLABSI in adult inpatients. Cases and controls were patients ≥18 years of age with central lines in situ for at least 48hrs from date of admission. Case definition was based on National Healthcare Safety Network (NHSN) framework to diagnose Bloodstream Infection (BSI) and CLABSI events. Controls had to be admitted within 30 days of the date of admission of the case patients and should not have developed CLABSI. Cases were matched to controls on a 1:2 ratio. Results 127 cases and 252 controls were included in the analysis. Cases and controls did not differ in age, gender, BMI, presence of diabetes mellitus or presently enforced infection prevention measures (e.g. Central line bundle care). More cases were receiving chemotherapy (10.2% versus 0.8%, p&lt; 0.001), were on TPN (17.3% versus 8.3%, p=0.015) and had been admitted to critical care (73.2% versus 60.7%, p=0.017). Cases were also more likely to have peripherally inserted central venous catheters (37% versus 25%, p=0.017) and have the insertion done in the radiology department under radiological guidance (69.3% versus 55.2%, p=0.011). The median length of stay (LOS) was 44 days (IQR: 0 – 86.8) for cases and 19 days (IQR: 0 - 66.6) for controls (p&lt; 0.001). Inpatient mortality was 25.2% (n=32) for cases 13.9% (n=35) for controls (p-value &lt; 0.010). In multivariate analysis, receiving chemotherapy (OR 11.1, 95%CI: 2.2 – 54.3, p=0.003), being admitted to intensive care unit (ICU) (OR 2.0, 95%CI: 1.1 – 3.8, p=0.019), having a Peripherally Inserted Central Cather (OR 1.8, 95% CI 1.0-3.4, p=0.045), and being colonized with MRSA (OR 1.9, 95%CI: 1.2 – 3.2, p=0.013) were associated with healthcare associated CLABSI. Conclusion Novel approaches are required to reduce risk of healthcare associated CLABSI, focusing on interventions for chemotherapy administration, care within ICUs and PICC lines. Disclosures All Authors: No reported disclosures

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