scholarly journals Re-integrating Archaeology: A Contribution to aDNA Studies and the Migration Discourse on the 3rd Millennium BC in Europe

2019 ◽  
Vol 85 ◽  
pp. 115-129 ◽  
Author(s):  
Martin Furholt
Keyword(s):  
Central Europe ◽  
Group Composition ◽  
Biological Data ◽  
Ongoing Debate ◽  
Archaeological Material ◽  
Archaeological Data ◽  
Archaeological Materials ◽  
Sophisticated Model ◽  
Burial Rituals

Since aDNA research suggested a marked gene influx from Eastern into Central Europe in the 3rd millenniumbc, outdated, simplistic narratives of massive migrations of closed populations have re-appeared in archaeological discussions. A more sophisticated model of migration from the steppes was proposed recently by Kristiansenet al. As a reaction to that proposal, this paper aims to contribute to this ongoing debate by refining the latter model, better integrating archaeological data and anthropological knowledge. It is argued that a polythetic classification of the archaeological material in Central Europe in the 3rd millennium reveals the presence of a new complex of single grave burial rituals which transcends the traditional culture labels. Genetic steppe ancestry is mainly connected to this new kind of burials, rather than to Corded Ware or Bell Beaker materials. Here it is argued that a polythetic view on the archaeological record suggests more complicated histories of migration, population mixtures and interaction than assumed by earlier models, and ways to better integrate detailed studies of archaeological materials with a deeper exploration of anthropological models of mobility and social group composition and the molecular biological data are explored.

scholarly journals ANCA Status or Clinical Phenotype — What Counts More?

2021 ◽  
Vol 23 (6) ◽  
Author(s):  
Martin Windpessl ◽  
Erica L. Bettac ◽  
Philipp Gauckler ◽  
Jae Il Shin ◽  
Duvuru Geetha ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Phenotype ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Cardiovascular Death ◽  
Genetic Associations ◽  
Ongoing Debate ◽  
The Past ◽  
Anca Associated Vasculitis

Abstract Purpose of Review There is ongoing debate concerning the classification of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. That is, whether classification should be based on the serotype (proteinase 3 (PR3)- or myeloperoxidase (MPO)-ANCA) or on the clinical phenotype (granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)). To add clarity, this review focused on integration of the most recent literature. Recent Findings Large clinical trials have provided evidence that a serology-based risk assessment for relapses is more predictive than distinction based on the phenotype. Research conducted in the past decade indicated that a serology-based approach more closely resembles the genetic associations, the clinical presentation (i.e., lung involvement), biomarker biology, treatment response, and is also predicting comorbidities (such as cardiovascular death). Summary Our review highlights that a serology-based approach could replace a phenotype-based approach to classify ANCA-associated vasculitides. In future, clinical trials and observational studies will presumably focus on this distinction and, as such, translate into a “personalized medicine.”

Classifying precontractual liability: a comparative analysis

Legal Studies ◽  
2001 ◽  
Vol 21 (2) ◽  
pp. 153-191 ◽  
Author(s):  
Joachim Dietrich
Keyword(s):  
Common Law ◽  
Civil Law ◽  
Tort Law ◽  
Contract Law ◽  
Common Elements ◽  
Ongoing Debate ◽  
Unjust Enrichment ◽  
The Common ◽  
Initial Focus

The common law has solved questions of liability arising in the context of precontractual negotiations by resort to a range of different doctrines and approaches, adopting in effect ‘piecemeal’ solutions to questions of precontractual liability. Consequently, debate has arisen as to how best to classify or categorise claims for precontractual work and as to which doctrines are best suited to solving problems arising from anticipated contracts. The purpose of this article is to consider this question of how best to classify (cases of) precontractual liability. The initial focus will be on the ongoing debate as to whether principles of contract law or principles of unjust enrichment can better solve problems of precontractual liability. I will be suggesting that unjust enrichment theory offers little by way of explanation of cases of precontractual liability and, indeed, draws on principles of contract law in determining questions of liability for precontractual services rendered, though it does so by formulating those principles under different guises. Irrespective, however, of the doctrines utilised by the common law to impose liability, it is possible to identify a number of common elements unifying all cases of precontractual liability. In identifying such common elements of liability, it is necessary to draw on principles of both contract and tort law. How, then, should cases of precontractual liability best be classified? A consideration of the issue of classification of precontractual liability from a perspective of German civil law will demonstrate that a better understanding of cases of precontractual liability will be gained by classifying such cases as lying between the existing categories of contract and tort.

Surface surveys in the northern Troad and the identification of Çiğlitepe as ancient Arisbe

2017 ◽  
Vol 67 ◽  
pp. 129-144 ◽  
Author(s):  
Nurettin Arslan
Keyword(s):  
Bronze Age ◽  
Western Anatolia ◽  
Late Bronze Age ◽  
Sea Of Marmara ◽  
Large Cities ◽  
Archaeological Material ◽  
Archaeological Data ◽  
Literary Sources ◽  
Ancient City

AbstractThe region known as the Troad in western Anatolia is famed not only as the setting of Homer's Iliad but also for the Hellespont strait (modern Çanakkale Boğazı) linking the Sea of Marmara to the Aegean. In addition to large cities such as Sigeum, Abydus and Lampsacus, ancient writers also mention smaller cities located on the Hellespont. In this article, the location of the ancient city of Arisbe, presumed to have existed between Abydus and Lampsacus, is examined in the light of new archaeological data. Between 2002 and 2010, the author conducted surveys in the northern Troad. These surveys revealed an ancient settlement with archaeological material belonging to the Late Bronze Age, late Geometric, Archaic, Classical and Hellenistic periods. The location of this settlement, the archaeological data and information from ancient literary sources all indicate that this site should be identified as Arisbe.

Alzheimer's Disease Classification Based on Multi-feature Fusion

2019 ◽  
Vol 15 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Nuwan Madusanka ◽  
Heung-Kook Choi ◽  
Jae-Hong So ◽  
Boo-Kyeong Choi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Feature Fusion ◽  
Biological Data ◽  
Correct Classification ◽  
Mr Images ◽  
Correct Classification Rate ◽  
Classification Rate ◽  
Morphometric Features

Background: In this study, we investigated the fusion of texture and morphometric features as a possible diagnostic biomarker for Alzheimer’s Disease (AD). Methods: In particular, we classified subjects with Alzheimer’s disease, Mild Cognitive Impairment (MCI) and Normal Control (NC) based on texture and morphometric features. Currently, neuropsychiatric categorization provides the ground truth for AD and MCI diagnosis. This can then be supported by biological data such as the results of imaging studies. Cerebral atrophy has been shown to correlate strongly with cognitive symptoms. Hence, Magnetic Resonance (MR) images of the brain are important resources for AD diagnosis. In the proposed method, we used three different types of features identified from structural MR images: Gabor, hippocampus morphometric, and Two Dimensional (2D) and Three Dimensional (3D) Gray Level Co-occurrence Matrix (GLCM). The experimental results, obtained using a 5-fold cross-validated Support Vector Machine (SVM) with 2DGLCM and 3DGLCM multi-feature fusion approaches, indicate that we achieved 81.05% ±1.34, 86.61% ±1.25 correct classification rate with 95% Confidence Interval (CI) falls between (80.75-81.35) and (86.33-86.89) respectively, 83.33%±2.15, 84.21%±1.42 sensitivity and 80.95%±1.52, 85.00%±1.24 specificity in our classification of AD against NC subjects, thus outperforming recent works found in the literature. For the classification of MCI against AD, the SVM achieved a 76.31% ± 2.18, 78.95% ±2.26 correct classification rate, 75.00% ±1.34, 76.19%±1.84 sensitivity and 77.78% ±1.14, 82.35% ±1.34 specificity. Results and Conclusion: The results of the third experiment, with MCI against NC, also showed that the multiclass SVM provided highly accurate classification results. These findings suggest that this approach is efficient and may be a promising strategy for obtaining better AD, MCI and NC classification performance.

scholarly journals Optimized artificial neural network for classification of biological data

2018 ◽  
Vol 7 (2) ◽  
pp. 817
Author(s):  
Senthilselvan Natarajan ◽  
Rajarajan S ◽  
Subramaniyaswamy V
Keyword(s):  
Neural Network ◽  
Mental Stress ◽  
Causes Of Death ◽  
Biological Data ◽  
High Dimensionality ◽  
Soft Computing Techniques ◽  
Artificial Neural ◽  
Multi Class Classification ◽  
Neural Networks Optimization

Biological data suffers from the problem of high dimensionality which makes the process of multi-class classification difficult and also these data have elements that are incomplete and redundant. Breast Cancer is currently one of the most pre-dominant causes of death in women around the globe. The current methods for classifying a tumour as malignant or benign involve physical procedures. This often leads to mental stress. Research has now sought to implement soft computing techniques in order to classify tumours based on the data available. In this paper, a novel classifier model is implemented using Artificial Neural Networks. Optimization is done in this neural network by using a meta-heuristic algorithm called the Whale Swarm Algorithm in order to make the classifier model accurate. Experimental results show that new technique outperforms other existing models.

scholarly journals Cardiomyopathy Classification: Ongoing Debate in the Genomics Era

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Charles McCartan ◽  
Robert Mason ◽  
S. R. Jayasinghe ◽  
Lyn R. Griffiths
Keyword(s):  
Adverse Effects ◽  
Genetic Information ◽  
Molecular Basis ◽  
Genetic Basis ◽  
Muscle Size ◽  
Systemic Diseases ◽  
Ongoing Debate ◽  
Traditional Classification ◽  
And Function

Cardiomyopathies represent a group of diseases of the myocardium of the heart and include diseases both primarily of the cardiac muscle and systemic diseases leading to adverse effects on the heart muscle size, shape, and function. Traditionally cardiomyopathies were defined according to phenotypical appearance. Now, as our understanding of the pathophysiology of the different entities classified under each of the different phenotypes improves and our knowledge of the molecular and genetic basis for these entities progresses, the traditional classifications seem oversimplistic and do not reflect current understanding of this myriad of diseases and disease processes. Although our knowledge of the exact basis of many of the disease processes of cardiomyopathies is still in its infancy, it is important to have a classification system that has the ability to incorporate the coming tide of molecular and genetic information. This paper discusses how the traditional classification of cardiomyopathies based on morphology has evolved due to rapid advances in our understanding of the genetic and molecular basis for many of these clinical entities.

ՈՒՇԱԳՐԱՎ ԹԱՂՈՒՄ ԲՈՎԵՐ ԴԱՄԲԱՐԱՆԱԴԱՇՏՈՒՄ

2021 ◽  
pp. 255-263
Author(s):  
Ani Saratikyan
Keyword(s):  
Sea Level ◽  
The West ◽  
General Picture ◽  
Archaeological Material ◽  
Archaeological Materials ◽  
The Republic ◽  
Ethnographic Narratives

Bover cemetery is located in the middle of the villages of Shnogh and Teghut of the Lori region of the Republic of Armenia, to the west of the central part of Bover church, at an average altitude of 930 m above sea level. According to the results of excavations in 2012, it turned out that the tomb No. 45 is a cultburial tomb. A dog was buried in that partially damaged tomb (beginning of the 1st millennium BC). The contemporary archaeological material both from Armenia and the surrounding regions shows that such burials were typical of the mentioned period. The archaeological materials, are certainly linked to ethnographic narratives, which make it possible to draw up a general picture of this phenomenon.

Classification of Biological Sequences

Data Mining ◽  
2013 ◽  
pp. 1019-1042
Author(s):  
Pratibha Rani ◽  
Vikram Pudi
Keyword(s):  
Naive Bayes ◽  
Analysis Data ◽  
Naïve Bayes ◽  
Biological Data ◽  
Rapid Progress ◽  
Biological Data Analysis ◽  
Depth Analysis ◽  
Iterative Scaling ◽  
Mining Methods

The rapid progress of computational biology, biotechnology, and bioinformatics in the last two decades has led to the accumulation of tremendous amounts of biological data that demands in-depth analysis. Data mining methods have been applied successfully for analyzing this data. An important problem in biological data analysis is to classify a newly discovered sequence like a protein or DNA sequence based on their important features and functions, using the collection of available sequences. In this chapter, we study this problem and present two Bayesian classifiers RBNBC (Rani & Pudi, 2008a) and REBMEC (Rani & Pudi, 2008c). The algorithms used in these classifiers incorporate repeated occurrences of subsequences within each sequence (Rani, 2008). Specifically, Repeat Based Naive Bayes Classifier (RBNBC) uses a novel formulation of Naive Bayes, and the second classifier, Repeat Based Maximum Entropy Classifier (REBMEC) uses a novel framework based on the classical Generalized Iterative Scaling (GIS) algorithm.

Toward a Theory of International Services: Marketing Intangibles in a World of Nations

1996 ◽  
Vol 4 (2) ◽  
pp. 9-28 ◽  
Author(s):  
Terry Clark ◽  
Daniel Rajaratnam ◽  
Timothy Smith
Keyword(s):  
Theoretical Model ◽  
Services Marketing ◽  
Ongoing Debate ◽  
Strong Position ◽  
International Services

This article defines and describes international services from the marketing perspective. A classification of four types of international services is proposed, and a theoretical model of one of these (contact-based services) is developed. With a rich literature on the nature of services, marketing scholars are in a strong position to make valuable contributions to the ongoing debate concerning international services, which has until now been dominated by international economists and trade statisticians.

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